A partir des données de la cohorte "NIH-AARP Diet and Health Study" incluant 491 841 participants, cette étude analyse l'association entre une consommation alimentaire de nitrates et de nitrites et le risque de carcinome à cellules rénales

Dietary intake of nitrate and nitrite and risk of renal cell carcinoma in the NIH-AARP Diet and Health Study

DellaValle, C. T. ; Daniel, C. R. ; Aschebrook-Kilfoy, B. ; Hollenbeck, A. R. ; Cross, A. J. ; Sinha, R. ; Ward, M. H.

Background: Nitrate and nitrite are present in many foods and are precursors of N-nitroso compounds, known animal carcinogens and potential human carcinogens. We prospectively investigated the association between nitrate and nitrite intake from dietary sources and risk of renal cell carcinoma (RCC) overall and clear cell and papillary histological subtypes in the NIH-AARP Diet and Health Study. Methods: Nitrate and nitrite intakes were estimated from a 124-item food frequency questionnaire. [...]

A partir des données de la cohorte "Agricultural Health Study" suivie de 1993 à 2007 et incluant 54 412 participants, cette étude évalue l'association entre une exposition à des pesticides agricoles et le risque d'un cancer de la prostate, en particulier de forme agressive

Risk of Total and Aggressive Prostate Cancer and Pesticide Use in the Agricultural Health Study

Koutros, Stella ; Beane Freeman, Laura E. ; Lubin, Jay H. ; Heltshe, Sonya L. ; Andreotti, Gabriella ; Barry, Kathryn Hughes ; DellaValle, Curt T. ; Hoppin, Jane A. ; Sandler, Dale P. ; Lynch, Charles F. ; Blair, Aaron ; Alavanja, Michael C. R.

Because pesticides may operate through different mechanisms, the authors studied the risk of prostate cancer associated with specific pesticides in the Agricultural Health Study (1993–2007). With 1,962 incident cases, including 919 aggressive prostate cancers among 54,412 applicators, this is the largest study to date. Rate ratios and 95% confidence intervals were calculated by using Poisson regression to evaluate lifetime use of 48 pesticides and prostate cancer incidence. Three [...]

A partir des données de la cohorte "Nurses’ Health Study II" incluant 81 807 participantes suivies de 1989 à 2007, cette étude prospective évalue l'association entre une mononucléose infectieuse et le risque de cancer du sein

Infectious mononucleosis and risk of breast cancer in a prospective study of women

Massa, J. ; Hamdan, A. ; Simon, K. C. ; Bertrand, K. ; Wulf, G. ; Tamimi, R. M. ; Ascherio, A.

Purpose The association between infectious mononucleosis (IM) and risk of breast cancer is unclear; no prospective studies have examined this relationship. We examined self-reported history and age at IM in relation to risk of invasive breast cancer. Methods Self-reported history and age at IM were examined in relation to risk of invasive breast cancer in a large cohort of women, the Nurses’ Health Study II (81,807 women followed from 1989 to 2007). Through questionnaires, women were asked [...]

Cette étude multicentrique (1 121 cas et 400 témoins) évalue l'association entre une infection par des variants génétiques du papillomavirus humain de type 16 et le risque de cancer du col de l'utérus, en Europe, en Asie et en Amérique

HPV16 genetic variation and the development of cervical cancer worldwide

Cornet, I. ; Gheit, T. ; Iannacone, M. R. ; Vignat, J. ; Sylla, B. S. ; Del Mistro, A. ; Franceschi, S. ; Tommasino, M. ; Clifford, G. M.

Background: Factors that favour a small proportion of HPV16 infections to progress to cancer are still poorly understood, but several studies have implicated a role of HPV16 genetic variation. Methods: To evaluate the association between HPV16 genetic variants and cervical cancer risk, we designed a multicentre case–control study based on HPV16-positive cervical samples (1121 cervical cancer cases and 400 controls) from the International Agency for Research on Cancer biobank. By sequencing the [...]

Menée en Suède, cette étude (1 526 cas et 15 260 témoins) évalue l'association entre des caractéristiques de l'histoire reproductive des femmes et le risque de cancer de l'intestin grêle, par sous-type histologique

Reproductive history and risk of small bowel cancer by histologic type: a population-based study

Lu, Yunxia ; Lambe, Mats ; Martling, Anna ; Lagergren, Jesper

Purpose The male predominance of the two main histologic malignancies of the small bowel cancer may reflect a role of sex hormones which will be examined in this study. Methods This was a nationwide population-based nested case–control study, based on a cohort of subjects born between 1932 and 2008, as identified in the Swedish Multi-Generation Register. For each case of small bowel cancer, 10 age- and sex-matched controls were randomly selected. Number of children and age at having the first [...]

Menée en Italie, cette étude (185 cas et 404 témoins) évalue l'association entre un syndrome métabolique et le risque de carcinome hépatocellulaire

Metabolic syndrome and hepatocellular carcinoma risk

Turati, F. ; Talamini, R. ; Pelucchi, C. ; Polesel, J. ; Franceschi, S. ; Crispo, A. ; Izzo, F. ; La Vecchia, C. ; Boffetta, P. ; Montella, M.

Background: Hepatocellular carcinoma (HCC) has been associated to diabetes and obesity, but a possible association with the metabolic syndrome (MetS) and its potential interaction with hepatitis is open to discussion. Methods: We analysed data from an Italian case–control study, including 185 HCC cases and 404 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed from unconditional logistic regression models. Results: Among the MetS components, diabetes and obesity (i.e, [...]

Menée aux Etats-Unis auprès de 41 188 patients suivis de 1990 à 2009, cette étude analyse l'association entre une mucoviscidose et le risque de divers types de cancer

Cancer Risk in Cystic Fibrosis: A 20-Year Nationwide Study From the United States

Maisonneuve, Patrick ; Marshall, Bruce C. ; Knapp, Emily A. ; Lowenfels, Albert B.

Background Many patients with cystic fibrosis (CF) now reach adulthood, at which time the risk of cancer is increased. The aim of this study was to determine cancer risks in nontransplanted and transplanted CF patients.Methods From 1990 to 2009, we followed 41,188 patients who received care at one of the 250 CF care center programs in the United States and compared the observed number of cancers in nontransplanted and transplanted patients with that expected in the general US population.Results [...]

Menée en Grèce, cette étude (292 cas et 294 témoins) évalue l'association entre des allergies et le risque de leucémie lymphoblastique aiguë chez les enfants âgés de 0 à 14 ans

Allergy and risk of acute lymphoblastic leukemia among children: A nationwide case control study in Greece

Lariou, Maria-Stella ; Dikalioti, Stavroula K. ; Dessypris, Nick ; Baka, Margarita ; Polychronopoulou, Sophia ; Athanasiadou-Piperopoulou, Fani ; Kalmanti, Maria ; Fragandrea, Ioanna ; Moschovi, Maria ; Germenis, Anastasios E. ; Petridou, Eleni T.

Background: Several reports point to inverse associations between allergies and ALL; yet, no study has explored this link using both self-reported-data on allergic history and biomarkers of atopic sensitization. Methods: Clinical information for the variables of interest was available for 252 out of 292 cases of childhood (0–14 years) ALL, newly diagnosed across Greece over a 4.5 year period as well as for 294 hospital controls. Allergen-specific-IgEs, as markers of allergic predisposition, [...]

A partir des données du système d'assurance maladie de Taïwan, cette étude en population (846 cas et 3 374 témoins) évalue l'association entre des allergies et le risque de leucémie lymphoblastique aiguë chez les enfants

Allergy and Risk of Childhood Acute Lymphoblastic Leukemia: A Population-based and Record-based Study

Chang, Jeffrey S. ; Tsai, Yi-Wen ; Tsai, Chia-Rung ; Wiemels, Joseph L.

A deficit of normal immune stimulation in early childhood is a suspected risk factor for both childhood acute lymphoblastic leukemia (ALL) and allergies. The present study utilized a population-based case-control design using medical claims data from the National Health Insurance Research Database of Taiwan to evaluate the association between allergy and childhood leukemia. Eight hundred forty-six childhood ALL patients who were newly diagnosed during 2000 to 2008 and were older than 1 but less [...]

Menée en Suède, cette étude de cohorte nationale incluant 3 571 574 participants nés entre 1973 et 2008 analyse l'association entre des facteurs familiaux et périnatals et le risque de lymphome hodgkinien durant l'enfance et au début de l'âge adulte

Perinatal and Family Risk Factors for Hodgkin Lymphoma in Childhood Through Young Adulthood

Crump, Casey ; Sundquist, Kristina ; Sieh, Weiva ; Winkleby, Marilyn A. ; Sundquist, Jan

The incidence of Hodgkin lymphoma has increased among adolescents and young adults in recent decades, but the relevant risk factors in early life are still unknown. A national cohort study was conducted of 3,571,574 individuals born in Sweden in 1973–2008 and followed up for Hodgkin lymphoma incidence through 2009, to examine perinatal and family risk factors for Hodgkin lymphoma in childhood through young adulthood (ages 0–37 years). There were 943 Hodgkin lymphoma cases identified in 66.3 [...]

A partir des données des cohortes "Nurses’ Health Study" et "Health Professionals Follow-up Study", cette étude prospective évalue l'association entre une histoire familiale de cancer et le risque de cancer colorectal en fonction du niveau de méthylation de LINE-1

Prospective Study of Family History and Colorectal Cancer Risk by Tumor LINE-1 Methylation Level

Ogino, Shuji ; Nishihara, Reiko ; Lochhead, Paul ; Imamura, Yu ; Kuchiba, Aya ; Morikawa, Teppei ; Yamauchi, Mai ; Liao, Xiaoyun ; Qian, Zhi Rong ; Sun, Ruifang ; Sato, Kaori ; Kirkner, Gregory J. ; Wang, Molin ; Spiegelman, Donna ; Meyerhardt, Jeffrey A. ; Schernhammer, Eva S. ; Chan, Andrew T. ; Giovannucci, Edward ; Fuchs, Charles S.

Background Beyond known familial colorectal cancer (CRC) syndromes, the mechanisms underlying the elevated CRC risk associated with CRC family history remain largely unknown. A recent retrospective study suggests familial clustering of CRC with hypomethylation in long interspersed nucleotide element 1 (LINE-1). We tested the hypothesis that CRC family history might confer a higher risk of LINE-1 methylation-low CRC.Methods Using the Nurses’ Health Study and the Health Professionals Follow-up [...]

A partir des données de la cohorte "NIH-AARP Diet and Health Study" incluant 114 409 participantes, cette étude analyse les facteurs de risque associés aux deux principaux types histologiques du carcinome de l'endomètre

Endometrial Cancer Risk Factors by 2 Main Histologic Subtypes: The NIH-AARP Diet and Health Study

Yang, Hannah P. ; Wentzensen, Nicolas ; Trabert, Britton ; Gierach, Gretchen L. ; Felix, Ashley S. ; Gunter, Marc J. ; Hollenbeck, Albert ; Park, Yikyung ; Sherman, Mark E. ; Brinton, Louise A.

On the basis of clinical and pathologic criteria, endometrial carcinoma has been distinguished as Types I (mainly endometrioid) and II (nonendometrioid). Limited data suggest that these subtypes have different risk factor profiles. The authors prospectively evaluated risk factors for Types I (n = 1,312) and II (n = 138) incident endometrial carcinoma among 114,409 women in the National Institutes of Health (NIH)-AARP Diet and Health Study (1995–2006). For individual risk factors, relative risks [...]

Menée en population danoise auprès de 1 353 femmes infectées par le papillomavirus humain et suivies pendant environ 13 ans, cette étude de cohorte analyse l'association entre les caractéristiques de leur histoire reproductive, l'utilisation de contraceptifs oraux et le risque de néoplasies cervicales intraépithéliales de grade supérieur ou égal à 3

Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up

Jensen, K. E. ; Schmiedel, S. ; Norrild, B. ; Frederiksen, K. ; Iftner, T. ; Kjaer, S. K.

BACKGROUND: Several environmental factors have been associated with increased risks for cervical cancer. We examined whether reproductive history, contraceptive use, or sexual behaviour increase the risk for cervical intraepithelial neoplasia grade 3 or worse (CIN3+) among women with persistent human papillomavirus (HPV) infection. METHODS: A population-based cohort of women participated in a personal interview and underwent a gynaecological examination at which cervical specimens were obtained [...]