A partir d'une revue systématique de la littérature publiée entre 1994 et 2013, cette étude fait le point sur l'évolution de la qualité de prise en charge de la douleur liée au cancer

Quality of Cancer Pain Management: An Update of a Systematic Review of Undertreatment of Patients With Cancer

Greco, Maria Teresa ; Roberto, Anna ; Corli, Oscar ; Deandrea, Silvia ; Bandieri, Elena ; Cavuto, Silvio ; Apolone, Giovanni

Purpose : Pain is a frequent symptom in patients with cancer, with substantial impact. Despite the availability of opioids and updated guidelines from reliable leading societies, undertreatment is still frequent. Methods : We updated a systematic review published in 2008, which showed that according to the Pain Management Index (PMI), 43.4% of patients with cancer were undertreated. This review included observational and experimental studies reporting negative PMI scores for adults with cancer [...]

Menée en Australie par entretiens auprès de 10 patients atteints d'un cancer du poumon, cette étude qualitative analyse leurs préférences et leurs besoins en soins de support

Supportive care needs and preferences of lung cancer patients: a semi-structured qualitative interview study

Brown, NatashaM K. ; Lui, Chi-Wai ; Robinson, PeterC ; Boyle, FrancesM

Purpose : Lung cancer patients report both high levels of unmet supportive care need and underutilisation of support services, but the existing literature offers limited understanding of their specific needs and preferences for help. This study aimed to address this research gap through qualitative exploration of the supportive care needs and preferences of lung cancer patients. Methods : Semi-structured interviews were conducted with ten lung cancer patients recruited from the Chest Clinic, [...]

Menée en Australie par entretiens auprès de 17 patientes atteintes d'un cancer du sein et ayant pris du poids durant leur chimiothérapie, cette étude qualitative analyse leurs pratiques alimentaires et leurs besoins en soins de support et en information

Dietary experiences and support needs of women who gain weight following chemotherapy for breast cancer

Kwok, Alastair ; Palermo, Claire ; Boltong, Anna

Purpose : Weight gain is common but poorly understood in women receiving chemotherapy for breast cancer. Overweight and obesity are associated with other co-morbidities, reduced self-esteem and an increased risk of cancer recurrence. The purpose of this study was to explore the experiences, dietary information and support needs of women who gain weight during chemotherapy treatment. Methods : This study used a qualitative approach to explore the experiences of women from three Melbourne breast [...]

Menée au Royaume-Uni auprès de 126 survivantes d'un cancer du sein, cette étude analyse la faisabilité d'un programme de détection du lymphœdème lié au cancer durant l'année suivant le traitement chirurgical, puis compare les performances de deux méthodes de diagnostic

Prospective surveillance of breast cancer-related lymphoedema in the first-year post-surgery: feasibility and comparison of screening measures

Blaney, J. M. ; McCollum, G. ; Lorimer, J. ; Bradley, J. ; Kennedy, R. ; Rankin, J. P.

Purpose : To examine the feasibility of a breast cancer-related lymphoedema (BCRL) screening programme. Additionally, to investigate the efficacy of bioimpedance analysis (BIA) compared to circumferential measurements (CM) in detecting BCRL. Methods : This was a 12-month prospective feasibility study. Participants were recruited from two diagnostic breast clinics and consented to be screened for BCRL. Pre-surgical assessments were conducted, and participants were followed up at quarterly [...]

A partir d'une revue systématique de la littérature (20 études, 2 916 participants), cette étude analyse la prévalence d'un état de faiblesse chez les patients âgés atteints de cancer, puis évalue les relations entre cet état de faiblesse et les risques d'intolérance à la chimiothérapie, de complications post-opératoires ou de décès

The prevalence and outcomes of frailty in older cancer patients: a systematic review

Handforth, C. ; Clegg, A. ; Young, C. ; Simpkins, S. ; Seymour, M.T. ; Selby, P.J. ; Young, J.

Background : Frailty is a state of vulnerability to poor resolution of homeostasis following a stressor event, such as chemotherapy or cancer surgery. Better knowledge of the epidemiology of frailty could help drive a global cancer care strategy for older people. The aim of this review was to establish the prevalence and outcomes of frailty and pre-frailty in older cancer patients. Methods : Observational studies that reported data on the prevalence and/or outcomes of frailty in older cancer [...]

A partir des données de deux études de cohortes prospectives portant sur 1 006 patients atteints d'un cancer du pancréas diagnostiqué entre1986 et 2010, cette étude américaine analyse l'impact d'un diabète sur leur survie

Survival Among Patients With Pancreatic Cancer and Long-Standing or Recent-Onset Diabetes Mellitus

Yuan, Chen ; Rubinson, Douglas A. ; Qian, Zhi Rong ; Wu, Chen ; Kraft, Peter ; Bao, Ying ; Ogino, Shuji ; Ng, Kimmie ; Clancy, Thomas E. ; Swanson, Richard S. ; Gorman, Megan J. ; Brais, Lauren K. ; Li, Tingting ; Stampfer, Meir J. ; Hu, Frank B. ; Giovannucci, Edward L. ; Kulke, Matthew H. ; Fuchs, Charles S. ; Wolpin, Brian M.

Purpose : Long-standing diabetes is a risk factor for pancreatic cancer, and recent-onset diabetes in the several years before diagnosis is a consequence of subclinical pancreatic malignancy. However, the impact of diabetes on survival is largely unknown. Patients and Methods : We analyzed survival by diabetes status among 1,006 patients diagnosed from 1986 to 2010 from two prospective cohort studies: the Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS). We validated [...]

Menée à partir de données portant sur 2 799 patients atteints d'un cancer de la prostate traité par radiothérapie, cette étude évalue, en fonction du type de récidive biochimique déctectée, la mortalité toutes causes confondues, le taux de survie globale à 5 ans et le taux de métastases distantes

Impact of biochemical failure classification on clinical outcome: A secondary analysis of Radiation Therapy Oncology Group 9202 and 9413

Hamstra, Daniel A. ; Bae, Kyounghwa ; Hanks, Gerald ; Hu, Chen ; Shipley, William U. ; Pan, Charlie C. ; Roach, Mack ; Lawton, Colleen A. ; Sandler, Howard M.

BACKGROUND : Biochemical failure (BF) after radiation therapy is defined on the basis of a rising prostate-specific antigen (PSA) level (A1 failure) or any event that prompts the initiation of salvage androgen-deprivation therapy without PSA failure (A2). It was hypothesized that A2 failure may have a different prognosis. METHODS : Data for 2799 eligible patients from Radiation Therapy Oncology Group (RTOG) 9202 and RTOG 9413 were analyzed. BF was defined according to the 1997 American Society [...]

A partir des données des registres américains des cancers portant sur 69 718 patients atteints d'un cancer colorectal et âgés de plus de 66 ans, cette étude estime la fraction attribuable au dépistage précoce ou aux traitements dans l'amélioration observée de la survie

Relative impact of earlier diagnosis and improved treatment on survival for colorectal cancer: A US database study among elderly patients

Tong, Liyue ; Ahn, Chul ; Symanski, Elaine ; Lai, Dejian ; Du, Xianglin L.

Purposes : To estimate what proportion of improvement in relative survival was attributable to smaller stage/size due to early detection and what proportion was attributable to cancer chemotherapy in patients with colorectal cancer (CRC). Methods : We studied 69,718 patients with CRC aged ≥66 years in 1992–2009 from Surveillance, Epidemiology, and End Results registries. Study periods were categorized into three periods according to the major changes or advances in screening and chemotherapy [...]

Menée aux Etats-Unis à partir de données portant sur 3 651 patients atteints d'un carcinome à cellules rénales, cette étude analyse la pertinence des recommandations du "National Comprehensive Cancer Network" et de l'"American Urological Association" en matière de durée de suivi des patients pour prévenir le risque de récidive après un traitement chirurgical

Evaluation of the National Comprehensive Cancer Network and American Urological Association Renal Cell Carcinoma Surveillance Guidelines

Stewart, Suzanne B. ; Thompson, R. Houston ; Psutka, Sarah P. ; Cheville, John C. ; Lohse, Christine M. ; Boorjian, Stephen A. ; Leibovich, Bradley C.

Purpose : The National Comprehensive Cancer Network (NCCN) and American Urological Association (AUA) provide guidelines for surveillance after surgery for renal cell carcinoma (RCC). Herein, we assess the ability of the guidelines to capture RCC recurrences and determine the duration of surveillance required to capture 90%, 95%, and 100% of recurrences. Patients and Methods : We evaluated 3,651 patients who underwent surgery for M0 RCC between 1970 and 2008. Patients were stratified as AUA low [...]

Menée aux Etats-Unis auprès de 3 136 cas et 31 031 témoins, cette étude évalue l'association entre une maladie rénale chronique et le risque de carcinome à cellules rénales en fonction de l'appartenance ethnique

Chronic Kidney Disease and Risk of Renal Cell Carcinoma: Differences by Race

Hofmann, Jonathan N. ; Corley, Douglas A. ; Zhao, Wei K. ; Colt, Joanne S. ; Shuch, Brian ; Chow, Wong-Ho ; Purdue, Mark P.

Background: The incidence of renal cell carcinoma in the United States differs by race/ethnicity. To better understand these disparities, we conducted a nested case-control study investigating renal cell carcinoma risk factors across racial/ethnic groups within the Kaiser Permanente Northern California health care network. Methods: Our study included 3 136 renal cell carcinoma cases (2152 whites, 293 blacks, 425 Hispanics, and 255 Asians) diagnosed between 1998 and 2008 and 31 031 individually [...]

A partir des données du registre néerlandais des cancers, cette étude analyse l'évolution de l'incidence du cancer des glandes salivaires, ainsi que la mortalité et la survie, sur la période 1989-2010

An epidemiological evaluation of salivary gland cancer in the Netherlands (1989–2010)

de Ridder, Mischa ; Balm, Alfons J. M. ; Smeele, Ludi E. ; Wouters, Michel W. J. M. ; van Dijk, Boukje A. C.

Background : The relative 5-year survival rate of salivary gland cancer is moderate at best. This study was set up to evaluate whether the improvements in diagnosis and treatment in the last decades impacted the incidence, mortality and survival of salivary gland cancer. Methods : Data on patients with salivary gland cancer from 1989 through 2010 were extracted from the Netherlands Cancer Registry (NCR); we examined incidence, mortality and relative survival. Furthermore, information on sex, [...]

A partir d'une revue sytématique de la littérature publiée entre 1990 et 2012 (116 études), cette méta-analyse évalue l'association entre des symptômes de stress post-traumatique (dépression, anxiété, etc) et la croissance post-traumatique chez des patients atteints de cancer

Correlates of post-traumatic stress symptoms and growth in cancer patients: a systematic review and meta-analysis

Shand, Lyndel K. ; Cowlishaw, Sean ; Brooker, Joanne E. ; Burney, Sue ; Ricciardelli, Lina A.

Objective : The aim of this study is to examine the relationships among demographic, medical, and psychosocial factors and post-traumatic stress symptoms (PTSS) and post-traumatic growth (PTG) in oncology populations. Method :A systematic search identified k = 116 relevant studies published between 1990 and 2012. Meta-analyses synthesized results from studies that reported data on correlates of PTSS (k = 26) or PTG (k = 48). A meta-analysis was performed for k = 5 studies reporting the [...]

Menée aux Etats-Unis auprès de 628 patients atteints d'un cancer de stade avancé et de 9 282 témoins en population générale, cette étude évalue l'association entre un cancer de stade avancé et le risque d'épisodes dépressifs majeurs

Advanced cancer as a risk for major depressive episodes

Meyer, Fremonta ; Fletcher, Kalen ; Prigerson, Holly G. ; Braun, Ilana M. ; Maciejewski, Paul K.

Objective : Major depression adversely affects health communication, quality of life, and survival in patients with advanced cancer. Prior research provides limited insight into how patients with advanced cancer differ from the general population in risk for developing a major depressive episode (MDE). This study aims to determine whether advanced cancer poses distinct risks for initial and recurrent MDEs. Methods : Advanced cancer patients (N = 628) from Coping with Cancer were compared with [...]

Mené aux Etats-Unis par questionnaire auprès de 337 participantes, cet essai randomisé analyse l'efficacité d'une intervention de soutien psychologique par téléphone pour réduire la détresse de femmes porteuses d'une mutation BRCA1 ou BRCA2

Randomized Controlled Trial of a Telephone-Based Peer-Support Program for Women Carrying a BRCA1 or BRCA2 Mutation: Impact on Psychological Distress

White, Victoria M. ; Young, Mary-Anne ; Farrelly, Ashley ; Meiser, Bettina ; Jefford, Michael ; Williamson, Elizabeth ; Ieropoli, Sandra ; Duffy, Jessica ; Winship, Ingrid

Purpose : To assess the effectiveness of a telephone-based peer-delivered intervention in reducing distress among women with a BRCA1 or BRCA2 gene mutation. The intervention involved trained peer volunteers contacting women multiple times over a 4-month period to provide informational, emotional, and practical support. Methods : Three hundred thirty-seven participants completed the baseline questionnaire, and those reporting interest in talking to other mutation carriers were randomly assigned [...]

Mené aux Etats-Unis auprès de 184 survivantes d'un cancer du sein ayant fait état de symptômes anxieux ou dépressifs, cet essai compare l'efficacité de deux programmes de soutien social en ligne

Comparing Standard Versus Prosocial Internet Support Groups for Patients With Breast Cancer: A Randomized Controlled Trial of the Helper Therapy Principle

Lepore, Stephen J. ; Buzaglo, Joanne S. ; Lieberman, Morton A. ; Golant, Mitch ; Greener, Judith R. ; Davey, Adam

Purpose : Internet support group (ISG) members benefit from receiving social support and, according to the helper therapy principle, by providing support to others. To test the mental health benefits of providing support to others, this trial compared the efficacy of a standard ISG (S-ISG) and an enhanced prosocial ISG (P-ISG). Methods : A two-armed randomized controlled trial with 1-month pretest and post-test assessments was conducted with women (N = 184) diagnosed in the past 36 months with [...]

Menée aux Etats-Unis par enquête auprès de 1 196 survivants à long terme d'un cancer, cette étude analyse les disparités ethniques dans la communication entre le patient et son soignant, dans leurs perceptions relatives à la qualité des soins et dans leurs sentiments d'auto-efficacité

Racial and Ethnic Disparities in Patient-Provider Communication, Quality-of-Care Ratings, and Patient Activation Among Long-Term Cancer Survivors

Palmer, Nynikka R.A. ; Kent, Erin E. ; Forsythe, Laura P. ; Arora, Neeraj K. ; Rowland, Julia H. ; Aziz, Noreen M. ; Blanch-Hartigan, Danielle ; Oakley-Girvan, Ingrid ; Hamilton, Ann S. ; Weaver, Kathryn E.

Purpose : We examined racial and ethnic disparities in patient-provider communication (PPC), perceived care quality, and patient activation among long-term cancer survivors. Methods : In 2005 to 2006, survivors of breast, prostate, colorectal, ovarian, and endometrial cancers completed a mailed survey on cancer follow-up care. African American, Asian/Pacific Islander (Asian), Hispanic, and non-Hispanic white (white) survivors who had seen a physician for follow-up care in the past 2 years (n = [...]

Menée aux Etats-Unis par enquête auprès de 1 000 oncologues, cette étude analyse leurs connaissances et leurs pratiques relatives à l'usage de médecines complémentaires (extraits de plantes, supplémentation) par leurs patients

National Survey of US Oncologists' Knowledge, Attitudes, and Practice Patterns Regarding Herb and Supplement Use by Patients With Cancer

Lee, Richard T. ; Barbo, Andrea ; Lopez, Gabriel ; Melhem-Bertrandt, Amal ; Lin, Heather ; Olopade, Olufunmilayo I. ; Curlin, Farr A.

Purpose : Patients with cancer commonly use complementary and alternative medicine, including herbs and supplements (HS), during cancer treatment. This national survey explored oncologists' knowledge, attitudes, and practice patterns regarding HS use by their patients. Methods : A survey was sent by mail and e-mail to a random sample of 1,000 members of the American Society for Clinical Oncology. The questions covered several topics: communication patterns, attitudes about HS, education about [...]