A partir d'une revue de la littérature (16 études), cette étude fait le point sur les troubles de l'équilibre associés aux traitements chez les survivants d'un cancer pédiatrique

Effect of treatment for paediatric cancers on balance: what do we know? A review of the evidence

Turner, M. ; Gagnon, D. ; Lagace, M. ; Gagnon, I.

This review aims to explore the literature investigating balance outcomes in survivors of childhood cancer. A structured search of five databases resulted in 16 articles included in this review. Nearly all were classified as Level 4 evidence using the updated Oxford Centre for Evidence-Based Medicine Levels of Evidence. Balance abilities have been investigated solely in survivors of acute lymphoblastic leukaemia or central nervous system tumours. The literature tends to support the idea that [...]

Cette étude analyse les expériences et les besoins de survivants à long terme de cancer afin d'améliorer la qualité et l'organisation des soins aux Etats-Unis

Perspectives of a lifelong cancer survivor- improving survivorship care

Rechis, Ruth ; Arvey, Sarah R. ; Beckjord, Ellen Burke

Many of the 14 million cancer survivors in the USA live with physical, emotional and day-to-day concerns related to their cancer long after their treatment ends. Addressing the needs of the growing cancer-survivor population will be a considerable task. In this article, Ruth Rechis—a 20-year survivor of Hodgkin lymphoma—describes her personal account of surviving cancer and her experience as a researcher and advocate in the field of survivorship. Results from a national USA survey on [...]

A partir d'une revue de la littérature (13 études), cette méta-analyse évalue l'impact d'une chimiothérapie sur les facultés cognitives de patients atteints de cancer

A meta-analysis of the effects of chemotherapy on cognition in patients with cancer

Hodgson, Kristy D. ; Hutchinson, Amanda D. ; Wilson, Carlene J. ; Nettelbeck, Ted

The aim of this meta-analysis was to assess whether chemotherapy-related cognitive impairment is consistently observed in cancer patients and to identify the areas of cognition affected. The meta-analysis included 13 studies and examined the effects of chemotherapy on seven different cognitive domains, across five cancer types. It was the intention of this meta-analysis to stringently exclude many studies, allowing for examination of cognition in carefully selected studies of chemotherapy [...]

Cette étude de cohorte rétrospective analyse l'incidence d'événements indésirables chez des patients atteints de cancer et traités avec des inhibiteurs du facteur de croissance de l’endothélium vasculaire

Selected adverse events in cancer patients treated with vascular endothelial growth factor inhibitors

Dreyfus, Brian ; Kawabata, Hugh ; Gomez, Andres

Introduction: To evaluate the safety profile of new drugs, it is important to quantify the rates of adverse events (AE). There has been little to no research on the safety of vascular endothelial growth factor (VEGF) inhibitors in population-based settings. The purpose of this study was to further the understanding of the incidence of AEs in a population-based representative cancer population receiving VEGF inhibitors where there currently is a deep lack of knowledge. Methods: We conducted a [...]

Menée auprès de 210 participantes, cette étude analyse l'impact de médicaments béta-bloquants sur la réduction de pensées négatives (souvenirs, cauchemars, visions) chez des patientes atteintes d'un cancer du sein nouvellement diagnostiqué

Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer patients

Lindgren, Monica E. ; Fagundes, Christopher P. ; Alfano, Catherine M. ; Povoski, Stephen P. ; Agnese, Doreen M. ; Arnold, Mark W. ; Farrar, William B. ; Yee, Lisa D. ; Carson, William E. ; Schmidt, Carl R. ; Kiecolt-Glaser, Janice K.

Objective A cancer diagnosis provokes significant levels of emotional distress, with intrusive thoughts being the most common manifestation among breast cancer survivors. Cancer-related intrusive thoughts can take the form of emotional memories, flashbacks, nightmares, and intrusive images. Emotional arousal after a severe life stressor prolongs adrenergic activation, which in turn may increase risk for post-traumatic symptomatology. However, antihypertensive beta-blockers block adrenergic [...]

Menée par questionnaire auprès de 632 participantes australiennes, cette étude analyse les facteurs prédictifs des effets d'un cancer de l'endomètre sur la qualité de vie et la survie à long terme des femmes

Predicting positive and negative impacts of cancer among long-term endometrial cancer survivors

Rowlands, Ingrid J. ; Lee, Christina ; Janda, Monika ; Nagle, Christina M. ; Obermair, Andreas ; Webb, Penelope M. ; Australian National Endometrial Cancer Study, Group

Objective Although the survival outcomes among women diagnosed with endometrial cancer are very favorable, little is known about the long-term impact of their cancer experience. This study identifies the extent of positive and negative impacts of cancer and factors associated with this, amongst long-term survivors of endometrial cancer. Methods Australian women diagnosed with endometrial cancer (N = 632) were sent questionnaires at the time of diagnosis and 3–5 years later. Hierarchical [...]

A partir des données du registre norvégien des cancers et d'un modèle statistique permettant d'estimer le taux de guérison, cette étude analyse l'évolution de la survie des patients atteints de cancer (23 localisations) sur la période 1963-2007

Proportion cured models applied to 23 cancer sites in Norway

Cvancarova, Milada ; Aagnes, Bjarte ; Fosså, Sophie D. ; Lambert, Paul C. ; Møller, Bjørn ; Bray, Freddie

Statistical cure is reached when a group of patients has the same mortality as cancer-free individuals. Cure models predict the cured proportion and the median survival of fatal cases. Cure models have seldom been applied and tested systematically across all major cancer sites. Incidence and follow-up data on 23 cancer sites recorded at the Cancer Registry of Norway 1963–2007 were obtained. Mixture cure models were fitted to obtain trends and up-to-date estimates (based on period approach) [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution de l'incidence de l'adénocarcinome de l'œsophage ainsi que le mortalité sur la période 1975-2009

Trends in esophageal adenocarcinoma incidence and mortality

Hur, Chin ; Miller, Melecia ; Kong, Chung Yin ; Dowling, Emily C. ; Nattinger, Kevin J. ; Dunn, Michelle ; Feuer, Eric J.

BACKGROUND: Over the past several decades, the incidence of esophageal adenocarcinoma (EAC) has rapidly increased. The purpose of this analysis was to examine temporal trends in EAC incidence and mortality within the US population and, in addition, to explore these trends within subgroups of the population. METHODS: The National Cancer Institute (NCI) Surveillance, Epidemiology and End Results (SEER 9) data were used to examine incidence and incidence-based (IB) mortality in EAC from 1975 to [...]

Menée auprès d'une population d'origine hispanique vivant dans le sud-ouest des Etats-Unis (746 participantes), cette étude analyse la prévalence d'une mutation des gènes BRCA1 et BRCA2 et son impact potentiel sur la prise en charge du risque génétique

Prevalence and Type of BRCA Mutations in Hispanics Undergoing Genetic Cancer Risk Assessment in the Southwestern United States: A Report From the Clinical Cancer Genetics Community Research Network

Weitzel, Jeffrey N. ; Clague, Jessica ; Martir-Negron, Arelis ; Ogaz, Raquel ; Herzog, Josef ; Ricker, Charité ; Jungbluth, Chelsy ; Cina, Cheryl ; Duncan, Paul ; Unzeitig, Gary ; Saldivar, J. Salvador ; Beattie, Mary ; Feldman, Nancy ; Sand, Sharon ; Port, Danielle ; Barragan, Deborah I. ; John, Esther M. ; Neuhausen, Susan L. ; Larson, Garrett P.

Purpose : To determine the prevalence and type of BRCA1 and BRCA2 (BRCA) mutations among Hispanics in the Southwestern United States and their potential impact on genetic cancer risk assessment (GCRA). Patients and Methods : Hispanics (n = 746) with a personal or family history of breast and/or ovarian cancer were enrolled in an institutional review board–approved registry and received GCRA and BRCA testing within a consortium of 14 clinics. Population-based Hispanic breast cancer cases (n = [...]

Cette étude de cohorte incluant 2 709 patients évalue l'association entre des variants génétiques et les disparités ethniques observées dans la survie des patients atteints de neuroblastome

Trans-population Analysis of Genetic Mechanisms of Ethnic Disparities in Neuroblastoma Survival

Gamazon, Eric R. ; Pinto, Navin ; Konkashbaev, Anuar ; Im, Hae Kyung ; Diskin, Sharon J. ; London, Wendy B. ; Maris, John M. ; Dolan, M. Eileen ; Cox, Nancy J. ; Cohn, Susan L.

Background Black patients with neuroblastoma have a higher prevalence of high-risk disease and worse outcome than white patients. We sought to investigate the relationship between genetic variation and the disparities in survival observed in neuroblastoma. Methods The analytic cohort was composed of 2709 patients. Principal components were used to assign patients to genomic ethnic clusters for survival analyses. Locus-specific ancestry was calculated for use in association analysis. The shorter [...]

A partir des données des registres américains des cancers, cette étude analyse et compare l'évolution, sur la période 1992-2008, de l'incidence du cancer de l'endomètre pour les femmes blanches et pour les femmes noires, ainsi que la prévalence des hystérectomies

Trends in Endometrial Cancer Incidence by Race and Histology with a Correction for the Prevalence of Hysterectomy, SEER 1992-2008

Jamison, Patricia M. ; Noone, Anne-Michelle ; Ries, Lynn G. ; Lee, Nancy C. ; Edwards, Brenda K.

Background:Incidence rates of endometrial cancer are routinely calculated without removing women who have had a hysterectomy from the denominator which leads to an underestimate. Furthermore, since the number of women who have had a hysterectomy (hysterectomy prevalence) varies by race, the estimate of racial difference in endometrial cancer incidence is incorrect. Methods: Data from 1992 to 2008 from the SEER Program were used to calculate incidence rates of endometrial cancer (corpus uterus [...]

Menée en Australie auprès de 403 participants, cette étude analyse l'association entre une infection par le papillomavirus humain, le tabagisme et le survie des patients atteints d'un carcinome épidermoïde des amygdales

Human papillomavirus, smoking status and outcomes in tonsillar squamous cell carcinoma

Hong, Angela M. ; Martin, Andrew ; Chatfield, Mark ; Jones, Deanna ; Zhang, Mei ; Armstrong, Bruce ; Lee, C. Soon ; Harnett, Gerald ; Milross, Christopher ; Clark, Jonathan ; Elliott, Michael ; Smee, Robert ; Corry, June ; Liu, Chen ; Porceddu, Sandro ; Rees, Guy ; Rose, Barbara

It is now clear that the two separate entitles of tonsillar cancer, HPV induced and non-HPV induced (smoking induced), have significantly different presenting stage and outcomes. A significant proportion of patients with human papillomavirus positive tonsillar cancer have had exposure to smoking. We examined the combined effect of human papillomavirus and smoking on the outcomes and determined whether smoking can modify the beneficial effect of human papillomavirus. A total of 403 patients from [...]

Mené en Irlande, cette étude qualitative analyse l'efficacité d'une intervention de nature psychosociale destinée aux jeunes enfants dont un des parents est diagnostiqué avec un cancer

Family life when a parent is diagnosed with cancer: impact of a psychosocial intervention for young children

Semple, C. J. ; McCaughan, E.

When a parent is diagnosed with cancer it can have a profound impact on the family, especially the children. This paper reports on the experience of parental cancer for parents' and their children and the impact of a psychosocial intervention for young children whose parent has cancer. Using a qualitative design, data were generated from separate focus groups with children (n=7) and parents (n=6). One-to-one interviews were conducted with professionals delivering the intervention (n=2). [...]

Menée à Hong-Kong auprès de 22 participants, cette étude pilote analyse l'efficacité d'une thérapie visant à réduire l'anxiété d'individus participant à un programme de tests génétiques de détection du cancer colorectal

Hope-based intervention for individuals susceptible to colorectal cancer: a pilot study

Ho, SamuelMun-yin ; Ho, JudyWai-chu ; Pau, BarbaraKa-yan ; Hui, BryantPui-hung ; Wong, RosaSze-mun ; Chu, AnnieTsz-wai

Individuals undergoing genetic testing for hereditary colorectal cancer (HCRC) are prone to develop psychological problems. This study investigated the short-term efficacy of a hope-based intervention program in increasing hope levels and decreasing psychopathology among HCRC genetic testing recipients. A longitudinal study was carried out on HCRC genetic testing recipients recruited by the Hereditary Gastrointestinal Cancer Registry. Participants joined a hope-based intervention program [...]

Menée aux Etats-Unis auprès de 147 participantes et de 9 chirurgiens, cette étude analyse l'impact de la communication avec le chirurgien sur la santé psychologique de patientes atteintes d'un cancer du sein récemment diagnostiqué

Consultations Between Patients With Breast Cancer and Surgeons: A Pathway From Patient-Centered Communication to Reduced Hopelessness

Robinson, Jeffrey D. ; Hoover, Donald R. ; Venetis, Maria K. ; Kearney, Thomas J. ; Street, Richard L.

Purpose Patient-centered communication (PCC) affects psychosocial health outcomes of patients. However, these effects are rarely direct, and our understanding of such effects are largely based on self-report (v observational) data. More information is needed on the pathways by which concrete PCC behaviors affect specific psychosocial outcomes in cancer care. We hypothesized that PCC behaviors increase the satisfaction of patients with surgeons, which, in turn, reduces the postconsultation [...]

Menée auprès de 226 participants, cette étude lituanienne évalue l'efficacité d'un outil, "The Patient Health Questionnaire-2", permettant de détecter la détresse psychologique de patients atteints de tumeurs cérébrales avant et après une opération chirurgicale

Screening for psychological distress in neurosurgical brain tumor patients using the Patient Health Questionnaire-2

Bunevicius, Adomas ; Deltuva, Vytenis ; Tamasauskas, Sarunas ; Tamasauskas, Arimantas ; Bunevicius, Robertas

Objective Psychological distress is highly prevalent but often undiagnosed in brain tumor patients. We evaluated the psychometric properties of the Patient Health Questionnaire-2 (PHQ-2) for screening of distressed neurosurgical brain tumor patients. Methods A total of 226 (69% women; mean age 55.6 ± 14.7 years) consecutive patients on admission for elective brain tumor surgery were evaluated for psychological distress using the PHQ-2, the Hospital Anxiety and Depression Scale (HADS; n = 206), [...]

Menée en Australie auprès de 101 participants, cette étude prospective analyse les symptômes de dépression et d'anxiété chez des patients atteints d'un cancer de la tête et du cou dans les 18 mois suivant leur radiothérapie

A longitudinal study of distress (depression and anxiety) up to 18 months after radiotherapy for head and neck cancer

Neilson, Kate ; Pollard, Annabel ; Boonzaier, Ann ; Corry, June ; Castle, David ; Smith, David ; Trauer, Tom ; Couper, Jeremy

Objective The aim of the study was to assess symptoms of depression and anxiety in patients with head and neck cancer up to 18 months after radiotherapy. Methods Prospective observational study of consecutive head and neck outpatients was conducted at a tertiary cancer centre (n=101). Eligibility included diagnosis of cancer in the head and neck region, where the patient agreed to radiotherapy with curative intent. Data were collected before commencement of radiotherapy and 3 weeks and 18 [...]

Cet essai randomisé incluant 150 patients atteints d'un cancer de stade avancé (âge moyen : 62 ans) évalue l'efficacité, et l'impact sur leur choix, d'un outil vidéo d'aide à la décision relative à la réanimation cardio-pulmonaire

Randomized Controlled Trial of a Video Decision Support Tool for Cardiopulmonary Resuscitation Decision Making in Advanced Cancer

Angelo E. Volandes ; Michael K. Paasche-Orlow ; Susan L. Mitchell

Abstract Purpose Decision making regarding cardiopulmonary resuscitation (CPR) is challenging. This study examined the effect of a video decision support tool on CPR preferences among patients with advanced cancer. Patients and Methods We performed a randomized controlled trial of 150 patients with advanced cancer from four oncology centers. Participants in the control arm (n = 80) listened to a verbal narrative describing CPR and the likelihood of successful resuscitation. Participants in the [...]

Menée auprès de 1 000 patients coréens, cette étude de cohorte prospective analyse leur volonté de participer ou non à un essai clinique ainsi que leurs connaissances relatives à ce sujet

Unique perception of clinical trials by Korean cancer patients

Lee, Su ; Park, Lee ; Lee, Jeeyun ; Kim, Seonwoo ; Choi, Moon ; Hong, Jung ; Park, Sylvia ; HoonMaeng, Chi ; Chang, Wonjin ; Kim, Young ; Park, Se ; Park, Joon ; Lim, Ho ; Kang, Won ; Park, Young

BACKGROUND:In the past few years, the number of clinical trials has increased rapidly in East Asia, especially for gastric and hepatobiliary cancer that are prevalent in Asian populations. However, the actual degree of understanding or perceptions of clinical trials by cancer patients in East Asian countries have seldom been studied. METHODS:Between July 1st and November 30th of 2011, we conducted a prospective study to survey cancer patients regarding their awareness of, and willingness to [...]

Menée dans le centre américain de lutte contre le cancer MD Anderson, cette étude analyse le recours et l'accès aux soins palliatifs de patients atteints d'un cancer en phase terminale

Access to Palliative Care Before Death Among Patients Treated at a Comprehensive Cancer Center

Hui, David ; Kim, Sun-Hyun ; Kwon, Jung Hye ; Tanco, Kimberson Cochien ; Zhang, Tao ; Kang, Jung Hun ; Rhondali, Wadih ; Chisholm, Gary ; Bruera, Eduardo

Background. Palliative care (PC) is a critical component of comprehensive cancer care. Previous studies on PC access have mostly examined the timing of PC referral. The proportion of patients who actually receive PC is unclear. We determined the proportion of cancer patients who received PC at our comprehensive cancer center and the predictors of PC referral.Methods. We reviewed the charts of consecutive patients with advanced cancer from the Houston region seen at MD Anderson Cancer Center who [...]

A partir des données de 86 registres européens des cancers de 32 pays, cette étude analyse l'exactitude et l'exhaustivité des données relatives aux indicateurs suivants : le stade au diagnostic, les délais d'accès aux traitements, l'adhésion aux recommandations en cancérologie

Availability of stage at diagnosis, cancer treatment delay and compliance with cancer guidelines as cancer registry indicators for cancer care in Europe: Results of EUROCHIP-3 survey

Siesling, Sabine ; Kwast, Annemiek ; Gavin, Anna ; Baili, Paolo ; Otter, Renee ; Eurochip- Workpackage

EUROCHIP (European Cancer Health Indicators Project) focuses on understanding inequalities in the cancer burden, care and survival by the indicators “stage at diagnosis,” “cancer treatment delay” and “compliance with cancer guidelines” as the most important indicators. Our study aims at providing insight in whether cancer registries collect well-defined variables to determine these indicators in a comparative way. Eighty-six general European population-based cancer registries (PBCR) from 32 [...]

Cette étude présente les actions d'un réseau américain de lutte contre le cancer en matière de surveillance après un cancer, d'amélioration d'accès aux soins, d'utilisation des services de santé, de communication sur le cancer, d'aide à la décision sur les traitements et d'interventions visant à améliorer le comportement de santé de survivants d'un cancer

Cancer research network: using integrated healthcare delivery systems as platforms for cancer survivorship research

Nekhlyudov, Larissa ; Greene, SarahM ; Chubak, Jessica ; Rabin, Borsika ; Tuzzio, Leah ; Rolnick, Sharon ; Field, TerryS

Introduction Much progress has been made in cancer survivorship research, but there are still many unanswered questions that can and need to be addressed by collaborative research consortia. Methods Since 1999, the National Cancer Institute-funded HMO Cancer Research Network (CRN) has engaged in a wide variety of research focusing on cancer survivorship. With a focus on thematic topics in cancer survivorship, we describe how the CRN has contributed to research in cancer survivorship and the [...]

Cette étude présente et analyse les indicateurs élaborés par un groupe d'experts européens relatifs aux besoins en matière de réadaptation après un cancer

Cancer rehabilitation indicators for Europe

Baili, Paolo ; Hoekstra-Weebers, Josette ; Van Hoof, Elke ; Bartsch, Hans Helge ; Travado, Luzia ; Garami, Miklos ; Di Salvo, Francesca ; Micheli, Andrea ; Veerus, Piret

Little is known of cancer rehabilitation needs in Europe. EUROCHIP-3 organised a group of experts to propose a list of population-based indicators used for describing cancer rehabilitation across Europe. The aim of this study is to present and discuss these indicators. A EUROCHIP-3 expert panel reached agreement on two types of indicators. (a) Cancer prevalence indicators. These were proposed as a means of characterising the burden of cancer rehabilitation needs by time from diagnosis and [...]