A partir des données de la cohorte "Nurses' Health Study II" incluant 108 916 participantes, cette étude américaine évalue l'association entre une exposition solaire tout au long de la vie et le risque de cancer de la peau

Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study

Wu, Shaowei ; Han, Jiali ; Laden, Francine ; Qureshi, Abrar A.

Background: Few prospective studies have examined the relationship between sun exposure, other potential risk factors, and risk of different skin cancers [including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma] simultaneously. Methods: We evaluated the association between a number of potential risk factors and skin cancer risk in a cohort of 108,916 US women, the Nurses' Health Study II (1989–2009). Results: During 2.05 million years of follow-up, we identified 6,955, [...]

Menée en Argentine à partir de 75 échantillons tumoraux prélevés sur des patients atteints d'un lymphome diffus à grandes cellules B, cette étude évalue la prévalence du virus d'Epstein-Barr en fonction de l'âge des patients

Epstein-Barr virus-positive diffuse large B-cell lymphoma association is not only restricted to elderly patients

Cohen, M. ; Narbaitz, M. ; Metrebian, F. ; Matteo, E. De ; Preciado, M. V. ; Chabay, P. A.

Diffuse large B-cell lymphoma (DLBCL), the most common group of malignant lymphomas, account for 30% of adult non-Hodgkin lymphomas. The 2008 World Health Organization (WHO) classification included a new entity, Epstein-Barr virus (EBV)+ DLBCL of the elderly, affecting patients aged 50 years or older. However, some reports of younger EBV+ DLBCL cases, without evidence of underlying immunosuppression, can be found. The role of EBV in tumor microenvironment composition in DLBCL is still not well [...]

Menée sur des échantillons tumoraux inclus en paraffine et provenant de 24 pays différents, cette étude analyse la prévalence d'une infection par le papillomavirus humain, par sous-type histologique, dans les cancers de l'anus

Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide

Alemany, Laia ; Saunier, Maëlle ; Alvarado-Cabrero, Isabel ; Quirós, Beatriz ; Salmeron, Jorge ; Shin, Hai-Rim ; Pirog, Edyta C. ; Guimerà, Núria ; Hernandez-Suarez, Gustavo ; Felix, Ana ; Clavero, Omar ; Lloveras, Belen ; Kasamatsu, Elena ; Goodman, Marc T. ; Hernandez, Brenda Y. ; Laco, Jan ; Tinoco, Leopoldo ; Geraets, Daan T. ; Lynch, Charles F. ; Mandys, Vaclav ; Poljak, Mario ; Jach, Robert ; Verge, Josep ; Clavel, Christine ; Ndiaye, Cathy ; Klaustermeier, JoEllen ; Cubilla, Antonio ; Castellsagué, Xavier ; Bravo, Ignacio G. ; Pawlita, Michael ; Quint, William G. ; Muñoz, Nubia ; Bosch, Francesc X. ; de Sanjose, Silvia ; on behalf of the, H. P. V. Vvap Study Group

Knowledge about human papillomaviruses (HPV) types involved in anal cancers in some world regions is scanty. Here, we describe the HPV DNA prevalence and type distribution in a series of invasive anal cancers and anal intraepithelial neoplasias (AIN) grades 2/3 from 24 countries. We analyzed 43 AIN 2/3 cases and 496 anal cancers diagnosed from 1986 to 2011. After histopathological evaluation of formalin-fixed paraffin-embedded samples, HPV DNA detection and genotyping was performed using [...]

A partir des données de la cohorte "NHANES" incluant 164 patients et 93 partenaires de vie, cette étude analyse les facteurs associés au risque d'infection orale par le papillomavirus humain et au risque de cancer chez les partenaires de vie de patients atteints d'un cancer de l'oropharynx lié à une infection

Oral Human Papillomavirus (HPV) Infection in HPV-Positive Patients With Oropharyngeal Cancer and Their Partners

D’Souza, Gypsyamber ; Gross, Neil D. ; Pai, Sara I. ; Haddad, Robert ; Anderson, Karen S. ; Rajan, Shirani ; Gerber, Jennifer ; Gillison, Maura L. ; Posner, Marshall R.

Purpose : To better understand oral human papillomavirus (HPV) infection and cancer risk among long-term sexual partners of patients with HPV-positive oropharyngeal cancer (HPV-OPC). Patients and Methods: An oral rinse sample, risk factor survey, cancer history, and oral examination (partners only) were collected from patients with HPV-OPC and their partners. Oral rinse samples were evaluated for 36 types of HPV DNA using PGMY 09/11 primers and line-blot hybridization and HPV16 copy number [...]

A partir d'une revue systématique de la littérature (28 956 cas et 28 372 témoins), cette méta-analyse évalue l'association entre un polymorphisme du gène RAD51 et le risque de cancer

Genetic 135G/C polymorphism of RAD51 gene and risk of cancer: a meta-analysis of 28,956 cases and 28,372 controls

Zhang, Bei-bei ; Wang, Dao-gang ; Xuan, Chao ; Sun, Gui-li ; Deng, Kai-feng

The RAD51 gene is essential for the repair of damaged DNA related to tumor development. Although a number of genetic studies have attempted to link the 135G/C polymorphism of RAD51 gene to the risk of cancer, the results were inconclusive. The present study aimed at investigating the pooled association using the more comprehensive meta-analysis. The PubMed, EBSCO, and BIOSIS databases were searched to identify eligible studies which were published in English before March 2014. Data were [...]

A partir de données portant sur un total de 21 594 cas de cancer du poumon et 54 156 témoins, cette étude identifie deux variants rares des gènes BRCA2 et CHEK2 associés à un risque de cancer épidermoïde du poumon

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Wang, Yufei ; McKay, James D. ; Rafnar, Thorunn ; Wang, Zhaoming ; Timofeeva, Maria N. ; Broderick, Peter ; Zong, Xuchen ; Laplana, Marina ; Wei, Yongyue ; Han, Younghun ; Lloyd, Amy ; Delahaye-Sourdeix, Manon ; Chubb, Daniel ; Gaborieau, Valérie ; Wheeler, William ; Chatterjee, Nilanjan ; Thorleifsson, Gudmar ; Sulem, Patrick ; Liu, Geoffrey ; Kaaks, Rudolf ; Henrion, Marc ; Kinnersley, Ben ; Vallee, Maxime ; LeCalvez-Kelm, Florence ; Stevens, Victoria L. ; Gapstur, Susan M. ; Chen, Wei V. ; Zaridze, David ; Szeszenia-Dabrowska, Neonilia ; Lissowska, Jolanta ; Rudnai, Peter ; Fabianova, Eleonora ; Mates, Dana ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Krokan, Hans E. ; Gabrielsen, Maiken Elvestad ; Skorpen, Frank ; Vatten, Lars ; Njolstad, Inger ; Chen, Chu ; Goodman, Gary ; Benhamou, Simone ; Vooder, Tonu ; Valk, Kristjan ; Nelis, Mari ; Metspalu, Andres ; Lener, Marcin ; Lubinski, Jan ; Johansson, Mattias ; Vineis, Paolo ; Agudo, Antonio ; Clavel-Chapelon, Françoise ; Bueno-de-Mesquita, H. Bas ; Trichopoulos, Dimitrios ; Khaw, Kay-Tee ; Johansson, Mikael ; Weiderpass, Elisabete ; Tjonneland, Anne ; Riboli, Elio ; Lathrop, Mark ; Scelo, Ghislaine ; Albanes, Demetrius ; Caporaso, Neil E. ; Ye, Yuanqing ; Gu, Jian ; Wu, Xifeng ; Spitz, Margaret R. ; Dienemann, Hendrik ; Rosenberger, Albert ; Su, Li ; Matakidou, Athena ; Eisen, Timothy ; Stefansson, Kari ; Risch, Angela ; Chanock, Stephen J. ; Christiani, David C. ; Hung, Rayjean J. ; Brennan, Paul ; Landi, Maria Teresa ; Houlston, Richard S. ; Amos, Christopher I.

We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and 38,295 controls for follow-up. We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10−20) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10−13). We also [...]

Menée aux Etats-Unis auprès de 887 hommes ayant subi une biopsie initiale de la prostate et ayant un même accès aux soins médicaux, cette étude de cohorte multiethnique évalue l'association entre l'appartenance ethnique et le risque de cancer de la prostate

The association between race and prostate cancer risk on initial biopsy in an equal access, multiethnic cohort

Gaines, AlexisR ; Turner, ElizabethL ; Moorman, PatriciaG ; Freedland, StephenJ ; Keto, ChristopherJ ; McPhail, MeganE ; Grant, DeloresJ ; Vidal, AdrianaC ; Hoyo, Cathrine

Purpose : Population-based studies have established a link between race and prostate cancer (PC) risk, but whether race predicts PC after adjusting for clinical characteristics is unclear. We investigated the association between race and risk of low- and high-grade PC in men undergoing initial prostate biopsy in an equal access medical center. Methods : We conducted a retrospective record review of 887 men (48.6 % black, 51.4 % white) from the Durham Veterans Affairs Medical Center who [...]

A partir des données du registre danois des cancers portant sur 125 208 participants nés entre 1930 et 1969, cette étude de cohorte évalue l'association entre l'indice de masse corporelle pendant l'enfance et le risque ultérieur de cancer de la prostate

Childhood body mass index and the risk of prostate cancer in adult men

Aarestrup, J. ; Gamborg, M. ; Cook, M. B. ; Sorensen, T. I. A. ; Baker, J. L.

Background: Prostate cancer aetiology is poorly understood. It may have origins early in life; previously we found a positive association with childhood height. The effects of early life body mass index (BMI; kg m−2) on prostate cancer remain equivocal. We investigated if childhood BMI, independently and adjusted for height, is positively associated with adult prostate cancer. Methods: Subjects were a cohort of 125 208 boys formed from the Copenhagen School Health Records Register, born [...]

Menée aux Etats-Unis auprès de 1 078 cas et 781 témoins, cette étude évalue l'association entre des polymorphismes à simple nucléotide impliqués dans le risque de cancer colorectal et le risque de polypes colorectaux, en fonction de leur type histologique (adénomes, polypes dentelés)

Variation in the Association Between Colorectal Cancer Susceptibility Loci and Colorectal Polyps by Polyp Type

Burnett-Hartman, Andrea N. ; Newcomb, Polly A. ; Hutter, Carolyn M. ; Peters, Ulrike ; Passarelli, Michael N. ; Schwartz, Malaika R. ; Upton, Melissa P. ; Zhu, Lee-Ching ; Potter, John D. ; Makar, Karen W.

We conducted a case-control study of the association between subsets of colorectal polyps, including adenomas and serrated polyps, and single-nucleotide polymorphisms (SNPs) related to colorectal cancer through prior genome-wide association studies (GWAS). Participants were enrollees in the Group Health Cooperative (Seattle, Washington) aged 24–79 years who received a colonoscopy from 1998 to 2007, donated a buccal or blood sample, and completed a structured questionnaire. We performed [...]

Menée en Chine auprès de 226 cas et 270 témoins, cette étude évalue l'association entre des polymorphismes du gène IL23R et le risque de cancer de la vessie

Association of interleukin-23 receptor gene polymorphisms with risk of bladder cancer in Chinese

Tang, Tielong ; Xue, Hui ; Cui, Shu ; Gong, Zhiyong ; Fei, Zhonghai ; Cheng, Shulin ; Gui, Chunyan

To assess whether polymorphisms of the interleukin-23 receptor (IL23R) gene are associated with bladder transitional cell carcinoma because chronic inflammation contributes to bladder cancer and the IL23R is known to be critically involved in the carcinogenesis of various malignant tumors. 226 patients with bladder cancer and 270 age-matched controls were involved in the study. Polymerase chain reaction–restriction fragment length polymorphism was used for genotyping. Genotype distribution and [...]