A partir des données de la cohorte "Nurses' Health Study II" incluant 17 221 femmes âgées de 34 à 51 ans, cette étude évalue l'association entre des régimes alimentaires pendant l'adolescence et le risque d'adénome colorectal au milieu de la vie adulte

Dietary patterns during high school and risk of colorectal adenoma in a cohort of middle-aged women

Nimptsch, Katharina ; Malik, Vasanti S. ; Fung, Teresa T. ; Pischon, Tobias ; Hu, Frank B. ; Willett, Walter C. ; Fuchs, Charles S. ; Ogino, Shuji ; Chan, Andrew T. ; Giovannucci, Edward ; Wu, Kana

Adolescent diet may be etiologically relevant for later risk of colorectal adenoma, a precursor of colorectal cancer. We aimed to examine associations between adolescent dietary patterns (derived using factor analysis) and risk of colorectal adenoma in middle adulthood. We analyzed data from 17,221 women participating in the Nurses' Health Study II, who had completed a validated high school (HS) food frequency questionnaire in 1998 when they were 34–51 years old, and had subsequently undergone [...]

A partir des données de la cohorte "Shanghai Women's Health Study" incluant 73 118 femmes âgées de 40 à 70 ans, cette étude prospective chinoise évalue l'association entre une ingestion de nitrites et nitrates d'origine alimentaire et le risque de cancer colorectal

Dietary nitrate and nitrite intake and risk of colorectal cancer in the Shanghai Women's Health Study

DellaValle, Curt T. ; Xiao, Qian ; Yang, Gong ; Shu, Xiao-Ou ; Aschebrook-Kilfoy, Briseis ; Zheng, Wei ; Lan Li, Hong ; Ji, Bu-Tian ; Rothman, Nathaniel ; Chow, Wong-Ho ; Gao, Yu-Tang ; Ward, Mary H.

Nitrate and nitrite are precursors of endogenously formed N-nitroso compounds (NOC), known animal carcinogens. Nitrosation reactions forming NOCs can be inhibited by vitamin C and other antioxidants. We prospectively investigated the association between dietary nitrate and nitrite intake and risk of colorectal cancer in the Shanghai Women's Health Study, a cohort of 73,118 women ages 40–70 residing in Shanghai. We evaluated effect modification by factors that affect endogenous formation of [...]

Menée en Australie à partir de données issues de deux études multicentriques en population (l'une portant sur 588 cas et 472 témoins, l'autre sur 1 079 cas et 2 181 témoins), cette étude évalue l'association entre une exposition solaire dans un contexte professionnel et le risque de mélanome, par localisation

Occupational sun exposure and risk of melanoma according to anatomical site

Vuong, Kylie ; McGeechan, Kevin ; Armstrong, Bruce K. ; Amfs Investigators ; G. E. M. Investigators ; Cust, Anne E.

Although sunburn and intermittent sun exposures are associated with increased melanoma risk, most studies have found null or inverse associations between occupational (more continuous pattern) sun exposure and melanoma risk. The association of melanoma with occupational sun exposure may differ according to anatomical site, with some studies finding a positive association with melanoma on the head and neck. We examined the association between occupational sun exposure (self-reported weekday sun [...]

Menée au Canada auprès de 445 cas et de 948 témoins sur la période 1997-2002, cette étude analyse l'association entre une exposition à long terme à des composés organiques volatils présents dans l'air ambiant et le risque de cancer du poumon

A Case-Control Study of Long-Term Exposure to Ambient Volatile Organic Compounds and Lung Cancer in Toronto, Ontario, Canada

Villeneuve, Paul J. ; Jerrett, Michael ; Brenner, Darren ; Su, Jason ; Chen, Hong ; McLaughlin, John R.

Few studies have investigated associations between nonoccupational exposure to ambient volatile organic compounds and lung cancer. We conducted a case-control study of 445 incident lung cancers and 948 controls (523 hospital, 425 general population) in Toronto, Ontario, Canada, between 1997 and 2002. Participants provided information on several risk factors, including tobacco use, secondhand exposure to cigarette smoke, obesity, and family history of cancer. Exposure to benzene, hydrocarbons, [...]

Menée en Californie auprès de 906 cas et de 38 253 témoins, cette étude analyse l'association entre la prise de médicaments antidépresseurs à base de fluoxétine et de paroxétine et le risque de cancer du testicule

Antidepressants and testicular cancer

Friedman, GaryD ; Schwalbe, Joan ; Achacoso, Ninah ; Meng, MaxwellV ; Kroenke, CandyceH ; Habel, LaurelA

Purpose : Re-examine association of fluoxetine and paroxetine with risk of testicular cancer noted in drug screening, with 4 years more follow-up and expanded study of these and other antidepressant drugs. Methods : In the Kaiser Permanente Medical Care Program in Northern California, 906 men with testicular cancer diagnosed August 1996–December 2010 were compared with 38,253 matched controls with race/ethnicity recorded regarding receipt of antidepressant drugs at least 2 years before [...]

A partir d'une revue de la littérature (19 études identifiées), cette méta-analyse évalue l'association entre trois polymorphismes du gène XRCC1 et le risque de leucémie

Genetic Polymorphisms of XRCC1 and Leukemia Risk: A Meta-Analysis of 19 Case-Control Studies

Zhang, Haijun ; Liu, Hang ; Jiang, Gaofeng

Objective : Three common X-ray repair cross-complementing groups 1 (XRCC1) polymorphisms, Arg399Gln, Arg194Trp, and Arg280His, have been reported to be implicated in the development of leukemia. However, previous results from different studies were inconsistent. Consequently, we performed a meta-analysis in order to accurately evaluate the association between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and leukemia risk. Methods : Through computerized searching of PubMed, ISI Web of [...]

Menée initialement sur 1 739 patients atteints d'une leucémie lymphocytaire chronique et 5 199 témoins, puis sur une cohorte complémentaire de 1 144 cas et 3 151 témoins, cette étude d'association sur le génome entier identifie de nouveaux loci de susceptibilité à la maladie

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia

Speedy, Helen E. ; Di Bernardo, Maria Chiara ; Sava, Georgina P. ; Dyer, Martin J. S. ; Holroyd, Amy ; Wang, Yufei ; Sunter, Nicola J. ; Mansouri, Larry ; Juliusson, Gunnar ; Smedby, Karin E. ; Roos, Goran ; Jayne, Sandrine ; Majid, Aneela ; Dearden, Claire ; Hall, Andrew G. ; Mainou-Fowler, Tryfonia ; Jackson, Graham H. ; Summerfield, Geoffrey ; Harris, Robert J. ; Pettitt, Andrew R. ; Allsup, David J. ; Bailey, James R. ; Pratt, Guy ; Pepper, Chris ; Fegan, Chris ; Rosenquist, Richard ; Catovsky, Daniel ; Allan, James M. ; Houlston, Richard S.

Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = [...]

A partir de données portant sur des parentes de 1 548 patientes atteintes d'un cancer épithélial de l'ovaire, cette étude britannique évalue le risque familial relatif de développer la maladie en fonction du statut des mutations BRCA1 et BRCA2

Ovarian cancer familial relative risks by tumour subtypes and by known ovarian cancer genetic susceptibility variants

Jervis, Sarah ; Song, Honglin ; Lee, Andrew ; Dicks, Ed ; Tyrer, Jonathan ; Harrington, Patricia ; Easton, Douglas F ; Jacobs, Ian J ; Pharoah, Paul P D ; Antoniou, Antonis C

Background Family history is one of the most important risk factors for epithelial ovarian cancer (EOC). Little is known, however, on how EOC familial relative risks (FRRs) vary by factors such as tumour subtype or the combined effects of common EOC susceptibility alleles. In addition, no data currently exist on the FRRs associated with EOC after exclusion of BRCA1 or BRCA2 mutation carriers. Methods EOC FRRs were computed from observed EOCs in relatives of 1548 patients with EOC recruited [...]

A partir des données de la cohorte "Physicians’ Health Study and Health Professionals Follow-Up Study" portant sur 1 243 participants, cette étude évalue l'association entre l'obésité, la sur-expression du gène de fusion TMPRSS2:ERG et le risque de cancer fatal de la prostate

Modification of the Association Between Obesity and Lethal Prostate Cancer by TMPRSS2:ERG

Pettersson, Andreas ; Lis, Rosina T. ; Meisner, Allison ; Flavin, Richard ; Stack, Edward C. ; Fiorentino, Michelangelo ; Finn, Stephen ; Graff, Rebecca E. ; Penney, Kathryn L. ; Rider, Jennifer R. ; Nuttall, Elizabeth J. ; Martin, Neil E. ; Sesso, Howard D. ; Pollak, Michael ; Stampfer, Meir J. ; Kantoff, Philip W. ; Giovannucci, Edward L. ; Loda, Massimo ; Mucci, Lorelei A.

Background : TMPRSS2:ERG is a hormonally regulated gene fusion present in about half of prostate tumors. We investigated whether obesity, which deregulates several hormonal pathways, interacts with TMPRSS2:ERG to impact prostate cancer outcomes. Methods : The study included 1243 participants in the prospective Physicians’ Health Study and Health Professionals Follow-Up Study diagnosed with prostate cancer between 1982 and 2005. ERG overexpression (a TMPRSS2:ERG marker) was assessed by [...]

Menée dans cinq pays différents auprès de 7 015 femmes porteuses d'une mutation d'un gène BRCA1 ou BRCA2, cette étude analyse le risque de cancer colorectal en fonction de l'âge et du gène muté

Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study

Phelan, C. M. ; Iqbal, J. ; Lynch, H. T. ; Lubinski, J. ; Gronwald, J. ; Moller, P. ; Ghadirian, P. ; Foulkes, W. D. ; Armel, S. ; Eisen, A. ; Neuhausen, S. L. ; Senter, L. ; Singer, C. F. ; Ainsworth, P. ; Kim-Sing, C. ; Tung, N. ; Llacuachaqui, M. ; Chornokur, G. ; Ping, S. ; Narod, S. A.

Background: The BRCA1 and BRCA2 genes confer increased susceptibility to breast and ovarian cancer and to a spectrum of other cancers. There is controversy regarding the risk of colorectal cancer conferred by germline mutations in these two genes. Methods: We followed 7015 women with a BRCA mutation for new cases of colorectal cancer. Incidence rates in carriers were compared with population-specific incidence rates, and standardised incidence ratios (SIRs) were estimated. The expected numbers [...]

Menée auprès de 49 participantes non porteuses de mutations génétiques BRCA1/2 mais parentes au premier degré de femmes porteuses de mutations BRCA1/2, cette étude prospective analyse leur risque de cancer du sein

Increased Rate of Phenocopies in All Age Groups in BRCA1/BRCA2 Mutation Kindred, but Increased Prospective Breast Cancer Risk Is Confined to BRCA2 Mutation Carriers

Evans, D. Gareth R. ; Ingham, Sarah L. ; Buchan, Iain ; Woodward, Emma R. ; Byers, Helen ; Howell, Anthony ; Maher, Eamonn R. ; Newman, William G. ; Lalloo, Fiona

Background: To establish, if among unaffected noncarrier relatives in a family with an established BRCA1/2 mutation, there is an increased risk of breast cancer. Methods: We identified 49 women with breast cancer who were first-degree relatives of a pathogenic mutation carrier among 807 BRCA1/2 families but who tested negative for the specific mutation. A prospective analysis of breast cancer from date of family ascertainment was performed for first-degree relatives of proven BRCA1/2 mutation [...]

Menée sur 582 familles porteuses de mutations du gène BRCA1 et 176 familles porteuses de mutations du gène BRCA2, cette étude néerlandaise analyse les risques de cancer du sein ou de l'ovaire en fonction de l'âge, de l'histoire familiale et de la localisation chromosomique des mutations

Breast and ovarian cancer risks in a large series of clinically ascertained families with a high proportion of BRCA1 and BRCA2 Dutch founder mutations

Brohet, Richard M ; Velthuizen, Maria E ; Hogervorst, Frans B L ; Meijers-Heijboer, Hanne EJ ; Seynaeve, Caroline ; Collée, Margriet J ; Verhoef, Senno ; Ausems, Margreet G E M ; Hoogerbrugge, Nicoline ; van Asperen, Christi J ; Gómez García, Encarna ; Menko, Fred ; Oosterwijk, Jan C ; Devilee, Peter ; Veer, Laura J van't ; van Leeuwen, Flora E ; Easton, Douglas F ; Rookus, Matti A ; Antoniou, Antonis C ; HEBON Resource

Background BRCA1 or BRCA2 mutations confer increased risks of breast and ovarian cancer, but risks have been found to vary across studies and populations. Methods We ascertained pedigree data of 582 BRCA1 and 176 BRCA2 families and studied the variation in breast and ovarian cancer risks using a modified segregation analysis model. Results The average cumulative breast cancer risk by age 70 years was estimated to be 45% (95% CI 36 to 52%) for BRCA1 and 27% (95% CI 14 to 38%) for BRCA2 mutation [...]

Menée en France auprès de 689 cas et de 3 481 témoins, cette étude en population évalue l'association entre une histoire familiale de cancer, des antécédents médicaux et le risque de cancer de la cavité buccale

Family history of cancer, personal history of medical conditions and risk of oral cavity cancer in France: the ICARE study

Radoi, Loredana ; Paget-Bailly, Sophie ; Guida, Florence ; Cyr, Diane ; Menvielle, Gwenn ; Schmaus, Annie ; Carton, Matthieu ; Cenée, Sylvie ; Sanchez, Marie ; Guizard, Anne-Valérie ; Tretarre, Brigitte ; Stücker, Isabelle ; Luce, Danièle

BACKGROUND:The aim of this study was to evaluate the role of family history of cancer and personal history of other medical conditions in the aetiology of the oral cavity cancer in France. METHODS:We used data from 689 cases of oral cavity squamous cell carcinoma and 3481 controls included in a population-based case--control study, the ICARE study. Odds-ratios (ORs) associated with family history of cancer and personal medical conditions and their 95% confidence intervals (95% CI) were [...]

Menée aux Etats-Unis auprès de 1 087 cas et de 1 090 témoins, cette étude analyse l'association entre des polymorphismes à simple nucléotide du gène RASSF3 et le risque de cancer de la tête et du cou

Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neck

Guo, Hongguang ; Liu, Hongliang ; Wei, Jianhua ; Li, Yangkai ; Yu, Hongping ; Guan, Xiaoxiang ; Li-E, Wang ; Li, GuoJun ; Sturgis, Erich M. ; Wei, Qingyi ; Liu, ZhenSheng

RASSF3 suppresses tumour formation through uncertain mechanisms, but it is an important gene of p53-dependent apoptosis. RASSF3 depletion impairs DNA repair after DNA damage, leading to polyploidy. The authors hypothesised that potential functional single-nucleotide polymorphisms (SNPs) of RASSF3 are associated with risk of squamous cell carcinoma of the head and neck (SCCHN). The authors used a functional SNP approach to evaluate the associations between common (minor allele frequency⩾0.05), [...]

Menée au Japon auprès de 472 cas et 464 témoins, cette étude analyse l'association entre certains modes de vie (nutrition, activité physique, facteurs reproductifs), des polymorphismes à simple nucléotide de gènes déjà identifiés dans des études antérieures sur le génome entier et le risque de cancer du sein

Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case--control study in Japanese women

Mizoo, Taeko ; Taira, Naruto ; Nishiyama, Keiko ; Nogami, Tomohiro ; Iwamoto, Takayuki ; Motoki, Takayuki ; Shien, Tadahiko ; Matsuoka, Junji ; Doihara, Hiroyoshi ; Ishihara, Setsuko ; Kawai, Hiroshi ; Kawasaki, Kensuke ; Ishibe, Youichi ; Ogasawara, Yutaka ; Komoike, Yoshifumi ; Miyoshi, Shinichiro

BACKGROUND:Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were to validate the association between reported SNPs and breast cancer risk in the Japanese population and to evaluate the effects of SNP genotypes and lifestyle factors on breast [...]