A partir des données de deux cohortes prospectives américaines incluant 2 793 cas, cette étude évalue l'association entre une consommation d'alcool et le risque de cancer colorectal, avant et après la publication en 1998 de recommandations américaines en matière de supplémentation en acide folique

Prospective study of alcohol consumption and the risk of colorectal cancer before and after folic acid fortification in the United States

Nan, Hongmei ; Lee, Jung Eun ; Rimm, Eric B. ; Fuchs, Charles S. ; Giovannucci, Edward L. ; Cho, Eunyoung

Purpose To evaluate the influence of alcohol consumption on the risk of colorectal cancer according to folic acid fortification period in the United States. Methods We evaluated the association between alcohol consumption and colorectal cancer by fortification period (before 1998 vs. after 1998) in 2 prospective cohort studies, the Nurses’ Health Study (NHS) of women and the Health Professionals Follow-up Study (HPFS) of men, in which 2793 cases of invasive colorectal cancer were documented. [...]

Menée auprès de 59 021 salariés français travaillant dans le secteur du nucléaire, cette étude de cohorte analyse l'association entre une exposition professionnelle aux rayonnements ionisants et la mortalité par cancers, qu'il s'agisse de tumeurs solides ou de leucémie

Mortality associated with chronic external radiation exposure in the French combined cohort of nuclear workers

Metz-Flamant, C ; Laurent, O ; Samson, E ; Caër-Lorho, S ; Acker, A ; Hubert, D ; Richardson, D B ; Laurier, D

Objective : The long-term effects of protracted low level ionising radiation exposure are investigated in a combined analysis of French nuclear workers employed by the Commissariat à l'Energie Atomique (CEA), AREVA Nuclear Cycle (AREVA NC) and Electricité de France (EDF). Associations between cumulative external radiation dose and mortality due to solid cancers, leukaemia and circulatory disease were examined. Methods : All workers hired by CEA, AREVA NC and EDF between 1950 and 1994 who were [...]

Menée auprès de 780 cas et de 1 044 témoins, cette étude italienne évalue l'association entre une exposition professionelle des parents à des solvants et autres agents cancérigènes (hydrocarbures, gaz d'échappement, huiles minérales, plomb) et le risque ultérieur de leucémie et de lymphome non-hodgkinien chez l'enfant

Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study

Miligi, Lucia ; Benvenuti, Alessandra ; Mattioli, Stefano ; Salvan, Alberto ; Tozzi, Giulio Andrea ; Ranucci, Alessandra ; Legittimo, Patrizia ; Rondelli, Roberto ; Bisanti, Luigi ; Zambon, Paola ; Cannizzaro, Santina ; Kirchmayer, Ursula ; Cocco, Pierluigi ; Celentano, Egidio ; Assennato, Giorgio ; Merlo, Domenico Franco ; Mosciatti, Paola ; Minelli, Liliana ; Cuttini, Marina ; Torregrossa, Valeria ; Lagorio, Susanna ; Haupt, Riccardo ; Risica, Serena ; Polichetti, Alessandro ; SETIL Working Group ; Magnani, Corrado

Aim : In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. Methods All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0–10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The [...]

A partir d'une revue systématique de la littérature publiée entre 1950 et 2011, cette méta-analyse évalue l'association entre une exposition professionnelle au trichloroéthylène et le risque de cancers du système lymphatique et de cancers hématopoïétiques

Occupational trichloroethylene exposure and risk of lymphatic and haematopoietic cancers: a meta-analysis

Karami, Sara ; Bassig, Bryan ; Stewart, Patricia A ; Lee, Kyoung-Mu ; Rothman, Nathaniel ; Moore, Lee E ; Lan, Qing

The carcinogenic potential of trichloroethylene (TCE) continues to generate much controversy, even after the US Environmental Protection Agency raised its classification to ‘carcinogenic to humans’. We conducted a meta-analysis of published cohort and case–control studies exploring occupational TCE exposure in relation to five different lymphatic and haematopoietic cancers: non-Hodgkin's lymphoma (NHL, N=24), Hodgkin's lymphoma (HL, N=13), multiple myeloma (MM, N=11), leukaemia (N=12) and [...]

Menée en Australie à partir d'échantillons tumoraux, cette étude évalue l'association entre une infection par le papillomavirus humain de types 6 et 11, le risque de carcinome spinocellulaire de l'anus et de la région péri-anale ainsi que des lésions intraépithéliales de haut grade

Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with “low-risk” HPV genotypes 6 and 11

Cornall, Alyssa M. ; Roberts, Jennifer M. ; Garland, Suzanne M. ; Hillman, Richard J. ; Grulich, Andrew E. ; Tabrizi, Sepehr N.

Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of “low-risk” HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital cancers, the overall distribution of these genotypes in the anal canal and perianal tissue may differ to that in the cervix. In addition, although the majority of anal and perianal [...]

A partir des données de la cohorte européenne EPIC incluant 363 426 participants, cette étude évalue l'association entre un diabète, l'âge au diagnostic, un traitement par insuline et le risque de cancer des voies biliaires ou de carcinome hépatocellulaire

Diabetes mellitus, insulin treatment, diabetes duration, and risk of biliary tract cancer and hepatocellular carcinoma in a European cohort

Schlesinger, S. ; Aleksandrova, K. ; Pischon, T. ; Jenab, M. ; Fedirko, V. ; Trepo, E. ; Overvad, K. ; Roswall, N. ; Tjønneland, A. ; Boutron-Ruault, M. C. ; Fagherazzi, G. ; Racine, A. ; Kaaks, R. ; Grote, V.A. ; Boeing, H. ; Trichopoulou, A. ; Pantzalis, M. ; Kritikou, M. ; Mattiello, A. ; Sieri, S. ; Sacerdote, C. ; Palli, D. ; Tumino, R. ; Peeters, P. H. ; Bueno-de-Mesquita, H. B. ; Weiderpass, E. ; Quiros, J. R. ; Zamora-Ros, R. ; Sanchez, M. J. ; Arriola, L. ; Ardanaz, E. ; Tormo, M. J. ; Nilsson, P. ; Lindkvist, B. ; Sund, M. ; Rolandsson, O. ; Khaw, K. T. ; Wareham, N. ; Travis, R. C. ; Riboli, E. ; Nöthlings, U.

Background : Evidence on associations between self-reported diabetes mellitus, diabetes duration, age at diabetes diagnosis, insulin treatment, and risk of biliary tract cancer (BTC) and hepatocellular carcinoma (HCC), independent of general and abdominal obesity is scarce. Patients and methods : We conducted a prospective analysis in the EPIC-cohort study among 363 426 participants with self-reported diabetes data. Multivariable adjusted relative risks and 95% confidence intervals were [...]

A partir d'une revue systématique de la littérature (7 études incluant 7 183 patients), cette méta-analyse évalue l'association entre une sclérose systémique (affection disséminée du tissu conjonctif caractérisée par une fibrose cutanée et vasculaire) et le risque de cancer

The risk of cancer development in systemic sclerosis: A meta-analysis

Zhang, Jun-qing ; Wan, Ya-nan ; Peng, Wen-jia ; Yan, Jun-wei ; Li, Bao-zhu ; Mei, Bin ; Chen, Bing ; Yao, Hua ; Yang, Guo-jun ; Tao, Jin-hui ; Wang, Jing

Objectives: Systemic sclerosis is a multi-system disorder of connective tissue characterized by Raynaud's phenomenon and fibrosis of various organs. The risk of development of cancer in systemic sclerosis (SSc) has been extensively investigated with inconclusive results. To shed some light on the controversy, we conducted a meta-analysis of all published articles linking SSc to the risk of cancer development. Methods: Relevant electronic databases were searched for English-language studies [...]

A partir d'une revue systématique de la littérature (160 études, dont 68 concernant le sein, 42 le poumon, 26 le côlon-rectum, 16 l'ovaire, 8 l'endomètre), cette étude ré-évalue l'association déjà établie entre un polymorphisme du gène TP53 et le risque de plusieurs cancers en prenant en compte les biais induits par le matériel tumoral utilisé

Genotype Misclassification in Genetic Association Studies of the rs1042522 TP53 (Arg72Pro) Polymorphism: A Systematic Review of Studies of Breast, Lung, Colorectal, Ovarian, and Endometrial Cancer

Dahabreh, Issa J. ; Schmid, Christopher H. ; Lau, Joseph ; Varvarigou, Vasileia ; Murray, Samuel ; Trikalinos, Thomas A.

Preferential loss of heterozygosity at the rs1042522 locus of the tumor protein 53 gene (TP53) (Arg72Pro) is observed in several tumors. Genetic association studies in oncology often use tumor tissue rather than unaffected tissue for genotyping; in such cases, loss of heterozygosity at the TP53 locus could lead to differential misclassification and could bias estimates of association. We searched multiple databases (through March 8, 2011) for studies investigating the association of Arg72Pro [...]

Menée en Chine auprès de 451 cas et de 631 témoins, cette étude évalue l'association entre des polymorphismes des gènes du métabolisme de l'acide arachidonique, le risque de cancer colorectal et le pronostic de la maladie

Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer

Li, Shuying ; Zhao, Xiaojuan ; Wu, Zhiwei ; Li, Ye ; Zhu, Lin ; Cui, Binbin ; Dong, Xinshu ; Tian, Suli ; Hu, Fulan ; Zhao, Yashuang

Cyclooxygenase-2 (COX-2), 12-lipoxygenase (12-LOX) and phospholipaseA2 (PLA2) played important roles in the modulation of apoptosis, angiogenesis, carcinogenesis and invasion of colorectal cancer (CRC). The polymorphisms in COX-2, 12-LOX and PLA2 may affect their roles. Therefore, we investigated if COX-2 −1195G > A, 12-LOX 261Arg > Gln and PLA2 c.349 + 191A > G polymorphisms were associated with risk and prognosis of CRC as well as possible interactions with the environmental factors on the [...]

A partir des données de 2 931 participants âgés de 55 à 74 ans, cette étude prospective américaine évalue l'association entre l'indice de masse corporelle, le risque d'adénome colorectal et le risque de récidive

Prospective Investigation of Body Mass Index, Colorectal Adenoma, and Colorectal Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Kitahara, Cari M. ; Berndt, Sonja I. ; Berrington de Gonzalez, Amy ; Coleman, Helen G. ; Schoen, Robert E. ; Hayes, Richard B. ; Huang, Wen-Yi

Purpose Obesity has consistently been linked to an increased risk of colorectal cancer, particularly among men. Whether body mass index (BMI) differentially influences the risk across the stages of colorectal cancer development remains unclear. We evaluated the associations of BMI with colorectal adenoma incidence, adenoma recurrence, and cancer in the context of a large screening trial, in which cases and controls had an equal chance for disease detection. Methods We prospectively evaluated [...]

Menée en Allemagne auprès de 203 177 participants suivis pendant 10 ans, cette étude de cohorte prospective évalue et compare l'association entre l'indice de masse corporelle, l'adiposité abdominale (mesurée par le tour de taille et le ratio taille-hanche), et le risque de cancer colorectal

Comparison of associations of body mass index, abdominal adiposity, and risk of colorectal cancer in a large prospective cohort study

Keimling, Marlen ; Renehan, Andrew G. ; Behrens, Gundula ; Fischer, Beate ; Hollenbeck, Albert R. ; Cross, Amanda J. ; Leitzmann, Michael F.

Background: Increased body-mass-index (BMI) is an established colorectal cancer (CRC) risk factor. High waist circumference (WC) or waist-hip-ratio (WHR) may better reflect an abnormal metabolic state and be more predictive of CRC risk than BMI. Methods: We examined BMI, WC, WHR, and hip circumference (HC) in relation to CRC risk among 203,177 participants followed for ten years. We derived standardized CRC risk estimates for each anthropometric parameter and compared predictive characteristics [...]

Menée sur 941 patiens atteints d'un ostéosarcome et 3 291 témoins, cette étude d'association sur le génome entier identifie deux loci, situés sur les régions chromosomiques 6p21.3 et 2p35.2, en association avec une susceptibilité à la maladie

Genome-wide association study identifies two susceptibility loci for osteosarcoma

Savage, Sharon A. ; Mirabello, Lisa ; Wang, Zhaoming ; Gastier-Foster, Julie M. ; Gorlick, Richard ; Khanna, Chand ; Flanagan, Adrienne M. ; Tirabosco, Roberto ; Andrulis, Irene L. ; Wunder, Jay S. ; Gokgoz, Nalan ; Patino-Garcia, Ana ; Sierrasesumaga, Luis ; Lecanda, Fernando ; Kurucu, Nilgun ; Ilhan, Inci Ergurhan ; Sari, Neriman ; Serra, Massimo ; Hattinger, Claudia ; Picci, Piero ; Spector, Logan G. ; Barkauskas, Donald A. ; Marina, Neyssa ; de Toledo, Silvia Regina Caminada ; Petrilli, Antonio S. ; Amary, Maria Fernanda ; Halai, Dina ; Thomas, David M. ; Douglass, Chester ; Meltzer, Paul S. ; Jacobs, Kevin ; Chung, Charles C. ; Berndt, Sonja I. ; Purdue, Mark P. ; Caporaso, Neil E. ; Tucker, Margaret ; Rothman, Nathaniel ; Landi, Maria Teresa ; Silverman, Debra T. ; Kraft, Peter ; Hunter, David J. ; Malats, Nuria ; Kogevinas, Manolis ; Wacholder, Sholom ; Troisi, Rebecca ; Helman, Lee ; Fraumeni, Joseph F. ; Yeager, Meredith ; Hoover, Robert N. ; Chanock, Stephen J.

Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 × 10−9) and a locus in the gene [...]

Menée auprès de 14 441 participantes, cette étude de cohorte australienne évalue l'association entre le poids au début de l'âge adulte, des variations de poids ultérieures et le risque de cancer du sein chez des femmes ménopausées

Associations between weight in early adulthood, change in weight and breast cancer risk in postmenopausal women

Krishnan, Kavitha ; Bassett, Julie K. ; MacInnis, Robert J. ; English, Dallas R. ; Hopper, John L. ; McLean, Catriona A. ; Giles, Graham G. ; Baglietto, Laura

BACKGROUND: Adult weight is positively associated with postmenopausal breast cancer but few studies have investigated whether there are associations with weight and body mass index (BMI) in early adulthood, or subsequent weight change. METHODS: 14,441 postmenopausal women from the Melbourne Collaborative Cohort Study were followed for 16.5 years (mean) and 668 incident breast cancers were identified. Hazard ratios (HRs) were estimated using Cox regression. RESULTS: Weight and BMI at 18-21 years [...]

A partir d'une revue de la littérature (7 études cas-témoins), cette méta-analyse évalue l'association entre des polymorphismes à simple nucléotide de deux gènes associés aux allergies, IL-4Rα et IL-13, et le risque de gliome

Association between polymorphisms in interleukin-4Rα and interleukin-13 and glioma risk: A meta-analysis

Sun, Guan ; Wang, Xiefeng ; Shi, Lei ; Yue, Xiao ; Fu, Linshan ; Chen, Chen ; Li, Zhengyi ; Pan, Tianhong ; Wan, Zhengqiang

Introduction: It has been suggested that allergies are inversely associated with glioma risk. Single nucleotide polymorphisms in two allergy-related genes [interleukin (IL)-4Rα, IL-13] have been implicated in susceptibility to glioma; however, results from the published studies remained inconclusive. Methods: To derive a more precise relationship, we conducted a meta-analysis including seven case–control studies that investigated the influence of IL-4Rα rs1801275 and IL13 rs20541 polymorphisms [...]

A partir de données portant sur 1 042 cas et sur 1 051 témoins, cette étude évalue l'association entre un travail posté, 100 polymorphismes à simple nucléotide de 14 gènes du rythme circadien et le risque de cancer du sein

Shift work, circadian gene variants and risk of breast cancer

Grundy, Anne ; Schuetz, Johanna M. ; Lai, Agnes S. ; Janoo-Gilani, Rozmin ; Leach, Stephen ; Burstyn, Igor ; Richardson, Harriet ; Brooks-Wilson, Angela ; Spinelli, John J. ; Aronson, Kristan J.

Abstract : Circadian (clock) genes have been linked with several functions relevant to cancer, and epidemiologic research has suggested relationships with breast cancer risk for variants in NPAS2, CLOCK, CRY2 and TIMELESS. Increased breast cancer risk has also been observed among shift workers, suggesting potential interactions in relationships of circadian genes with breast cancer. Relationships with breast cancer of 100 SNPs in 14 clock-related genes, as well as potential interactions with [...]

A partir des données d'une étude en population américaine incluant 1 227 cas et 1 325 témoins, cette étude évalue l'association entre des polymorphismes des gènes de réparation par excision de nucléotides, le tabagisme et le risque de cancer de la tête et du cou

Single Nucleotide Polymorphisms in Nucleotide Excision Repair Genes, Cigarette Smoking, and the Risk of Head and Neck Cancer

Wyss, Annah B. ; Herring, Amy H. ; Avery, Christy ; Weissler, Mark Christian ; Bensen, Jeannette T. ; Barnholtz-Sloan, Jill S. ; Funkhouser, William K. ; Olshan, Andrew F.

Background: Cigarette smoking is associated with increased head and neck cancer (HNC) risk. Tobacco-related carcinogens are known to cause bulky DNA adducts. Nucleotide excision repair (NER) genes encode enzymes that remove adducts and may be independently associated with HNC, as well as modifiers of the association between smoking and HNC. Methods: Using population-based case-control data from the Carolina Head and Neck Cancer Epidemiology Study (1,227 cases, 1,325 controls), race-stratified [...]