Menée aux Etats-Unis auprès de 726 patients atteints d'un cancer de la vessie, cette étude évalue l'association entre l'indice de masse corporelle, le tabagisme et le risque de récidive du cancer

Body mass and smoking are modifiable risk factors for recurrent bladder cancer

Wyszynski, Asaf ; Tanyos, Sam A. ; Rees, Judy R. ; Marsit, Carmen J. ; Kelsey, Karl T. ; Schned, Alan R. ; Pendleton, Eben M. ; Celaya, Maria O. ; Zens, Michael S. ; Karagas, Margaret R. ; Andrew, Angeline S.

BACKGROUND In the Western world, bladder cancer is the fourth most common cancer in men and the eighth most common in women. Recurrences frequently occur, and continued surveillance is necessary to identify and treat recurrent tumors. Efforts to identify risk factors that are potentially modifiable to reduce the rate of recurrence are needed. METHODS Cigarette smoking behavior and body mass index were investigated at diagnosis for associations with bladder cancer recurrence in a [...]

A partir des données d'une cohorte multiethnique conduite à Hawaii et en Californie et incluant 85 089 femmes, cette étude évalue l'association entre une consommation modérée d'alcool et le risque de cancer du sein après la ménopause

Alcohol consumption and breast cancer risk among women from five ethnic groups with light to moderate intakes: The Multiethnic Cohort Study

Park, Song-Yi ; Kolonel, Laurence N. ; Lim, Unhee ; White, Kami K. ; Henderson, Brian E. ; Wilkens, Lynne R.

Higher alcohol consumption, even at moderate levels, has been associated with an increased risk of breast cancer in epidemiological studies. However, prior studies were conducted in mostly white populations. To assess the relationship of alcohol consumption to postmenopausal breast cancer risk in a multiethnic population of largely never, light or moderate drinkers, we prospectively examined the association in 85,089 women enrolled in the Multiethnic Cohort in Hawaii and California. During a [...]

A partir de données d'études menées en Italie et en Suisse sur la période 1991-2009 et portant sur un total de 10 484 cas et 11 656 témoins, cette étude analyse l'association entre une consommation de viande rouge et le risque de cancer, en fonction de la température et du temps de cuisson

Red meat and cancer risk in a network of case–control studies focusing on cooking practices

Di Maso, M. ; Talamini, R. ; Bosetti, C. ; Montella, M. ; Zucchetto, A. ; Libra, M. ; Negri, E. ; Levi, F. ; La Vecchia, C. ; Franceschi, S. ; Serraino, D. ; Polesel, J.

Background : Consumption of red meat has been related to increased risk of several cancers. Cooking methods could modify the magnitude of this association, as production of chemicals depends on the temperature and duration of cooking. Methods : We analyzed data from a network of case–control studies conducted in Italy and Switzerland between 1991 and 2009. The studies included 1465 oral and pharyngeal, 198 nasopharyngeal, 851 laryngeal, 505 esophageal, 230 stomach, 1463 colon, 927 rectal, 326 [...]

Menée auprès de 224 femmes américaines d'origine chinoise âgées de 36 à 58 ans, cette étude évalue l'association entre la consommation d'isoflavones d'origine alimentaire, la densité mammaire et le risque de cancer du sein en fonction de leur capacité à métaboliser la daidzéine en equol

Equol-Producing Status, Isoflavone Intake, and Breast Density in a Sample of U.S. Chinese Women

Tseng, Marilyn ; Byrne, Celia ; Kurzer, Mindy S. ; Fang, Carolyn Y.

Background: Differences in ability to metabolize daidzein to equol might help explain inconsistent findings about isoflavones and breast cancer. We examined equol-producing status in relation to breast density, a marker of breast cancer risk, and evaluated whether an association of isoflavone intake with breast density differs by equol-producing status in a sample of Chinese immigrant women. Methods: Participants were 224 women, ages 36 to 58 years, enrolled in a study on diet and breast [...]

A partir des données des registres américains du cancer et de la base Medicare portant sur 15 318 cas et 200 000 témoins, cette étude analyse l'association entre des infections par des virus ou des bactéries et le risque subséquent de myélome multiple

Common community-acquired infections and subsequent risk of multiple myeloma: A population-based study

McShane, Charlene M. ; Murray, Liam J. ; Engels, Eric A. ; Landgren, Ola ; Anderson, Lesley A.

The role of bacteria and viruses as aetiological agents in the pathogenesis of cancer has been well established for several sites, including a number of haematological malignancies. Less clear is the impact of such exposures on the subsequent development of multiple myeloma (MM). Using the population-based U.S. Surveillance Epidemiology and End Results-Medicare dataset, 15,318 elderly MM and 200,000 controls were identified to investigate the impact of 14 common community-acquired infections [...]

Menée en Suède auprès de 6 009 participantes, cette étude évalue l'association entre une anorexie mentale, le risque de cancer et la mortalité par cancer

Cancer incidence and mortality patterns in women with anorexia nervosa

Karamanis, Georgios ; Skalkidou, Alkistis ; Tsakonas, Georgios ; Brandt, Lena ; Ekbom, Anders ; Ekselius, Lisa ; Papadopoulos, Fotios C.

Caloric restriction in animals is an effective way to reduce carcinogenesis. Anorexia nervosa (AN) is considered a model of extreme caloric restriction in humans. The aim of our study was to assess cancer incidence and mortality in women with AN. A total of 6,009 women with at least one inpatient treatment for AN during the period 1973–2003 were included in the study. Standardized incidence ratios (SIR) and standardized mortality ratios (SMR) were calculated. Overall, there was no statistically [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2013 (6 études prospectives et 8 études cas-témoins), cette méta-analyse fait le point sur l'association entre la parité et le risque de cancer du rein

Parity and kidney cancer risk: evidence from epidemiological studies

Guan, Hong-Bo ; Wu, Qi-Jun ; Gong, Ting-Ting

Background: Observational studies have reported conflicting results between parity and kidney cancer risk. To our knowledge, a comprehensive and quantitative assessment of the association between parity and kidney cancer has not been reported. Thus, we conducted a systematic review and dose-response meta-analysis of published epidemiological studies to summarize the evidence of this association. Methods: Relevant published studies of parity and kidney cancer were identified using MEDLINE [...]

Menée en deux phases sur 2 390 cas d'adénocarcinome de l'œsophage, 3 175 cas d'endobrachyœsophage et 10 120 témoins, cette étude d'association sur le génome entier identifie trois nouveaux loci de susceptibilité

A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus

Levine, David M. ; Ek, Weronica E. ; Zhang, Rui ; Liu, Xinxue ; Onstad, Lynn ; Sather, Cassandra ; Lao-Sirieix, Pierre ; Gammon, Marilie D. ; Corley, Douglas A. ; Shaheen, Nicholas J. ; Bird, Nigel C. ; Hardie, Laura J. ; Murray, Liam J. ; Reid, Brian J. ; Chow, Wong-Ho ; Risch, Harvey A. ; Nyrén, Olof ; Ye, Weimin ; Liu, Geoffrey ; Romero, Yvonne ; Bernstein, Leslie ; Wu, Anna H. ; Casson, Alan G. ; Chanock, Stephen J. ; Harrington, Patricia ; Caldas, Isabel ; Debiram-Beecham, Irene ; Caldas, Carlos ; Hayward, Nicholas K. ; Pharoah, Paul D. ; Fitzgerald, Rebecca C. ; MacGregor, Stuart ; Whiteman, David C. ; Vaughan, Thomas L.

Esophageal adenocarcinoma is a cancer with rising incidence and poor survival. Most such cancers arise in a specialized intestinal metaplastic epithelium, which is diagnostic of Barrett's esophagus. In a genome-wide association study, we compared esophageal adenocarcinoma cases (n = 2,390) and individuals with precancerous Barrett's esophagus (n = 3,175) with 10,120 controls in 2 phases. For the combined case group, we identified three new associations. The first is at 19p13 (rs10419226: P = [...]

A partir des données de la cohorte "Women's Health Initiative", cette étude évalue l'association entre le quotient respiratoire et le risque de cancer du sein après la ménopause

An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer

Prentice, Ross L. ; Neuhouser, Marian L. ; Tinker, Lesley F. ; Pettinger, Mary ; Thomson, Cynthia A. ; Mossavar-Rahmani, Yasmin ; Thomas, Fridtjof ; Qi, Lihong ; Huang, Ying

Background: The respiratory quotient (RQ), defined as the ratio of carbon dioxide exhaled to oxygen uptake, reflects substrate utilization when energy is expended. Fat and alcohol have RQ values of about 0.7, compared to 1.0 for carbohydrate, and about 0.8 for protein. Here, the association between RQ and postmenopausal breast cancer risk is studied. Methods: Paired RQ measurements were obtained, separated by about 6 months, for women in the reliability subset of a Women's Health Initiative [...]

Menée dans la ville de New York et dans l'Etat du New Jersey auprès de 978 cas et de 958 témoins, cette étude évalue l'association entre l'indice de masse corporelle, des indicateurs liés à l'obésité et le risque de cancer du sein chez des femmes afro-américaines

Body fatness and breast cancer risk in women of African ancestry

Bandera, Elisa ; Chandran, Urmila ; Zirpoli, Gary ; Gong, Zhihong ; McCann, Susan ; Hong, Chi-Chen ; Ciupak, Gregory ; Pawlish, Karen ; Ambrosone, Christine

BACKGROUND:Obesity has been shown to be inversely associated with breast cancer risk in premenopausal women, while increasing risk in postmenopausal women. However, the current evidence is largely based on studies in Caucasian populations. Associations in women of African ancestry (AA), who have a higher prevalence of obesity, have been evaluated in few studies and results suggest different effects. METHODS:We evaluated the impact of body size, body fat distribution, and body composition on [...]

Menée sur des bases de données et in vitro, cette étude identifie un polymorphisme à simple nucléotide, situé sur la région chromosomique régulant le gène KITLG, en association avec un risque de cancer du testicule différent selon l'origine ethnique des patients

A Polymorphic p53 Response Element in KIT Ligand Influences Cancer Risk and Has Undergone Natural Selection

Zeron-Medina, Jorge ; Wang, Xuting ; Repapi, Emmanouela ; Campbell, Michelle R ; Su, Dan ; Castro-Giner, Francesc ; Davies, Benjamin ; Peterse, Elisabeth F P. ; Sacilotto, Natalia ; Walker, Graeme J ; Terzian, Tamara ; Tomlinson, Ian P ; Box, Neil F ; Meinshausen, Nicolai ; De Val, Sarah ; Bell, Douglas A ; Bond, Gareth L

The ability of p53 to regulate transcription is crucial for tumor suppression and implies that inherited polymorphisms in functional p53-binding sites could influence cancer. Here, we identify a polymorphic p53 responsive element and demonstrate its influence on cancer risk using genome-wide data sets of cancer susceptibility loci, genetic variation, p53 occupancy, and p53-binding sites. We uncover a single-nucleotide polymorphism (SNP) in a functional p53-binding site and establish its [...]

A partir des données de la cohorte chinoise "Shanghai Men’s Health Study" portant sur 1 013 participants, cette étude évalue l'association entre une consommation de légumes crucifères, des polymorphismes du gène GST et le risque de cancer colorectal chez les hommes

Cruciferous vegetables, glutathione S-transferase polymorphisms and the risk of colorectal cancer among Chinese men

Vogtmann, Emily ; Xiang, Yong-Bing ; Li, Hong-Lan ; Cai, Quiyin ; Wu, Qi-Jun ; Xie, Li ; Li, Guo-Liang ; Yang, Gong ; Waterbor, John W. ; Levitan, Emily B. ; Zhang, Bin ; Zheng, Wei ; Shu, Xiao-Ou

Purpose : To assess the associations between cruciferous vegetable (CV) intake, GST gene polymorphisms and colorectal cancer (CRC) in a population of Chinese men. Methods : Using incidence density sampling, CRC cases (N = 340) diagnosed prior to December 31, 2010 within the Shanghai Men’s Health Study were matched to non-cases (N = 673). CV intake was assessed from a food frequency questionnaire and by isothiocyanate (ITC) levels from spot urine samples. GSTM1 and GSTT1 were categorized as null [...]

Menée au Chili auprès de 538 cas et de 640 témoins, cette étude évalue l'association entre une consommation d'eau contaminée par l'arsenic, le tabagisme, une exposition professionnelle à divers produits chimiques et le risque de cancer du poumon ou de la vessie

Arsenic, Tobacco Smoke, and Occupation: Associations of Multiple Agents with Lung and Bladder Cancer

Ferreccio, Catterina ; Yuan, Yan ; Calle, Jacqueline ; Benítez, Hugo ; Parra, Roxana L. ; Acevedo, Johanna ; Smith, Allan H. ; Liaw, Jane ; Steinmaus, Craig

Background:Millions of people worldwide are exposed to arsenic in drinking water, and many are likely coexposed to other agents that could substantially increase their risks of arsenic-related cancer. Methods:We performed a case-control study of multiple chemical exposures in 538 lung and bladder cancer cases and 640 controls in northern Chile, an area with formerly high drinking water arsenic concentrations. Detailed information was collected on lifetime arsenic exposure, smoking, secondhand [...]