A partir d'une revue systématique de la littérature (50 études), cette méta-analyse évalue l'association entre la mastication de bétel pratiquée en Asie et le risque de cancers buccaux et de l'oropharynx

Betel quid chewing and the risk of oral and oropharyngeal cancers: A meta-analysis with implications for cancer control

Guha, Neela ; Warnakulasuriya, Saman ; Vlaanderen, Jelle ; Straif, Kurt

We conducted a random-effects meta-analysis of 50 publications assessing the relationship between oral/oropharyngeal cancer and chewing betel quid, with (BQ+T) or without added tobacco (BQ-T), a common practice in many parts of Asia and globally among Asian immigrants. Exposure-response, by daily amount and years of BQ chewed, was assessed using spline models. Attributable fractions (PAF%) were calculated to estimate the public health impact if BQ were no longer chewed. The meta-relative risk [...]

A partir des données de deux registres américains des cancers et d'une cohorte constituée de 9 027 salariés travaillant dans l'industrie chimique, cette étude analyse l'association entre une exposition professionnelle à du perfluorooctanoate d'ammonium, le risque de cancer et la mortalité spécifique

Mortality and cancer incidence in ammonium perfluorooctanoate production workers

Raleigh, Katherine K ; Alexander, Bruce H ; Olsen, Geary W ; Ramachandran, Gurumurthy ; Morey, Sandy Z ; Church, Timothy R ; Logan, Perry W ; Scott, Laura L F ; Allen, Elizabeth M

Objective : To evaluate mortality and cancer incidence in a cohort of ammonium perfluorooctanoate (APFO) exposed workers. Methods : We linked a combined cohort (n=9027) of employees from APFO and non-APFO production facilities in Minnesota to the National Death Index and to cancer registries of Minnesota and Wisconsin. Industrial hygiene data and expert evaluation were used to create a task-based job exposure matrix to estimate APFO exposure. Standardised mortality ratios were estimated using [...]

Menée en Suède auprès de 17 035 participantes, cette étude de cohorte prospective évalue l'association entre des facteurs reproductifs (âge à la naissance du premier enfant, utilisation d'une contraception orale,...) et le risque d'un cancer du sein en fonction du statut du récepteur aux androgènes

Age at first childbirth and oral contraceptive use are associated with risk of androgen receptor-negative breast cancer: the Malmö Diet and Cancer Cohort

Elebro, Karin ; Butt, Salma ; Dorkhan, Mozhgan ; Jernström, Helena ; Borgquist, Signe

Purpose : Risk factors for breast cancer vary according to breast cancer subtype. This study analyzes the impact of potential risk factors in breast cancer by androgen receptor (AR) status. Methods : A total of 17,035 women were followed in the population-based prospective Malmö Diet and Cancer Study. Baseline data included lifestyle factors including anthropometry, reproductive history, and exogenous hormone use. During follow-up (mean: 12.8 years), 747 invasive breast cancers were diagnosed. [...]

Menée in vitro et à partir d'échantillons sériques prélevés sur 190 patients, cette étude suggère qu'une infection chronique par le parasite Trichomonas vaginalis favorise le développement et la progression d'un cancer de la prostate

Trichomonas vaginalis homolog of macrophage migration inhibitory factor induces prostate cell growth, invasiveness, and inflammatory responses

Twu, Olivia ; Dessí, Daniele ; Vu, Anh ; Mercer, Frances ; Stevens, Grant C. ; de Miguel, Natalia ; Rappelli, Paola ; Cocco, Anna Rita ; Clubb, Robert T. ; Fiori, Pier Luigi ; Johnson, Patricia J.

The human-infective parasite Trichomonas vaginalis causes the most prevalent nonviral sexually transmitted infection worldwide. Infections in men may result in colonization of the prostate and are correlated with increased risk of aggressive prostate cancer. We have found that T. vaginalis secretes a protein, T. vaginalis macrophage migration inhibitory factor (TvMIF), that is 47% similar to human macrophage migration inhibitory factor (HuMIF), a proinflammatory cytokine. Because HuMIF is [...]

Menée aux Etats-Unis auprès de 322 cas et de 322 témoins, cette étude évalue l'association entre des caractéristiques maternelles (nombre de visites prénatales, anémie, saignements anormaux durant la grossesse, etc), des caractéristiques de la naissance (poids de l'enfant à la naissance, naissance avant terme, mode de délivrance) et le risque de rhabdomyosarcome chez l'enfant

Maternal and birth characteristics and childhood rhabdomyosarcoma: a report from the Children’s Oncology Group

Lupo, PhilipJ ; Danysh, HeatherE ; Skapek, StephenX ; Hawkins, DouglasS ; Spector, LoganG ; Zhou, Renke ; Okcu, M. Fatih ; Papworth, Karin ; Erhardt, ErikB ; Grufferman, Seymour

Purpose : previous assessments of childhood rhabdomyosarcoma have indicated maternal and birth characteristics may be associated with tumor development; however, much work remains to identify novel and confirm suspected risk factors. Our objective was to evaluate the associations between maternal and birth characteristics and childhood rhabdomyosarcoma. Methods : This case–control study included 322 cases and 322 pair-matched controls. Cases were enrolled in a trial run by the Intergroup [...]

A partir des données de la cohorte européenne EPIC portant sur 205 723 participantes, cette étude évalue l'association entre des changements de poids au milieu de l'âge adulte (40-50 ans) et le risque de cancer du sein

Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study

Emaus, Marleen J. ; van Gils, Carla H. ; Bakker, Marije F. ; Bisschop, Charlotte N. Steins ; Monninkhof, Evelyn M. ; Bueno-de-Mesquita, H. Bas ; Travier, Noemie ; Berentzen, Tina Landsvig ; Overvad, Kim ; Tjønneland, Anne ; Romieu, Isabelle ; Rinaldi, Sabina ; Chajès, Veronique ; Gunter, Marc J. ; Clavel-Chapelon, Françoise ; Fagherazzi, Guy ; Mesrine, Sylvie ; Chang-Claude, Jenny ; Kaaks, Rudolf ; Boeing, Heiner ; Aleksandrova, Krasimira ; Trichopoulou, Antonia ; Naska, Androniki ; Orfanos, Philippos ; Palli, Domenico ; Agnoli, Claudia ; Tumino, Rosario ; Vineis, Paolo ; Mattiello, Amalia ; Braaten, Tonje ; Borch, Kristin Benjaminsen ; Lund, Eiliv ; Menéndez, Virginia ; Sánchez, María-José ; Navarro, Carmen ; Barricarte, Aurelio ; Amiano, Pilar ; Sund, Malin ; Andersson, Anne ; Borgquist, Signe ; Olsson, Åsa ; Khaw, Kay-Tee ; Wareham, Nick ; Travis, Ruth C. ; Riboli, Elio ; Peeters, Petra H. M. ; May, Anne M.

Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40–50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition [...]

A partir des données agrégées issues de cinq études prospectives incluant plus de 800 000 participants, cette étude américaine analyse la faisabilité de diverses méthodes d'estimation des facteurs de risque de seconds cancers

Pooling prospective studies to investigate the etiology of second cancers

Black, Amanda ; Gibson, Todd M. ; Shiels, Meredith S. ; Park, Yikyung ; Robien, Kim ; Albanes, Demetrius ; Weinstein, Stephanie J. ; Beane Freeman, Laura E. ; Andreotti, Gabriella ; Purdue, Mark P. ; Fraumeni, Joseph F. ; Hartge, Patricia ; Tucker, Margaret A. ; Hoover, Robert N. ; Cerhan, James R. ; Zeleniuch-Jacquotte, Anne ; Curtis, Rochelle E. ; Elena, Joanne ; Sampson, Joshua N. ; Berrington de Gonzalez, Amy ; Morton, Lindsay M.

Background: With over 13 million cancer survivors in the United States today, second cancers are of rapidly growing importance. However, data on non-treatment risk factors for second cancers are sparse. We explored the feasibility of pooling data from cohort studies of cancer incidence to investigate second cancer etiology. Methods: We combined data from five prospective studies including more than 800,000 individuals. We compared study designs and populations; evaluated availability of and [...]