Menée auprès de 444 adolescents ayant survécu à un cancer pédiatrique et de 189 frères ou sœurs de ces patients, cette étude analyse leur santé et leur qualité de vie

Health and well-being in adolescent survivors of early childhood cancer: a report from the Childhood Cancer Survivor Study

Mertens, Ann C. ; Brand, Sarah ; Ness, Kirsten K. ; Li, Zhenghong ; Mitby, Pauline A. ; Riley, Anne ; Patenaude, Andrea Farkas ; Zeltzer, Lonnie

Objective : With the growing number of childhood cancer survivors in the US, it is important to assess the well-being of these individuals, particularly during the transitional phase of adolescence. Data about adolescent survivors' overall health and quality of life will help identify survivor subgroups most in need of targeted attention to successfully transition to adulthood. Participants and methods This ancillary study to the Childhood Cancer Survivor Study focused on children 15-19 years [...]

A partir d'une revue systématique de la littérature (15 essais randomisés), cette méta-analyse évalue l'intérêt d'une éducation du patient atteint de cancer pour améliorer sa propre capacité à gérer la douleur liée à la maladie

Optimal patient education for cancer pain: a systematic review and theory-based meta-analysis

Marie, N. ; Luckett, T. ; Davidson, P. M. ; Lovell, M. ; Lal, S.

Purpose : Previous systematic reviews have found patient education to be moderately efficacious in decreasing the intensity of cancer pain, but variation in results warrants analysis aimed at identifying which strategies are optimal. Methods : A systematic review and meta-analysis was undertaken using a theory-based approach to classifying and comparing educational interventions for cancer pain. The reference lists of previous reviews and MEDLINE, PsycINFO, and CENTRAL were searched in May [...]

Menée en Espagne auprès de 667 participants, cette étude prospective multicentrique évalue l'intérêt d'un questionnaire destiné à mesurer la fatigue de patients atteints de cancer et souffrant d'anémie

Usefulness of the PERFORM questionnaire to measure fatigue in cancer patients with anemia: a prospective, observational study

Gascón, Pere ; Rodríguez, CésarA ; Valentín, Vicente ; Mata, JesúsGarcía ; Carulla, Joan ; Cassinello, Javier ; Colomer, Ramón ; Baró, Eva

Background : The PERFORM Questionnaire is a 12-item scale developed for assessing fatigue in cancer patients in the clinical practice. It has advantages over other tools in that it is short and includes beliefs and attitudes of patients about fatigue. It was psychometrically validated in cancer patients with and without anemia. Purpose : We evaluated the usefulness of the PERFORM scale to measure fatigue in a large study focusing exclusively on anemic patients. Methods : This was an [...]

Menée auprès de 187 patients atteints d'un cancer du poumon et recevant une chimiothérapie à l'hôpital, cette étude autrichienne analyse leur qualité de vie en fonction de la ligne de traitement

Quality of life during chemotherapy in lung cancer patients: results across different treatment lines

Wintner, L. M. ; Giesinger, J. M. ; Zabernigg, A. ; Sztankay, M. ; Meraner, V. ; Pall, G. ; Hilbe, W. ; Holzner, B.

Background: Most lung cancer patients are diagnosed at an advanced disease stage and predominantly receive palliative treatment, which increasingly consists of several chemotherapy lines. We report on patients’ quality of life (QOL) to gain knowledge on QOL during and across multiple lines of chemotherapy. This includes patients with (neo)adjuvant therapy up to 3rd or above line palliative chemotherapy. Methods: Lung cancer patients receiving outpatient chemotherapy at the Kufstein County [...]

Mené auprès de 120 participants âgés de 46 à 91 ans, cet essai randomisé analyse l'efficacité de la venlafaxine et de protéines de soja sous forme de poudre pour atténuer la sévérité des bouffées de chaleur et améliorer la qualité de vie des patients atteints d'un cancer de la prostate

Randomized Trial to Assess the Impact of Venlafaxine and Soy Protein on Hot Flashes and Quality of Life in Men With Prostate Cancer

Vitolins, Mara Z. ; Griffin, Leah ; Tomlinson, W. Vic ; Vuky, Jacqueline ; Adams, Paul T. ; Moose, Dawn ; Frizzell, Bart ; Lesser, Glenn J. ; Naughton, Michelle ; Radford, James E. ; Shaw, Edward G.

Purpose : Hot flashes occur in approximately 80% of androgen-deprived men. Few intervention studies have been conducted to relieve hot flashes in men. Patients And methods : Eligible androgen-deprived men were randomly assigned to one of four daily regimens (2 × 2 factorial design) for 12 weeks: milk protein powder and placebo pill, venlafaxine and milk protein powder, soy protein powder and placebo pill, or venlafaxine and soy protein powder. The primary end point was hot flash symptom [...]

A partir des données d'un registre australien des cancers portant sur la période 1999-2007, cette étude analyse les caractéristiques des cas de cancer de la prostate enregistrés avec un stade inconnu, et évalue la survie des patients

Characteristics of cases with unknown stage prostate cancer in a population-based cancer registry

Luo, Qingwei ; Yu, Xue Qin ; Cooke-Yarborough, Claire ; Smith, David P. ; O’Connell, Dianne L.

Background : The New South Wales Central Cancer Registry (NSW CCR) is the only population-based cancer registry in Australia that has routinely collected summary stage at diagnosis since its inception in 1972. However, a large proportion of prostate cancer cases have “unknown” stage recorded by the registry. We investigated the characteristics of prostate cancer cases with “unknown” stage recorded by the NSW CCR, and examined survival for this group. Methods : Data were obtained from the NSW [...]

Cette étude présente les estimations de l'American Cancer Society sur l'incidence, la mortalité, le dépistage du cancer du sein aux Etats-Unis en 2013

Breast cancer statistics, 2013

DeSantis, Carol ; Ma, Jiemin ; Bryan, Leah ; Jemal, Ahmedin

In this article, the American Cancer Society provides an overview of female breast cancer statistics in the United States, including data on incidence, mortality, survival, and screening. Approximately 232,340 new cases of invasive breast cancer and 39,620 breast cancer deaths are expected to occur among US women in 2013. One in 8 women in the United States will develop breast cancer in her lifetime. Breast cancer incidence rates increased slightly among African American women; decreased among [...]

A partir des données du registre californien des cancers portant sur 179 143 cas, cette étude analyse les disparités ethniques et socioéconomiques dans la mortalité des patientes atteintes d'un cancer du sein invasif, sur la période 2000-2010

Disparities in race/ethnicity and socioeconomic status: risk of mortality of breast cancer patients in the California Cancer Registry, 2000-2010

Parise, Carol ; Caggiano, Vincent

BACKGROUND:Racial disparities in breast cancer survival have been well documented. This study examines the association of race/ethnicity and socioeconomic status (SES) on breast cancer-specific mortality in a large population of women with invasive breast cancer. METHODS:We identified 179,143 cases of stages 1-3 first primary female invasive breast cancer from the California Cancer Registry from January, 2000 through December, 2010. Cox regression, adjusted for age, year of diagnosis, grade, [...]

Menée à partir des données des registres américains des cancers portant sur une cohorte de 22 777 patients atteints d'un glioblastome diagnostiqué entre 1988 et 2007, cette étude évalue l'utilisation de la radiothérapie, identifie les facteurs associés à sa non utilisation, puis analyse le bénéfice du traitement en terme de survie globale à deux ans

Underutilization of radiation therapy in patients with glioblastoma

Aizer, Ayal A. ; Ancukiewicz, Marek ; Nguyen, Paul L. ; Shih, Helen A. ; Loeffler, Jay S. ; Oh, Kevin S.

BACKGROUND : Randomized trials have demonstrated that radiation improves survival in patients with glioblastoma. The purpose of this study was to characterize the risk factors and impact of omission of radiation therapy in such patients. METHODS : The Surveillance, Epidemiology, and End Results (SEER) program was used to identify 22,777 patients diagnosed with glioblastoma between 1988 and 2007. Multivariable logistic regression was employed to identify predictors associated with omission of [...]

Menée auprès de 963 patients atteints de cancer, cette étude espagnole analyse l'efficacité et la pertinence d'un outil permettant de mesurer leur détresse psychologique

The Distress Thermometer in Spanish cancer patients: convergent validity and diagnostic accuracy

Martínez, Paula ; Galdón, MaríaJosé ; Andreu, Yolanda ; Ibáñez, Elena

Purpose : International organizations such as National Comprehensive Cancer Network and NICE recommend implementation of routine screening programs for detecting and managing psychosocial distress among cancer patients. The selection of an adequate screening tool is crucial to the effectiveness of these programs. The present study examines the emotional symptomatology captured by the Distress Thermometer (DT) and its accuracy and validity as a screening tool in cancer. It also explores the [...]

Menée par entretiens auprès de 1 217 patients atteints de cancer, cette étude chinoise analyse la prévalence ainsi que les facteurs de risque associés à des symptômes de dépression et d'anxiété

Prevalence of anxiety and depression and their risk factors in Chinese cancer patients

Hong, JinSheng ; Tian, Jun

Purpose : This paper aimed to obtain information on the levels of anxiety and depression among cancer patients in China. The factors influencing these psychological problems were also analyzed. Methods : A total of 1,217 cancer patients were interviewed, and each participant was asked to complete a self-administered questionnaire. The anxiety status, depression status, disease stage, tumor site, pain status, and performance status of the patients during the week prior to the interview were [...]

A partir d'entretiens menés avec 42 patients atteints d'un cancer du poumon, cette étude propose et analyse un modèle conceptuel destiné à rapporter et mesurer la stigmatisation liée à la maladie dont ils se sentent victimes

Stigma among patients with lung cancer: a patient-reported measurement model

Hamann, Heidi A. ; Ostroff, Jamie S. ; Marks, Emily G. ; Gerber, David E. ; Schiller, Joan H. ; Lee, Simon J. Craddock

Background : Although stigma may have negative psychosocial and behavioral outcomes for patients with lung cancer, its measurement has been limited. A conceptual model of lung cancer stigma and a patient-reported outcome measure are needed to mitigate these sequelae. This study identified key stigma-related themes to provide a blueprint for item development through a thematic analysis of semi-structured interviews and focus groups with lung cancer patients. Methods : Participants were recruited [...]

A partir d'une revue systématique de la littérature, cette étude fait le point sur la prévalence des symptômes dépressifs chez les patientes atteintes d'un cancer du sein et recense les essais cliniques pharmacologiques et psychothérapeutiques

Major depressive disorder in breast cancer: A critical systematic review of pharmacological and psychotherapeutic clinical trials

Carvalho, André F. ; Hyphantis, Thomas ; Sales, Paulo Marcelo G. ; Soeiro-de-Souza, Márcio G. ; Macêdo, Danielle S. ; Cha, Danielle S. ; McIntyre, Roger S. ; Pavlidis, Nicholas

While women with breast cancer often face varying levels of psychological distress, there is a subgroup whose symptomatology reaches a threshold for diagnosis of major depressive disorder (MDD). Major depressive disorder is known to influence patient outcomes, such as health-related quality of life and treatment adherence. There are no systematic reviews that evaluate pharmacological and psychotherapeutic treatment trials for MDD among individuals with breast cancer. Two authors independently [...]

Mené au Japon, cet essai randomisé contrôlé analyse le rapport coût-efficacité d'une chimiothérapie adjuvante par S-1 pour améliorer la survie sans récidive de patients ayant subi une résection d'un cancer de l'estomac

Cost-effectiveness of adjuvant chemotherapy for curatively resected gastric cancer with S-1

Hisashige, Akinori ; Sasako, Mitsuru ; Nakajima, Toshifusa

BACKGROUND:The effectiveness of specific regimens of adjuvant therapy for gastric cancer has not been verified by large clinical trials. Recently, several large trials attempted to verify the effectiveness of adjuvant therapy. The Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer in Japan, a randomized controlled trial of adjuvant S-1 therapy for resected gastric cancer, demonstrated significant improvement in overall and relapse-free survival, compared to surgery alone. To evaluate value [...]

Menée auprès de 1 130 oncologues médicaux et de 1 020 médecins généralistes, cette étude américaine analyse la mise en œuvre de leur coordination, au travers de la transmission d'informations thérapeutiques et du dossier médical du patient, dans le suivi des soins dédiés aux patients après leur traitement

Use of Survivorship Care Plans in the United States: Associations With Survivorship Care

Forsythe, Laura P. ; Parry, Carla ; Alfano, Catherine M. ; Kent, Erin E. ; Leach, Corinne R. ; Haggstrom, David A. ; Ganz, Patricia A. ; Aziz, Noreen ; Rowland, Julia H.

Background : Survivorship care plans (SCPs), including a treatment summary and follow-up plan, intend to promote coordination of posttreatment cancer care; yet, little is known about the provision of these documents by oncologists to primary care physicians (PCPs). This study compared self-reported oncologist provision and PCP receipt of treatment summaries and follow-up plans, characterized oncologists who reported consistent provision of these documents to PCPs, and examined associations [...]

A partir des données issues des dossiers médicaux électroniques de 551 patients (âge moyen : 62 ans), cette étude britannique analyse l'efficacité et les coûts associés à la mise en place de réunions de concertation pluridisciplinaire en oncologie

A study of the decision outcomes and financial costs of multidisciplinary team meetings (MDMs) in oncology

De Ieso, P. B. ; Coward, J. I. ; Letsa, I. ; Schick, U. ; Nandhabalan, M. ; Frentzas, S. ; Gore, M. E.

Background: The benefits of multidisciplinary working in oncology are now accepted as the norm and widely accepted as being pivotal to the delivery of optimal cancer care. Central to this are the multidisciplinary meetings (MDMs) and we have evaluated decision outcomes and financial costs of these. Methods: We reviewed the electronic patient records of 551 newly referred patients, discussed at 14 tumour site-specific MDMs for adult solid tumours and lymphoma (paediatric oncology and acute [...]

Menée en population américaine masculine bénéficiant de la couverture médicale Médicare (âge : 66-99 ans), cette étude analyse les coûts associés à un dépistage du cancer de la prostate à l'aide du PSA

The cost implications of prostate cancer screening in the Medicare population

Ma, Xiaomei ; Wang, Rong ; Long, Jessica B. ; Ross, Joseph S. ; Soulos, Pamela R. ; Yu, James B. ; Makarov, Danil V. ; Gold, Heather T. ; Gross, Cary P.

BACKGROUND Recent debate about prostate-specific antigen (PSA)-based testing for prostate cancer screening among older men has rarely considered the cost of screening. METHODS A population-based cohort of male Medicare beneficiaries aged 66 to 99 years, who had never been diagnosed with prostate cancer at the end of 2006 (n = 94,652), was assembled, and they were followed for 3 years to assess the cost of PSA screening and downstream procedures (biopsy, pathologic analysis, and hospitalization [...]

Menée à Taïwan auprès de 257 participants, cette étude analyse l'efficacité d'un programme de développement des compétences en communication des soignants pour révéler la vérité de leur pronostic aux patients atteints de cancer et à leurs familles

Effectiveness of Japanese SHARE model in improving Taiwanese healthcare personnel's preference for cancer truth telling

Tang, Woung-Ru ; Chen, Kuan-Yu ; Hsu, Sheng-Hui ; Juang, Yeong-Yuh ; Chiu, Shin-Che ; Hsiao, Shu-Chun ; Fujimori, Maiko ; Fang, Chun-Kai

Background : Communication skills training (CST) based on the Japanese SHARE model of family-centered truth telling in Asian countries has been adopted in Taiwan. However, its effectiveness in Taiwan has only been preliminarily verified. This study aimed to test the effect of SHARE model-centered CST on Taiwanese healthcare providers' truth-telling preference, to determine the effect size, and to compare the effect of 1-day and 2-day CST programs on participants' truth-telling preference. [...]

Cette étude évalue l'efficacité d'une intervention pédagogique, culturelle et linguistique, destinée à améliorer les connaissances d'une population américaine d'origine chinoise sur les essais cliniques en cancérologie et de les inciter à y participer

The Impact of a Community-Based Clinical Trial Educational Intervention Among Underrepresented Chinese Americans

Ma, Grace X. ; Tan, Yin ; Blakeney, Natasha C. ; Seals, Brenda F. ; Ma, Xiang S. ; Zhai, Shumenghui ; Liu, Amy ; Tai, Yanfei ; Michaels, Margo

Background: Clinical trials are a critical resource for the discovery of new prevention, diagnostic and treatment methods for cancer. The most effective prevention and treatment modalities are based on previous clinical trial results. However, participation in clinical trials is underrepresented by racial/ethnic minority populations, Asian Americans in particular. Asian Americans are the least represented of any ethnic groups in clinical trials. Objective: The purpose of this study is to [...]

Menée auprès de 62 parents, cette étude transversale américaine analyse leurs préférences en matière d'informations communiquées dans le cadre du dispositif d'annonce du diagnostic de cancer de leur enfant

Day One Talk: parent preferences when learning that their child has cancer

Kessel, RachelM ; Roth, Michael ; Moody, Karen ; Levy, Adam

Purpose : The discussion that occurs between a pediatric oncologist and a family when they first learn about their child’s new diagnosis of cancer is known as the “Day One Talk.” Few studies have addressed parent preferences when learning that their child has been diagnosed with cancer. The objective of this study is to assess what information parents of children with newly diagnosed cancer believe is important to learn during the Day One Talk. Methods : In this cross-sectional study, a survey [...]

Menée auprès de 266 patients atteints de cancer et traités à l'extérieur de l'hôpital, cette étude observationnelle américaine analyse l'efficacité des visites de suivi pour dispenser des soins palliatifs, traiter les symptômes des patients et améliorer leur qualité de vie

Palliative and oncologic co-management: symptom management for outpatients with cancer

Bischoff, Kara ; Weinberg, Vivian ; Rabow, MichaelW

Purpose : Although outpatient palliative care clinics are increasingly common, evidence for their efficacy remains limited. Methods : We conducted an observational study at the palliative care clinic of an academic cancer center to assess the association between palliative care co-management and symptoms and quality of life. Two hundred sixty-six adult outpatients were seen for a minimum of two palliative care visits within 120 days. A subset of 142 patients was seen for a third visit within [...]