Menée aux Etats-Unis auprès de 50 survivants d'une leucémie lymphoblastique aiguë et de 50 survivants de tumeurs cérébrales âgés de 12 à 17 ans, cette étude met en évidence différents types de déficiences cognitives consécutives aux traitements

Slower processing speed after treatment for pediatric brain tumor and acute lymphoblastic leukemia

Kahalley, Lisa S. ; Conklin, Heather M. ; Tyc, Vida L. ; Hudson, Melissa M. ; Wilson, Stephanie J. ; Wu, Shengjie ; Xiong, Xiaoping ; Hinds, Pamela S.

Background : Acute lymphoblastic leukemia (ALL) and brain tumor (BT) survivors are at risk for post-treatment IQ declines. The extent to which lower scores represent global cognitive decline versus domain-specific impairment remains unclear. This study examined discrepancies between processing speed and estimated IQ (EIQ) scores and identified clinical characteristics associated with score discrepancies in a sample of pediatric cancer survivors. Procedure : Survivors (50 ALL, 50 BT) ages 12–17 [...]

Menée aux Pays-Bas par entretiens, cette étude qualitative analyse les expériences de survivants de cancer lors de leur retour au travail, et évalue l'efficacité d'un programme d'exercices physiques pour améliorer leurs performances et leurs capacités professionnelles

Physical exercise and return to work: cancer survivors’ experiences

Groeneveld, IrisF ; Boer, AngelaG E. M. ; Frings-Dresen, MoniqueH W.

Purpose : In this qualitative study, we aimed to explore cancer survivors’ experiences with (1) return to work (RtW) and work performance, (2) a physical exercise program after treatment, and (3) the perceived link between physical exercise and work. Methods : Semi-structured individual interviews were held with ten cancer survivors of working age who had been treated with chemotherapy and had afterwards completed a group-based supervised physical exercise program. The interviews were [...]

Menée en Australie, cette étude en population analyse et compare, chez des immigrants de première génération (nés dans un pays de langue chinoise, arabe ou grecque) et chez des anglo-australiens, la qualité de vie et le bien-être psychosocial de survivants de cancer

Inferior health-related quality of life and psychological well-being in immigrant cancer survivors: A population-based study

Butow, Phyllis N. ; Aldridge, Lynley ; Bell, Melanie L. ; Sze, Ming ; Eisenbruch, Maurice ; Jefford, Michael ; Schofield, Penelope ; Girgis, Afaf ; King, Madeleine ; Duggal-Beri, Priya ; McGrane, Joshua ; Goldstein, David

This study compared health-related quality of life (QOL) and psychological morbidity in a population-based sample of first generation immigrant and Anglo-Australian cancer survivors. Eligible participants, recruited via three State Cancer Registries, included those: with a new diagnosis of one of 12 most incident cancers (all stages) 1–6years earlier; aged 18–80 at diagnosis; born in a Chinese, Arabic, or Greek speaking country and able to speak one of these languages. A random sample of [...]

Menée par téléphone auprès de 438 participantes, cette étude américaine analyse l'association entre l'orientation sexuelle et les facteurs associés à la qualité de vie de survivantes d'un cancer du sein

Breast cancer survivors of different sexual orientations: which factors explain survivors' quality of life and adjustment?

Boehmer, U. ; Glickman, M. ; Winter, M. ; Clark, M. A.

Background : Little is known about differences by sexual orientation in explanatory factors of breast cancer survivors' quality of life, anxiety, and depression. Patients and methods : Survivors were recruited from a cancer registry and additional survivors recruited through convenience methods. Data were collected via telephone survey from all 438 survivors, who were disease free and diagnosed with non-metastatic breast cancer an average of 5 years earlier. To explain quality of life, anxiety, [...]

Menée en Italie auprès de 72 couples, cette étude analyse la qualité de vie de patients atteints d'une tumeur cérébrale et celle de leur partenaire de vie

Living with a brain tumor

Petruzzi, Alessandra ; Finocchiaro, ClaudiaYvonne ; Lamperti, Elena ; Salmaggi, Andrea

Purpose : The psychological burden induced by brain tumor is profound both for the sick person and for their own family. This particular tumor not only impacts patients’ quality of life, but also reduces seriously the caregivers’ quality of life. We aim to describe brain tumor patients and their caregivers’ quality of life during the illness and assess the existing relation between clinical and psychological features of patients and their caregivers. Methods : The study involved 72 [...]

Menée en population suédoise auprès de 5 462 patients atteints d'un lymphome hodgkinien diagnostiqué entre 1973 et 2006, cette étude de cohorte analyse l'évolution de la mortalité liée à des maladies de l'appareil circulatoire

Temporal Trends in Mortality From Diseases of the Circulatory System After Treatment for Hodgkin Lymphoma: A Population-Based Cohort Study in Sweden (1973 to 2006)

Eloranta, Sandra ; Lambert, Paul C. ; Sjöberg, Jan ; Andersson, Therese M.L. ; Björkholm, Magnus ; Dickman, Paul W.

Purpose : Hodgkin lymphoma (HL) survival in Sweden has improved dramatically over the last 40 years, but little is known about the extent to which efforts aimed at reducing long-term treatment-related mortality have contributed to the improved prognosis. Methods : We used population-based data from Sweden to estimate the contribution of treatment-related mortality caused by diseases of the circulatory system (DCS) to temporal trends in excess HL mortality among 5,462 patients diagnosed at ages [...]

Menée en Italie auprès de 151 patients atteints d'un sarcome, cette étude analyse l'impact de l'adhésion aux recommandations cliniques sur la survie

Adherence to treatment guidelines for primary sarcomas affects patient survival: a side study of the European CONnective TIssue CAncer NETwork (CONTICANET)

Rossi, C. R. ; Vecchiato, A. ; Mastrangelo, G. ; Montesco, M. C. ; Russano, F. ; Mocellin, S. ; Pasquali, S. ; Scarzello, G. ; Basso, U. ; Frasson, A. ; Pilati, P. ; Nitti, D. ; Lurkin, A. ; Ray-Coquard, I.

Background The impact of adherence to clinical practice guidelines (CPGs) for loco-regional treatment (i.e. surgery and radiotherapy) and chemotherapy on local disease control and survival in sarcoma patients was investigated in a European study conducted in an Italian region (Veneto). Patients and methods The completeness of the adherence to the Italian CPGs for sarcomas treatment was assessed by comparing the patient's charts and the CPGs. Propensity score-adjusted multivariate survival [...]

A partir des données des registres australies, canadien, danois, norvégien, suédois et britannique portant sur la période 2000-2007 et incluant 257 362 femmes, cette étude analyse et compare, dans ces pays, les disparités de survie des patientes atteintes d'un cancer du sein, en fonction du stade au diagnostic

Breast cancer survival and stage at diagnosis in Australia, Canada, Denmark, Norway, Sweden and the UK, 2000-2007: a population-based study

Walters, S. ; Maringe, C. ; Butler, J. ; Rachet, B. ; Barrett-Lee, P. ; Bergh, J. ; Boyages, J. ; Christiansen, P. ; Lee, M. ; Warnberg, F. ; Allemani, C. ; Engholm, G. ; Fornander, T. ; Gjerstorff, M. L. ; Johannesen, T. B. ; Lawrence, G. ; McGahan, C. E. ; Middleton, R. ; Steward, J. ; Tracey, E. ; Turner, D. ; Richards, M. A. ; Coleman, M. P.

Background: We investigate whether differences in breast cancer survival in six high-income countries can be explained by differences in stage at diagnosis using routine data from population-based cancer registries. Methods: We analysed the data on 257 362 women diagnosed with breast cancer during 2000–7 and registered in 13 population-based cancer registries in Australia, Canada, Denmark, Norway, Sweden and the UK. Flexible parametric hazard models were used to estimate net survival and the [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution de l'incidence du cancer du sein avec métastases à distance, sur la période 1976-2009

Incidence of breast cancer with distant involvement among women in the United States, 1976 to 2009

Johnson Rh ; Chien F. L. ; Bleyer A.

Importance : Evidence from the US National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database suggests that the incidence of advanced breast cancer in young women is increasing. Objective  : To quantify this trend and analyze it as a function of stage at diagnosis, race/ethnicity, residence, and hormone receptor status.Design, Setting, and Patients  Breast cancer incidence, incidence trends, and survival rates as a function of age and extent of disease at diagnosis [...]

A partir d'une revue de la littérature, cette étude fait le point sur l'incidence, les traitements, le coût et la mortalité associés au cancer du sein dans les pays d'Amérique latine

A Review of Breast Cancer Care and Outcomes in Latin America

Justo, Nahila ; Wilking, Nils ; Jönsson, Bengt ; Luciani, Silvana ; Cazap, Eduardo

Abstract : This review presents an overview of breast cancer care, burden, and outcomes in Latin America, as well as the challenges and opportunities for improvement. Information was gleaned through a review of the literature, public databases, and conference presentations, in addition to a survey of clinical experts and patient organizations from the region. Breast cancer annual incidence (114,900 cases) and mortality (37,000 deaths) are the highest of all women's cancers in Latin America, and [...]

A partir des données des registres américains des cancers portant sur la période 1973-2009, cette étude évalue l'évolution de l'incidence, de la survie et de la mortalité par cancer de la vessie

Incidence, survival and mortality rates of stage-specific bladder cancer in United States: A trend analysis

Abdollah, Firas ; Gandaglia, Giorgio ; Thuret, Rodolphe ; Schmitges, Jan ; Tian, Zhe ; Jeldres, Claudio ; Passoni, Niccolò Maria ; Briganti, Alberto ; Shariat, Shahrokh F. ; Perrotte, Paul ; Montorsi, Francesco ; Karakiewicz, Pierre I. ; Sun, Maxine

Purpose : To examine the overall and stage-specific age-adjusted incidence, 5-year survival and mortality rates of bladder cancer (BCa) in the United States, between 1973 and 2009. Materials and methods : A total of 148,315 BCa patients were identified in the Surveillance, Epidemiology and End Results database, between years 1973 and 2009. Incidence, mortality, and 5-year cancer-specific survival rates were calculated. Temporal trends were quantified using the estimated annual percentage change [...]

A partir d'une revue de la littérature, cet article présente deux approches relatives à la mesure, par un patient et par un professionnel de santé, du bien-être psychosocial de patients atteints de cancer

Measuring psychosocial outcomes: is the consumer or the professional the best judge?

Paul, C. ; Sanson-Fisher, R. ; Carey, M.

In this review, we explore professionally-driven and consumer-driven paradigms in measuring psychosocial outcomes for cancer care. Early measures of psychosocial well-being focussed on clinically-derived concepts of dysfunction. Recent literature reflects a paradigm shift toward a consumer-driven approach to the conceptualisation and measurement of psychosocial well-being. The key distinction between the two approaches rests on whether the professional or consumer retains judgement authority [...]

Menée en Australie auprès de 454 participants, cette étude analyse les facteurs associés aux symptômes de dépression et d'anxiété chez des patients atteints de cancer et recevant une radiothérapie

Psychological distress in cancer patients undergoing radiation therapy treatment

Mackenzie, L. J. ; Carey, M. L. ; Sanson-Fisher, R. W. ; D’Este, C. A.

Purpose : The objective of this study was to examine the likely presence of, and factors associated with, anxiety, depression and overall psychological distress in cancer outpatients undergoing radiation therapy treatment in Sydney, Australia. Methods :A touchscreen computer survey was conducted in four radiation therapy treatment centre waiting rooms. Patients waiting to receive treatment completed the survey which included questions about demographic and disease characteristics, survey [...]

Menée auprès de 254 patients atteints d'un cancer, affiliés à une assurance maladie et recherchant une aide financière complémentaire pour payer leurs médicaments, cette étude évalue l'impact des dépenses de santé restant à leur charge sur leur qualité de vie et sur l'observance des traitements

The Financial Toxicity of Cancer Treatment: A Pilot Study Assessing Out-of-Pocket Expenses and the Insured Cancer Patient’s Experience

Zafar, S. Yousuf ; Peppercorn, Jeffrey M. ; Schrag, Deborah ; Taylor, Donald H. ; Goetzinger, Amy M. ; Zhong, Xiaoyin ; Abernethy, Amy P.

Purpose. Cancer patients carry rising burdens of health care–related out-of-pocket expenses, and a growing number of patients are considered “underinsured.” Our objective was to describe experiences of insured cancer patients requesting copayment assistance and to describe the impact of health care expenses on well-being and treatment. Methods. We conducted baseline and follow-up surveys regarding the impact of health care costs on well-being and treatment among cancer patients who contacted a [...]

A partir de données recueillies par questionnaires adressés aux parents de 550 enfants et à leurs médecins généralistes, cette étude en population danoise évalue l'intervalle de temps entre la présence de symptômes chez l'enfant et le diagnostic de cancer, et son impact sur le pronostic

Childhood cancer and factors related to prolonged diagnostic intervals: a Danish population-based study

Ahrensberg, J. M. ; Olesen, F. ; Hansen, R. P. ; Schroder, H. ; Vedsted, P.

Background: Early diagnosis of childhood cancer provides hope for better prognoses. Shorter diagnostic intervals (DI) in primary care require better knowledge of the association between presenting symptoms, interpretation of symptoms and the wording of the referral letter. Methods:A Danish nationwide population-based study. Data on 550 children aged <15 years with an incident cancer diagnosis (January 2007–December 2010) were collected through questionnaires to parents (response rate=69%) and [...]

Menée aux Pays-Bas auprès de 336 cas et 938 témoins, cette étude analyse le recours au médecin généraliste chez des survivantes d'un cancer du sein après la fin de leur premier traitement

Increased primary healthcare utilisation among women with a history of breast cancer

Roorda, Carriene ; Berendsen, AnnetteJ ; Groenhof, Feikje ; Meer, Klaas ; Bock, GeertruidaH

Purpose : Little is known about the current role of the general practitioner (GP) in breast cancer follow-up care. This study explores primary healthcare use in the period after completion of primary breast cancer treatment. Methods : A total of 336 women with a history of early-stage breast cancer treated with curative intent were identified in the primary care database of the Registration Network Groningen (RNG) (1998–2007) and matched with a reference population of 983 women without breast [...]

Menée en population britannnique auprès de 2 024 participants âgés de 50 ans, cette étude analyse leurs attitudes vis-à-vis de la pertinence des conseils en matière de comportement de santé donnés par les médecins aux survivants d'un cancer

Health behaviour advice to cancer patients: the perspective of social network members

Williams, K. ; Beeken, R. J. ; Wardle, J.

Background: Survival for many cancers is improved by healthier lifestyles, but giving lifestyle advice to cancer patients may seem insensitive. We investigated attitudes of members of cancer patients’ social networks towards doctors giving lifestyle advice. Methods: We identified social network members through a population survey of UK adults (n=2024, age 50) by asking respondents whether anyone close to them had ever had cancer (n=1273). Individuals with a cancer diagnosis themselves (n=222) [...]

Cette étude transversale internationale analyse les disparités, selon les pays, dans l'usage de médicaments au cours de la phase terminale de patients atteints d'un cancer

Variation in medication use in cancer patients at the end of life: a cross-sectional analysis

Raijmakers, N. J. H. ; Zuylen, L. ; Furst, C. J. ; Beccaro, M. ; Maiorana, L. ; Pilastri, P. ; Rossi, C. ; Flego, G. ; Heide, A. ; Costantini, M.

Purpose : Despite advances in cancer treatment, patients still die with unnecessary suffering. Therefore, high-quality end-of-life care is needed. Variations in medication use at the end of life may suggest areas for improvement. This study aims to describe the use of medications during the last days of life of cancer patients and to explore the possibility of using it as a quality measure. Methods : We conducted an international survey on experts’ opinions regarding potentially inappropriate [...]

Menée au Royaume-Uni à partir des données d'un registre spécialisé des cancers concernant 2 508 enfants âgés de moins de 19 ans, cette étude analyse l'association entre le recours à des services de soins palliatifs pédiatriques et le nombre d'admissions à l'hôpital en fin de vie

Does referral to specialist paediatric palliative care services reduce hospital admissions in oncology patients at the end of life

Fraser, L. K. ; van Laar, M. ; Miller, M. ; Aldridge, J. ; McKinney, P. A. ; Parslow, R. C. ; Feltbower, R. G.

Background:Despite advances in the treatment of childhood cancer, some children continue to die from their disease. This study aimed to assess the impact of specialist paediatric palliative care services (SPPCSs) on the number of hospital admissions in children who subsequently died from cancer in Yorkshire, UK. Methods: An extract of patients aged 0–19 years from the Yorkshire Specialist Register of Cancer in Children and Young People (YSRCCYP) diagnosed from 1990 to 2009 were linked to [...]

Cet article fait le point sur l'évolution en matière d'éthique de la gestion des données génomiques

Evolving approaches to the ethical management of genomic data

McEwen, Jean E. ; Boyer, Joy T. ; Sun, Kathie Y.

The ethical landscape in the field of genomics is rapidly shifting. Plummeting sequencing costs, along with ongoing advances in bioinformatics, now make it possible to generate an enormous volume of genomic data about vast numbers of people. The informational richness, complexity, and frequently uncertain meaning of these data, coupled with evolving norms surrounding the sharing of data and samples and persistent privacy concerns, have generated a range of approaches to the ethical management [...]