Menée en Ecosse à partir des données des registres des cancers et celui des hospitalisations, cette étude évalue le risque de cancer de l'œsophage chez une population ayant été hospitalisée pour des troubles de l'alimentation induits par des vomissements auto-provoqués

Risk of oesophageal cancer among patients previously hospitalised with eating disorder

Brewster, David H. ; Nowell, Siân L. ; Clark, David N.

Background : It has been suggested that the risk of oesophageal adenocarcinoma might be increased in patients with a history of eating disorders due to acidic damage to oesophageal mucosa caused by self-induced vomiting practiced as a method of weight control. Eating disorders have also been associated with risk factors for squamous cell carcinoma of the oesophagus, including alcohol use disorders, as well as smoking and nutritional deficiencies, which have been associated with both main [...]

A partir des données de la cohorte française E3N incluant 63 830 participantes, cette étude prospective évalue l'association entre une exposition aux dioxines contenues dans l'alimentation et le risque de cancer du sein

Estimated dietary dioxin exposure and breast cancer risk among women from the French E3N prospective cohort

Danjou, Aurelie ; Fervers, Beatrice ; Boutron-Ruault, Marie-Christine ; Philip, Thierry ; Clavel-Chapelon, Françoise ; Dossus, Laure

INTRODUCTION:Dioxins are environmental and persistent pollutants mostly emitted from combustion facilities (e.g. waste incinerators, metal and cement industries). Known to be endocrine disrupting chemicals, dioxins are suspected to increase breast cancer (BC) risk. Although diet is considered the primary source of dioxin exposure, no previous study has been published on dietary dioxin exposure in relation to BC risk. We aimed to assess dietary dioxin exposure among women from the E3N cohort and [...]

Menée aux Etats-Unis à partir des données de la cohorte "California Teachers Study" incluant 75 093 participantes, cette étude évalue l'association entre divers régimes alimentaires et le risque de cancer de l'endomètre (937 cas)

Dietary patterns and endometrial cancer risk in the California Teachers Study cohort

Canchola, AlisonJ ; Lacey, JamesV, Jr. ; Bernstein, Leslie ; Horn-Ross, PamelaL

Purpose : Information on the role of dietary patterns and endometrial cancer risk is limited. We investigated whether dietary patterns are associated with endometrial cancer risk among women in the California Teachers Study cohort. Methods : Among 75,093 eligible women, 937 developed invasive endometrial cancer between 1995 and 2011. Multivariate Cox regression was performed to estimate relative risks (RR) and 95 % confidence intervals (CI) associated with five dietary patterns identified by [...]

Menée aux Etats-Unis auprès de 2 342 salariés travaillant dans une industrie de production de terre de diatomée (un insecticide naturel à base de silice minérale), cette étude analyse l'association entre une exposition à de la silice cristalline, le risque de cancer du poumon, et la mortalité spécifique

Extended follow-up of lung cancer and non-malignant respiratory disease mortality among California diatomaceous earth workers

Gallagher, Lisa G ; Park, Robert M ; Checkoway, Harvey

Objectives : Millions of workers worldwide are employed in occupations involving potentiality hazardous exposure to crystalline silica. The diatomaceous earth industry can have particularly high exposures, but there is a lower likelihood of simultaneously occurring confounding exposures. We extended follow-up for diatomaceous earth industry workers previously studied for mortality. Methods : The cohort included 2342 white men who were employed for at least 1 year at a diatomaceous earth plant [...]

A partir des données de deux cohortes asiatiques "Yucheng" incluant 1 803 participants (830 hommes, 973 femmes) et "Yusho" incluant 1 664 participants (860 hommes, 804 femmes), cette méta-analyse évalue l'association entre une exposition accidentelle à de hautes doses de composés polychlorobiphényles et polychlorodibenzo-furanes et la mortalité par cancer

Mortality after exposure to polychlorinated biphenyls and polychlorinated dibenzofurans: A meta-analysis of two highly exposed cohorts

Li, Ming-Chieh ; Chen, Pau-Chung ; Tsai, Pei-Chien ; Furue, Masutaka ; Onozuka, Daisuke ; Hagihara, Akihito ; Uchi, Hiroshi ; Yoshimura, Takesumi ; Guo, Yue Leon

Both Yucheng and Yusho were events of accidental exposure to highly doses of polychlorinated biphenyls and dibenzofurans in Asian people. Mortality experiences caused by various diseases were reported in both cohorts with similar and dissimilar findings. We thus conducted a meta-analysis of two cohorts to reevaluate the effects of PCBs and PCDFs on major causes of mortalities. Two recently updated Yucheng and Yusho mortality studies were included. For selected diseases, standardized mortality [...]

Menée aux Etats-Unis à partir des données de la cohorte "The California Teachers Study" incluant 112 379 participantes, cette étude évalue l'association entre une exposition, sur leur lieu de résidence, à des perturbateurs endocriniens présents dans l'air ambiant et le risque de cancer du sein (5 361 cas)

Residential Exposure to Estrogen Disrupting Hazardous Air Pollutants and Breast Cancer Risk: The California Teachers Study

Liu, Ruiling ; Nelson, David O. ; Hurley, Susan ; Hertz, Andrew ; Reynolds, Peggy

Background: Some studies show increased breast cancer risk from exposure to xenoestrogens, but few have explored exposures via ambient air, which could impact large populations. Objectives: This study explored the association between breast cancer risk and residential exposures to ambient estrogen disruptors among participants in a large cohort study, the California Teachers Study. Methods: Participants consisted of 112,379 women free of breast cancer and living at a California address in [...]

Menée au Royaume-Uni à partir des données de la cohorte "Million Women Study" incluant 1, 3 million de participantes sur la période 1996-2001, cette étude évalue l'association entre des facteurs liés au mode de vie (tabagisme, vie célibataire ou en couple), des facteurs reproductifs (utilisation d'une contraception orale, nulliparité, ligature des trompes) et le risque de cancer anal (517 cas)

Lifestyle and reproductive risk factors associated with anal cancer in women aged over 50 years

Coffey, K. ; Beral, V. ; Green, J. ; Reeves, G. ; Barnes, I.

Background: Anal cancer incidence increases with age and is higher in women than men. Risk factors in this group other than high-risk human papillomavirus infection are unclear. Methods: In all, 1.3 million women were recruited in 1996–2001 and followed for incident anal cancer. Cox regression models were used to calculate relative risks (RRs) for anal cancer by various potential risk factors. Results: Five hundred and seventeen incident anal cancers were registered over 13 years of follow-up. [...]

A partir d'échantillons tumoraux prélevés sur un patient atteint de multiples paragangliomes malins, puis in vitro, cette étude de séquençage de l'exome entier identifie des mutations du gène MDH2 associées au risque familial de paragangliome

Whole-Exome Sequencing Identifies MDH2 as a New Familial Paraganglioma Gene

Cascón, Alberto ; Comino-Méndez, Iñaki ; Currás-Freixes, María ; de Cubas, Aguirre A. ; Contreras, Laura ; Richter, Susan ; Peitzsch, Mirko ; Mancikova, Veronika ; Inglada-Pérez, Lucía ; Pérez-Barrios, Andrés ; Calatayud, María ; Azriel, Sharona ; Villar-Vicente, Rosa ; Aller, Javier ; Setién, Fernando ; Moran, Sebastian ; Garcia, Juan F. ; Río-Machín, Ana ; Letón, Rocío ; Gómez-Graña, Álvaro ; Apellániz-Ruiz, María ; Roncador, Giovanna ; Esteller, Manel ; Rodríguez-Antona, Cristina ; Satrústegui, Jorgina ; Eisenhofer, Graeme ; Urioste, Miguel ; Robledo, Mercedes

Disruption of the Krebs cycle is a hallmark of cancer. IDH1 and IDH2 mutations are found in many neoplasms, and germline alterations in SDH genes and FH predispose to pheochromocytoma/paraganglioma and other cancers. We describe a paraganglioma family carrying a germline mutation in MDH2, which encodes a Krebs cycle enzyme. Whole-exome sequencing was applied to tumor DNA obtained from a man age 55 years diagnosed with multiple malignant paragangliomas. Data were analyzed with the two-sided [...]

Menée aux Etats-Unis auprès de 679 cas et 403 témoins, cette étude évalue l'association entre le niveau plasmatique de lipides et le risque d'adénome colorectal, en fonction de l'utilisation de médicaments à base de statines

Plasma lipid levels and colorectal adenoma risk

Coppola, John-Anthony ; Shrubsole, MarthaJ ; Cai, Qiuyin ; Smalley, WalterE ; Dai, Qi ; Ness, ReidM ; Fazio, Sergio ; Zheng, Wei ; Murff, HarveyJ

Purpose : Abnormalities in lipid levels have been associated with colorectal neoplasm risk; however, few studies have adjusted for use of cholesterol-lowering medications. The objective of this study was to determine the association of plasma lipid levels with adenoma risk while accounting for statin medication use. Methods : We included 254 subjects with advanced adenoma, 246 with single small adenoma, 179 with multiple small adenoma cases, and 403 control participants in the Tennessee [...]

A partir de données de quatre études menées aux Etats-Unis et au Japon (1 699 cas et 2 422 témoins), cette étude analyse l'association entre la densité mammaire, une histoire familiale de cancer du sein et le risque de cancer du sein chez une population blanche ou d'origine asiatique

Mammographic density and breast cancer risk by family history in women of white and Asian ancestry

Maskarinec, Gertraud ; Nakamura, KaylaeL ; Woolcott, ChristyG ; Conroy, ShannonM ; Byrne, Celia ; Nagata, Chisato ; Ursin, Giske ; Vachon, CelineM

Purpose : Mammographic density, i.e., the radiographic appearance of the breast, is a strong predictor of breast cancer risk. To determine whether the association of breast density with breast cancer is modified by a first-degree family history of breast cancer (FHBC) in women of white and Asian ancestry, we analyzed data from four case–control studies conducted in the USA and Japan. Methods : The study population included 1,699 breast cancer cases and 2,422 controls, of whom 45 % reported [...]