Menée par entretiens auprès de 44 patients atteints de cancer, de 35 indidivus partageant la vie d'un patient et de 37 professionnels de santé travaillant dans le domaine de l'oncologie, cette étude australienne analyse les problématiques associées à la sexualité dans le contexte d'un cancer

Constructions of sex and intimacy after cancer: Q methodology study of people with cancer, their partners, and health professionals

Perz, Janette ; Ussher, Jane ; Gilbert, Emilee

BACKGROUND:The increasing number of individuals living with cancer has led to a focus on the quality of life of survivors, and their families. Sexual wellbeing is a central component of quality of life, with a growing body of research demonstrating the association between cancer and changes to sexuality and intimacy. However, little is known about patient and professional understanding of cancer and sexuality post-cancer. This study was designed to explore the complex perspectives that people [...]

A partir d'une revue systématique de la littérature publiée entre 2006 et 2013 (222 publications), cette étude présente et met à jour les recommandations américaines relatives aux techniques de préservation de la fertilité pour les patients atteints de cancer

Fertility Preservation for Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update

Loren, Alison W. ; Mangu, Pamela B. ; Beck, Lindsay Nohr ; Brennan, Lawrence ; Magdalinski, Anthony J. ; Partridge, Ann H. ; Quinn, Gwendolyn ; Wallace, W. Hamish ; Oktay, Kutluk

Purpose To update guidance for health care providers about fertility preservation for adults and children with cancer.Methods A systematic review of the literature published from March 2006 through January 2013 was completed using MEDLINE and the Cochrane Collaboration Library. An Update Panel reviewed the evidence and updated the recommendation language.Results There were 222 new publications that met inclusion criteria. A majority were observational studies, cohort studies, and case series or [...]

Menée auprès de 657 patients atteints de cancer (colorectal, pancréas, prostate, poumon ou ovaire), cette étude mesure leur niveau d'activité du nerf vague, en utilisant l'indice de variabilité de fréquence cardiaque

Norms of vagal nerve activity, indexed by Heart Rate Variability, in cancer patients

De Couck, M. ; Gidron, Y.

Recent research has begun to show the role of the activity of the vagus nerve in cancer prognosis. However, it remains unknown whether cancer severity can impair vagal nerve activity. This study combined data (N = 657) of five different cancers (colorectal, pancreas, prostate, lung and ovarian) concerning patients’ Heart Rate Variability (HRV), a vagal nerve activity index. These data were compared to HRV levels of a healthy sample in another study. In addition, we examined the moderating [...]

Mené sur 409 patientes atteintes d'un cancer du sein et recevant une chimiothérapie adjuvante à base de taxane, cet essai évalue l'efficacité d'une supplémentation en acétyl-L carnitine pour prévenir ou traiter une neuropathie périphérique liée à la chimiothérapie

Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy

Hershman, Dawn L. ; Unger, Joseph M. ; Crew, Katherine D. ; Minasian, Lori M. ; Awad, Danielle ; Moinpour, Carol M. ; Hansen, Lisa ; Lew, Danika L. ; Greenlee, Heather ; Fehrenbacher, Louis ; Wade, James L. ; Wong, Siu-Fun ; Hortobagyi, Gabriel N. ; Meyskens, Frank L. ; Albain, Kathy S.

Purpose : Chemotherapy-induced peripheral neuropathy (CIPN) is common and leads to suboptimal treatment. Acetyl-L-carnitine (ALC) is a natural compound involved in neuronal protection. Studies have suggested ALC may be effective for the prevention and treatment of CIPN. Patients and Methods : A 24-week randomized double-blind trial comparing ALC (3,000 mg per day) with placebo in women undergoing adjuvant taxane-based chemotherapy was conducted. The primary objective was to determine if ALC [...]

Menée auprès de 70 patients atteints d'un cancer de la tête et du cou, cette étude américaine analyse les facteurs associés à la prise continue d'un traitement à base d'opioïdes trois mois après une radiothérapie avec ou sans chimiothérapie

Predictors of Long-Term Opioid Treatment Among Patients Who Receive Chemoradiation for Head and Neck Cancer

Kwon, Jung Hye ; Hui, David ; Chisholm, Gary ; Bruera, Eduardo

Abstract Introduction. The factors associated with successful opioid discontinuation after cancer treatment are not well-known. We determined the proportion of patients with advanced head and neck cancer who continued using opioids 3 months after the completion of radiation therapy with or without chemotherapy. Methods. We included 70 patients with head and neck cancer referred to our institution’s supportive care center between January 1, 2008, and December 31, 2010. Patients who no longer [...]

Menée aux Pays-Bas à partir d'enregistrements vocaux et de données de vidéofluoroscopie sur 51 patients ayant été traités pour un cancer de la cavité buccale ou un cancer de l'oropharynx, cette étude analyse la qualité de leur voix et leurs fonctions de déglutition

Associations between voice quality and swallowing function in patients treated for oral or oropharyngeal cancer

Bruijn, MariekeJ ; Rinkel, RicoN P. M. ; Cnossen, IngridC ; Witte, BirgitI ; Langendijk, JohannesA ; Leemans, C. René ; Leeuw, IrmaM Verdonck-de

Purpose : The purpose of this study was to investigate associations between voice quality and swallowing function in patients treated for oral or oropharyngeal cancer. Methods : Recordings of speech and videofluoroscopy of 51 patients after treatment for oral or oropharyngeal cancer were analysed. Acoustic voice parameters (fundamental frequency (F0), perturbation (jitter %, shimmer %), harmonics-to-noise ratio (HNR), and intensity (extracted from the vowels /a/, /i/, and /u/)) were compared to [...]

Menée auprès de 38 060 patients atteints de pathologies hématologiques malignes et traités dans des centres américains et canadiens, cette étude analyse l'évolution, sur la période 1994-2005, du recours à la greffe allogénique de cellules souches hématopoïétiques et des techniques utilisées, puis évalue l'évolution de la survie des patients

Significant Improvement in Survival After Allogeneic Hematopoietic Cell Transplantation During a Period of Significantly Increased Use, Older Recipient Age, and Use of Unrelated Donors

Hahn, Theresa ; McCarthy, Philip L. ; Hassebroek, Anna ; Bredeson, Christopher ; Gajewski, James L. ; Hale, Gregory A. ; Isola, Luis M. ; Lazarus, Hillard M. ; Lee, Stephanie J. ; LeMaistre, Charles F. ; Loberiza, Fausto ; Maziarz, Richard T. ; Rizzo, J. Douglas ; Joffe, Steven ; Parsons, Susan ; Majhail, Navneet S.

Purpose Over the past four decades, allogeneic hematopoietic cell transplantation (alloHCT) has evolved as a curative modality for patients with hematologic diseases. This study describes changes in use, technique, and survival in a population-based cohort. Patients and Methods : The study included 38,060 patients with hematologic malignancies or disorders who underwent first alloHCT in a US or Canadian center from 1994 to 2005 and were reported to the Center for International Blood and Marrow [...]

A partir de données portant sur 17 244 participants vivant au Bangladesh, cette étude prospective évalue l'association entre le niveau d'énergie issue des protéines et des graisses d'origine alimentaire et le risque de mortalité toutes causes confondues, par cancers et par cancers des organes digestifs

A population-based prospective study of energy-providing nutrients in relation to all-cause cancer mortality and cancers of digestive organs mortality

Argos, Maria ; Melkonian, Stephanie ; Parvez, Faruque ; Rakibuz-Zaman, Muhammad ; Ahmed, Alauddin ; Chen, Yu ; Ahsan, Habibul

The effect of dietary composition on mortality in low-income countries is largely unknown. We evaluated whether percentages of dietary energy derived from protein, fat and carbohydrates were associated with all-cause and cancer mortalities in a Bangladeshi population. Data from a prospective population-based cohort study of 17,244 men and women were used. Percentages of dietary energy derived from protein, fat and carbohydrates, assessed using a validated food-frequency questionnaire at [...]

A partir des données du registre français des maladies hématologiques pédiatriques, cette étude analyse l'évolution, sur la période 1990-2007, de l'incidence de la leucémie lymphoblastique aiguë pédiatrique

Time trends and seasonal variations in the diagnosis of childhood acute lymphoblastic leukaemia in France

Goujon-Bellec, S. ; Mollié, A. ; Rudant, J. ; Guyot-Goubin, A. ; Clavel, J.

Background: Several studies have evidenced an increase in the incidence of childhood leukaemia since the 1970s but the variations since 2000 have received little attention. Seasonal variations in incidence have also been widely investigated, with however inconsistent conclusions. The present study aimed to investigate jointly the temporal trends and the seasonal variations in the month of diagnosis of childhood acute lymphoblastic leukaemia (ALL). Methods: All the cases of ALL registered in the [...]

Menée en Chine auprès de 950 patients atteints d'un cancer du poumon, cette étude évalue l'association entre la prévalence d'une infection par l'hépatite B et la survenue de dysfonctionnements hépatiques induits par une chimiothérapie

Relationships between hepatitis B infection status and liver dysfunction after chemotherapy of lung cancer patients in mainland China

Ruofan, Huang ; Qiong, Zhan ; Xinli, Zhou ; Zhaohui, Chu ; Jingwei, Jiang ; Xiaohua, Liang

Purpose: A preliminary analysis on the risk factors of liver dysfunction was made after the investigation of hepatitis B prevalence and chemotherapy-related hepatic dysfunction occurrence for patients with lung cancer. Patients and methods : Consecutively diagnosed 950 lung cancer patients treated in Huashan Hospital, Fudan University from 1999 to 2009 were enrolled in the study. We investigated hepatitis B (HB) prevalence and analyzed chemotherapy-related hepatic dysfunction occurrence and its [...]

A partir des données des registres américains des cancers portant sur 2 506 patients afro-américains et 21 454 patients de type caucasien atteints d'un cancer de la prostate diagnostiqué entre 2004 et 2007, cette étude analyse les disparités ethniques dans le délai entre le diagnostic et le début des traitements

Racial differences in time from prostate cancer diagnosis to treatment initiation

Stokes, William A. ; Hendrix, Laura H. ; Royce, Trevor J. ; Allen, Ian M. ; Godley, Paul A. ; Wang, Andrew Z. ; Chen, Ronald C.

BACKGROUND Timely delivery of care has been identified by the Institute of Medicine as an indicator for quality health care, and treatment delay is a potentially modifiable obstacle that can contribute to the disparities among African American (AA) and Caucasian patients in prostate cancer recurrence and mortality. Using the Surveillance, Epidemiologic and End Results (SEER)-Medicare linked database, we compared time from diagnosis to treatment in AA and Caucasian prostate cancer patients. [...]

Menée auprès de 2 953 participantes, cette étude canadienne analyse le risque de mortalité chez des anciennes fumeuses survivantes d'un cancer du sein et conclut à la nécessité, pour calculer et prédire le risque de mortalité, de choisir la durée d'exposition au tabagisme tout au long de la vie plutôt que le statut tabagique actuel

Mortality risk in former smokers with breast cancer: Pack-years vs. smoking status

Saquib, Nazmus ; Stefanick, Marcia L. ; Natarajan, Loki ; Pierce, John P.

It is unclear why successful quitting at time of breast cancer diagnosis should remove risk from a significant lifetime of smoking. Studies concluding this may be biased by how smoking is measured in many epidemiological cohorts. In the late 1990s, a randomized trial of diet and breast cancer outcomes enrolled early-stage female breast cancer survivors diagnosed within the previous 4 years. Smoking history and key covariate measures were available at study entry for 2,953 participants. [...]

A partir de données portant sur 20 738 femmes atteintes d'un cancer du sein dans l'est dans l'Angleterre, cette étude évalue l'impact des disparités socioéconomiques dans le stade au diagnostic sur la survie des patientes

How much of the deprivation gap in cancer survival can be explained by variation in stage at diagnosis: An example from breast cancer in the East of England

Rutherford, M. J. ; Hinchliffe, S. R. ; Abel, G. A. ; Lyratzopoulos, G. ; Lambert, P. C. ; Greenberg, D. C.

Socioeconomic differences in cancer patient survival exist in many countries and across cancer sites. In our article, we estimated the number of deaths in women with breast cancer that could be avoided within 5 years from diagnosis if it were possible to eliminate socioeconomic differences in stage at diagnosis. We analysed data on East of England women with breast cancer (2006–2010). We estimated survival for different stage-age-deprivation strata using both the observed and a hypothetical [...]

A partir d'une revue de la littérature, cette étude américaine identifie les raisons d'une augmentation, sur les quinze dernières années, du nombre de mastectomies pour réduire le risque de cancer controlatéral chez les patientes atteintes d'un cancer sporadique du sein, puis analyse le rapport bénéfices/risques d'une telle intervention chirurgicale

Contralateral risk-reducing mastectomy in sporadic breast cancer

Murphy, John A. ; Milner, Thomas D. ; O'Donoghue, Joseph M.

Recent studies have shown that the number of women undergoing risk-reducing mastectomy has increased rapidly in the USA in the past 15 years. Although a small rise in the number of bilateral risk-reducing procedures has been noted in high-risk gene mutation carriers who have never had breast cancer, this number does not account for the overall increase in procedures undertaken. In patients who have been treated for a primary cancer and are judged to be at high risk of a contralateral breast [...]

Menée en Grèce auprès de 1 170 cas et de 244 témoins, cette étude analyse et compare les profils hormonaux (niveaux sériques d'estrogène, de testostérone et du facteur de croissance analogue à l'insuline) de patientes atteintes d'un cancer du sein ou d'une maladie proliférative bénigne du sein

A comparison of hormonal profiles between breast cancer and benign breast disease: a case–control study

Lagiou, P. ; Samoli, E. ; Lagiou, A. ; Zourna, P. ; Barbouni, A. ; Georgila, C. ; Tsikkinis, A. ; Vassilarou, D. ; Minaki, P. ; Sfikas, C. ; Spanos, E. ; Trichopoulos, D.

Background Benign breast disease (BBD), particularly proliferative BBD, is an established breast cancer risk factor. However, there has been no systematic attempt to compare the hormonal profiles of the two conditions. In a case–control investigation in Athens, Greece, we compared levels of estrogens, testosterone and insulin-like growth factor-1 (IGF-1), as well as their principal binding proteins, between breast cancer patients, women with BBD by histological type (proliferative and [...]

Menée au Royaume-Uni auprès de 2 956 participantes âgées de 18 à 40 ans, cette étude de cohorte prospective analyse les facteurs associés au pronostic chez des patientes atteintes d'un cancer du sein, notamment le statut tumoral, le stade de la maladie, les traitements reçus et la survie

Prospective Observational Study of Breast Cancer Treatment Outcomes for UK Women Aged 18–40 Years at Diagnosis: The POSH Study

Copson, Ellen ; Eccles, Bryony ; Maishman, Tom ; Gerty, Sue ; Stanton, Louise ; Cutress, Ramsey I. ; Altman, Douglas G. ; Durcan, Lorraine ; Simmonds, Peter ; Lawrence, Gill ; Jones, Louise ; Bliss, Judith ; Eccles, Diana ; POSH Study Steering Group

Background : Breast cancer at a young age is associated with poor prognosis. The Prospective Study of Outcomes in Sporadic and Hereditary Breast Cancer (POSH) was designed to investigate factors affecting prognosis in this patient group. Methods : Between 2000 and 2008, 2956 patients aged 40 years or younger were recruited to a UK multicenter prospective observational cohort study (POSH). Details of tumor pathology, disease stage, treatment received, and outcome were recorded. Overall survival [...]

A partir d'une revue systématique de la littérature publiée entre 1996 et 2012, cette étude analyse les aspects positifs du rôle d'aidant familial dans le cadre de soins dispensés à un conjoint atteint de cancer

The positive aspects of caregiving for cancer patients: a critical review of the literature and directions for future research

Li, Q. P. ; Loke, Alice Yuen

Objective : Although there is a vast body of studies exploring the negative aspects of spousal caregiving for cancer patients, there have also been reports on the positive aspects. The objective of this review was to summarize and appraise the positive aspects of spousal caregiving and to identify directions for future research. Methods : A systematic search was conducted to identity articles published in English or Chinese from January 1996 to July 2012. Studies were located using an [...]

Menée aux Etats-Unis auprès de 199 enfants atteints de cancer, de 108 enfants non malades et de leurs parents, cette étude analyse l'association entre des symptômes de stress post-traumatique chez les parents et les symptômes de stress post-traumatique chez les enfants

Concordance of parent proxy report and child self-report of posttraumatic stress in children with cancer and healthy children: influence of parental posttraumatic stress

Clawson, Ashley H. ; Jurbergs, Niki ; Lindwall, Jennifer ; Phipps, Sean

Objective : This study examined the relationships between parental posttraumatic stress symptoms (PTSS), child PTSS, and parent–child concordance for child PTSS. Method : Participants were children with cancer (n=199), and healthy children (n=108) and their parents. Children self-reported on PTSS and parents completed measures of child and parent PTSS Results In the cancer group, child and parent reports of child PTSS were significantly correlated with no mean differences between reporters. In [...]

Menée en Australie auprès de 207 hommes avec des antécédents familiaux de cancer de la prostate et de 239 témoins, cette étude analyse la prévalence et les facteurs prédictifs d'une détresse psychologique chez les hommes dont un parent au premier degré a eu un cancer de la prostate

Prevalence and predictors of cancer specific distress in men with a family history of prostate cancer

McDowell, M. E. ; Occhipinti, S. ; Gardiner, R. A. ; Chambers, S. K.

Objective : To examine prevalence and predictors of cancer-specific distress in undiagnosed men with and without a family history of prostate cancer, and to examine the contribution of perceptions of an affected relative's cancer experience on the distress of unaffected male relatives. Methods : Men with a first degree relative with prostate cancer (n=207) and men without a family history (n=239) from Australia completed a Computer Assisted Telephone Interview. Participants completed the [...]

Menée aux Pays-Bas auprès de 1 300 survivants d'un cancer colorectal, cette étude évalue l'association entre leur statut socioéconomique et leur état de santé psychique

Low socioeconomic status and mental health outcomes in colorectal cancer survivors: disadvantage? advantage? … or both?

Andrykowski, Michael A. ; Aarts, Mieke J. ; van de Poll-Franse, Lonneke V. ; Mols, Floortje ; Slooter, Gerrit D. ; Thong, Melissa S. Y.

Objective The goal of this study is to examine the relationship between socioeconomic status (SES) and both positive and negative mental health (MH) outcomes in a population-based sample of colorectal cancer survivors. On the basis of theoretical conceptualizations of trauma and posttraumatic growth, low SES was hypothesized to be positively associated with both greater negative MH outcomes (e.g., distress) and greater positive MH outcomes (e.g., growth). Methods Colorectal cancer survivors [...]

Cette étude prospective incluant 124 participantes évalue les symptômes d'anxiété et de dépression associés aux décisions thérapeutiques ainsi que la qualité de vie de patientes atteintes d'un cancer du sein non métastatique

Anxiety, depression and defense mechanisms associated with treatment decisional preferences and quality of life in non-metastatic breast cancer: a 1-year prospective study

Hyphantis, Thomas ; Almyroudi, Augoustina ; Paika, Vassiliki ; Degner, Lesley F. ; Carvalho, André F. ; Pavlidis, Nicholas

Objective : Treatment decisional preferences impact breast cancer patients' health-related quality of life (HRQoL) and may relate to psychological variables, although many aspects of this relationship remain unknown. This prospective study aimed to assess psychological correlates of treatment decisional preferences and predictors of HRQoL in women with early non-metastatic breast cancer. Methods : Of the 124 women initially assessed for anxiety (Spielberger's State–Trait Anxiety Inventory) and [...]

Cette étude américaine analyse et compare le rapport coût-efficacité de deux traitements d'un cancer du poumon non à petites cellules de stade I, une radiothérapie stéréotaxique corporelle et une lobectomie

Cost-effectiveness of stereotactic body radiation therapy versus surgical resection for stage I non–small cell lung cancer

Shah, Anand ; Hahn, Stephen M. ; Stetson, Robert L. ; Friedberg, Joseph S. ; Pechet, Taine T. V. ; Sher, David J.

BACKGROUND : The traditional treatment for clearly operable (CO) patients with stage I non–small cell lung cancer (NSCLC) is lobectomy, with wedge resection (WR) and stereotactic body radiation therapy (SBRT) serving as alternatives in marginally operable (MO) patients. Given an aging population with an increasing prevalence of screening, it is likely that progressively more people will be diagnosed with stage I NSCLC, and thus it is critical to compare the cost-effectiveness of these [...]

Cet essai randomisé contrôlé incluant 743 patients atteints de cancer évalue l'efficacité d'un outil en ligne d'aide à la décision thérapeutique destiné à améliorer la communication entre patients et oncologues

A Web-based communication aid for patients with cancer

Meropol, Neal J. ; Egleston, Brian L. ; Buzaglo, Joanne S. ; Balshem, Andrew ; Benson, Al B. ; Cegala, Donald J. ; Cohen, Roger B. ; Collins, Michael ; Diefenbach, Michael A. ; Miller, Suzanne M. ; Fleisher, Linda ; Millard, Jennifer L. ; Ross, Eric A. ; Schulman, Kevin A. ; Silver, Allison ; Slater, Elyse ; Solarino, Nicholas ; Sulmasy, Daniel P. ; Trinastic, Jonathan ; Weinfurt, Kevin P.

BACKGROUND: Cancer patients and their oncologists often report differing perceptions of consultation discussions and discordant expectations regarding treatment outcomes. CONNECT, a computer-based communication aid, was developed to improve communication between patients and oncologists. METHODS: CONNECT includes assessment of patient values, goals, and communication preferences; patient communication skills training; and a preconsultation physician summary report. CONNECT was tested in a [...]

Cette étude italienne analyse l'efficacité et l'utilisation des traitements à base d'opioïdes pour gérer la douleur des patients atteints de cancer dans des unités de soins palliatifs

Opioid use and effectiveness of its prescription at discharge in an acute pain relief and palliative care unit

Mercadante, Sebastiano ; Prestia, Giovanna ; Ranieri, Maurizio ; Giarratano, Antonello ; Casuccio, Alessandra

The aim of this study was to present how opioids are used in an acute pain relief and palliative care unit (APRPCU), where many patients with difficult pain conditions are admitted from GPs, home palliative care programs, oncology departments, other hospitals or emergency units, and other regional places. From a consecutive sample of cancer patients admitted to an APRPCU for a period of 6 months, patients who had been administered opioids were included in this survey. Basic information was [...]