Menée sur deux cohortes incluant au total 1 585 patientes atteintes d'un cancer du sein et 2 940 témoins, cette étude évalue l'association entre les niveaux sanguins de la 25-hydroxy-vitamine D circulante et le risque de cancer du sein

Circulating levels of 25-hydroxyvitamin D and risk of breast cancer: a nested case-control study

Scarmo, Stephanie ; Afanasyeva, Yelena ; Lenner, Per ; Koenig, Karen ; Horst, Ronald ; Clendenen, Tess ; Arslan, Alan ; Chen, Yu ; Hallmans, Göran ; Lundin, Eva ; Rinaldi, Sabina ; Toniolo, Paolo ; Shore, Roy ; Zeleniuch-Jacquotte, Anne

INTRODUCTION:Experimental evidence suggests a protective role for circulating 25-hydroxyvitamin D (25(OH)D) in breast cancer development, but the results of epidemiological studies have been inconsistent.METHODS:We conducted a case-control study nested within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Mammary Screening Cohort. Blood samples were collected at enrollment, and women were followed up for breast cancer ascertainment. A total of [...]

Menée sur une cohorte de 319 985 femmes (durée moyenne de suivi : 8,8 ans), cette étude évalue, en fonction du statut ménopausique, l'association entre la consommation de vitamine D ou de calcium et le risque de cancer du sein (7 760 cas)

Dietary Intake of Vitamin D and Calcium and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition

Abbas, Sascha ; Linseisen, Jakob ; Rohrmann, Sabine ; Chang-Claude, Jenny ; Peeters, Petra H. ; Engel, Pierre ; Brustad, Magritt ; Lund, Eiliv ; Skeie, Guri ; Olsen, Anja ; Tjønneland, Anne ; Overvad, Kim ; Boutron-Ruault, Marie-Christine ; Clavel-Chapelon, Françoise ; Fagherazzi, Guy ; Kaaks, Rudolf ; Boeing, Heiner ; Buijsse, Brian ; Adarakis, George ; Ouranos, Vassilis ; Trichopoulou, Antonia ; Masala, Giovanna ; Krogh, Vittorio ; Mattiello, Amalia ; Tumino, Rosario ; Sacerdote, Carlotta ; Buckland, Genevieve ; Suárez, Marcial Vicente Argüelles ; Sánchez, María-José ; Chirlaque, María-Dolores ; Barricarte, Aurelio ; Amiano, Pilar ; Manjer, Jonas ; Wirfalt, Elisabet ; Lenner, Per ; Sund, Malin ; Bueno-de-Mesquita, H. B. ; van Duijnhoven, Fränzel J. B. ; Khaw, Kay-Tee ; Wareham, Nick ; Key, Timothy J. ; Fedirko, Veronika ; Romieu, Isabelle ; Gallo, Valentina ; Norat, Teresa ; Wark, Petra A. ; Riboli, Elio

Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional [...]

Menée à partir d'enquêtes par questionnaires ou entretiens auprès de 689 patients atteints d'un cancer de la cavité buccale et de 3 481 témoins, cette étude française évalue l'association entre la consommation de thé et/ou de café et le risque de développer la maladie

Tea and coffee consumption and risk of oral cavity cancer: Results of a large population-based case-control study, the ICARE study

Radoi, Loredana ; Paget-Bailly, Sophie ; Menvielle, Gwenn ; Cyr, Diane ; Schmaus, Annie ; Carton, Matthieu ; Guida, Florence ; Cenée, Sylvie ; Sanchez, Marie ; Guizard, Anne-Valérie ; Velten, Michel ; Stücker, Isabelle ; Luce, Danièle

Background Results on the relationship between coffee and tea drinking and the risk of oral cavity cancer are contrasted. The aim of this study was to evaluate the relation between coffee and tea drinking and the risk of oral cavity cancer in France, a high incidence area. Material and methods We conducted a population based case–control study with face-to-face interviews and standardized questionnaires (the ICARE study, Investigation of occupational and environmental causes of respiratory [...]

Menée sur des lignées cellulaires humaines de cancer de la prostate et de cancer du sein, cette étude montre que les flavanols extraits du coing japonais peuvent inhiber l'invasion des cellules tumorales et modifier favorablement le rapport entre les ARNs messagers Bax et Bcl-2

Flavanols from Japanese Quince (Chaenomeles Japonica) Fruit Inhibit Human Prostate and Breast Cancer Cell Line Invasiveness and Cause Favorable Changes in Bax/Bcl-2 mRNA Ratio

Lewandowska, Urszula ; Szewczyk, Karolina ; Owczarek, Katarzyna ; Hrabec, Zbigniew ; Podsędek, Anna ; Koziołkiewicz, Maria ; Hrabec, Elżbieta

Polyphenols are natural compounds of high structural diversity which translates into a very wide spectrum of biological activities, including chemoprevention. Here we report that a Japanese quince fruit flavanol preparation (JQFFP) caused favorable changes in Bax/Bcl-2 mRNA ratio, which rendered normal and cancer cells more resistant and more sensitive, respectively, to apoptosis. DU145 human prostate cancer cells were characterized by the most advantageous Bax/Bcl-2 ratio. The growth and [...]

Menée sur des lignées cellulaires humaines de cancer du poumon, cette étude montre qu'un composé dérivé du sulfure de sulindac, le N,N-diméthyléthylamine, peut inhiber la croissance cellulaire d'un adénocarcinome du poumon via la suppression de la voie de signalisation Akt/mTOR et l'activation du processus d'autophagie

A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy

Gurpinar, Evrim ; Grizzle, William E ; Shacka, John J ; Mader, Burton J ; Li, Nan ; Piazza, Nicholas A ; Russo, Suzanne ; Keeton, Adam B. ; Piazza, Gary A

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac sulfide (SS) have shown promising antineoplastic activity in multiple tumor types, but toxicities resulting from cyclooxygenase (COX) inhibition limit their use in cancer therapy. We recently described a N,N-dimethylethyl amine derivative of SS, sulindac sulfide amide (SSA), that does not inhibit COX-1 or -2, yet displays potent tumor cell growth inhibitory activity. Here, we studied the basis for the growth inhibitory effects of [...]

Menée à l'aide d'un modèle murin transgénique de cancer du sein, cette étude analyse les effets chimiopréventifs du dipyridamole sur la tumorigenèse et le processus métastatique

Chemoprevention Activity of Dipyridamole in the MMTV-PyMT Transgenic Mouse Model of Breast Cancer

Wang, Chunmei ; Schwab, Luciana P. ; Seagroves, Tiffany N. ; Fan, Meiyun ; Buolamwini, John K.

Dipyridamole (DPM) is widely used to prevent strokes and vascular thrombosis. Combination therapy of DPM and antimetabolites has shown synergistic anticancer activity. This study investigated the chemopreventive effects of DPM in the mouse mammary tumor virus promoter driven polyoma middle T oncoprotein (MMTV-PyMT) metastatic breast cancer model. We also investigated the effects of DPM on gene and miRNA expression. Chemopreventive activity was assessed by comparing the time to onset of palpable [...]

A partir des données de registres médicaux danois, cette étude évalue l'association entre l'utilisation de faibles doses d'aspirine ou d'autres anti-inflammatoires non stéroïdiens et le risque de gliome (2 688 cas ; 18 848 témoins ; âge : 20 à 85 ans)

Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study

Gaist, D. ; Garcia-Rodriguez, L. A. ; Sorensen, H. T. ; Hallas, J. ; Friis, S.

Background : Few studies have examined the association between use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) and risk of glioma and the results have been equivocal. We therefore investigated the influence of NSAID use on glioma risk in a nationwide setting. Methods : We used national registries in Denmark to identify all patients aged 20–85 years with a first diagnosis of histologically verified glioma during 2000–2009. Each case was matched on birth year and sex to [...]

Menée à partir des données d'un essai américain incluant 142 034 participants (durée moyenne de suivi : 9 ans), cette étude évalue l'association entre la consommation régulière d'aspirine ou d'ibuprofène et le risque de cancer de la tête et du cou

Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer

Wilson, J. C. ; Murray, L. J. ; Hughes, C. M. ; Black, A. ; Anderson, L. A.

Background : Evidence for non-steroidal anti-inflammatory drugs (NSAIDs) preventing head and neck cancer (HNC) is inconclusive; however, there is some suggestion that aspirin may exert a protective effect. Methods : Using data from the United States National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined the association between aspirin and ibuprofen use and HNC. Results : Regular aspirin use was associated with a significant 22% reduction in HNC [...]

Mené au Canada auprès de 928 adultes fumeurs participant, dans le cadre de la médecine familiale, à un programme d'aides au sevrage tabagique reposant sur 5 stratégies recommandées par un groupe d'experts américains, cet essai randomisé évalue l'intérêt d'ajouter des séances de conseil par téléphone pour améliorer le taux d'abstinence tabagique

Effectiveness of telephone-based follow-up support delivered in combination with a multi-component smoking cessation intervention in family practice: A cluster-randomized trial

Papadakis, Sophia ; McDonald, Paul ; Pipe, Andrew ; Letherdale, Scott ; Reid, Robert D. ; Brown, K. Stephen

Objective To determine whether telephone-based smoking cessation follow-up counselling (FC), when delivered as part of a multi-component intervention program is associated with increased rates of follow-up support and smoking abstinence. Methods A cluster randomized controlled-trial was conducted within family medicine practices in Ontario, Canada. Consecutive adult patients who smoked were enrolled at two time points, the baseline period (2009) and the post-intervention period (2009–2011). [...]