Menée au Japon auprès de 69 752 participants âgés de 40 à 79 ans, cette étude de cohorte évalue l'association entre une activité physique de faible intensité (marche), un comportement sédentaire (temps passé assis devant la télévision) et la mortalité par cancer du foie

Associations of daily walking and television viewing time with liver cancer mortality: findings from the Japan Collaborative Cohort Study

Ukawa, Shigekazu ; Tamakoshi, Akiko ; Wakai, Kenji ; Kurozawa, Youichi

Background and purpose : Several studies have suggested that daily vigorous physical activity reduces the risk of liver cancer, whereas sedentary behavior increases the risk of several cancers. However, the link between liver cancer and low-intensity physical activity (walking) and sedentary behavior is unclear. Therefore, we explored the links between liver cancer mortality and daily walking time/television (TV) viewing time in Japanese adults aged 40–79 years in a large-scale nationwide [...]

A partir des données de la cohorte "Nurses’ Health Study" portant sur 764 cas (durée de suivi : 28 ans), cette étude américaine évalue l'association entre une consommation de produits laitiers à des périodes spécifiques de la vie (université, avant et après la ménopause) et le risque de cancer de l'ovaire

Dairy food and nutrient intake in different life periods in relation to risk of ovarian cancer

Merritt, MelissaA ; Poole, ElizabethM ; Hankinson, SusanE ; Willett, WalterC ; Tworoger, ShelleyS

Purpose : High lactose intake has been suggested to increase epithelial ovarian cancer (EOC) risk. We evaluated the association between lactose consumed during specific life periods (high school, premenopause, and postmenopause) and later risk of EOC. Methods : We assessed the association of dairy food and nutrient intake with risk of EOC during 28 years of follow-up including 764 cases in the Nurses’ Health Study (NHS) and NHSII. Cox proportional hazards regression was used to model the hazard [...]

Menée en Suède auprès de 3 571 574 partipants nés entre 1973 et 2008, cette étude de cohorte évalue l'association entre la saison de naissance, plus ou moins propice à des expositions à des infections durant les premiers mois de vie, et le risque de lymphome

Season of birth and risk of Hodgkin and non-Hodgkin lymphoma

Crump, Casey ; Sundquist, Jan ; Sieh, Weiva ; Winkleby, Marilyn A. ; Sundquist, Kristina

Infectious etiologies have been hypothesized for Hodgkin and non-Hodgkin lymphoma (HL and NHL) in early life, but findings to date for specific lymphomas and periods of susceptibility are conflicting. We conducted the first national cohort study to examine whether season of birth, a proxy for infectious exposures in the first few months of life, is associated with HL or NHL in childhood through young adulthood. A total of 3,571,574 persons born in Sweden in 1973–2008 were followed up through [...]

A partir de données de deux études rétrospectives et d'une étude prospective portant sur 3 083 cas et 4 328 témoins, cette étude met en évidence une absence d'association entre une infection par le papillomavirus humain et le risque de cancer du poumon

No causal association identified for human papillomavirus infections in lung cancer

Anantharaman, Devasena ; Gheit, Tarik ; Waterboer, Tim ; Halec, Gordana ; Carreira, Christine ; Abedi-Ardekani, Behnoush ; McKay-Chopin, Sandrine ; Zaridze, David ; Mukeria, Anush ; Szeszenia-Dabrowska, Neonila ; Lissowska, Jolanta ; Mates, Dana ; Janout, Vladimir ; Foretova, Lenka ; Bencko, Vladimir ; Rudnai, Peter ; Fabianova, Eleonora ; Tjonneland, Anne ; Travis, Ruth C. ; Boeing, Heiner ; Quiros, J Ramon ; Johansson, Mikael ; Krogh, Vittorio ; Bueno-de-Mesquita, H. Bas ; Kotanidou, Anastasia ; Clavel-Chapelon, Françoise ; Weiderpass, Elisabete ; Johansson, Mattias ; Pawlita, Michael ; Scelo, Ghislaine ; Tommasino, Massimo ; Brennan, Paul

Human papillomavirus (HPV) infections have been implicated in lung carcinogenesis, but causal associations remain uncertain. We evaluated a potential causal role for HPV infections in lung cancer through an analysis involving serology, tumor DNA, RNA and p16 protein expression. Association between type-specific HPV antibodies and risk of lung cancer was examined among 3083 cases and 4328 controls in two case-control studies (retrospective) and one nested case-control study (prospective design). [...]

A partir des données de la cohorte "National Health and Nutrition Examination Survey" portant sur 164 patients et 93 partenaires de vie, cette étude évalue l'association entre une infection orale par le papillomavirus humain (HPV) et le risque de cancer chez les partenaires de patients déjà atteints d'un cancer de l'oropharynx lié à une infection par le HPV

Oral Human Papillomavirus (HPV) Infection in HPV-Positive Patients With Oropharyngeal Cancer and Their Partners

D’Souza, Gypsyamber ; Gross, Neil D. ; Pai, Sara I. ; Haddad, Robert ; Anderson, Karen S. ; Rajan, Shirani ; Gerber, Jennifer ; Gillison, Maura L. ; Posner, Marshall R.

Purpose : To better understand oral human papillomavirus (HPV) infection and cancer risk among long-term sexual partners of patients with HPV-positive oropharyngeal cancer (HPV-OPC). Patients and Methods : An oral rinse sample, risk factor survey, cancer history, and oral examination (partners only) were collected from patients with HPV-OPC and their partners. Oral rinse samples were evaluated for 36 types of HPV DNA using PGMY 09/11 primers and line-blot hybridization and HPV16 copy number [...]

Menée en Suède à partir de données portant sur 138 723 participants, cette étude de cohorte évalue l'association entre une rhinite allergique et le risque de cancer

Risk of cancer in patients with medically diagnosed hay fever or allergic rhinitis

Hemminki, Kari ; Försti, Asta ; Fallah, Mahdi ; Sundquist, Jan ; Sundquist, Kristina ; Ji, Jianguang

Data on allergic conditions as risk or protective factors for cancer are controversial probably because most studies have used self-reported data on mixed groups of allergies in a case–control setting. We define cancer risks in medically diagnosed hay fever/allergic rhinitis patients in a nationwide cohort study. A total of 138,723 hay fever/allergic rhinitis patients were identified from three Swedish health care databases and standardized incidence ratios (SIRs) were calculated for subsequent [...]

Menée sur une cohorte de 1 153 hommes d'âge supérieur à 70 ans, cette étude met en évidence une association entre la perte du chomosome Y, observée dans le sang périphérique, et le risque de cancer

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

Forsberg, Lars A. ; Rasi, Chiara ; Malmqvist, Niklas ; Davies, Hanna ; Pasupulati, Saichand ; Pakalapati, Geeta ; Sandgren, Johanna ; de Stahl, Teresita Diaz ; Zaghlool, Ammar ; Giedraitis, Vilmantas ; Lannfelt, Lars ; Score, Joannah ; Cross, Nicholas C. P. ; Absher, Devin ; Janson, Eva Tiensuu ; Lindgren, Cecilia M. ; Morris, Andrew P. ; Ingelsson, Erik ; Lind, Lars ; Dumanski, Jan P.

Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is largely unexplained. Furthermore, age-related loss of chromosome Y (LOY) is frequent in normal hematopoietic cells, but the phenotypic consequences of LOY have been elusive. From analysis of 1,153 elderly men, we report that LOY in peripheral blood was associated with risks of all-cause mortality (hazards ratio (HR) = 1.91, 95% confidence interval (CI) = 1.17–3.13; 637 events) and non-hematological cancer [...]

A partir des données du registre danois des cancers portant sur 1 709 456 enfants nés entre 1977 et 2007, cette étude de cohorte évalue l'association entre des malformations congénitales du système nerveux ou circulatoire et le risque de cancer pédiatrique

Cancer risks in children with congenital malformations in the nervous and circulatory system—A population based cohort study

Sun, Yuelian ; Overvad, Kim ; Olsen, Jørn

Aim : We estimated the age and organ-specific cancer risk for children with a congenital malformation (CM) in the nervous or in the circulatory system. Methods : We identified 1,709,456 live born singletons in Denmark between 1 January 1977 and 31 December 2007 and excluded children with chromosomal birth defects. Information on CMs was obtained from the Danish National Hospital Register. Information on cancer occurrence was obtained from the Danish Cancer Registry. We applied Cox proportional [...]

Menée aux Etats-Unis à partir des données d'une cohorte en population à faibles revenus ("Southern Community Cohort Study") incluant 372 cas et 716 témoins, cette étude prospective évalue, en fonction de l'appartenance ethnique, l'association entre le niveau sérique de sélénium et le risque de cancer du poumon

A Prospective Study of Plasma Selenoprotein P and Lung Cancer Risk Among Low-Income Adults

Epplein, Meira ; Burk, Raymond F. ; Cai, Qiuyin ; Hargreaves, Margaret K. ; Blot, William J.

Background: Epidemiologic studies have shown increased risks of lung cancer among adults with low blood levels of selenium, although evidence is inconsistent. In the United States the incidence of lung cancer is higher and mean serum selenium levels lower among blacks than whites, but prior studies have not assessed the selenium-lung cancer association among blacks. Methods: From the prospective Southern Community Cohort Study we identified 372 participants who provided blood samples and [...]

A partir des données du registre suédois des cancers portant sur 28 434 cas et 284 340 témoins nés entre 1932 et 2008, cette étude en population analyse l'association entre divers facteurs liés à la reproduction (nombre d'enfants, âges au premier et dernier accouchement, ...) et le risque d'adénocarcinome colorectal

Reproductive History and Risk of Colorectal Adenocarcinoma

Lu, Yunxia ; Oddsberg, Jenny ; Martling, Anna ; Lagergren, Jesper

Background: Sex hormones may be associated with colorectal adenocarcinoma, although the association of pregnancy history and risk of colorectal cancer is not consistent. Methods: We conducted a population-based nested case-control study of persons born between 1932 and 2008 who are in the Swedish Multi-Generation Register. In total, 12,915 women and 15,519 men with colorectal adenocarcinoma were identified during follow-up in the Swedish Cancer Register; 10 age- and sex-matched controls were [...]

A partir des données de la cohorte "Nurses’ Health Study II" portant sur 584 cas et 584 témoins, cette étude évalue l'association entre le niveau plasmatique d'un métabolite de la vitamine D ou de la protéine liant la vitamine D et le risque de cancer du sein, principalement avant la ménopause

Plasma free 25-hydroxyvitamin D, vitamin D binding protein, and risk of breast cancer in the Nurses’ Health Study II

Wang, Jun ; Eliassen, A. Heather ; Spiegelman, Donna ; Willett, WalterC ; Hankinson, SusanE

Purpose : Prior prospective studies, including our own, have evaluated total plasma 25-hydroxyvitamin D [25(OH)D] and breast cancer risk with inconsistent results. However, recent studies suggest that some vitamin D functions may be more relevant to the unbound (free) fraction of 25(OH)D. Vitamin D binding protein (DBP) influences the free 25(OH)D levels and thus possibly the biological activities of vitamin D. Methods : We conducted a case–control study nested within the Nurses’ Health Study [...]

Menée en Norvège auprès de 21 532 participantes nées entre 1886 et 1928, cette étude de cohorte prospective évalue l'association entre divers facteurs liés à la reproduction (âge des premières règles, du premier accouchement, ...) et le risque de cancer du sein, par sous-type moléculaire

Reproductive history and the risk of molecular breast cancer subtypes in a prospective study of Norwegian women

Horn, Julie ; Opdahl, Signe ; Engstrøm, MonicaJ ; Romundstad, PålR ; Tretli, Steinar ; Haugen, OlavA ; Bofin, AnnaM ; Vatten, LarsJ ; Åsvold, BjørnOlav

Purpose : Breast cancer can be classified into molecular subtypes that differ in clinical characteristics and prognosis. There is some but conflicting evidence that reproductive risk factors may differ between distinct breast cancer subtypes. Methods : We investigated associations of reproductive factors with the risk for six molecular breast cancer subtypes in a cohort of 21,532 Norwegian women who were born between 1886 and 1928 and followed up for breast cancer incidence between 1961 and [...]

Menée en Norvège auprès de 18 562 participantes nées entre 1886 et 1923, cette étude évalue l'association entre la taille et le poids à l'âge adulte et le risque de cancer du sein après la ménopause, en fonction de son sous-type histologique et moléculaire

Anthropometric factors and risk of molecular breast cancer subtypes among postmenopausal Norwegian women

Horn, Julie ; Alsaker, Mirjam D. K. ; Opdahl, Signe ; Engstrøm, Monica J. ; Tretli, Steinar ; Haugen, Olav A. ; Bofin, Anna M. ; Vatten, Lars J. ; Åsvold, Bjørn Olav

Adult height and body weight are positively associated with breast cancer risk after menopause, but few studies have investigated these factors according to molecular breast cancer subtype. A total of 18,562 postmenopausal Norwegian women who were born between 1886 and 1928 were followed up for breast cancer incidence from the time (between 1963 and 1975) height and weight were measured until 2008. Immunohistochemical and in situ hybridization techniques were used to subtype 734 incident breast [...]

Couplée aux données de deux cohortes prospectives, l'une américaine et l'autre suédoise, incluant 499 cas et 499 témoins, cette étude évalue l'association entre le niveau d'œstrogènes circulants et le risque de cancer du sein après la ménopause

Circulating Estrogen Metabolites and Risk of Breast Cancer in Postmenopausal Women

Arslan, Alan A ; Koenig, Karen L ; Lenner, Per ; Afanasyeva, Yelena ; Shore, Roy E ; Chen, Yu ; Lundin, Eva ; Toniolo, Paolo ; Hallmans, Göran ; Zeleniuch-Jacquotte, Anne

Background: It has been hypothesized that predominance of the 2-hydroxylation estrogen metabolism pathway over the 16α-hydroxylation pathway may be inversely associated with breast cancer risk. Methods: We examined the associations of invasive breast cancer risk with circulating 2-OHE1, 16α-OHE1, and the 2-OHE1:16α-OHE1 ratio in a case-control study of postmenopausal women nested within two prospective cohorts: the New York University Women's Health Study (NYUWHS) and the Northern Sweden [...]

Menée en population chinoise auprès de 1 050 cas et 1 404 témoins, cette étude analyse les relations entre 14 variants génétiques précédemment identifiés dans des études d'association sur le génome entier et le risque de cancer de la vessie

Cumulative effect of genome-wide association study-identified genetic variants for bladder cancer

Wang, Meilin ; Chu, Haiyan ; Lv, Qiang ; Wang, Li ; Yuan, Lin ; Fu, Guangbo ; Tong, Na ; Qin, Chao ; Yin, Changjun ; Zhang, Zhengdong ; Xu, Jianfeng

Recent genome-wide association studies have identified 14 genetic variants associated with bladder cancer in Caucasians. The effects of these risk variants and their cumulative effects in Asian populations are unknown. We genotyped these newly identified variants in a case–control study of 1,050 patients diagnosed with bladder cancer and 1,404 controls in the Chinese population. Odds rations (ORs) and 95% confidence intervals (CIs) were computed by logistic regression, and cumulative effect of [...]

A partir des données de la cohorte européenne EPIC incluant 390 878 participants, cette étude prospective évalue l'association entre des mesures anthropométriques (taille, poids, tour de taille, indice de masse corporelle) et le risque de cancer de la vessie

Anthropometric measures and bladder cancer risk: A prospective study in the EPIC cohort

Roswall, Nina ; Freisling, Heinz ; Bueno-de-Mesquita, H. B. ; Ros, Martine ; Christensen, Jane ; Overvad, Kim ; Boutron-Ruault, Marie-Christine ; Severi, Gianluca ; Fagherazzi, Guy ; Chang-Claude, Jenny ; Kaaks, Rudolf ; Steffen, Annika ; Boeing, Heiner ; Argüelles, Marcial ; Agudo, Antonio ; Sánchez, María-José ; Chirlaque, María-Dolores ; Barricarte Gurrea, Aurelio ; Amiano, Pilar ; Wareham, Nick ; Khaw, Kay-Tee ; Bradbury, Kathryn Erica ; Trichopoulou, Antonia ; Papatesta, Helen-Maria ; Trichopoulos, Dimitrios ; Palli, Domenico ; Pala, Valeria ; Tumino, Rosario ; Sacerdote, Carlotta ; Mattiello, Amalia ; Peeters, Petra H. ; Ehrnström, Roy ; Brennan, Paul ; Ferrari, Pietro ; Ljungberg, Börje ; Norat, Teresa ; Gunter, Marc ; Riboli, Elio ; Weiderpass, Elisabete ; Halkjær, Jytte

Anthropometric measures have been related to risk of several cancers. For bladder cancer, however, evidence is sparse. Comparability of existing studies is hampered by use of different obesity-measures, inadequate control for smoking, and few female cases. This study examined associations between height, weight, waist and hip circumference, waist–hip ratio, waist–height ratio, body mass index (BMI), recalled weight at age 20 and bladder cancer, and investigated effect modification by age, tumor [...]