A partir des données de l'essai randomisé contrôlé "PediQUEST" incluant des enfants âgés de plus de deux ans atteints d'un cancer de stade avancé, cette étude analyse l'intérêt d'un outil informatique d'auto-déclaration des symptômes et de la transmission des informations aux oncologues et aux familles pour améliorer leur qualité de vie

Improving the Care of Children With Advanced Cancer by Using an Electronic Patient-Reported Feedback Intervention: Results From the PediQUEST Randomized Controlled Trial

Wolfe, Joanne ; Orellana, Liliana ; Cook, E. Francis ; Ullrich, Christina ; Kang, Tammy ; Geyer, Jeffrey Russell ; Feudtner, Chris ; Weeks, Jane C. ; Dussel, Veronica

Purpose : This study aimed to determine whether feeding back patient-reported outcomes (PROs) to providers and families of children with advanced cancer improves symptom distress and health-related quality of life (HRQoL). Patients and Methods : This study was a parallel, multicentered pilot randomized controlled trial. At most once per week, children age ≥ 2 years old with advanced cancer or their parent completed the computer-based Pediatric Quality of Life and Evaluation of Symptoms [...]

Menée en Norvège auprès de 305 participants (âge moyen : 60 ans), cette étude transversale analyse la prévalence et l'intensité de la douleur chez des patients atteints de cancer traités en ambulatoire

A cross-sectional study on prevalence of pain and breakthrough pain among an unselected group of outpatients in a tertiary cancer clinic

Raj, SunilX ; Thronaes, Morten ; Brunelli, Cinzia ; Hjermstad, MarianneJ ; Klepstad, Pål ; Kaasa, Stein

Purpose : Systematic knowledge about the prevalence and the treatment effects of cancer pain in patients attending a general oncology outpatient department is limited. The purpose of this study was to investigate the prevalence of pain in a large representative cohort of patients attending a general oncology outpatient department in order to guide further screening, classification, and treatment of pain. Material and methods : A cross-sectional study among patients visiting the outpatient [...]

Cette étude américaine présente un calendrier pour la mise en place de politiques de promotion de la santé et d'interventions destinées à augmenter l'activité physique chez des survivants d'un cancer

Accelerating Translation of Physical Activity and Cancer Survivorship Research into Practice: Recommendations for a More Integrated and Collaborative Approach

Phillips, Siobhan M. ; Alfano, Catherine M. ; Perna, Frank ; Glasgow, Russell E.

Physical activity has been deemed safe and effective in reducing many negative side effects of treatment for cancer survivors and promoting better overall health. However, most of this research has focused on highly controlled randomized trials and little of this research has been translated into care or policy for survivors. The purpose of the present paper is to present a research agenda for the field to accelerate the dissemination and implementation of empirically-supported physical [...]

A partir d'une revue systématique de la littérature portant sur 374 patients, cette méta-analyse évalue l'efficacité et la toxicité du moxibustion pour traiter la fatigue liée au cancer

The effectiveness and safety of moxibustion for treating cancer-related fatigue: a systematic review and meta-analyses

Lee, Seunghoon ; Jerng, UiMin ; Liu, Yan ; Kang, JungWon ; Nam, Dongwoo ; Lee, Jae-dong

Purpose : Among cancer patients, cancer-related fatigue (CRF) is one of the most common symptoms and adversely affects physical ability and quality of life even several years after treatment. This study aims to evaluate the current evidence for moxibustion in patients with CRF. Methods : Eighteen databases were searched from their inception to April 2013. All randomized controlled trials (RCTs) of moxibustion for treating CRF without language restriction were considered for inclusion. The risk [...]

Menée auprès de 145 patientes atteintes d'un cancer du sein et de 92 patients atteints d'un cancer de la prostate, cette étude évalue l'efficacité de deux modèles d'analyse permettant d'appréhender leurs comportements de santé, leur nutrition et leur activité physique après le diagnostic de cancer

Health behaviour models and patient preferences regarding nutrition and physical activity after breast or prostate cancer diagnosis

Green, H. J. ; Steinnagel, G. ; Morris, C. ; Laakso, E. L.

This study aimed to improve understanding of prostate and breast cancer survivors' physical activity and nutrition and the association of these behaviours with two models. The first model, the Commonsense Self-Regulation Model (CSM), addresses cognitive and emotional perceptions of illness whereas the Transtheoretical Model (TTM) focuses on stage of readiness to engage in a behaviour. Participants who had been diagnosed with either breast (n = 145) or prostate cancer (n = 92) completed measures [...]

Menée au Royaume-Uni auprès de 342 participantes, cette étude rétrospective analyse l'efficacité d'une prophylaxie primaire par facteur de stimulation des colonies de granulocytes (G-CSF) afin de diminuer les taux de neutropénie fébrile chez des patientes atteintes d'un cancer du sein de stade précoce

Reducing febrile neutropenia rates in early breast cancer. Experience of two UK cancer centres

Mullard, A. P. ; Misra, V. ; Sumra, P. ; Ali, Z. ; O’Reilly, S. M. ; Malik, Z.

Purpose : Primary prophylaxis with granulocyte colony-stimulating factor (G-CSF) is used in many institutions across the UK due to unacceptable febrile neutropenia (FN) rates with FEC-D (fluorouracil, epirubicin, cyclophosphamide–docetaxel). The resultant reduction in FN rate is thought to maintain dose intensity and improve patient experience. This retrospective study was performed to assess whether the addition of G-CSF primary prophylaxis into daily clinical practice has achieved these aims. [...]

Menée en France auprès de 180 060 agriculteurs hommes et femmes, cette étude de cohorte prospective analyse, sur la période 2005-2009, les causes de mortalité, notamment par cancer

The AGRIculture and CANcer (AGRICAN) cohort study: enrollment and causes of death for the 2005–2009 period

Levêque-Morlais, Noémie ; Tual, Séverine ; Clin, Bénédicte ; Adjemian, Annie ; Baldi, Isabelle ; Lebailly, Pierre

Objective : To elaborate and describe a large prospective agricultural cohort including males and females in France with various agricultural activities and to study causes of death. Methods : To date, few large prospective cohorts have been conducted among agricultural population. AGRIculture and CANcer cohort is a large prospective cohort of subjects in agriculture studying cancer among active and retired males and females, farm owners and workers, living in eleven areas of France with a [...]

A partir des données de la cohorte "NIH-AARP Diet and Health study" incluant 4 213 patients atteints d'un cancer du côlon et 1 514 patients atteints d'un cancer du rectum, cette étude analyse l'association entre des facteurs liés au mode de vie avant le diagnostic et la survie des patients

Prediagnostic lifestyle factors and survival after colon and rectal cancer diagnosis in the National Institutes of Health (NIH)-AARP Diet and Health Study

Pelser, Colleen ; Arem, Hannah ; Pfeiffer, Ruth M. ; Elena, Joanne W. ; Alfano, Catherine M. ; Hollenbeck, Albert R. ; Park, Yikyung

BACKGROUND Few studies have examined the relationship of lifestyle factors with mortality among patients with colorectal cancer. METHODS Among NIH-AARP Diet and Health study participants, 4213 colon and 1514 rectal cancer cases were identified through linkage to state cancer registries and determined date and cause of death using the National Death Index. Lifestyle factors were assessed at baseline and included: healthy diet (measured by Healthy Eating Index 2005 [HEI-2005]), body mass index [...]

Menée dans les 50 plus grandes villes des Etats-Unis, cette étude analyse l'évolution des disparités ethniques dans la mortalité par cancer du sein, sur la période 1990-2009

Increasing Black:White disparities in breast cancer mortality in the 50 largest cities in the United States

Hunta, Bijou R. ; Whitman, Steve

Introduction: This paper presents race-specific breast cancer mortality rates and the corresponding rate ratios for the 50 largest U.S. cities for each of the 5-year intervals between 1990 and 2009. Methods: The 50 largest cities in the U.S. were the units of analysis. Numerator data were abstracted from national death files where the cause was malignant neoplasm of the breast (ICD-9 = 174 and ICD-10 = C50) for women. Population-based denominators were obtained from the U.S. Census Bureau for [...]

+A partir d'une revue systématique de la littérature (10 études prospectives, 17 696 cas de cancer, 1 558 décès par cancer du sein), cette méta-analyse évalue l'association entre une consommation de vitamine C d'origine alimentaire ou une supplémentation en vitamine C et la survie de patientes atteintes d'un cancer du sein

Vitamin C and survival among women with breast cancer: A Meta-analysis

Harrisa, Holly R. ; Orsinia, Nicola ; Wolka, Alicja

Background : The association between dietary vitamin C intake and breast cancer survival is inconsistent and few studies have specifically examined vitamin C supplement use among women with breast cancer. The purpose of this study was to summarise results from prospective studies on the association between vitamin C supplement use and dietary vitamin C intake and breast cancer-specific mortality and total mortality. Methods : Studies were identified using the PubMed database through February 6, [...]

Menée en France auprès de 497 patientes atteintes d'un cancer du sein après la ménopause (âge moyen : 63,8 ans), cette étude analyse l'incidence de fractures osseuses et l'évolution de la densité minérale osseuse après trois années de traitement par inhibiteurs de l'aromatase

Fracture incidence after 3 years of aromatase inhibitor therapy

Bouvard, B. ; Soulié, P. ; Hoppé, E. ; Georgin-Mege, M. ; Royer, M. ; Mesgouez-Nebout, N. ; Lassalle, C. ; Cellier, P. ; Jadaud, E. ; Abadie-Lacourtoisie, S. ; Tuchais, C. ; Vinchon-Petit, S. ; Audran, M. ; Chappard, D. ; Legrand, E.

Background : The purpose of this study was to describe the fracture incidence and bone mineral density (BMD) evolution in a large cohort of post-menopausal women with breast cancer after 3 years of aromatase inhibitor (AI) therapy. Patients and methods : A prospective, longitudinal study in real-life setting. Each woman had an extensive medical assessment, a biological evaluation, a BMD measurement, and systematic spinal X-rays at baseline and after 3 years of AI therapy. Women with [...]

A partir des données des registres danois, norvégien, suédois et suisse des cancers portant sur 352 cas et 646 témoins, cette étude internationale évalue l'association entre des troubles atopiques et le risque de tumeurs cérébrales chez l'enfant et l'adolescent (âge : 7-19 ans)

Atopic conditions and brain tumor risk in children and adolescents—an international case–control study (CEFALO)

Shu, X. ; Prochazka, M. ; Lannering, B. ; Schuz, J. ; Roosli, M. ; Tynes, T. ; Kuehni, C. E. ; Andersen, T. V. ; Infanger, D. ; Schmidt, L. S. ; Poulsen, A. H. ; Klaeboe, L. ; Eggen, T. ; Feychting, M.

Background : A number of epidemiological studies indicate an inverse association between atopy and brain tumors in adults, particularly gliomas. We investigated the association between atopic disorders and intracranial brain tumors in children and adolescents, using international collaborative CEFALO data. Patients and methods : CEFALO is a population-based case–control study conducted in Denmark, Norway, Sweden, and Switzerland, including all children and adolescents in the age range 7–19 [...]

Menée à partir des données d'une cohorte de 4,5 millions d'anciens combattants américains, cette étude évalue l'association entre diverses pathologies liées au système immunitaire (allergie, atopie, maladie autoimmune, diabète, maladie infectieuse et/ou inflammatoire) et le risque subséquent de cancer du cerveau

Immune-related conditions and subsequent risk of brain cancer in a cohort of 4.5 million male US veterans

Cahoon, E. K. ; Inskip, P. D. ; Gridley, G. ; Brenner, A. V.

Background: Case–control studies have reported an inverse association between self-reported history of allergy and risk of glioma, but cohort data are limited. Our objectives were to evaluate the associations of major groups of medically diagnosed immune-related conditions (allergy/atopy, autoimmune disease, diabetes, infectious/inflammatory disease) and to explore associations with specific conditions in relation to subsequent diagnosis of brain cancer in a large cohort study. Methods: We used [...]

A partir d'une revue systématique des essais cliniques randomisés (33 études), cette étude analyse la typologie et l'efficacité d'interventions, du point de vue de critères d'auto-évaluation, pour permettre aux patients atteints de cancer de faire face à la maladie et d'améliorer leur qualité de vie

A systematic review on patient-reported outcomes in cancer survivors of randomised clinical trials: direction for future research

Li, Qiuping ; Lin, Yi ; Liu, Xiwen ; Xu, Yongyong

Objective : With increasing expectations of a 5-year survival rate among cancer patients, there is growing interest in patient-reported outcome (PRO) measures, particularly measures of health-related quality of life (HRQOL) in cancer practice. The purpose of this review was to explore the existing interventions for patients coping with cancer in terms of intervention type, PRO measurements and outcomes; and to identify directions for future research. Methods : Systematic review of randomised [...]

Mené au Canada auprès de 301 participantes, cet essai multicentrique randomisé évalue les effets d'exercices physiques, en fonction de leur intensité et de leur nature, pour réduire les symptômes dépressifs de patientes atteintes d'un cancer du sein et recevant une chimiothérapie

A Multicenter Randomized Trial of the Effects of Exercise Dose and Type on Psychosocial Distress in Breast Cancer Patients Undergoing Chemotherapy

Courneya, Kerry S. ; McKenzie, Donald ; Gelmon, Karen A. ; Mackey, John ; Reid, Robert D. ; Yasui, Yutaka ; Friedenreich, Christine M. ; Forbes, Cynthia C ; Trinh, Linda ; Jespersen, Diana ; Cook, Diane ; Proulx, Carolyn ; Wooding, Evyanne ; Dolan, Lianne B ; Segal, Roanne J

Background: Exercise may improve psychosocial distress in cancer patients; however, few studies have examined the effects of different types or doses of exercise, or whether exercise effects are related to baseline depression levels. Methods: In a multicenter trial in Canada, we randomized 301 breast cancer patients initiating chemotherapy to thrice weekly, supervised exercise consisting of either a standard dose of 25-30 minutes of aerobic exercise (STAN; n=96), a higher dose of 50-60 minutes [...]

Cette étude européenne présente des recommandations pour la prise en charge des problématiques psychosociales chez des patients atteints d'un cancer de la tête et du cou

Best practices in the management of the psycho-oncologic aspects of head and neck cancer patients: Recommendations from the European Head and Neck Cancer Society Make Sense Campaign

Reich, M. ; Leemans, C. R. ; Vermorken, J. B. ; Bernier, J. ; Licitra, L. ; Parmar, S. ; Goluninski, W. ; Lefebvre, J. L.

Squamous cell carcinoma of the head and neck (SCCHN) is considered a worldwide health care problem. The majority of patients have a history of alcohol abuse and high-level tobacco consumption; however SCCHN is also associated with exposure to viruses including HPV and EBV. A major problem facing SCCHN patients is that their disease is often diagnosed at an advanced stage where treatment options may not be curative, or can have severe post-treatment consequences. Confronted with their diagnosis [...]

A partir des données des registres américains des cancers, cette étude analyse le rapport coût-efficacité de différentes modalités de radiothérapie pour les femmes âgées de 70 à 74 ans atteintes d'un cancer du sein à pronostic favorable

Examining the Cost-Effectiveness of Radiation Therapy Among Older Women With Favorable-Risk Breast Cancer

Sen, Sounok ; Wang, Shi-Yi ; Soulos, Pamela R. ; Frick, Kevin D. ; Long, Jessica B. ; Roberts, Kenneth B. ; Yu, James B. ; Evans, Suzanne B. ; Chagpar, Anees B. ; Gross, Cary P.

Background : Little is known about the cost-effectiveness of external beam radiation therapy (EBRT) or newer radiation therapy (RT) modalities such as intensity modulated radiation (IMRT) or brachytherapy among older women with favorable-risk breast cancer. Methods : Using a Markov model, we estimated the cost-effectiveness of no RT, EBRT, and IMRT over 10 years. We estimated the incremental cost-effectiveness ratio (ICER) of IMRT compared with EBRT under different scenarios to determine the [...]

Menée aux Pays-Bas auprès de 345 patients atteints de cancer, cette étude analyse les éléments permettant d'améliorer les capacités de communication des oncologues et d'améliorer la confiance des patients envers leurs médecins

How can communication by oncologists enhance patients' trust? An experimental study

Hillen, M. A. ; de Haes, H. C. J. M. ; Stalpers, L. J. A. ; Klinkenbijl, J. H. G. ; Eddes, E. H. ; Butow, P. N. ; van der Vloodt, J. ; van Laarhoven, H. W. M. ; Smets, E. M. A.

Background : Cancer patients need to trust their oncologist to embark in the process of oncologic treatment. Yet, it is unclear how oncologist communication contributes to such trust. The aim of this study was to investigate the effect of three elements of oncologists' communication on cancer patients' trust: conferring competence, honesty, and caring. Methods : Eight videotaped consultations, ‘vignettes’, were created, reflecting an encounter between an oncologist and a patient with colorectal [...]

Menée par enquête auprès de 2 998 oncologues, cette étude américaine analyse leur satisfaction relative à leur évolution de carrière et à l'équilibre vie professionnelle-vie privée

Satisfaction With Work-Life Balance and the Career and Retirement Plans of US Oncologists

Shanafelt, Tait D. ; Raymond, Marilyn ; Kosty, Michael ; Satele, Daniel ; Horn, Leora ; Pippen, John ; Chu, Quyen ; Chew, Helen ; Clark, William Benton ; Hanley, Amy E. ; Sloan, Jeff ; Gradishar, William J.

Purpose : To evaluate satisfaction with work-life balance (WLB) and career plans of US oncologists. Methods : The American Society of Clinical Oncology conducted a survey of US oncologists evaluating satisfaction with WLB and career plans between October 2012 and March 2013. The sample included equal numbers of men and women from all career stages. Results : Of 2,998 oncologists contacted, 1,490 (49.7%) returned surveys. From 1,117 oncologists (37.3% of overall sample) completing full-length [...]