Cette étude transversale norvégienne évalue la prévalence de symptômes associés à la fatigue chronique chez des patients ayant survécu à une leucémie lymphoblastique aiguë ou à un lymphome développés durant l'enfance (290 cas : 143 hommes et 147 femmes ; 1 405 témoins)

High Prevalence of Chronic Fatigue in Adult Long-Term Survivors of Acute Lymphoblastic Leukemia and Lymphoma During Childhood and Adolescence

Hanne Hamre; ; Bernward Zeller; ; Adriani Kanellopoulos; ; Cecilie E. Kiserud; ; Svend Aakhus; ; May B. Lund; ; Jon H. Loge; ; Sophie D. Fosså; ; Ellen Ruud

Purpose: Chronic fatigue (CF) is a frequent late effect of cancer, but has been poorly studied in adult survivors of childhood cancer. This cross-sectional study compares the prevalence of CF among adult survivors (childhood leukemia/lymphoma survivors; CLSs) of childhood acute lymphoblastic leukemia (ALL), Hodgkin lymphoma (HL), and non-Hodgkin lymphoma (NHL) to controls, and explored CF's association with disease characteristics, treatment, mental and somatic late effects, and selected [...]

A partir de questionnaires auprès de 30 patients atteints d'un cancer de l'œsophage, cette étude prospective évalue l'impact d'une œsophagectomie, combinée ou non à une chimiothérapie néo-adjuvante, sur la condition physique et la qualité de vie des patients

Impact of oesophagectomy on physical fitness and health-related quality of life in patients with oesophageal cancer

Tatematsu, N. ; Hasegawa, S. ; Tanaka, E. ; Sakai, Y. ; Tsuboyama, T.

Although several studies have reported the impact of oesophagectomy on health-related quality of life (HRQOL), none has objectively assessed its impact on physical fitness. This study aimed to evaluate the impact of oesophagectomy on physical fitness and HRQOL in patients with oesophageal cancer. In this prospective study, we investigated 30 consecutive patients with newly diagnosed resectable oesophageal cancer who were scheduled to receive either neoadjuvant chemotherapy followed by surgery [...]

A partir de questionnaires auprès de 385 patientes atteintes d'un cancer avancé du sein avec ou sans métastases, cette étude évalue, du point de vue de l'état psychologique, physique et fonctionnel, leur qualité de vie

Quality of life among advanced breast cancer patients with and without distant metastasis

Wyatt, G. ; Sikorskii, A. ; Tamkus, D. ; You, M.

This study presents the results of a secondary analysis of data collected during a trial of reflexology that aimed to improve health-related quality of life (HRQOL) among women with advanced breast cancer in treatment. A comparison of HRQOL (functioning, symptoms, spirituality) of those with (n = 298) and without (n = 87) distant metastasis is presented. Following the intake interview, 385 women were randomised to reflexology, lay foot manipulation or conventional care control, and were [...]

A partir de questionnaires auprès de 336 patientes ayant été opérées pour un cancer du sein de stade I-III, cet essai randomisé danois montre qu'un programme d'intervention psychosociale d'une durée de 8 semaines peut réduire significativement le niveau auto-rapporté de stress, d'anxiété et de dépression des participantes

Mindfulness significantly reduces self-reported levels of anxiety and depression: Results of a randomised controlled trial among 336 Danish women treated for stage I–III breast cancer

Würtzen, Hanne ; Dalton, Susanne Oksbjerg ; Elsass, Peter ; Sumbundu, Antonia D. ; Steding-Jensen, Marianne ; Karlsen, Randi Valbjørn ; Andersen, Klaus Kaae ; Flyger, Henrik L. ; Pedersen, Anne E. ; Johansen, Christoffer

Introduction As the incidence of and survival from breast cancer continue to raise, interventions to reduce anxiety and depression before, during and after treatment are needed. Previous studies have reported positive effects of a structured 8-week group mindfulness-based stress reduction program (MBSR) among patients with cancer and other conditions. Purpose To test the effect of such a programme on anxiety and depression among women with breast cancer in a population-based randomised [...]

Menée sur une cohorte suédoise comportant plus de 12 millions de participants (dont plus de 1 million de cas de cancer primitif), cette étude prospective évalue le risque de développer un cancer de type familial en fonction de l'âge au diagnostic du parent atteint et de la localisation de la maladie

Familial risk of early and late onset cancer: nationwide prospective cohort study

E Kharazmi ; M Fallah ; K Sundquist ; K Hemminki

Objective : To determine whether familial risk of cancer is limited to early onset cases. Design : Nationwide prospective cohort study. Setting : Nationwide Swedish Family-Cancer Database. Participants : All Swedes born after 1931 and their biological parents, totalling >12.2 million individuals, including >1.1 million cases of first primary cancer. Main outcome measures Familial risks of the concordant cancers by age at diagnosis. Results The highest familial risk was seen for offspring whose [...]

A partir de données administratives portant sur 7 471 patients atteints d'un cancer de l'oesophage ou de l'estomac et sur 32 877 témoins, cette étude britannique identifie et quantifie les symptômes de la maladie repérés par le médecin généraliste

The risk of oesophago-gastric cancer in symptomatic patients in primary care : a large case-control study using electronic records

Stapley, S. ; Peters, T. J. ; Neal, R. D. ; Rose, P. W. ; Walter, F. M. ; Hamilton, W.

Background : Over 15 000 new oesophago-gastric cancers are diagnosed annually in the United Kingdom, with most being advanced disease. We identified and quantified features of this cancer in primary care. Methods : Case–control study using electronic primary-care records of the UK patients aged greater than or equal to 40 years was performed. Cases with primary oesophago-gastric cancer were matched to controls on age, sex and practice. Putative features of cancer were identified in the year [...]

Menée sur 231 patients atteints d'un cancer colorectal traité chirurgicalement, cette étude rétrospective analyse la qualité des lymphadénectomies en fonction de la catégorie d'âge des patients

Impact of Age on the Quality of Lymphadenectomy for Colorectal Cancer

Torre, Carlo ; Paliogiannis, Panagiotis ; Pulighe, Fabio ; Scognamillo, Fabrizio ; Castiglia, Paolo ; Trignano, Mario

The aim of this study was to evaluate the impact of patient age on the number of lymph nodes dissected during surgery for colorectal cancer. Clinical and histopathological data of 231 consecutive patients who underwent elective surgery for colorectal cancer were reviewed retrospectively. Patients were divided into those aged ≤70 years and >70 years. Our findings suggest that patient's age influences the number of lymph nodes detected in surgical specimens; this number was lower in patients aged [...]

Menée en Floride et dans l'Ontario auprès de 1 626 patientes atteintes d'un cancer invasif de l'ovaire diagnostiqué entre 1995 et 2004 (durée moyenne de suivi : 6,9 ans), cette étude évalue l'association entre une mutation du gène BRCA1 ou BRCA2 et la survie à long terme des patientes

Long-Term Ovarian Cancer Survival Associated With Mutation in BRCA1 or BRCA2

McLaughlin, John R. ; Rosen, Barry ; Moody, Joel ; Pal, Tuya ; Fan, Isabel ; Shaw, Patricia A. ; Risch, Harvey A. ; Sellers, Thomas A. ; Sun, Ping ; Narod, Steven A.

Background Studies have suggested that the 5-year survival of women with ovarian cancer and a BRCA1 or BRCA2 mutation is better than expected. We sought to evaluate the impact of carrying a BRCA1 or BRCA2 mutation on long-term survival of women after a diagnosis of invasive ovarian cancer.Methods One thousand six hundred twenty-six unselected women diagnosed with invasive ovarian cancer in Ontario, Canada, or in Tampa, Florida, between 1995 and 2004 were followed for a mean of 6.9 years (range [...]

A partir d'une revue systématique de la littérature publiée entre 1990 et 2012 (61 études), cette étude évalue l'association entre le coût et la qualité des soins de santé

The Association Between Health Care Quality and Cost : A Systematic Review

Hussey, Peter S. ; Wertheimer, Samuel ; Mehrotra, Ateev

Background: Although there is broad policy consensus that both cost containment and quality improvement are critical, the association between costs and quality is poorly understood.Purpose: To systematically review evidence of the association between health care quality and cost.Data Sources: Electronic literature search of PubMed, EconLit, and EMBASE databases for U.S.-based studies published between 1990 and 2012.Study Selection: Title, abstract, and full-text review to identify relevant [...]

Cet article fait le point sur les améliorations possibles concernant l'organisation structurelle et fonctionnelle des soins palliatifs destinés aux patients atteints d'un cancer

Palliative care reduces morbidity and mortality in cancer

Rocque, Gabrielle B. ; Cleary, James F.

Despite improvements in cancer therapies, cancer is the leading cause of death worldwide. Many patients experience severe, unnecessary symptoms during treatment as well as at the end of life. Often, patients receive 'aggressive' care at the end of life that is discordant with their preferences. Palliative care is an approach that focuses on communication and quality of life, including treatment of physical, psychosocial, and spiritual suffering. This approach is appropriate for patients with [...]

Cet article fait le point sur les principes élaborés par un projet anglais ("England’s National Cancer Survivorship Initiative") pour améliorer la qualité des soins destinés aux patients ayant survécu à un cancer et présente quelques pistes de réflexion provenant d'Australie, du Canada ou des Etats-Unis

Implementing improved post-treatment care for cancer survivors in England, with reflections from Australia, Canada and the USA

Jefford, M. ; Rowland, J. ; Grunfeld, E. ; Richards, M. ; Maher, J. ; Glaser, A.

Increasing cancer incidence together with improved survival rates are contributing to the growing number of cancer survivors. Survivors may encounter a range of potential effects as a result of the cancer itself or cancer treatments. Traditionally, the major focus of follow-up care has been on detection of cancer recurrence; however, the efficacy of such strategies is questionable. Traditional follow-up frequently fails to identify or adequately address many survivors’ concerns. Aftercare needs [...]