Menée auprès de 127 participants, cette étude taïwanaise analyse l'efficacité d'un outil permettant de mesurer l'activité physique de survivants d'un cancer

Measurement of physical activity in cancer survivors: a validity study

Su, Ching-Ching ; Lee, Kuan-Der ; Yeh, Chung-Hung ; Kao, Ching-Chiu ; Lin, Chia-Chin

Purpose : The purpose of the study was to validate the Taiwanese version of the Physical Activity Scale for the Elderly (PASE-T) and to assess physical activity in Taiwanese cancer survivors. Methods : One hundred twenty-seven cancer survivors participated in this study. Instruments consisted of the PASE-T, the Taiwanese version of the MD Anderson Symptom Inventory (MDASI-T), Karnofsky performance status (KPS), and actigraph. Reliability was assessed by calculating the test–retest reliability. [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2012 (14 essais randomisés, 648 participants), cette étude fait le point sur les effets des interventions destinées à encourager l'activité physique chez des personnes sédentaires pendant et après leurs traitements pour un cancer

Interventions to improve exercise behaviour in sedentary people living with and beyond cancer: a systematic review

Bourke, L. ; Homer, K. E. ; Thaha, M. A. ; Steed, L. ; Rosario, D. J. ; Robb, K. A. ; Saxton, J. M. ; Taylor, S. J. C.

Background: To systematically review the effects of interventions to improve exercise behaviour in sedentary people living with and beyond cancer. Methods: Only randomised controlled trials (RCTs) that compared an exercise intervention to a usual care comparison in sedentary people with a homogeneous primary cancer diagnosis, over the age of 18 years were eligible. The following electronic databases were searched: Cochrane Central Register of Controlled Trials MEDLINE; EMBASE; AMED; CINAHL; [...]

A partir d'une revue systématique de la littérature publiée de 1980 à 2013 (10 études), cette étude évalue l'impact d'une activité physique sur la réduction des effets indésirables d'une hormonothérapie anti-androgénique chez des patients atteints d'un cancer de la prostate

Effects of Exercise on Treatment-Related Adverse Effects for Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Systematic Review

Gardner, Jason R. ; Livingston, Patricia M. ; Fraser, Steve F.

Purpose : Androgen-deprivation therapy is a commonly used treatment for men with prostate cancer; however, the adverse effects can be detrimental to patient health and quality of life. Exercise has been proposed as a strategy for ameliorating a range of these treatment-related adverse effects. We conducted a systematic review of the literature regarding the effects of exercise on treatment-related adverse effects in men receiving androgen-deprivation therapy for prostate cancer. Methods : An [...]

Menée auprès de 69 patients atteints de tumeurs des cellules germinales non séminomateuses, cette étude prospective analyse les effets d'une chimiothérapie adjuvante sur leurs dysfonctionnements cognitifs

A prospective study of cognitive function in men with non-seminomatous germ cell tumors

Wefel, Jeffrey S. ; Vidrine, Damon J. ; Marani, Salma K. ; Swartz, Richard J. ; Veramonti, Tracy L. ; Meyers, Christina A. ; Hoekstra, Harald J. ; Hoekstra-Weebers, Josette E. H. M. ; Gritz, Ellen R.

Objective : Longitudinal neuropsychological assessments were performed to determine if adjuvant chemotherapy was associated with cognitive dysfunction in men with non-seminomatous germ cell tumors (NSGCT). Methods : Patients with NSGCT status post-orchiectomy that either received adjuvant chemotherapy (n=55) or did not (n=14) were recruited. Patients were tested before chemotherapy, 1 week post-chemotherapy (or 3 months later in the surveillance group) and 12 months after the baseline [...]

A partir des données d'un registre américain des cancers portant sur 1 155 survivants, cette étude analyse les disparités entre populations rurales et urbaines relatives à l'impact d'un diagnostic de cancer sur l'emploi et les conditions de travail

The impact of cancer diagnosis on employment: is there a difference between rural and urban populations?

Sowden, Michelle ; Vacek, Pamela ; Geller, BertaM

Purpose : To determine if living in a rural or urban area influences the impact of cancer diagnosis on employment. Method : Surveys that asked about changes in employment status related to a cancer diagnosis or treatment were sent to 2,005 cancer survivors enrolled in the Vermont Cancer Survivor Surveillance Registry. Data on cancers were obtained from hospital cancer registries. Respondents indicating that they were working at the time of diagnosis were included in this study for a total of [...]

A partir des données des registres norvégiens portant sur 200 008 patients atteints de cancer sur la période 1996-2005 et suivis jusqu'en 2010, cette étude analyse et compare l'évolution de deux indicateurs de survie en fonction de la localisation du cancer et de l'âge du patient

A comparison of relative and cause-specific survival by cancer site, age and time since diagnosis

Skyrud, Katrine Damgaard ; Bray, Freddie ; Møller, Bjørn

Relative survival (RS) estimates are widely used by cancer registries, mainly because they do not rely on the well-documented deficiencies of cause of death information. The aim of our study was to compare 5-year cause-specific survival (CSS) estimates and 5-year RS estimates for different cancer sites by age and time since diagnosis, and discuss possible reasons for observed differences. Using data from the Cancer Registry of Norway, we identified 200,008 patients diagnosed with cancer at one [...]

Ce rapport annuel de l'American Society of Clinical Oncology présente les avancées de la recherche clinique en 2013

Clinical Cancer Advances 2013: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology

Patel, Jyoti D. ; Krilov, Lada ; Adams, Sylvia ; Aghajanian, Carol ; Basch, Ethan ; Brose, Marcia S. ; Carroll, William L. ; de Lima, Marcos ; Gilbert, Mark R. ; Kris, Mark G. ; Marshall, John L. ; Masters, Gregory A. ; O’Day, Steven J. ; Polite, Blasé ; Schwartz, Gary K. ; Sharma, Sunil ; Thompson, Ian ; Vogelzang, Nicholas J. ; Roth, Bruce J.

Since its founding in 1964, the American Society of Clinical Oncology (ASCO) has been committed to improving cancer outcomes through research and the delivery of quality care. Research is the bedrock of discovering better treatments—providing hope to the millions of individuals who face a cancer diagnosis each year.The studies featured in “Clinical Cancer Advances 2013: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology” represent the invaluable [...]

Menée aux Etats-Unis, cette étude analyse les disparités ethniques dans la participation à des essais cliniques de patients atteints d'un cancer, le taux de refus, les raisons de ces refus ainsi que les critères d'éligibilité

Racial/ethnic differences in clinical trial enrollment, refusal rates, ineligibility, and reasons for decline among patients at sites in the National Cancer Institute's Community Cancer Centers Program

Langford, Aisha T. ; Resnicow, Ken ; Dimond, Eileen P. ; Denicoff, Andrea M. ; Germain, Diane St ; McCaskill-Stevens, Worta ; Enos, Rebecca A. ; Carrigan, Angela ; Wilkinson, Kathy ; Go, Ronald S.

BACKGROUND This study examined racial/ethnic differences among patients in clinical trial (CT) enrollment, refusal rates, ineligibility, and desire to participate in research within the National Cancer Institute's Community Cancer Centers Program (NCCCP) Clinical Trial Screening and Accrual Log. METHODS Data from 4 509 log entries were evaluated in this study. Four logistic regression models were run using physical/medical conditions, enrollment into a CT, patient eligible but declined a CT, [...]

A partir des données des registres américains des cancers sur la période 1975-2010, ce rapport annuel présente et analyse les données nationales d'évolution de l'incidence et de mortalité, ainsi que la prévalence des comorbidités chez les patients atteints d'un cancer du poumon, du côlon-rectum, du sein ou de la prostate

Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer

Edwards, Brenda K. ; Noone, Anne-Michelle ; Mariotto, Angela B. ; Simard, Edgar P. ; Boscoe, Francis P. ; Henley, S. Jane ; Jemal, Ahmedin ; Cho, Hyunsoon ; Anderson, Robert N. ; Kohler, Betsy A. ; Eheman, Christie R. ; Ward, Elizabeth M.

BACKGROUND The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate annually to provide updates on cancer incidence and death rates and trends in these outcomes for the United States. This year's report includes the prevalence of comorbidity at the time of first cancer diagnosis among patients with lung, colorectal, breast, or prostate cancer [...]

A partir des données de 14 registres américains des cancers portant sur la période 2000-2010, cette étude analyse la prévalence d'une infection par le VIH dans les cas de lymphomes hodgkiniens

Prevalence of HIV infection among U.S. Hodgkin lymphoma cases

Shiels, Meredith S. ; Koritzinsky, Erik ; Clarke, Christina A. ; Suneja, Gita ; Morton, Lindsay M. ; Engels, Eric A.

Background: Hodgkin Lymphoma (HL) is uncommon in the U.S. general population; however, HL risk is elevated in people with human immunodeficiency virus (HIV) infection. Thus, despite the low HIV prevalence in the U.S, the HIV epidemic may have contributed substantially to the general population burden of HL. Methods: We used data from 14 U.S. cancer registries in the Surveillance, Epidemiology and End Results Program that recorded HIV status of HL cases at diagnosis during 2000-2010. We computed [...]

A partir des données de la cohorte "Nurses’ Health Study II" incluant 116 430 infirmières âgées de 25 à 42 ans en 1989, cette étude américaine évalue l'association entre des traits pigmentaires, une histoire familiale de mélanome et le risque d'endométriose

Pigmentary traits, family history of melanoma and the risk of endometriosis: a cohort study of US women

Kvaskoff, Marina ; Han, Jiali ; Qureshi, Abrar A ; Missmer, Stacey A

Background : Endometriosis has been associated with a higher risk of cutaneous melanoma, but the mechanisms underlying this association are unknown. Some constitutional factors known to influence melanoma risk have been associated with endometriosis in some retrospective studies. However, prospective data are scarce, and more research is needed to confirm this potentially novel endometriosis risk profile. Methods : To investigate the relationships between pigmentary traits, family history of [...]

Menée aux Etats-Unis sur la période 1996-2009, cette étude analyse les disparités ethniques dans la qualité des soins chirurgicaux reçus par les patients atteints d'un cancer de la vessie

Racial variation in the quality of surgical care for bladder cancer

Barocas, Daniel A. ; Alvarez, JoAnn ; Koyama, Tatsuki ; Anderson, Christopher B. ; Gray, Darryl T. ; Fowke, Jay H. ; You, Chaochen ; Chang, Sam S. ; Cookson, Michael S. ; Smith, Joseph A. ; Penson, David F.

BACKGROUND Differences in quality of care may contribute to racial variation in outcomes of bladder cancer (BCa). Quality indicators in patients undergoing surgery for BCa include the use of high-volume surgeons and high-volume hospitals, and, when clinically indicated, receipt of pelvic lymphadenectomy, receipt of continent urinary diversion, and undergoing radical cystectomy instead of partial cystectomy. The authors compared these quality indicators as well as adverse perioperative outcomes [...]

A partir d'une revue systématique de la littérature (16 études), cette méta-synthèse fait le point sur les expériences d'enfants et d'adolescents dont un des parents est atteint de cancer

School-aged and adolescent children's experience when a parent has non-terminal cancer: a systematic review and meta-synthesis of qualitative studies

Huang, Xiaoyan ; O'Connor, Margaret ; Lee, Susan

Objective : The purpose of this study was to systematically review and synthesise qualitative studies pertinent to male and female school-aged and adolescent children's experience when a parent is diagnosed with non-terminal cancer. Methods : A rigorous systematic review and meta-synthesis process were conducted. Seven computerised databases were searched, and 2027 articles were retrieved. After screening the titles and abstracts, full texts of 24 articles were critically appraised, and [...]

Menée au Royaume-Uni dans trois centres hospitaliers, cette étude analyse le recours de patients venant de recevoir une greffe de cellules souches hématopoïétiques à des services de soins de support psychosocial

Psychosocial supportive care services for haematopoietic stem cell transplant patients; a service evaluation of three UK transplant centres

Horne, B. ; Gilleece, M. ; Jackson, G. ; Snowden, J. A. ; Liebersbach, S. ; Velikova, G. ; Wright, P.

Following haematopoietic stem cell transplant (HSCT) some patients experience long-term physical and psychosocial problems which impact on everyday life. The aim of this service evaluation was to investigate the psychosocial supportive care available for HSCT patients in three UK centres, particularly related to five identified areas of concern: fatigue; psychological distress; vocational and financial issues; sexuality, and fertility. HSCT health professionals were invited to audio-recorded [...]

Mené auprès de 752 participants, cet essai américain multicentrique évalue l'efficacité d'une intervention pédagogique en ligne destinée à aider les patients atteints d'un cancer récemment diagnostiqué à gérer leurs symptômes de détresse pendant et après les traitements

Electronic Self-Report Assessment for Cancer and Self-Care Support: Results of a Multicenter Randomized Trial

Berry, Donna L. ; Hong, Fangxin ; Halpenny, Barbara ; Partridge, Ann H. ; Fann, Jesse R. ; Wolpin, Seth ; Lober, William B. ; Bush, Nigel E. ; Parvathaneni, Upendra ; Back, Anthony L. ; Amtmann, Dagmar ; Ford, Rosemary

Purpose : The purpose of this trial was to evaluate the effect of a Web-based, self-report assessment and educational intervention on symptom distress during cancer therapy. Patients and Methods : A total of 752 ambulatory adult participants were randomly assigned to symptom/quality-of-life (SxQOL) screening at four time points (control) versus screening, targeted education, communication coaching, and the opportunity to track/graph SxQOL over time (intervention). A summary of the [...]

A partir d'une revue systématique de la littérature (17 études), cette étude analyse les symptômes et la qualité de vie de patients atteints d'un gliome de haut grade en fin de vie

The end-of-life phase of high-grade glioma patients: a systematic review

Sizoo, EefjeM ; Pasman, H. RoelineW ; Dirven, Linda ; Marosi, Christine ; Grisold, Wolfgang ; Stockhammer, Günther ; Egeter, Jonas ; Grant, Robin ; Chang, Susan ; Heimans, JanJ ; Deliens, Luc ; Reijneveld, JaapC ; Taphoorn, MartinJ B.

Background : High-grade gliomas (HGG) are rare and incurable; yet, these neoplasms result in a disproportionate share of cancer morbidity and mortality. Treatment of HGG patients is directed not merely towards prolonging life but also towards quality of life, which becomes the major goal in the end of life (EOL). The latter has received increasing attention over the last decade. Methods : We reviewed the literature related to the EOL phase of HGG patients from 1966 up to April 2012. Articles [...]

Cet article plaide pour la prise en compte, par la communauté scientifique, médicale et politique, des morbidités à long terme des survivants d'un cancer de l'enfance ou de l'adolescence

Survivors of childhood and adolescent cancer: life-long risks and responsibilities

Robison, Leslie L. ; Hudson, Melissa M.

Survival rates for most paediatric cancers have improved at a remarkable pace over the past four decades. In developed countries, cure is now the probable outcome for most children and adolescents who are diagnosed with cancer: their 5-year survival rate approaches 80%. However, the vast majority of these cancer survivors will have at least one chronic health condition by 40 years of age. The burden of responsibility to understand the long-term morbidity and mortality that is associated with [...]

Cet article présente la position de la Société Européenne d'Oncologie Médicale relative au rôle de l'oncologue médical dans l'amélioration de la qualité des soins dédiés aux patients atteints de cancer

The current and future role of the medical oncologist in the professional care for cancer patients: a position paper by the European Society for Medical Oncology (ESMO)

Popescu, R. A. ; Schäfer, R. ; Califano, R. ; Eckert, R. ; Coleman, R. ; Douillard, J.-Y. ; Cervantes, A. ; Casali, P. G. ; Sessa, C. ; Van Cutsem, E. ; de Vries, E. ; Pavlidis, N. ; Fumasoli, K. ; Wörmann, B. ; Samonigg, H. ; Cascinu, S. ; Cruz Hernández, J. J. ; Howard, A. J. ; Ciardiello, F. ; Stahel, R. A. ; Piccart, M.

The number of cancer patients in Europe is rising and significant advances in basic and applied cancer research are making the provision of optimal care more challenging. The concept of cancer as a systemic, highly heterogeneous and complex disease has increased the awareness that quality cancer care should be provided by a multidisciplinary team (MDT) of highly qualified healthcare professionals. Cancer patients also have the right to benefit from medical progress by receiving optimal [...]

Cet article plaide pour une approche différente de la lutte contre le cancer en y intégrant une vision globale des thérapies ciblées et des mécanismes de résistance développés par les tumeurs

Rethinking the war on cancer

Hanahan, Douglas

Some 40 years ago a metaphor was posed that cancer was such an insidious adversary that a declaration of war on the disease was justified. Although this statement was a useful inspiration for enlistment of resources, despite extraordinary progress in our understanding of disease pathogenesis, in most cases and for most forms of cancer this war has not been won. A second metaphor was about magic bullets?targeted therapies based on knowledge of mechanisms that were envisaged to strike with [...]