A partir d'une revue systématique de la littérature (3 études de cohorte et 10 études cas-témoins), cette méta-analyse évalue l'association entre une consommation de viande et le risque d'adénocarcinome de l'œsophage

Red and processed meat intake and risk of esophageal adenocarcinoma: a meta-analysis of observational studies

Huang, Wen ; Han, Yujing ; Xu, Jiping ; Zhu, Wei ; Li, Zhaoshen

Aims Inconsistent results relating dietary red and processed meat intake and risk of esophageal adenocarcinoma (EAC) have been reported. This article summarizes and quantifies the current evidence in a meta-analysis of observational studies. Methods Electronic search of MEDLINE and EMBASE databases was performed to identify peer-reviewed manuscripts up to 31 May 2012. Random-effects models were used to pool study results. Results Ten manuscripts from 3 cohort studies and 7 case–control studies [...]

Menée en population canadienne, cette étude (1 681 cas et 2 053 témoins) évalue l'association entre une exposition professionnelle à l'amiante et le risque de cancer du poumon chez les hommes

Occupational exposure to asbestos and lung cancer in men: evidence from a population-based case-control study in eight Canadian provinces

Villeneuve, Paul ; Parent, Marie-Élise ; Harris, Shelley ; Johnson, Kenneth

BACKGROUND:Asbestos is classified as a human carcinogen, and studies have consistently demonstrated that workplace exposure to it increases the risk of developing lung cancer. Few studies have evaluated risks in population-based settings where there is a greater variety in the types of occupations, and exposures.METHODS:This was a population based case--control study with 1,681 incident cases of lung cancer, and 2,053 controls recruited from 8 Canadian provinces between 1994 and 1997. [...]

A partir d'une revue de la littérature (19 études), cette méta-analyse néerlandaise évalue l'asssociation entre une faible exposition à l'amiante, calculée par niveaux cumulés, et le risque de cancer du poumon

Lung cancer risk at low cumulative asbestos exposure: meta-regression of the exposure–response relationship

Bij, Sjoukje ; Koffijberg, Hendrik ; Lenters, Virissa ; Portengen, Lützen ; Moons, KarelG M. ; Heederik, Dick ; Vermeulen, RoelC H.

Purpose Existing estimated lung cancer risks per unit of asbestos exposure are mainly based on, and applicable to, high exposure levels. To assess the risk at low cumulative asbestos exposure, we provide new evidence by fitting flexible meta-regression models, a notably new and more robust method. Methods Studies were selected if lung cancer risk per cumulative asbestos exposure in at least two exposure categories was reported. From these studies (n = 19), we extracted 104 risk estimates over a [...]

Cette étude néerlandaise passe en revue les travaux récents sur l'identification de facteurs environnementaux (infection par Helicobacter pylori, tabagisme, nutrition) et héréditaires du cancer de l'estomac

Familial gastric cancer: detection of a hereditary cause helps to understand its etiology

Vogelaar, Ingrid ; van der Post, Rachel ; Bisseling, Tanya ; van Krieken, J ; Ligtenberg, Marjolijn ; Hoogerbrugge, Nicoline

Worldwide, gastric cancer is one of the most common forms of cancer, with a high morbidity and mortality. Several environmental factors predispose to the development of gastric cancer, such as Helicobacter pylori infection, diet and smoking. Familial clustering of gastric cancer is seen in 10% of cases, and approximately 3% of gastric cancer cases arise in the setting of hereditary diffuse gastric cancer (HDGC). In families with HDGC, gastric cancer presents at relatively young age. Germline [...]

Menée initialement sur 1 161 patients porteurs du virus de l'hépatite B et 1 353 témoins, puis validée sur 4 319 cas et 4 966 témoins, cette étude chinoise d'association sur le génome entier identifie des variants des gènes STAT4 et HLA-DQ en association avec un risque accru de carcinome hépatocellulaire

Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma

Jiang, De-Ke ; Sun, Jielin ; Cao, Guangwen ; Liu, Yao ; Lin, Dongxin ; Gao, Yu-Zhen ; Ren, Wei-Hua ; Long, Xi-Dai ; Zhang, Hongxing ; Ma, Xiao-Pin ; Wang, Zhong ; Jiang, Wei ; Chen, Tao-Yang ; Gao, Yong ; Sun, Liang-Dan ; Long, Ji-Rong ; Huang, Hui-Xing ; Wang, Dan ; Yu, Hongjie ; Zhang, Pengyin ; Tang, Li-Sha ; Peng, Bo ; Cai, Hao ; Liu, Ting-Ting ; Zhou, Ping ; Liu, Fang ; Lin, Xiaoling ; Tao, Sha ; Wan, Bo ; Sai-Yin, He-Xi Ge ; Qin, Lun-Xiu ; Yin, Jianhua ; Liu, Li ; Wu, Chen ; Pei, Yan ; Zhou, Yuan-Feng ; Zhai, Yun ; Lu, Pei-Xin ; Tan, Aihua ; Zuo, Xian-Bo ; Fan, Jia ; Chang, Jiang ; Gu, Xiaoli ; Wang, Neng-Jin ; Li, Yang ; Liu, Yin-Kun ; Zhai, Kan ; Zhang, Hongwei ; Hu, Zhibin ; Liu, Jun ; Yi, Qing ; Xiang, Yongbing ; Shi, Rong ; Ding, Qiang ; Zheng, Wei ; Shu, Xiao-Ou ; Mo, Zengnan ; Shugart, Yin Yao ; Zhang, Xue-Jun ; Zhou, Gangqiao ; Shen, Hongbing ; Zheng, S. Lilly ; Xu, Jianfeng ; Yu, Long

To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, we carried out a genome-wide association study (GWAS) in 2,514 chronic HBV carriers (1,161 HCC cases and 1,353 controls) followed by a 2-stage validation among 6 independent populations of chronic HBV carriers (4,319 cases and 4,966 controls). The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, Pmeta [...]

A partir d'échantillons tumoraux d'individus vivant en Iran et dans le nord de l'Inde, cette étude évalue l'association entre des mutations du récepteur du facteur de croissance épidermique et le risque de carcinome épidermoïde de l'œsophage

Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia

Abedi-Ardekani, Behnoush ; Dar, Nazir ; Mir, Mohammad ; Zargar, Showkat ; Lone, M ; Martel-Planche, Ghyslaine ; Villar, Stephanie ; Mounawar, Mounia ; Saidi, Farrokh ; Malekzadeh, Reza ; Hainaut, Pierre

BACKGROUND:Esophageal squamous cell carcinoma (ESCC) shows geographic variations in incidence, with high incidences (>50/105 person-years) in central Asia, including North Eastern Iran (Golestan) and Northern India (Kashmir). In contrast to Western countries, smoking does not appear to be a significant risk factor for ESCC in central Asia. In lung adenocarcinoma, activating mutations in the gene encoding epidermal growth factor receptor (EGFR) are frequent in tumors of never smokers of Asian [...]

A partir d'une revue de la littérature (22 études), cette méta-analyse évalue l'association entre l'âge à la première menstruation et le risque de cancer de l'ovaire

Age at menarche and risk of ovarian cancer: A meta-analysis of epidemiological studies

Gong, Ting-Ting ; Wu, Qi-Jun ; Vogtmann, Emily ; Lin, Bei ; Wang, Yong-Lai

Epidemiological studies have reported inconsistent associations between menarcheal age and ovarian cancer risk. To our knowledge, a meta-analysis for the association between menarcheal age and ovarian cancer has not been reported. Relevant published studies of menarcheal age and ovarian cancer were identified using MEDLINE, EMBASE and Web of Science through the end of April 2012. Two authors (T-T.G. and Q-J.W.) independently assessed eligibility and extracted data. We pooled the relative risks [...]

Menée auprès d'une population d'origine hispanique (2 111 cas et 2 597 témoins) et d'une population blanche (1 481 cas et 1 586 témoins), cette étude américaine évalue l'association entre des variants des gènes codant pour des protéines de la morphogenèse osseuse et le risque de cancer du sein

Genetic variation in bone morphogenetic proteins and breast cancer risk in hispanic and non-hispanic white women: The breast cancer health disparities study

Slattery, Martha L. ; John, Esther M. ; Torres-Mejía, Gabriela ; Herrick, Jennifer S. ; Giuliano, Anna R. ; Baumgartner, Kathy B. ; Hines, Lisa M. ; Wolff, Roger K.

Bone morphogenetic proteins (BMP) are thought to be important in breast cancer promotion and progression. We evaluated genetic variation in BMP-related genes and breast cancer risk among Hispanic (2,111 cases, 2,597 controls) and non-Hispanic White (NHW) (1,481 cases, 1,586 controls) women who participated in the 4-Corner's Breast Cancer Study, the Mexico Breast Cancer Study and the San Francisco Bay Area Breast Cancer Study. BMP genes and their receptors evaluated include ACVR1, AVCR2A, [...]

Menée sur plusieurs cohortes de patientes et témoins, cette étude identifie des mutations en mosaïque du gène PPM1D en association avec un risque accru de cancer du sein ou de l'ovaire

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

Ruark, Elise ; Snape, Katie ; Humburg, Peter ; Loveday, Chey ; Bajrami, Ilirjana ; Brough, Rachel ; Rodrigues, Daniel Nava ; Renwick, Anthony ; Seal, Sheila ; Ramsay, Emma ; Duarte, Silvana Del Vecchio ; Rivas, Manuel A. ; Warren-Perry, Margaret ; Zachariou, Anna ; Campion-Flora, Adriana ; Hanks, Sandra ; Murray, Anne ; Pour, Naser Ansari ; Douglas, Jenny ; Gregory, Lorna ; Rimmer, Andrew ; Walker, Neil M. ; Yang, Tsun-Po ; Adlard, Julian W. ; Barwell, Julian ; Berg, Jonathan ; Brady, Angela F. ; Brewer, Carole ; Brice, Glen ; Chapman, Cyril ; Cook, Jackie ; Davidson, Rosemarie ; Donaldson, Alan ; Douglas, Fiona ; Eccles, Diana ; Evans, D. Gareth ; Greenhalgh, Lynn ; Henderson, Alex ; Izatt, Louise ; Kumar, Ajith ; Lalloo, Fiona ; Miedzybrodzka, Zosia ; Morrison, Patrick J. ; Paterson, Joan ; Porteous, Mary ; Rogers, Mark T. ; Shanley, Susan ; Walker, Lisa ; Gore, Martin ; Houlston, Richard ; Brown, Matthew A. ; Caufield, Mark J. ; Deloukas, Panagiotis ; McCarthy, Mark I. ; Todd, John A. ; Turnbull, Clare ; Reis-Filho, Jorge S. ; Ashworth, Alan ; Antoniou, Antonis C. ; Lord, Christopher J. ; Donnelly, Peter ; Rahman, Nazneen

Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease. However, there are considerable challenges with respect to study design, data analysis and replication. Using pooled next-generation sequencing of 507 genes implicated in the repair of DNA in 1,150 samples, an analytical strategy focused on protein-truncating variants (PTVs) and a large-scale sequencing case–control replication experiment in 13,642 [...]

A partir d'échantillons sanguins prélevés sur 393 patientes chinoises et 434 témoins, cette étude évalue l'association entre des polymorphismes à simple nucléotide du gène p21 et le risque de cancer du col de l'utérus

Association of p21 SNPs and risk of cervical cancer among Chinese women

Wang, Ning ; Wang, Shizhuo ; Zhang, Qiao ; Lu, Yanming ; Wei, Heng ; Li, Wei ; Zhang, Shulan ; Yin, Duo ; Ou, Yangling

BACKGROUND:The p21 codon 31 single nucleotide polymorphism (SNP), rs1801270, has been linked to cervical cancer but with controversial results. The aims of this study were to investigate the role of p21 SNP-rs1801270 and other untested p21 SNPs in the risk of cervical cancer in a Chinese population.METHODS:We genotyped five p21 SNPs (rs762623, rs2395655, rs1801270, rs3176352, and rs1059234) using peripheral blood DNA from 393 cervical cancer patients and 434 controls.RESULTS:The frequency of [...]