A partir des données de 18 études incluant 2 504 cas et 7 276 témoins n'ayant jamais fumé et 10 184 cas et 7 176 témoins fumeurs, cette étude évalue l'association entre une exposition au tabagisme passif et le risque de cancer du poumon par sous-type histologique

Exposure to secondhand tobacco smoke and lung cancer by histological type: A pooled analysis of the International Lung Cancer Consortium (ILCCO)

Kim, Claire H. ; Lee, Yuan-Chin Amy ; Hung, Rayjean J. ; McNallan, Sheila R. ; Coté, Michele L. ; Lim, Wei-Yen ; Chang, Shen-Chih ; Kim, Jin Hee ; Ugolini, Donatella ; Chen, Ying ; Liloglou, Triantafillos ; Andrew, Angeline S. ; Onega, Tracy ; Duell, Eric J. ; Field, John K. ; Lazarus, Philip ; Marchand, Loïc Le ; Neri, Monica ; Vineis, Paolo ; Kiyohara, Chikako ; Hong, Yun-Chul ; Morgenstern, Hal ; Matsuo, Keitaro ; Tajima, Kazuo ; Christiani, David C. ; McLaughlin, John R. ; Bencko, Vladimir ; Holcatova, Ivana ; Boffetta, Paolo ; Brennan, Paul ; Fabianova, Eleonora ; Foretova, Lenka ; Janout, Vladimir ; Lissowska, Jolanta ; Mates, Dana ; Rudnai, Peter ; Szeszenia-Dabrowska, Neonila ; Mukeria, Anush ; Zaridze, David ; Seow, Adeline ; Schwartz, Ann G. ; Yang, Ping ; Zhang, Zuo-Feng

While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined the association by histological type. In this study, we evaluated the secondhand smoke-lung cancer relationship by histological type based on pooled data from 18 case–control studies in the International Lung Cancer Consortium (ILCCO), including 2,504 cases and 7,276 control who were never smokers and 10,184 cases and 7,176 controls who were ever [...]

A partir des données de la cohorte "Northern California Childhood Leukemia Study", cette étude américaine ré-évalue, en prenant en compte des biais de sélection dans la population, l'association entre une exposition à des champs magnétiques en milieu résidentiel et le risque, précédemment observé dans des études cas-témoins, de leucémie pédiatrique

Potential role of selection bias in the association between childhood leukemia and residential magnetic fields exposure: A population-based assessment

Slusky, Danna A. ; Does, Monique ; Metayer, Catherine ; Mezei, Gabor ; Selvin, Steve ; Buffler, Patricia A.

Purpose : Data from the Northern California Childhood Leukemia Study (NCCLS) were used to assess whether selection bias may explain the association between residential magnetic fields (assessed by wire codes) and childhood leukemia as previously observed in case–control studies. Methods : Wiring codes were calculated for participating cases, n = 310; and non-participating cases, n = 66; as well as for three control groups: first-choice participating, n = 174; first-choice non-participating, n = [...]

Menée aux Etats-Unis auprès de 215 cas et 676 témoins, cette étude en population évalue l'association entre certaines pathologies ou conditions médicales telles une lithiase biliaire, une cholécystectomie, une ablation des amygdales palatines et le risque de cancer du pancréas

Cholecystectomy, gallstones, tonsillectomy, and pancreatic cancer risk: a population-based case-control study in minnesota

Zhang, J. ; Prizment, A. E. ; Dhakal, I. B. ; Anderson, K. E.

Background: Associations between medical conditions and pancreatic cancer risk are controversial and are thus evaluated in a study conducted during 1994–1998 in Minnesota. Methods: Cases (n=215) were ascertained from hospitals in the metropolitan area of the Twin Cities and the Mayo Clinic. Controls (n=676) were randomly selected from the general population and frequency matched to cases by age and sex. The history of medical conditions was gathered with a questionnaire during in-person [...]

A partir des données de neuf registres américains des cancers portant sur 2 038 074 survivants d'un cancer à un an ou plus, cette étude évalue le risque de développer des secondes tumeurs cérébrales bénignes, en particulier un méningiome, en lien avec l'exposition aux rayonnements thérapeutiques du cancer primitif

Risk of second benign brain tumors among cancer survivors in the surveillance, epidemiology, and end results program

Kutsenko, Alina ; Berrington de Gonzalez, Amy ; Curtis, RochelleE ; Rajaraman, Preetha

Purpose : To assess risk of developing a second benign brain tumor in a nationwide population of cancer survivors. Methods : We evaluated the risk of developing second benign brain tumors among 2,038,074 1-year minimum cancer survivors compared to expected risk in the general population between 1973 and 2007 in nine population-based cancer registries in the NCI’s surveillance, epidemiology, and end results program. Excess risk was estimated using standardized incidence ratios (SIRs) for all [...]

Menée à partir du dosage sanguin de l'hémoglobine glyquée, cette étude évalue l'association entre une hyperglycémie chronique et le risque de cancer, indépendamment de la présence d'un diabète

Does cancer risk increase with HbA1c, independent of diabetes ?

de Beer, J. C. ; Liebenberg, L.

Background: The risks for several cancer types are increased in people with diabetes. Hyperglycaemia, hyperinsulinaemia, inflammation and altered hormonal concentrations are common characteristics between the two diseases and can all be linked to hyperglycaemia. Methods: Here, we use glycated haemoglobin (HbA1c) as a biomarker for chronic hyperglycaemia. We explore whether cancer risk increases with HbA1c, independent of diabetes, and, therefore, if risk is already increased below the diabetic [...]

A partir des données de deux cohortes incluant 18 023 cas et 60 543 témoins, cette étude américaine évalue l'association entre 165 polymorphismes à simple nucléotide, précédemment identifiés dans des études d'association sur le génome entier et impliqués dans l'étiologie de 16 localisations de cancer autres que le poumon, et le risque de cancer du poumon

Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia

Park, S. Lani ; Fesinmeyer, Megan D. ; Timofeeva, Maria ; Caberto, Christian P. ; Kocarnik, Jonathan M. ; Han, Younghun ; Love, Shelly-Ann ; Young, Alicia ; Dumitrescu, Logan ; Lin, Yi ; Goodloe, Robert ; Wilkens, Lynne R. ; Hindorff, Lucia ; Fowke, Jay H. ; Carty, Cara ; Buyske, Steven ; Schumacher, Frederick R. ; Butler, Anne ; Dilks, Holli ; Deelman, Ewa ; Coté, Michele L. ; Chen, Wei ; Pande, Mala ; Christiani, David C. ; Field, John K. ; Bickebӧller, Heike ; Risch, Angela ; Heinrich, Joachim ; Brennan, Paul ; Wang, Yufei ; Eisen, Timothy ; Houlston, Richard S. ; Thun, Michael ; Albanes, Demetrius ; Caporaso, Neil ; Peters, Ulrike ; North, Kari E. ; Heiss, Gerardo ; Crawford, Dana C. ; Bush, William S. ; Haiman, Christopher A. ; Landi, Maria Teresa ; Hung, Rayjean J. ; Kooperberg, Charles ; Amos, Christopher I. ; Le Marchand, Loic ; Cheng, Iona

Background : Genome-wide association studies have identified hundreds of genetic variants associated with specific cancers. A few of these risk regions have been associated with more than one cancer site; however, a systematic evaluation of the associations between risk variants for other cancers and lung cancer risk has yet to be performed. Methods : We included 18023 patients with lung cancer and 60543 control subjects from two consortia, Population Architecture using Genomics and [...]

Menée en Allemagne auprès de 1 792 cas et 1 805 témoins, cette étude en population analyse la relation entre 28 variants génétiques associés à l'obésité, et précédemment identifiés dans des études d'association sur le génome entier, et le risque de cancer colorectal

GWAS-Identified Common Variants for Obesity Are Not Associated with the Risk of Developing Colorectal Cancer

Sainz, Juan ; Frank, Bernd ; da Silva Filho, Miguel I. ; Hoffmeister, Michael ; Rudolph, Anja ; Butterbach, Katja ; Chang-Claude, Jenny ; Brenner, Hermann ; Hemminki, Kari ; Försti, Asta

Background: Observational studies have consistently associated obesity with colorectal cancer (CRC) risk. Because both traits are genetically determined and share some metabolic biomarkers, we hypothesized that obesity-related polymorphisms could also influence the risk of developing CRC. Methods: We conducted a comprehensive population-based case-control study in 1792 German CRC cases and 1805 controls to explore associations between 28 obesogenic variants identified through genome-wide [...]

Menée initialement sur 355 cas de carcinome à cellules rénales et 362 témoins, puis validée sur 647 cas et 660 témoins, cette étude identifie des polymorphismes à simple nucléotide, notamment dans le gène du micro-ARN196a2, en association avec la susceptibilité à ce type de cancer et avec le pronostic de la maladie

Genetic variations in microRNAs and the risk and survival of renal cell cancer

Du, Mulong ; Lu, Desheng ; Wang, Qiaoyan ; Chu, Haiyan ; Tong, Na ; Pa, Xuping ; Qin, Chao ; Yin, Changjun ; Wang, Meilin ; Zhang, Zhengdong

MicroRNAs (miRNAs) are a class of short non-coding, single stranded RNAs, which perform post-transcriptional regulatory functions as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) genes are currently being identified for contributing to cancer risk, prognosis and survival. We investigated whether genetic variations of miRNAs were associated with the risk and prognosis of renal cell carcinoma (RCC). We genotyped four common miRNA SNPs (i.e., miR-146a [...]