Menée en Italie auprès de 75 patients atteints de cancer, cette étude prospective évalue l'efficacité à long terme du fentanyl administré par voie nasale pour prendre en charge un accès douloureux paroxystique

Long-term efficacy and tolerability of intranasal fentanyl in the treatment of breakthrough cancer pain

Mercadante, Sebastiano ; Vellucci, Renato ; Cuomo, Arturo ; Adile, Claudio ; Cortegiani, Andrea ; Valle, Alessandro ; Villari, Patrizia ; Casuccio, Alessandra

Purpose : The aim of the present study was to assess the long-term tolerability and efficacy of intranasal fentanyl (INFS) in opioid-tolerant patients with breakthrough cancer pain (BTP). Patients and methods : A 6 months, observational, prospective, cohort study design was employed to follow advanced cancer patients with BTP receiving INFS under routine clinical practice. Eligible adult cancer patients suffering from BTP had been prescribed INFS at effective doses. Data were collected at T0 [...]

A partir d'une revue systématique de la littérature (11 études qualitatives), cette étude évalue l'intérêt des parcours de soins personnalisés après le cancer

Cancer survivors’ experiences of using survivorship care plans: a systematic review of qualitative studies

Keesing, Sharon ; McNamara, Beverley ; Rosenwax, Lorna

Purpose : Cancer survivorship care plans (SCPs) are currently used in care settings to assist survivors during the transition from treatment to survivorship. In this paper, the experiences of cancer survivors are examined to provide their perspective of how survivorship care plans are used in practice. Methods : A systematic review and critical review of the qualitative literature regarding the experiences of cancer survivors using survivorship care plans was completed. Databases reviewed [...]

Menée auprès de 1 469 patients en surpoids ou obèses et atteints d'un cancer métastatique, cette étude internationale évalue l'efficacité d'un outil permettant d'évaluer le risque de malnutrition et leurs besoins de prise en charge

Nutritional assessment in overweight and obese patients with metastatic cancer: Does it make sense?

Gioulbasanis, I. ; Martin, L. ; Baracos, V. E. ; Thezenas, S. ; Koinis, F. ; Senesse, P.

Background : Obesity is causally related with tumor development and, thus, many cancer patients are overweight or obese at diagnosis. Whether these patients need regular nutritional assessment is not known. In the present study we evaluated the utility of Mini Nutritional Assessment (MNA), a nutritional screening/assessment questionnaire, in overweight or obese patients with metastatic tumors. Patients and Methods : Overweight or obese patients referred for initiation of systemic therapy in 3 [...]

Menée en Argentine auprès de 123 patients atteints d'un cancer traité à l'aide d'une greffe de cellules souches hématopoïétiques, cette étude prospective analyse l'évolution de leur statut nutritionnel à trois moments différents (lors de leur admission dans l'unité hospitalière de transplantation, à leur sortie de l'hôpital et lors du suivi)

Evolution of nutritional status in patients with autologous and allogeneic hematopoietic stem cell transplant

de Defranchi, RominaL Barritta ; Bordalejo, Andrea ; Cañueto, Inés ; Villar, Angeles ; Navarro, Elizabet

Purpose : To describe the nutritional status in patients undergoing hematopoietic stem cell transplant (HSCT) in three different defined moments: at admission to the Bone Marrow Transplant Unit (BMTU), at discharge from the BMTU and at follow-up. We hypothesized that nutrition status declines during hospitalization and recovers at follow-up. Methods : Prospective cohort study. Nutritional status was determined using the patient-generated subjective global assessment (PG-SGA) at three different [...]

Menée aux Etats-Unis auprès de 832 survivants à long terme d'un cancer du poumon ou d'un cancer colorectal diagnostiqué entre 2003 et 2005, cette étude analyse l'efficacité d'un parcours personnalisé de soins après le cancer

Survivorship care planning and its influence on long-term patient-reported outcomes among colorectal and lung cancer survivors: the CanCORS disease-free survivor follow-up study

Chrischilles, ElizabethA ; McDowell, BradleyD ; Rubenstein, Linda ; Charlton, Mary ; Pendergast, Jane ; Juarez, GreldaYazmin ; Arora, NeerajK

Purpose : This study aims to evaluate the relationship between survivorship care planning (SCP) and survivorship care and health outcomes reported by long-term lung and colorectal cancer survivors. Methods : Participants (n = 832) were diagnosed and enrolled during 2003–2005. In 2012, patient-reported outcomes (survivorship care and health outcomes) and two patient-reported SCP measures (receipt of written summary of cancer treatment and receipt of instructions on who to see for routine cancer [...]

A partir des données de la cohorte française "Leucémies de l'Enfant et de l'Adolescent", cette étude cas-témoins analyse la qualité de vie des frères et soeurs de survivants d'une leucémie pédiatrique (durée moyenne de suivi après le diagnostic : 8,8 ans)

Quality of life in minor siblings of childhood leukemia survivors, long-term after diagnosis: A LEA study (for Leucemies de l'Enfant et de l'Adolescent—childhood and adolescent leukemia)

Berbis, Julie ; Oudin, Claire ; Alessandrini, Marine ; Vercasson, Camille ; Barlogis, Vincent ; Chambost, Hervé ; Michel, Gérard ; Auquier, Pascal

Objective : The objectives of this study are to assess the quality of life (QoL) of siblings of childhood leukemia survivors in comparison with population controls and to identify determinants of sibling's QoL. Method: s The nearest-aged siblings (8–17 years) of minor CLS participating in the French LEA cohort (Childhood and Adolescent Leukemia), at the Marseilles center, were included. Siblings' QoL was self-reported using the ‘Vécu et Santé Perçue de l'Adolescent et l'enfant’ questionnaire. [...]

A partir des données de l'essai randomisé "AFFIRM " portant sur 938 patients atteints d'un cancer métastatique de la prostate résistant à la castration, cette étude évalue les effets de l'enzalutamide sur leur qualité de vie après une chimiothérapie

Impact of enzalutamide on quality of life in men with metastatic castration-resistant prostate cancer after chemotherapy: additional analyses from the AFFIRM randomized clinical trial

Cella, D. ; Ivanescu, C. ; Holmstrom, S. ; Bui, C. N. ; Spalding, J. ; Fizazi, K.

Background : To present longitudinal changes in Functional Assessment of Cancer Therapy–Prostate (FACT-P) scores during 25-week treatment with enzalutamide or placebo in men with progressive metastatic castration-resistant prostate cancer (mCRPC) after chemotherapy in the AFFIRM trial. Patients and methods : Patients were randomly assigned to enzalutamide 160 mg/day or placebo. FACT-P was completed prior to randomization, at weeks 13, 17, 21, and 25, and every 12 weeks thereafter while on study [...]

A partir d'une revue systématique de la littérature, cette étude analyse l'association entre le docétaxel et le risque d'œdème chez des patientes atteintes d'un cancer du sein

The effect of docetaxel on developing oedema in patients with breast cancer: a systematic review

Hugenholtz-Wamsteker, W. ; Robbeson, C. ; Nijs, J. ; Hoelen, W. ; Meeus, M.

Docetaxel is extensively used in chemotherapy for the treatment of breast cancer. Little attention has been given to oedema as a possible side effect of docetaxel-containing therapies. Until now, no review was conducted to evaluate docetaxel-containing therapies versus docetaxel-free therapies on the magnitude of the risk of developing oedema. In this systematic review, we investigated the risk of developing oedema in patients being treated for breast cancer with or without docetaxel. In this [...]

Menée en Italie auprès de 2 784 patients atteints d'une leucémie myéloïde chronique, cette étude analyse les caractéristiques de la maladie (incidence, agressivité) selon l'âge des patients (jeunes adultes, adultes, personnes âgées)

Differences among young adults, adults, and elderly chronic myeloid leukemia patients

Castagnetti, F. ; Gugliotta, G. ; Baccarani, M. ; Breccia, M. ; Specchia, G. ; Levato, L. ; Abruzzese, E. ; Rossi, G. ; Iurlo, A. ; Martino, B. ; Pregno, P. ; Stagno, F. ; Cuneo, A. ; Bonifacio, M. ; Gobbi, M. ; Russo, D. ; Gozzini, A. ; Tiribelli, M. ; de Vivo, A. ; Alimena, G. ; Cavo, M. ; Martinelli, G. ; Pane, F. ; Saglio, G. ; Rosti, G.

Background : The incidence of chronic myeloid leukemia (CML) increases with age, but it is unclear how the characteristics of the disease vary with age. In children, where CML is very rare, it presents with more aggressive features, including huge splenomegaly, higher cell count and higher blast cell percentage. Patients and methods : To investigate if after childhood the disease maintains or loses these characteristics of aggressiveness, we analysed 2784 adult patients, at least 18 years old, [...]

Menée en Italie à partir de données portant sur 1 372 survivants d'un mélanome de stade I-II et sans récidive depuis au moins 10 ans, cette étude rétrospective analyse les facteurs associés à un risque de métastases à long terme

Risk factors related to late metastases in 1,372 melanoma patients disease free more than 10 years

Osella-Abate, Simona ; Ribero, Simone ; Sanlorenzo, Martina ; Maule, Milena Maria ; Richiardi, Lorenzo ; Merletti, Franco ; Tomasini, Carlo ; Marra, Elena ; Macripò, Giuseppe ; Fierro, Maria Teresa ; Quaglino, Pietro

In many centers, Stage I–II melanoma patients are considered “cured” after 10 years of disease-free survival and follow-up visits are interrupted. However, melanoma may relapse also later. We retrospectively analyzed a cohort of 1,372 Stage I–II melanoma patients who were disease-free 10 years after diagnosis. The aim of this study was to characterize patients who experienced a late recurrence and to compare them to those who remained disease-free to identify possible predictive factors. [...]

Menée au Danemark à partir de données portant sur 1 206 survivants d'un cancer des cellules germinales, cette étude de cohorte analyse le risque à long terme de déficiences du système rénal et de maladies cardiovasculaires associées à une chimothérapie par bléomycine-étoposide-cisplatine

Renal impairment and late toxicity in germ cell cancer survivors

Lauritsen, J. ; Mortensen, M. S. ; Kier, M. G. G. ; Christensen, I. J. ; Agerbaek, M. ; Gupta, R. ; Daugaard, G.

Background : Treatment with bleomycin-etoposide-cisplatin (BEP) impairs renal function and increases the risk of late cardiovascular disease (CVD) and death. We investigated the influence of BEP on glomerular filtration rate (GFR) and assessed the importance of GFR changes on CVD and death in a large cohort of germ cell cancer survivors. Patients and methods : BEP-treated patients (N=1,206) were identified in the Danish DaTeCa database, and merged with national registers to identify late [...]

Menée au Royaume-Uni auprès de 2 956 patientes âgées de moins de 40 ans lors d'un diagnostic de cancer du sein, cette étude prospective évalue l'association entre l'obésité et la survie des patientes

Obesity and the outcome of young breast cancer patients in the UK: the POSH study

Copson, E.R. ; Cutress, R.I. ; Maishman, T. ; Eccles, B.K. ; Gerty, S. ; Stanton, L. ; Altman, D.G. ; Durcan, L. ; Wong, C. ; Simmonds, P.D. ; Jones, L. ; POSH Study Steering Group ; Eccles, D.M.

Background : Obese breast cancer patients have a poorer prognosis than non-obese patients. We examined data from a large prospective cohort study to explore the associations of obesity with tumour pathology, treatment and outcome in young British breast cancer patients receiving modern oncological treatments. Patients and Methods : 2956 patients aged ≤40 at breast cancer diagnosis were recruited from 126 UK hospitals from 2001-2007. Height and weight were measured at registration. Tumour [...]

Menée aux Etats-Unis auprès de 279 patientes atteintes d'un cancer du col de l'utérus (âge médian : 49 ans), cette étude analyse les morbidités associées à une hydronéphrose ainsi que la survie des patientes

Hydronephrosis in patients with cervical cancer: an assessment of morbidity and survival

Patel, Krishna ; Foster, NathanR ; Kumar, Amanika ; Grudem, Megan ; Longenbach, Sherri ; Bakkum-Gamez, Jamie ; Haddock, Michael ; Dowdy, Sean ; Jatoi, Aminah

Purpose : Hydronephrosis is a frequently observed but understudied complication in patients with cervical cancer. To better characterize hydronephrosis in cervical cancer patients, the current study sought (1) to describe hydronephrosis-associated morbidity and (2) to analyze the prognostic effect of hydronephrosis in patients with a broad range of cancer stages over time. Methods : The Mayo Clinic Tumor Registry was interrogated for all invasive cervical cancer patients seen at the Mayo Clinic [...]

Menée aux Etats-Unis et portant sur 422 patients atteints d'un carcinome épidermoïde de la tête et du cou de stade avancé, cette étude prospective analyse l'évolution de la survie des patients, selon la localisation de la maladie dans l'oropharynx ou non, sur la période 1993-2010

Comparison of outcomes of locoregionally advanced oropharyngeal and non-oropharyngeal squamous cell carcinoma over two decades

Das, L. C. ; Karrison, T. G. ; Witt, M. E. ; Muller, C. ; Stenson, K. ; Blair, E. A. ; Cohen, E. E. W. ; Seiwert, T. Y. ; Haraf, D. J. ; Vokes, E. E.

Background : Human papillomavirus (HPV) has emerged as a causative agent and positive prognostic factor for oropharyngeal (OP) head and neck squamous cell cancer (HNSCC). This prompts inquiry into whether therapy improvements or increasing incidence of HPV drives the apparent improvements in HNSCC outcomes observed in non-randomized clinical trials. Patients and Methods : We reviewed all locoregionally advanced HNSCC patients treated with chemotherapy and radiation in prospective institutional [...]

Menée aux Etats-Unis à partir de données 2010 portant sur 3 550 survivants d'un cancer âgés de plus de 18 ans et sur 26 917 adultes sans histoire de cancer, cette étude analyse la prévalence d'une dépression en relation avec le cancer et identifie les facteurs associés

Current depression among adult cancer survivors: Findings from the 2010 Behavioral Risk Factor Surveillance System

Zhao, Guixiang ; Okoro, Catherine A. ; Li, Jun ; White, Arica ; Dhingra, Satvinder ; Li, Chaoyang

Background : A cancer diagnosis and subsequent treatments constitute a significantly increased psychological burden among cancer patients. This study examined the prevalence of current depression and the risk factors associated with a high burden of depression among cancer survivors in the US. Methods : We analyzed data from 3 550 cancer survivors (aged ≥18 years) and 26,917 adults without cancer who participated in the 2010 Behavioral Risk Factor Surveillance System. Depressive symptoms were [...]

Menée en Australie par enquête auprès de 386 patients atteints d'un mélanome cutané invasif de stade IB-II, cette étude analyse leurs symptômes d'anxiété, de dépression, leur qualité de vie ainsi que leurs besoins en soins de support

Supportive care needs, anxiety, depression and quality of life amongst newly diagnosed patients with localised invasive cutaneous melanoma in Queensland, Australia

Beesley, Vanessa L. ; Smithers, B. Mark ; Khosrotehrani, Kiarash ; Khatun, Mohsina ; O'Rourke, Peter ; Hughes, Maria Celia B. ; Malt, Maryrose K. ; Zonta, Mark J. ; Bayley, Gerard J. ; Barbour, Andrew P. ; Brown, Lee J. ; D'Arcy, Justin ; Allan, Christopher P. ; Green, Adèle C.

Objective : The aim of this paper is to determine levels of supportive care needs, anxiety, depression and symptoms amongst patients newly diagnosed with localised invasive primary melanoma and if these varied amongst patients who had a sentinel lymph node biopsy (SLNB). We also considered quality of life compared with general population norms. Methods : Patients newly diagnosed with clinical stage IB-II invasive melanoma were ascertained through Queensland hospitals, specialist clinics and [...]

Menée aux Etats-Unis auprès de 7 patientes atteintes d'un cancer du sein (âge compris entre 42 et 59 ans), cette étude analyse leurs façons de faire face aux changements cognitifs consécutifs à une chimiothérapie

The experience of cognitive change in women with breast cancer following chemotherapy

Kanaskie, MaryLouise ; Loeb, SusanJ

Purpose : Change in cognitive function is one side effect of chemotherapy reported in some breast cancer survivors sometimes years after treatment. These symptoms include subtle changes in memory, concentration, and executive functioning. The purpose of this study was to uncover the meaning of cognitive change in women with breast cancer, how symptoms are experienced and become evident, how symptoms impact roles in personal and professional lives, and how women cope with these changes. Methods [...]

Menée en Allemagne auprès de 154 conjoints de patients atteints d'un cancer des voies aérodigestives supérieures et ayant subi une laryngectomie totale, cette étude analyse leur détresse psychologique et leurs besoins en soins de support psychosocial

Psychological distress and need for psycho-oncological support in spouses of total laryngectomised cancer patients—results for the first 3 years after surgery

Meyer, A. ; Keszte, J. ; Wollbrück, D. ; Dietz, A. ; Oeken, J. ; Vogel, H. J. ; Koscielny, S. ; Breitenstein, K. ; Meister, E. F. ; Pabst, F. ; Schock, J. ; Bourkas, S. ; Singer, S.

Purpose : A total laryngectomy (TLE) leads to a variety of functional restrictions, which reduce the quality of life of cancer patients as well as their spouses. However, to date, there is little research focusing on the psychological distress of spouses of total laryngectomised cancer patients. The current study assesses psychological distress, need for psycho-oncological treatment and use of professional psychological care among spouses of total laryngectomised cancer patients. Methods : A [...]

Menée en Allemagne par entretiens auprès de 12 médecins et de 6 infirmières, cette étude qualitative analyse leurs difficultés à aborder le sujet des soins palliatifs suffisamment tôt avec leurs patients en fin de vie

What Keeps Oncologists From Addressing Palliative Care Early on With Incurable Cancer Patients? An Active Stance Seems Key

Pfeil, Timo A. ; Laryionava, Katsiaryna ; Reiter-Theil, Stella ; Hiddemann, Wolfgang ; Winkler, Eva C.

Background : Sympathetic and frank communication about the terminal nature of advanced cancer is important to improve patients’ prognostic understanding and, thereby, to allow for adjustment of treatment intensity to realistic goals; however, decisions against aggressive treatments are often made only when death is imminent. This qualitative study explores the factors that hinder such communication and reconstructs how physicians and nurses in oncology perceive their roles in preparing patients [...]

Cet article passe en revue les défis dans le recrutement de médecins et de scientifiques pour mener des études en recherche translationnelle sur les cancers

How will we recruit, train, and retain physicians and scientists to conduct translational cancer research?

Pickering, Curtis R. ; Bast, Robert C. ; Keyomarsi, Khandan

Advances in clinical medicine require effective translational research. Ideally, this research will be performed by multidisciplinary teams that include both physicians and basic scientists. However, the current system does not appropriately train either physicians or basic scientists for these careers. In addition, translational researchers are often not properly rewarded, and this creates a disincentive for pursuing this kind of research. The roles and challenges for physicians and basic [...]

Menée en Espagne, cette étude analyse le nombre de cas de cancers liés à l'amiante ayant bénéficié d'une reconnaissance en maladie professionnelle entre 1978 et 2011

Asbestos-related occupational cancers compensated under the Spanish National Insurance System, 1978–2011

Garcia-Gomez, Montserrat ; Menendez-Navarro, Alfredo ; López, Rosario Castañeda

Background: In 1978, asbestos-related occupational cancers were added to the Spanish list of occupational diseases. However, there are no full accounts of compensated cases since their inclusion. Objective:To analyze the cases of asbestos-related cancer recognized as occupational in Spain between 1978 and 2011. Methods:Cases were obtained from the Spanish Employment Ministry. Specific incidence rates by year, economic activity, and occupation were obtained. We compared mortality rates of [...]