Menée en Allemagne à partir des données de deux registres des cancers portant sur 976 patients ayant des enfants âgés de 6 à 18 ans, cette étude analyse leur qualité de vie et leurs besoins en soins de support psychosociaux

Parental cancer: Health-related quality of life and current psychosocial support needs of cancer survivors and their children

Bultmann, Johanna Christine ; Beierlein, Volker ; Romer, Georg ; Möller, Birgit ; Koch, Uwe ; Bergelt, Corinna

The presence of cancer and additional parental responsibilities can increase strain for individual patients as well as for their children. The construct of health-related quality of life (HRQL) is appropriate to measure a combination of physical, mental and social consequences as a result of disease. However, previous research has merely focused on symptom checklists. This study addresses the following questions: (i) does HRQL in children and their parents with cancer differ compared to the [...]

Menée en Australie auprès de 1 399 survivantes d'un cancer de l'endomètre, cette étude de cohorte analyse les facteurs cliniques, sociodémographiques, physiques et psychologiques associés à la qualité de leur vie sexuelle 3 à 5 ans après les traitements

Predictors of sexual well-being after endometrial cancer: results of a national self-report survey

Rowlands, IngridJ ; Lee, Christina ; Beesley, VanessaL ; Webb, PenelopeM

Purpose : We examined whether sociodemographic, physical, reproductive, psychological and clinical factors at the time of diagnosis were related to women’s sexual well-being 3–5 years following treatment for endometrial cancer. Methods : Of the 1,399 women in the Australian National Endometrial Cancer Study, 644 completed a follow-up questionnaire 3–5 years after diagnosis. Of these, 395 women completed the Sexual-Function Vaginal Changes Questionnaire, which was used to assess sexual [...]

A partir d'une revue systématique de la littérature (22 études), cette étude analyse les facteurs associés à l'observance d'une chimiothérapie orale chez les patients atteints de cancer

Adherence influencing factors in patients taking oral anticancer agents: A systematic review

Mathes, Tim ; Pieper, Dawid ; Antoine, Sunya-Lee ; Eikermann, Michaela

Background : The use of oral anticancer agents increased steadily in the last decades. Although oral anticancer agent adherence is important for a successful treatment, many patients are insufficiently adherent. Purpose : To evaluate adherence influencing factors in patients taking oral anticancer agents. Methods : A systematic literature search was performed in Medline and Embase. Titles and abstracts and in case of relevance, full-texts were screened according to predefined inclusion [...]

A partir d'une revue systématique de la littérature (9 essais, 2 997 patients inclus), cette méta-analyse évalue l'incidence d'événements indésirables fatals ainsi que la mortalité associés à un traitement par évérolimus chez des patients atteints de cancer

Treatment-Related Mortality With Everolimus in Cancer Patients

Wesolowski, Robert ; Abdel-Rasoul, Mahmoud ; Lustberg, Maryam ; Paskell, Maria ; Shapiro, Charles L. ; Macrae, Erin R.

Introduction : The overall incidence and odds of fatal adverse events (FAEs) after exposure to everolimus are not well defined. We performed a comprehensive meta-analysis of published randomized controlled trials (RCTs) to determine the role of everolimus in treatment-related mortality in patients with cancer. Methods. PubMed databases and abstracts from the proceedings of the American Society of Clinical Oncology and the San Antonio Breast Cancer Symposium were searched for RCTs of everolimus [...]

A partir des données des registres canadiens du cancer, cette étude évalue l'association entre différentes professions, notamment l'enseignement, et le risque de cancer de l'ovaire

Occupational exposure and ovarian cancer risk

Le, NhuD ; Leung, Andy ; Brooks-Wilson, Angela ; Gallagher, RichardP ; Swenerton, KennethD ; Demers, PaulA ; Cook, LindaS

Purpose : Relatively little work has been done concerning occupational risk factors in ovarian cancer. Although studies conducted in occupational settings have reported positive associations, their usefulness is generally limited by the lack of information on important confounders. In a population-based case–control study, we assessed risk for developing epithelial ovarian cancer (EOC) associated with occupational exposure while accounting for important confounders. Methods : Participants were [...]

A partir des données de l'essai "PLCO" incluant 504 participants, cette étude de cohorte prospective évalue l'association entre un diabète et la survie des patients atteints d'un cancer du pancréas

Diabetes and pancreatic cancer survival: a prospective cohort-based study

Toriola, A. T. ; Stolzenberg-Solomon, R. ; Dalidowitz, L. ; Linehan, D. ; Colditz, G.

Background: Diabetes is a risk factor for pancreatic cancer but its association with survival from pancreatic cancer is poorly understood. Our objective was to investigate the association of diabetes with survival among pancreatic cancer patients in a prospective cohort-based study where diabetes history was ascertained before pancreatic cancer diagnosis. Methods: We evaluated survival by baseline (1993–2001) self-reported diabetes history (n=62) among 504 participants that developed exocrine [...]

Couplée aux données britanniques des registres des cancers et portant sur 1 184 cas et 3 531 témoins, cette étude évalue l'association entre une utilisation de béta-bloquants après un diagnostic de cancer de la prostate et la mortalité spécifique

Beta-blocker usage and prostate cancer survival: A nested case–control study in the UK Clinical Practice Research Datalink cohort

Cardwell, Chris R. ; Coleman, Helen G. ; Murray, Liam J. ; O'Sullivan, Joe M. ; Powe, Des G.

Background : Recent laboratory and epidemiological evidence suggests that beta-blockers could inhibit prostate cancer progression. Methods: We investigated the effect of beta-blockers on prostate cancer-specific mortality in a cohort of prostate cancer patients. Prostate cancer patients diagnosed between 1998 and 2006 were identified from the UK Clinical Practice Research Database and confirmed by cancer registries. Patients were followed up to 2011 with deaths identified by the Office of [...]

A partir d'une revue de la littérature (23 études, 11 592 participants), cette méta-analyse évalue la concordance entre les données des dossiers médicaux et celles auto-rapportées par le patient sur ses antécédents en matière de dépistage du cancer colorectal

Agreement between self-reported and registered colorectal cancer screening: a meta-analysis

Dodou, D. ; de Winter, J. C. F.

This random-effects meta-analysis investigates the accuracy of self-reported colorectal cancer screening history as a function of screening mode (colonoscopy, flexible sigmoidoscopy, faecal occult blood testing – FOBT, double-contrast barium enema – DCBE) and survey mode (written, telephone, face-to-face). Summary estimates of sensitivity, specificity, positive predictive value (PPV) and area under the receiver operating characteristic curve (AUC) were calculated. Medical record data were used [...]

Menée auprès de 3 553 patientes atteintes d'un cancer du sein avec métastases distantes, cette étude évalue l'association entre l'âge au diagnostic, les facteurs prédictifs du développement de métastases et la survie

Age at diagnosis and distant metastasis in breast cancer – A surprising inverse relationship

Purushotham, A. ; Shamil, E. ; Cariati, M. ; Agbaje, O. ; Muhidin, A. ; Gillett, C. ; Mera, A. ; Sivanadiyan, K. ; Harries, M. ; Sullivan, R. ; Pinder, S. E. ; Garmo, H. ; Holmberg, L.

Introduction : Predictors for site of distant metastasis and impact on survival in breast cancer are incompletely understood. Methods : Clinico-pathological risk factors for site of distant metastasis and survival were analysed in patients with invasive breast cancer treated between 1986 and 2006. Results : Of 3553 patients, with median follow-up 6.32 years, 825 (23%) developed distant metastasis. The site of metastasis was bone in 196/825 (24%), viscera in 540/825 (65%) and unknown in 89 [...]

Menée aux Etats-Unis par enquête auprès de 3 133 participantes, cette étude de cohorte multicentrique analyse les effets d'une chimiothérapie adjuvante sur l'emploi et la situation professionnelle à long terme de survivantes d'un cancer du sein de stade précoce

Impact of adjuvant chemotherapy on long-term employment of survivors of early-stage breast cancer

Jagsi, Reshma ; Hawley, Sarah T. ; Abrahamse, Paul ; Li, Yun ; Janz, Nancy K. ; Griggs, Jennifer J. ; Bradley, Cathy ; Graff, John J. ; Hamilton, Ann ; Katz, Steven J.

BACKGROUND Many women with early-stage breast cancer are working at the time of diagnosis and survive without disease recurrence. The short-term impact of chemotherapy receipt on employment has been demonstrated, but the long-term impact merits further research. METHODS The authors conducted a longitudinal multicenter cohort study of women diagnosed with nonmetastatic breast cancer between 2005 and 2007, as reported to the population-based Los Angeles and Detroit Surveillance, Epidemiology, and [...]

Menée aux Etats-Unis auprès de 55 patientes atteintes d'un cancer du sein, cette étude longitudinale évalue l'association entre une chimiothérapie adjuvante, le génotype APOE4+, le tabagisme, et l'évolution des performances et capacités cognitives après le traitement

Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: the impact of APOE and smoking

Ahles, Tim A. ; Li, Yuelin ; McDonald, Brenna C. ; Schwartz, Gary N. ; Kaufman, Peter A. ; Tsongalis, Gregory J. ; Moore, Jason H. ; Saykin, Andrew J.

Purpose : This study examined the association of post-treatment changes in cognitive performance, apolipoprotein E (APOE), and smoking in breast cancer patients treated with adjuvant therapy. Participants and Methods : Breast cancer patients treated with chemotherapy (N = 55, age = 51.9 ± 7.1, education = 15.7 ± 2.6) were evaluated with a battery of neuropsychological tests prior to chemotherapy and at 1, 6, and 18 months post-chemotherapy. Matched groups of breast cancer patients not exposed [...]

Menée au Royaume-Uni auprès de 370 participantes, cette étude évalue l'association entre les sous-types de papillomavirus humain et le pronostic des patientes atteintes d'un cancer invasif du col de l'utérus

Influence of HPV type on prognosis in patients diagnosed with invasive cervical cancer

Cuschieri, K. ; Brewster, D. H. ; Graham, C. ; Nicoll, S. ; Williams, A. R. W. ; Murray, G. I. ; Millan, D. ; Johannessen, I. ; Hardie, A. ; Cubie, H. A.

While much is known about the influence of HPV type on the progression of pre-invasive cervical lesions, the impact of HPV type on cervical cancer prognosis is less evidenced. Thus, we assessed the impact of HPV type on the survival of women diagnosed with cervical cancer. A total of 370 cases of cervical cancer were assessed. Univariate analysis is presented using Kaplan–Meier survival curves and log-rank statistics and multivariable Cox proportional hazard models were generated using age [...]

Cette étude présente les recommandations de sociétés savantes américaines relatives à la mise en œuvre, dans les centres de lutte contre le cancer, des programmes de détection de la détresse psychologique des patients

Recommendations for the implementation of distress screening programs in cancer centers: Report from the American Psychosocial Oncology Society (APOS), Association of Oncology Social Work (AOSW), and Oncology Nursing Society (ONS) joint task force

Pirl, William F. ; Fann, Jesse R. ; Greer, Joseph A. ; Braun, Ilana ; Deshields, Teresa ; Fulcher, Caryl ; Harvey, Elizabeth ; Holland, Jimmie ; Kennedy, Vicki ; Lazenby, Mark ; Wagner, Lynne ; Underhill, Meghan ; Walker, Deborah K. ; Zabora, James ; Zebrack, Bradley ; Bardwell, Wayne A.

In 2015, the American College of Surgeons (ACoS) Commission on Cancer will require cancer centers to implement screening programs for psychosocial distress as a new criterion for accreditation. A joint task force from the American Psychosocial Oncology Society, the Association of Oncology Social Work, and the Oncology Nursing Society developed consensus-based recommendations to guide the implementation of this requirement. In this review, the authors provide recommendations regarding each of [...]

Menée en Suède à partir de données portant sur 46 309 patients atteints de lymphome, de myélome ou de leucémie et sur 107 736 participants sans histoire de cancer, cette étude analyse les facteurs de risque associés à un comportement suicidaire

Risk and predictors of attempted and completed suicide in patients with hematological malignancies

Mohammadi, Mohammad ; Moradi, Tahereh ; Bottai, Matteo ; Reutfors, Johan ; Cao, Yang ; Smedby, Karin E.

Background : Hematological malignancies can cause high levels of distress, but few studies have assessed risk of suicidal behavior among these patients. Methods : We evaluated risk of attempted and completed suicide in a cohort of 46,309 patients diagnosed with malignant lymphoma, myeloma and leukemia in Sweden 1992 to 2009 and 107,736 cancer-free subjects, using Poisson regression. Results : In all, 146 suicide attempts and 63 completed suicides occurred during a median follow up of 3.1 years [...]

Menée au Canada auprès de 56 survivantes d'un cancer du sein ou de l'ovaire, cette étude analyse la faisabilité et l'efficacité d'une intervention psychociale de groupe pour mieux gérer la peur de la récidive

Addressing fear of cancer recurrence among women with cancer: a feasibility and preliminary outcome study

Lebel, Sophie ; Maheu, Christine ; Lefebvre, Monique ; Secord, Scott ; Courbasson, Christine ; Singh, Mina ; Jolicoeur, Lynne ; Benea, Aronela ; Harris, Cheryl ; Fung, MichaelFungKee ; Rosberger, Zeev ; Catton, Pamela

Background : Evidence suggests that fear of cancer recurrence (FCR) is one of the most frequently cited unmet needs among cancer survivors and is associated with psychological distress, stress-response symptoms, and lower quality of life, as well as increased use of health care resources. Despite these factors, few manualized interventions exist to address FCR among cancer survivors. Purpose : To develop, manualize, and pilot test the feasibility and preliminary efficacy of a 6-week [...]

Menée à Taïwan auprès de 8 800 participants, cette étude analyse l'efficacité d'un outil permettant de détecter les symptômes de dépression chez des patients atteints de cancer

Routine depression screening and diagnosing strategy for cancer inpatients

Tu, Chun-Hsien ; Hsu, Mei-Chi ; Chi, Shu-Ching ; Lin, Hung-Yen ; Yen, Yung-Chieh

Background : Clinical practice guidelines frequently recommend systematic screening for depression in cancer patients to improve recognition and prompt appropriate management. We aimed to screen major depressive disorder (MDD) in cancer inpatients using a structured tool and explore its applicability. Methods : Cancer inpatients were routinely screened by nurses using the Taiwanese Depression Questionnaire (TDQ), and for those screened positive, this was followed by a non-mandated referral to a [...]

Menée dans la ville de New York auprès de 21 aidants familiaux de patients atteints d'un cancer du poumon, cette étude qualitative analyse les obstacles à l'accès aux services de santé psychosociaux pour soulager leur détresse psychologique

Barriers to mental health service use among distressed family caregivers of lung cancer patients

Mosher, C. E. ; Given, B. A. ; Ostroff, J. S.

Although family caregivers of patients with lung and other cancers show high rates of psychological distress, they underuse mental health services. This qualitative study aimed to identify barriers to mental health service use among 21 distressed family caregivers of lung cancer patients. Caregivers had not received mental health services during the patient's initial months of care at a comprehensive cancer centre in New York City. Thematic analysis of interview data was framed by Andersen's [...]

Menée aux Etats-Unis par questionnaire auprès de 163 participants, cette étude analyse la détresse psychologique et la qualité de vie d'aidants familiaux de patients atteints d'un cancer du poumon

Family caregivers' distress levels related to quality of life, burden, and preparedness

Fujinami, Rebecca ; Sun, Virginia ; Zachariah, Finly ; Uman, Gwen ; Grant, Marcia ; Ferrell, Betty

Objective : Family caregivers (FCGs) caring for loved ones with lung cancer are at risk for psychological distress and impaired quality of life (QOL). This study explores the relationship between FCGs' distress, per the distress thermometer (DT) and FCGs' QOL, burden, and preparedness. The purpose is to identify types of problems unique to FCGs in cancer care. Methods : Family caregivers of patients diagnosed with non-small cell lung cancer were recruited from an adult outpatient setting at a [...]

Menée en Australie auprès de 156 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre une hormonothérapie et divers symptômes d'anxiété et de dépression

Differences in major depressive disorder and generalised anxiety disorder symptomatology between prostate cancer patients receiving hormone therapy and those who are not

Sharpley, Christopher F. ; Bitsika, Vicki ; Wootten, Addie C. ; Christie, David R. H.

Objective : The aim of this study is to explore the associations between hormone treatment variables and depression, and the nature of depression in prostate cancer (PCa) patients by comparing the severity and symptom profile of anxiety and depression in men who were currently receiving hormone therapy (HT) versus those who were not. Method : Self-reports of anxiety and depression on standardized scales of GAD and major depressive disorder (MDD) were collected from 156 PCa patients across two [...]

Mené auprès de 1 235 participantes âgées de 40 à 74 ans, cet essai californien évalue l'efficacité d'une intervention destinée à améliorer la communication entre le médecin généraliste et sa patiente sur le risque individuel de cancer du sein

A randomized, controlled trial to increase discussion of breast cancer in primary care

Kaplan, Celia P. ; Livaudais-Toman, Jennifer ; Tice, Jeffrey A. ; Kerlikowske, Karla ; Gregorich, Steven E. ; Perez-Stable, Eliseo J. ; Pasick, Rena J. ; Chen, Alice ; Quinn, Jessica ; Karliner, Leah S.

Background: Assessment and discussion of individual risk for breast cancer within the primary care setting are crucial to discussion of risk reduction and timely referral. Methods: We conducted a randomized controlled trial of a multiethnic, multilingual sample of women aged 40-74 years from two primary care practices (one academic, one safety-net) to test a breast cancer risk assessment and education intervention. Patients were randomly assigned to control or intervention group. All patients [...]

A partir d'une revue systématique de la littérature publiée entre 1982 et 2012 (22 études), cette étude analyse les causes attribuées par les patientes au cancer du sein dont elles sont atteintes et les compare avec les facteurs de risque identifiés dans la littérature scientifique

What causes breast cancer? A systematic review of causal attributions among breast cancer survivors and how these compare to expert-endorsed risk factors

Dumalaon-Canaria, JoAnne ; Hutchinson, AmandaD ; Prichard, Ivanka ; Wilson, Carlene

Purpose : The aim of this paper was to review published research that analyzed causal attributions for breast cancer among women previously diagnosed with breast cancer. These attributions were compared with risk factors identified by published scientific evidence in order to determine the level of agreement between cancer survivors’ attributions and expert opinion. Methods : A comprehensive search for articles, published between 1982 and 2012, reporting studies on causal attributions for [...]

Menée en Allemagne, cette étude observationnelle qualitative analyse le rôle et la place du patient dans la prise de décision thérapeutique en oncologie

Medical Expertise and Patient Involvement: A Multiperspective Qualitative Observation Study of the Patient’s Role in Oncological Decision Making

Salloch, Sabine ; Ritter, Peter ; Wäscher, Sebastian ; Vollmann, Jochen ; Schildmann, Jan

Background : Decision making in oncology poses intricate ethical questions because treatment decisions should account not only for evidence-based standards but also for the patient’s individual values and preferences. However, there is a scarcity of empirical knowledge about patient involvement in oncological decision making. Methods : Direct, nonparticipant observation was used as a qualitative research method to gain an understanding of the interplay between medical expertise and patient [...]