Menée aux Etats-Unis par enquête auprès de 300 participants, cette étude analyse les modalités d'utilisation et de mise à disposition des médicaments opioïdes pour les patients atteints de cancer et traités à l'extérieur de l'hôpital

Patterns of Storage, Use, and Disposal of Opioids Among Cancer Outpatients

Reddy, Akhila ; de la Cruz, Maxine ; Rodriguez, Eden Mae ; Thames, Jessica ; Wu, Jimin ; Chisholm, Gary ; Liu, Diane ; Frisbee-Hume, Susan ; Yennurajalingam, Sriram ; Hui, David ; Cantu, Hilda ; Marin, Alejandra ; Gayle, Vicki ; Shinn, Nancy ; Xu, Angela ; Williams, Janet ; Bruera, Eduardo

Purpose : Improper storage, use, and disposal of prescribed opioids can lead to diversion or accidental poisoning. Our objective was to determine the patterns of storage, utilization, and disposal of opioids among cancer outpatients. Patients and Methods : We surveyed 300 adult cancer outpatients receiving opioids in our supportive care center and collected information regarding opioid use, storage, and disposal, along with scores on the CAGE (cut down, annoyed, guilty, eye-opener) alcoholism [...]

Menée aux Etats-Unis auprès de 1 544 patientes atteintes d'un cancer du sein et 718 patients atteints d'un cancer colorectal, cette étude prospective analyse la prévalence, la nature et le degré de sévérité des symptômes selon l'âge des patients (avant et après 40 ans)

Symptom burden among young adults with breast or colorectal cancer

Sanford, Stacy D. ; Zhao, Fengmin ; Salsman, John M. ; Chang, Victor T. ; Wagner, Lynne I. ; Fisch, Michael J.

BACKGROUND Cancer incidence has increased among young adults (YAs) and survival rates have not improved compared with other age groups. Patient-reported outcomes may enhance our understanding of this vulnerable population. METHODS In a multisite prospective study, patients completed a cancer symptom inventory at the time of enrollment (T1) and 4 weeks to 5 weeks later (T2). YAs (those aged ≤ 39 years) with breast or colorectal cancer were compared with older adults (those aged ≥ 40 years) with [...]

Menée en Belgique auprès de 34 cas et de 17 témoins à l'aide d'une IRM fonctionnelle, cette étude met en évidence des modifications de l'activité cérébrale chez les patientes rapportant des troubles cognitifs après une chimiothérapie

Longitudinal Assessment of Chemotherapy-Induced Alterations in Brain Activation During Multitasking and Its Relation With Cognitive Complaints

Deprez, Sabine ; Vandenbulcke, Mathieu ; Peeters, Ronald ; Emsell, Louise ; Smeets, Ann ; Christiaens, Marie-Rose ; Amant, Frederic ; Sunaert, Stefan

Purpose : To examine whether cognitive complaints after treatment for breast cancer are associated with detectable changes in brain activity during multitasking. Patients and Methods : Eighteen patients who were scheduled to receive chemotherapy performed a functional magnetic resonance imaging multitasking task in the scanner before the start of treatment (t1) and 4 to 6 months after finishing treatment (t2). Sixteen patients who were not scheduled to receive chemotherapy and 17 matched [...]

A partir des données des registres américains des cancers, cette étude analyse, pour l'année 2014, le nombre de survivants d'un cancer, par âge et par localisation, les traitements reçus ainsi que les besoins en soins de support, puis présente des projections pour l'année 2024

Cancer treatment and survivorship statistics, 2014

DeSantis, Carol E. ; Lin, Chun Chieh ; Mariotto, Angela B. ; Siegel, Rebecca L. ; Stein, Kevin D. ; Kramer, Joan L. ; Alteri, Rick ; Robbins, Anthony S. ; Jemal, Ahmedin

The number of cancer survivors continues to increase due to the aging and growth of the population and improvements in early detection and treatment. In order for the public health community to better serve these survivors, the American Cancer Society and the National Cancer Institute collaborated to estimate the number of current and future cancer survivors using data from the Surveillance, Epidemiology, and End Results (SEER) program registries. In addition, current treatment patterns for the [...]

Menée aux Etats-Unis à partir de données portant sur quelque 3 millions de cas de cancer diagnostiqué entre 2005 et 2009, cette étude analyse l'association entre le statut socioéconomique du lieu de résidence et le risque de cancer (39 types différents)

The relationship between area poverty rate and site-specific cancer incidence in the United States

Boscoe, Francis P. ; Johnson, Christopher J. ; Sherman, Recinda L. ; Stinchcomb, David G. ; Lin, Ge ; Henry, Kevin A.

BACKGROUND The relationship between socioeconomic status and cancer incidence in the United States has not traditionally been a focus of population-based cancer surveillance systems. METHODS Nearly 3 million tumors diagnosed between 2005 and 2009 from 16 states plus Los Angeles were assigned into 1 of 4 groupings based on the poverty rate of the residential census tract at time of diagnosis. The sex-specific risk ratio of the highest-to-lowest poverty category was measured using Poisson [...]

A partir des données des registres américains des cancers portant sur la période 1973-2010, cette étude de cohorte analyse l'évolution de l'incidence du lymphome hodgkinien chez les adultes âgés de 20 à 44 ans, en fonction du sexe de l'individu

Different time trends by gender for the incidence of Hodgkin’s lymphoma among young adults in the USA: a birth cohort phenomenon

Zhu, Cairong ; Bassig, BryanA ; Shi, Kunchong ; Boyle, Peter ; Guo, Huan ; Zheng, Tongzhang

Objectives : Hodgkin’s lymphoma (HL) is one of the most common cancers among young adults. We investigated the time trends for HL among the 20–44 age group in the USA by gender to identify the potential factors accounting for the incidence trends. Methods : Using data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results program for 1973–2010, we conducted age–period–cohort modeling to evaluate birth cohort patterns on incidence trends of HL over time. Results : For [...]

Menée aux Etats-Unis auprès de 160 survivants d'un mélanome, cette étude analyse leurs comportements de santé, notamment en matière de protection solaire, leurs symptômes à long terme et leurs besoins en soins de support

Health behaviors and needs of melanoma survivors

Palesh, Oxana ; Aldridge-Gerry, Arianna ; Bugos, Kelly ; Pickham, David ; Chen, JieJane ; Greco, Ralph ; Swetter, SusanM

Purpose : Little is known about melanoma survivors’ long-term symptoms, sun protection practices, and support needs from health providers. Methods : Melanoma survivors treated at Stanford Cancer Center from 1995 through 2011 were invited to complete a heath needs survey. We compared responses of survivors by sex, education, time since diagnosis (long-term vs. short-term survivors), and extent of treatment received (wide local excision (WLE) alone versus WLE plus additional surgical or medical [...]

A partir des données du registre spécialisé des cancers de Basse-Normandie portant sur la période 1997-2005, cette étude analyse l'évolution de l'incidence des gammapathies monoclonales de signification indéterminée, un état précancéreux associé au risque de myélome multiple, ainsi que la survie des patients

Epidemiology of Monoclonal Gammopathy of Undetermined Significance (MGUS): The experience from the specialized registry of hematologic malignancies of Basse-Normandie (France)

Cabrera, Quentin ; Macro, Margaret ; Hebert, Benedikte ; Cornet, Edouard ; Collignon, Albert ; Troussard, Xavier

Multiple myeloma (MM) is the third most common haematologic malignancy in European countries, and is usually preceded by Monoclonal Gammopathy of Undetermined Significance (MGUS). Therefore epidemiologic studies of MGUS are very limited in a population-based status. Here we report all new cases of MGUS exhaustively recorded by the Basse-Normandie Regional Registry for Hematologic Malignancies (a French region registry) between January 1997 and December 2005, and analyze outcome of patients [...]

Menée au Royaume-Uni, cette étude cas-témoins analyse l'évolution de l'incidence du carcinome basocellulaire sur la période 2000-2011, puis identifie les facteurs de risque et les comorbidités associés

Epidemiology of basal cell carcinoma in the United Kingdom: incidence, lifestyle factors, and comorbidities

Reinau, D. ; Surber, C. ; Jick, S. S. ; Meier, C. R.

Background: Little is known about the epidemiology of basal cell carcinoma (BCC). Methods: Using the Clinical Practice Research Datalink, we calculated annual incidence rates. In a case–control analysis, we examined lifestyle factors and comorbidities. Results: Incidence rose significantly between 2000 and 2011. Basal cell carcinoma risk was increased in alcohol drinkers (slightly) and immunocompromised patients, but reduced in smokers and individuals with abnormal weight. Conclusions:Basal [...]

Menée en Suède sur une cohorte de patients atteints d'un cancer non métastatique de la prostate entre 2000 et 2010, cette étude rétrospective analyse la survenue de métastases après un traitement anti-androgénique et évalue la survie des patients

Survival and clinical metastases among prostate cancer patients treated with androgen deprivation therapy in Sweden

Banefelt, J. ; Liede, A. ; Mesterton, J. ; Stålhammar, J. ; Hernandez, R. K. ; Sobocki, P. ; Persson, B. E.

Objectives : To examine the incidence of metastases and clinical course of prostate cancer patients who are without confirmed metastasis when initiating androgen deprivation therapy (ADT). Methods : Retrospective cohort study conducted using electronic medical records from Swedish outpatient urology clinics linked to national mandatory registries to capture medical and demographic data. Prostate cancer patients initiating ADT between 2000 and 2010 were followed from initiation of ADT to [...]

A partir des données d'une base nationale portant sur 10 197 patientes atteintes d'un cancer inflammatoire du sein, cette étude américaine analyse les facteurs associés à une sous-utilisation d'un traitement combinant chimiothérapie, chirurgie et radiothérapie, puis évalue son impact sur la survie

Underuse of Trimodality Treatment Affects Survival for Patients With Inflammatory Breast Cancer: An Analysis of Treatment and Survival Trends From the National Cancer Database

Rueth, Natasha M. ; Lin, Heather Y. ; Bedrosian, Isabelle ; Shaitelman, Simona F. ; Ueno, Naoto T. ; Shen, Yu ; Babiera, Gildy

Purpose : To analyze factors that predict the use of trimodality treatment (chemotherapy, surgery, and radiation therapy [RT]) and evaluate the impact that trimodality treatment use has on survival for patients with inflammatory breast cancer (IBC). Methods : Using the National Cancer Data Base, patients who underwent surgical treatment of nonmetastatic IBC from 1998 to 2010 were identified. We collected demographic, tumor, and treatment data and analyzed treatment and survival trends over [...]

A partir des données des registres américains des cancers portant sur 3 567 patientes atteintes d'un cancer du sein de stade précoce et âgées de plus de 65 ans, cette étude analyse le risque d'hospitalisations liées à divers protocoles de chimiothérapie

Risk of Hospitalization According to Chemotherapy Regimen in Early-Stage Breast Cancer

Barcenas, Carlos H. ; Niu, Jiangong ; Zhang, Ning ; Zhang, Yufeng ; Buchholz, Thomas A. ; Elting, Linda S. ; Hortobagyi, Gabriel N. ; Smith, Benjamin D. ; Giordano, Sharon H.

Purpose : To compare the risk of hospitalization between patients with early-stage breast cancer who received different chemotherapy regimens. Patient and Methods : We identified 3,567 patients older than age 65 years from the SEER/Texas Cancer Registry-Medicare database and 9,327 patients younger than age 65 years from the MarketScan database who were diagnosed with early-stage breast cancer between 2003 and 2007. The selection was nonrandomized and nonprospectively collected. We categorized [...]

Menée au Canada auprès de 28 176 patientes atteintes d'un cancer du sein et ayant subi une mastectomie, cette étude de cohorte rétrospective évalue leur recours immédiat à une reconstruction mammaire et analyse les facteurs liés au système de soins influençant leurs décisions

Barriers to Immediate Breast Reconstruction in the Canadian Universal Health Care System

Zhong, Toni ; Fernandes, Kimberly A. ; Saskin, Refik ; Sutradhar, Rinku ; Platt, Jennica ; Beber, Brett A. ; Novak, Christine B. ; McCready, David R. ; Hofer, Stefan O.P. ; Irish, Jonathan C. ; Baxter, Nancy N.

Purpose : To describe the population-based rates of immediate breast reconstruction (IBR) for all women undergoing mastectomy for treatment or prophylaxis of breast cancer in the past decade, and to evaluate geographic, institutional, and patient factors that influence use in the publically funded Canadian health care system. Methods : This population-based retrospective cohort study used administrative data that included 28,176 women who underwent mastectomy (25,141 mastectomy alone and 3,035 [...]

Menée aux Etats-Unis auprès de 67 survivants d'un cancer de la prostate, cette étude met en évidence un lien entre des difficultés cognitives, une moindre capacité à affronter l'incertitude et la survenue, à long terme, de symptômes de détresse liés au cancer

Intolerance of uncertainty, cognitive complaints, and cancer-related distress in prostate cancer survivors

Eisenberg, Stacy A. ; Kurita, Keiko ; Taylor-Ford, Megan ; Agus, David B. ; Gross, Mitchell E. ; Meyerowitz, Beth E.

Objective : Prostate cancer survivors have reported cognitive complaints following treatment, and these difficulties may be associated with survivors' ongoing cancer-related distress. Intolerance of uncertainty may exacerbate this hypothesized relationship by predisposing individuals to approach uncertain situations such as cancer survivorship in an inflexible and negative manner.We investigated whether greater cognitive complaints and higher intolerance of uncertainty would interact in their [...]

Menée aux Etats-Unis auprès de 937 patients atteints d'un cancer colorectal, cette étude analyse les coûts des complications post-opératoires à la charge des patients

The personal financial burden of complications after colorectal cancer surgery

Regenbogen, Scott E. ; Veenstra, Christine M. ; Hawley, Sarah T. ; Banerjee, Mousumi ; Ward, Kevin C. ; Kato, Ikuko ; Morris, Arden M.

BACKGROUND Patients with colorectal cancer (CRC) may suffer significant economic hardship during treatment. Complications are common after surgery for CRC and may exacerbate the financial burden of CRC even further. METHODS Within a population-based survey of patients with stage III CRC, the authors investigated the effects of disease and treatment on personal finances and computed a composite measure of financial burden. Correlations were examined between components of financial burden and [...]