Menée aux Etats-Unis, cette étude de cohorte évalue l'association entre l'utilisation de substances diurétiques et le risque de carcinome basocellulaire

Prescription diuretic use and risk of basal cell carcinoma in the nationwide U.S. Radiologic Technologists cohort

McDonald, Emily C. ; Freedman, D. Michal ; Alexander, Bruce ; Doody, Michele M. ; Tucker, Margaret A. ; Linet, Martha S. ; Cahoon, Elizabeth K.

Background:Ultraviolet radiation (UVR) exposure is the primary risk factor for basal cell carcinoma (BCC). While prescription diuretics have photosensitizing properties, the relationship between diuretic use and BCC remains unclear. Methods:Using data from the United States Radiologic Technologists Study, a large, nationwide prospective cohort, we assessed the relationship between diuretic use and first primary BCC while accounting for sun exposure history, constitutional characteristics, [...]

Menée en Corée auprès de 62 171 participants ayant subi une coloscopie de dépistage, cette étude transversale analyse les facteurs associés au risque de développer des tumeurs neuro-endocrines rectales

Risk Factors Associated with Rectal Neuroendocrine Tumors: A Cross-Sectional Study

Jung, Yoon Suk ; Yun, Kyung Eun ; Chang, Yoosoo ; Ryu, Seungho ; Park, Jung Ho ; Kim, Hong Joo ; Cho, Yong Kyun ; Sohn, Chong Il ; Jeon, Woo Kyu ; Kim, Byung Ik ; Park, Dong Il

Background: The incidence of rectal neuroendocrine tumors (NETs) has been increasing since the implementation of the screening colonoscopy. However, very little is known about risk factors associated with rectal NETs. We examined the prevalence of and the risk factors for rectal NETs in a Korean population. Methods: A cross-sectional study was performed on 62,171 Koreans who underwent screening colonoscopy. The clinical characteristics and serum biochemical parameters of subjects with rectal [...]

Menée en France auprès de 447 cas (diagnostiqués entre 2004 et 2006) et de 892 témoins, cette étude multicentrique analyse l'association entre l'utilisation de la téléphonie mobile et le risque de tumeurs cérébrales, gliomes et méningiomes

Mobile phone use and brain tumours in the CERENAT case-control study

Coureau, Gaelle ; Bouvier, Ghislaine ; Lebailly, Pierre ; Fabbro-Peray, Pascale ; Gruber, Anne ; Leffondre, Karen ; Guillamo, Jean-Sebastien ; Loiseau, Hugues ; Mathoulin-Pelissier, Simone ; Salamon, Roger ; Baldi, Isabelle

The carcinogenic effect of radiofrequency electromagnetic fields in humans remains controversial. However, it has been suggested that they could be involved in the aetiology of some types of brain tumours. Objectives : The objective was to analyse the association between mobile phone exposure and primary central nervous system tumours (gliomas and meningiomas) in adults. Methods : CERENAT is a multicenter case-control study carried out in four areas in France in 2004–2006. Data about mobile [...]

A partir des données de la cohorte européenne EPIC et portant sur 464 cas et 464 témoins, cette étude évalue l'association entre la longueur des télomères des leucocytes et le risque de lymphome à grandes cellules B

Prediagnostic telomere length and risk of B-cell lymphoma—Results from the EPIC cohort study

Hosnijeh, Fatemeh Saberi ; Matullo, Giuseppe ; Russo, Alessia ; Guarrera, Simonetta ; Modica, Federica ; Nieters, Alexandra ; Overvad, Kim ; Guldberg, Per ; Tjønneland, Anne ; Canzian, Federico ; Boeing, Heiner ; Aleksandrova, Krasimira ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Tagliabue, Giovanna ; Tumino, Rosario ; Panico, Salvatore ; Palli, Domenico ; Olsen, Karina Standahl ; Weiderpass, Elisabete ; Dorronsoro, Miren ; Ardanaz, Eva ; Chirlaque, María-Dolores ; Sánchez, María-José ; Quirós, J. Ramón ; Venceslá, Adoración ; Melin, Beatrice ; Johansson, Ann Sofie ; Nilsson, Peter ; Borgquist, Signe ; Peeters, Petra H. ; Onland-Moret, N. Charlotte ; Bueno-de-Mesquita, H. Bas ; Travis, Ruth C. ; Khaw, Kay-Tee ; Wareham, Nick ; Brennan, Paul ; Ferrari, Pietro ; Gunter, Marc J. ; Vineis, Paolo ; Vermeulen, Roel

Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case–control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA [...]

A partir des données de la cohorte "Nordic Twin Study of Cancer" incluant 18 680 paires de jumeaux monozygotes et 30 054 paires de jumeaux dizygotes masculins, cette étude analyse les facteurs génétiques impliqués dans le développement du cancer de la prostate

The Heritability of Prostate Cancer in the Nordic Twin Study of Cancer

Hjelmborg, Jacob B. ; Scheike, Thomas ; Holst, Klaus ; Skytthe, Axel ; Penney, Kathryn L. ; Graff, Rebecca E. ; Pukkala, Eero ; Christensen, Kaare ; Adami, Hans-Olov ; Holm, Niels V. ; Nuttall, Elizabeth ; Hansen, Steinbjorn ; Hartman, Mikael ; Czene, Kamila ; Harris, Jennifer R. ; Kaprio, Jaakko ; Mucci, Lorelei A.

Background: Prostate cancer is thought to be the most heritable cancer, although little is known about how this genetic contribution varies across age. Methods: To address this question, we undertook the world's largest prospective study in the Nordic Twin Study of Cancer cohort, including 18,680 monozygotic and 30,054 dizygotic same sex male twin pairs. We incorporated time-to-event analyses to estimate the risk concordance and heritability while accounting for censoring and competing risks of [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2013 (44 articles identifiés), cette méta-analyse identifie un ensemble de facteurs susceptibles de modifier le risque de cancer du sein associé à une mutation constitutionnelle du gène BRCA1 ou BRCA2

Modifiers of Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: Systematic Review and Meta-Analysis

Friebel, Tara M. ; Domchek, Susan M. ; Rebbeck, Timothy R.

Background : There is substantial variability in cancer risk in women who have inherited a BRCA1 or BRCA2 (BRCA1/2) mutation. Numerous factors have been hypothesized to modify these risks, but studies are of variable quality, and it remains unclear which of these may be of value in clinical risk assessment. Methods : PubMed and Web of Science databases were searched for articles published through September 2013. Fixed effects meta-analysis was done using the hazard ratios and/or odds ratios to [...]

A partir des données de la cohorte "NIH-AARP Diet and Health Study" incluant 190 872 femmes ménopausées âgées de 50 à 71 ans, cette étude américaine analyse les facteurs de risque de cancer du sein en fonction de différentes tranches d'âge (de 50 à 59 ans, de 60 à 69 ans et au-delà de 70 ans)

Breast cancer risk in older women: results from the NIH-AARP Diet and Health Study

Brinton, LouiseA ; Smith, Llewellyn ; Gierach, GretchenL ; Pfeiffer, RuthM ; Nyante, SarahJ ; Sherman, MarkE ; Park, Yikyung ; Hollenbeck, AlbertR ; Dallal, CherM

Background : Divergent risk factors exist for premenopausal and postmenopausal breast cancers, but it is unclear whether differences by age exist among postmenopausal women. Methods : We examined relationships among 190,872 postmenopausal women, ages 50–71 years recruited during 1995–1996 for the NIH-AARP Diet and Health Study, in whom 7,384 incident invasive breast carcinomas were identified through 2006. Multivariable Cox regression hazard ratios (HRs) and 95 % confidence intervals (CIs) were [...]

Menée aux Etats-Unis auprès de 228 cas et 82 témoins, cette étude analyse les interactions entre un polymorphisme à simple nucléotide du gène JAZF1, une exposition professionnelle ou domestique au plomb et le risque de cancer de la prostate chez des hommes afro-américains

Gene–environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men

Neslund-Dudas, Christine ; Levin, AlbertM ; Beebe-Dimmer, JenniferL ; Bock, CathrynH ; Nock, NoraL ; Rundle, Andrew ; Jankowski, Michelle ; Krajenta, Richard ; Dou, Q. Ping ; Mitra, Bharati ; Tang, Deliang ; Rebbeck, TimothyR ; Rybicki, BenjaminA

Purpose : A single nucleotide polymorphism, rs10486567, in JAZF1 has consistently been associated with increased risk of prostate cancer. The physical interaction of zinc finger proteins, such as JAZF1, with heavy metals may play a role in carcinogenesis. This study assessed potential gene–environment statistical interactions (G×E) between rs10486567 and heavy metals in prostate cancer. Methods : In a case-only study of 228 African American prostate cancer cases, G×E between rs10486567 and [...]