A partir des données de la cohorte américaine "Black Women’s Health Study", cette étude prospective évalue l'association entre le tabagisme et le risque de cancer du sein chez les femmes afro-américaines

A prospective study of smoking and breast cancer risk among African-American women

Rosenberg, Lynn ; Boggs, DeborahA ; Bethea, TraciN ; Wise, LaurenA ; Adams-Campbell, LucileL ; Palmer, JulieR

Purpose : Active smoking and passive smoking have been associated with increased risk of breast cancer. The purpose of the present study was to prospectively assess associations of smoking with breast cancer and identify subgroups at higher risk among African-American women. Methods : Based on 1,377 incident cases identified during 14 years of follow-up in the Black Women’s Health Study, we assessed active and passive smoking in relation to breast cancer incidence by menopausal status, estrogen [...]

Menée auprès de 803 patientes et de 889 témoins afro-américaines, de 755 patientes et de 701 témoins de type caucasien, cette étude analyse les disparités ethniques dans l'association entre une consommation alimentaire de viande rouge et de volaille et le risque de cancer du sein

Racial disparities in red meat and poultry intake and breast cancer risk

Chandran, Urmila ; Zirpoli, Gary ; Ciupak, Gregory ; McCann, SusanE ; Gong, Zhihong ; Pawlish, Karen ; Lin, Yong ; Demissie, Kitaw ; Ambrosone, ChristineB ; Bandera, ElisaV

Purpose : Research on the role of red meat and poultry consumption in breast carcinogenesis is inconclusive, but the evidence in African-American (AA) women is lacking. The association between consuming meat and breast cancer risk was examined in the Women’s Circle of Health Study involving 803 AA cases, 889 AA controls, 755 Caucasian cases, and 701 Caucasian controls. Methods : Dietary information was collected using a Food Frequency Questionnaire. Odds ratios (OR) and 95 % confidence [...]

A partir d'une revue systématique de la littérature (21 études, 19 études cas-témoins et 2 études de cohorte incluant 6 49 cas), cette méta-analyse évalue l'association entre une consommation de viande rouge, de viandes transformées et le risque de carcinome épidermoïde de l'œsophage

Consumption of red and processed meat and risk for esophageal squamous cell carcinoma based on a meta-analysis

Xudong, Qu ; qiwen, Ben ; Ying, Jiang

Purpose To provide a quantitative assessment of the association between red and processed meat intake and the risk of esophageal squamous cell carcinoma (ESCC), we summarized the evidence from observational studies. Methods Relevant studies were identified in MEDLINE and EMBASE until October 31, 2012. Summary relative risks (SRRs) with 95% confidence intervals (CIs) were pooled with high versus low and linear dose-response random-effects models. Results A total of 21 studies (19 case-control [...]

A partir de données portant sur 4 433 tumeurs et 19 types de cancer, cette étude dresse une cartographie des associations entre tumeurs et virus qui ne confirme pas l'étiologie virale postulée pour plusieurs types de cancer

The landscape of viral expression and host gene fusion and adaptation in human cancer

Tang, Ka-Wei ; Alaei-Mahabadi, Babak ; Samuelsson, Tore ; Lindh, Magnus ; Larsson, Erik

Viruses cause 10–15% of all human cancers. Massively parallel sequencing has recently proved effective for uncovering novel viruses and virus–tumour associations, but this approach has not yet been applied to comprehensive patient cohorts. Here we screen a diverse landscape of human cancer, encompassing 4,433 tumours and 19 cancer types, for known and novel expressed viruses based on >700 billion transcriptome sequencing reads from The Cancer Genome Atlas Research Network. The resulting map [...]

Couplée à une étude de cohorte finlandaise incluant des fumeurs masculins et menée auprès de 353 cas et de 353 témoins, cette étude évalue l'association entre une séropositivité à Helicobacter pylori et le risque de cancer du pancréas

Seropositivity to Helicobacter pylori and risk of pancreatic cancer

Yu, Guoqin ; Murphy, Gwen ; Michel, Angelika ; Weinstein, Stephanie J. ; Mannisto, Satu ; Albanes, Demetrius ; Pawlita, Michael ; Stolzenberg-Solomon, Rachael Z.

Helicobacter pylori seropositivity has been inconsistently associated with pancreatic cancer. We, therefore, investigated the association between H. pylori seropositivity and pancreatic cancer in a case-control study nested within Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) cohort of male Finnish male smokers. Pancreatic cancer cases (n=353) and control subjects (n=353) were matched on date of baseline serum collection, age at randomization, and follow-up time (up to 23.9 [...]

Menée auprès d'une cohorte française de 14 203 participants (dont 10 506 hommes et 3 697 femmes), cette étude évalue l'association entre des symptômes dépressifs et le risque de cancer

Depression and the Risk of Cancer: A 15-year Follow-up Study of the GAZEL Cohort

Lemogne, Cédric ; Consoli, Silla M. ; Melchior, Maria ; Nabi, Hermann ; Coeuret-Pellicer, Mireille ; Limosin, Frédéric ; Goldberg, Marcel ; Zins, Marie

Depression has long been hypothesized to be associated with cancer incidence. However, there is evidence for a positive publication bias in this field. In the present study, we examined the association between various measures of depression and cancer incidence at several sites. A total of 14,203 members of the French GAZEL (Gaz et Electricité) cohort (10,506 men, 3,697 women) were followed up for diagnoses of primary cancers from January 1, 1994, to December 31, 2009. All medically certified [...]

Menée à Taïwan auprès de 63 381 participants, cette étude rétrospective évalue l'association entre des troubles du sommeil et le risque de cancer

The Risk of Cancer Among Patients With Sleep Disturbance: A Nationwide Retrospective Study in Taiwan

Hu, Li-Yu ; Chen, Pan-Ming ; Hu, Yu-Wen ; Shen, Cheng-Che ; Perng, Chin-Lin ; Su, Tung-Ping ; Yen, Sang-Hue ; Tzeng, Cheng-Hwai ; Chiou, Tzeon-Jye ; Yeh, Chiu-Mei ; Chen, Tzeng-Ji ; Wang, Wei-Shu ; Liu, Chia-Jen

Objective : To investigate the risk of cancer among patients with non-apnea sleep disorders (SD). Methods : We included newly diagnosed SD patients aged 20 years and older without antecedent cancer between 2000 and 2010 from the National Health Insurance Research Database (NHIRD). Standardized incidence ratios (SIRs) of cancers were calculated to compare the cancer incidence of patients with SD with that of the general population. Results : During the 10-year study period, 2,062 cancers [...]

Couplée aux données de la cohorte américaine "Black Women's Health Study" et menée auprès de 917 cas et de 2 751 témoins, cette étude évalue l'association entre un diabète de type 2, un traitement par insuline et le risque d'adénome colorectal chez des femmes afro-américaines

Type 2 Diabetes and the Risk of Colorectal Adenomas: Black Women's Health Study

Dash, Chiranjeev ; Palmer, Julie R. ; Boggs, Deborah A. ; Rosenberg, Lynn ; Adams-Campbell, Lucile L.

Evidence for the association of type 2 diabetes mellitus (DM) with colorectal neoplasms is contradictory, and African Americans have been underrepresented in the studies published to date. In a nested case-control study (1995–2009), we examined DM and insulin therapy as risk factors for colorectal adenomas in African American women enrolled in the ongoing Black Women's Health Study. From women reporting ever having undergone a gastrointestinal endoscopy, 917 cases of colorectal adenoma were [...]

A partir de données taïwanaises portant sur 1 521 cas et sur 6 084 témoins, cette étude de cohorte analyse l'association entre une thyroïdite chronique lymphocytaire et le risque de cancer, sur la période 1998-2010

Cancer risk in patients with Hashimoto's thyroiditis: a nationwide cohort study

Chen, Y. K. ; Lin, C. L. ; Cheng, F. T. F. ; Sung, F. C. ; Kao, C. H.

Background: This study examined the risk of cancer in patients with Hashimoto’s thyroiditis (HT). Methods: The Taiwanese National Health Insurance Research Database (NHIRD) was used to identify 1521 newly diagnosed HT patients from 1998–2010, and 6084 frequency-matched non-HT patients. The risk of developing cancer for HT patients was measured using the Cox proportional hazard model. Results: The incidence of developing cancer in the HT cohort was 5.07 per 1000 person-years, which was 1.68-fold [...]

Menée sur 5 patients pédiatriques, cette étude française montre que des mutations des gènes IL-10RA ou IL-10RB prédisposent au développement d'un lymphome non hodgkinien à cellules B entre 5 et 6 ans

A Mendelian predisposition to B cell lymphoma caused by IL-10R deficiency

Neven, Bénédicte ; Mamessier, Emilie ; Bruneau, Julie ; Kaltenbach, Sophie ; Kotlarz, Daniel ; Suarez, Felipe ; Masliah-Planchon, Julien ; Billot, Katy ; Canioni, Danielle ; Frange, Pierre ; Radford-weiss, Isabelle ; Asnafi, Vahid ; Murugan, Dhaarini ; Bole, Christine ; Nitschke, Patrick ; Goulet, Olivier ; Casanova, Jean-Laurent ; Blanche, Stéphane ; Picard, Capucine ; Hermine, Olivier ; Rieux-Laucat, Frederic ; Brousse, Nicole ; Davi, Frederic ; Baud, Veronique ; Klein, Christoph ; Nadel, Bertrand ; Ruemmele, Frank ; Fischer, Alain

Monogenic interleukin (IL)-10 and IL-10 receptor (IL-10R) deficiencies cause very early-onset, severe inflammatory bowel disease. Here, we report that five patients with an IL-10R1 (n=1) or IL-10R2 (n=4) deficiency developed B cell non-Hodgkin's lymphoma between the ages of 5 and 6 years (which were recurrent in one patient). These lymphomas had some of the characteristics of diffuse large B cell lymphomas and contained monoclonal, Epstein-Barr-virus-negative germinal center B cells. The tumors [...]

A partir des données d'un registre scolaire danois portant sur 372 636 élèves nés entre 1930 et 1969, cette étude de cohorte évalue l'association entre la taille de l'enfant, son poids de naissance et le risque de cancer de la prostate

Childhood height and birth weight in relation to future prostate cancer risk: a cohort study based on the Copenhagen School Health Records Register

Cook, Michael B. ; Gamborg, Michael ; Aarestrup, Julie ; Sorensen, Thorkild I.A. ; Baker, Jennifer L.

Background: Adult height has been positively associated with prostate cancer risk. However, the exposure window of importance is currently unknown and assessments of height during earlier growth periods are scarce. In addition, the association between birth weight and prostate cancer remains undetermined. We assessed these relationships a cohort of the Copenhagen School Health Records Register (CSHRR). Methods: The CSHRR comprises 372,636 school children. For boys born between the 1930's and [...]

Menée initialement sur 139 patients atteints d'un adénome colorectal avancé et 1 267 témoins, puis validée sur 4 175 cas et 5 036 témoins, cette étude en population d'origine européenne identifie divers polymorphismes à simple nucléotide associés aux risques de développement d'un adénome avancé ou d'un cancer colorectal

Germline Variants and Advanced Colorectal Adenomas: Adenoma Prevention with Celecoxib Trial Genomewide Association Study

WANG, JIPING ; Carvajal-Carmona, Luis G ; Chu, Jen-Hwa ; Zauber, Ann G. ; Collaborators, APC Trial ; Kubo, Michiaki ; Matsuda, Koichi ; Dunlop, Malcolm ; Houlston, Richard S. ; Sieber, Oliver M ; Lipton, Lara ; Gibbs, Peter ; Martin, Nicholas G ; Montgomery, Grant W ; Young, Joanne P. ; Baird, Paul N. ; Ratain, Mark J. ; Nakamura, Yusuke ; Weiss, Scott ; Tomlinson, Ian ; Bertagnolli, Monica M.

Purpose: Identification of single nucleotide polymorphisms (SNPs) associated with development of advanced colorectal adenomas. Experimental Design: Discovery Phase: 1,406 Caucasian patients (139 advanced adenoma cases and 1,267 controls) from the Adenoma Prevention with Celecoxib (APC) trial were included in a genome-wide association study (GWAS) to identify variants associated with post-polypectomy disease recurrence. Genome-wide significance was defined as false discovery rate < 0.05, [...]

A partir des données de l'essai américain PLCO incluant 36 115 participantes, cette étude de cohorte prospective évalue l'association entre une consommation de glucides, l'indice et la charge glycémique et le risque de cancer de l'endomètre

Dietary Carbohydrate Intake, Glycemic Index, and Glycemic Load and Endometrial Cancer Risk: A Prospective Cohort Study

Coleman, Helen G. ; Kitahara, Cari M. ; Murray, Liam J. ; Dodd, Kevin W. ; Black, Amanda ; Stolzenberg-Solomon, Rachael Z. ; Cantwell, Marie M.

Endometrial cancer risk has been directly associated with glycemic load. However, few studies have investigated this link, and the etiological role of specific dietary carbohydrate components remains unclear. Our aim was to investigate associations of carbohydrate intake, glycemic index, and glycemic load with endometrial cancer risk in the US Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Recruitment took place in 1993–2001. Over a median of 9.0 years of follow-up through 2009, [...]

Cet article présente les conclusions d'un colloque organisé par le National Cancer Institute sur les méthodes d'analyse des interactions gènes et environnement dans les cancers

Gene-Environment Interactions in Cancer Epidemiology: A National Cancer Institute Think Tank Report

Hutter, Carolyn M. ; Mechanic, Leah E. ; Chatterjee, Nilanjan ; Kraft, Peter ; Gillanders, Elizabeth M. ; on behalf of the, N. C. I. Gene-Environment Think Tank

Cancer risk is determined by a complex interplay of genetic and environmental factors. Genome-wide association studies (GWAS) have identified hundreds of common (minor allele frequency [MAF] > 0.05) and less common (0.01 < MAF < 0.05) genetic variants associated with cancer. The marginal effects of most of these variants have been small (odds ratios: 1.1–1.4). There remain unanswered questions on how best to incorporate the joint effects of genes and environment, including gene-environment (G × [...]

Couplée aux données de la cohorte européenne EPIC et menée auprès de 754 cas et de 833 témoins, cette étude évalue l'association entre le gène NAT2 lié à une acétylation lente, une exposition professionelle à divers facteurs de risque et le risque de cancer de la vessie

NAT2 acetylator phenotype, occupation and bladder cancer risk: Results from the EPIC cohort

Pesch, Beate ; Gawrych, Katarzyna ; Rabstein, Sylvia ; Weiss, Tobias ; Casjens, Swaantje ; Rihs, Hans-Peter ; Ding, Hui ; Angerer, Jürgen ; Illig, Thomas ; Klopp, Norman ; Bueno-de-Mesquita, H. Bas ; Ros, Martine M ; Kaaks, Rudolph ; Chang-Claude, Jenny ; Roswall, Nina ; Tjonneland, Anne ; Overvad, Kim ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Dossus, Laure ; Boeing, Heiner ; Weikert, Steffen ; Trichopoulos, Dimitrios ; Palli, Domenico ; Sieri, Sabina ; Tumino, Rosario ; Panico, Salvatore ; Quiros, Jose R. ; González, Carlos A. ; Sánchez, María-José ; Dorronsoro, Miren ; Navarro, Carmen ; Barricarte, Aurelio ; Ljungberg, Börje ; Johansson, Mattias ; Ulmert, David ; Ehrnström, Roy ; Khaw, Kay-Tee ; Wareham, Nicholas ; Key, Timothy J. ; Ferrari, Pietro ; Romieu, Isabelle ; Riboli, Elio ; Brüning, Thomas ; Vineis, Paolo

Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiological studies. Evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. Methods: Exposure to aromatic amines and polycyclic aromatic [...]