Menée en Angleterre auprès de 69 participants (24 patientes, 5 conjoints, 20 professionnels de santé), cette étude ethnographique analyse les facteurs influençant l'évaluation clinique des problèmes sexuels induits par une radiothérapie pelvienne chez les patientes atteintes de cancer

The re-construction of women’s sexual lives after pelvic radiotherapy: a critique of social constructionist and biomedical perspectives on the study of female sexuality after cancer treatment

White, I. D. ; Faithfull, S. ; Allan, H.

Pelvic radiotherapy creates physical effects and psychological responses that negatively affect the sexual health of women and couples, yet these sexual consequences are not frequently researched or clinically assessed. This focused ethnographic study explored factors that influence the clinical assessment of treatment-induced female sexual difficulties after pelvic radiotherapy within routine medical follow-up. Participant observation of follow-up clinics (n = 69) and in-depth interviews with [...]

Mené dans 23 centres d'Australie et de Nouvelle-zélande, cet essai randomisé de phase III analyse la qualité de vie de patients atteints d'un cancer localisé de la prostate de stade avancé et traités avec de la leuproréline et une radiothérapie avec ou sans acide zolédronique

Quality of life in men with locally advanced prostate cancer treated with leuprorelin and radiotherapy with or without zoledronic acid (TROG 03.04 RADAR): secondary endpoints from a randomised phase 3 factorial trial

Denham, James W. ; Wilcox, Chantelle ; Joseph, David ; Spry, Nigel A. ; Lamb, David S. ; Tai, Keen-Hun ; Matthews, John ; Atkinson, Chris ; Turner, Sandra ; Christie, David ; Gogna, Nirdosh Kumar ; Kenny, Lizbeth ; Duchesne, Gillian ; Delahunt, Brett ; McElduff, Patrick

Adjuvant androgen suppression and bisphosphonates with escalating doses of radiotherapy might improve efficacy outcomes in men with locally advanced prostate cancer. In this study, we investigated whether these treatments had a detrimental effect on patient-reported-outcome (PRO) scores. We undertook a phase 3 trial with a 2×2 factorial design in 23 centres in Australia and New Zealand in men with non-metastatic adenocarcinoma of the prostate (stage T2b?4 or T2a, Gleason score ?7, and baseline [...]

Menée en Corée auprès de 465 patients atteints d'un carcinome épidermoïde de la tête et du cou, cette étude analyse les facteurs de risque d'évènements indésirables non liés au cancer affectant la qualité de vie et la survie des patients

Risk factors for non-cancer health events in patients with head and neck squamous cell carcinoma

Ryu, C. H. ; Roh, J.-L. ; Kim, S.-B. ; Lee, S.-W. ; Choi, S.-H. ; Nam, S. Y. ; Kim, S. Y.

Background Cancer progression and non-cancer-related morbidities can affect the quality of life and survival of patients with head and neck squamous cell carcinomas (HNSCC). The aim of this study was to investigate the risk factors for the development of non-cancer health events (NCHEs) in HNSCC.Patients and methods The study involved 465 previously-untreated patients with HNSCC diagnosed between 2005 and 2009 at the Asan Medical Center. Non-cancer-associated morbidity was defined as [...]

A partir de différentes bases de données médicales du Royaume-Uni, cette étude (83 203 cas et 577 207 témoins) analyse l'incidence d'une thromboembolie veineuse chez des patients atteints de cancer

Incidence of venous thromboembolism in patients with cancer – A cohort study using linked United Kingdom databases

Walker, Alex J. ; Card, Tim R. ; West, Joe ; Crooks, Colin ; Grainge, Matthew J.

Accurate population-based data are needed on the incidence of venous thromboembolism (VTE) in patients with different cancers in order to inform guidelines on which hospitalised and ambulatory cancer patients should receive VTE prophylaxis. We conducted a cohort study using data from the Clinical Practice Research Datalink, linked to Hospital Episode Statistics, Cancer Registry data and Office for National Statistics cause of death data. We determined the incidence rates (cases per 1000 [...]

Cette étude de cohorte incluant 573 survivants néerlandais d'un cancer de l'enfance évalue l'effet de diverses modalités de radiothérapie sur leur taille à l'âge adulte

Final height in survivors of childhood cancer compared with Height Standard Deviation Scores at diagnosis

Knijnenburg, S. L. ; Raemaekers, S. ; van den Berg, H. ; van Dijk, I. W. E. M. ; Lieverst, J. A. ; van der Pal, H. J. ; Jaspers, M. W. M. ; Caron, H. N. ; Kremer, L. C. ; van Santen, H. M.

Background Our study aimed to evaluate final height in a cohort of Dutch childhood cancer survivors (CCS) and assess possible determinants of final height, including height at diagnosis.Patients and methods We calculated standard deviation scores (SDS) for height at initial cancer diagnosis and height in adulthood in a cohort of 573 CCS. Multivariable regression analyses were carried out to estimate the influence of different determinants on height SDS at follow-up.Results Overall, survivors [...]

A partir des données des registres néerlandais du cancer portant sur des patients atteints d'un cancer du colon de stade III et âgés de plus de 75 ans, cette étude en population analyse les facteurs associés à la tolérance à une chimiothérapie adjuvante

Treatment and complications in elderly stage III colon cancer patients in the Netherlands

Hoeben, K. W. J. ; van Steenbergen, L. N. ; van de Wouw, A. J. ; Rutten, H. J. ; van Spronsen, D. J. ; Janssen-Heijnen, M. L. G.

Background We evaluated which patient factors were associated with treatment tolerance and outcome in elderly colon cancer patients.Design Population-based data from five regions included in the Netherlands Cancer Registry were used. Patients with resected stage III colon cancer aged ≥75 years diagnosed in 1997–2004 who received adjuvant chemotherapy (N = 216) were included as well as a random sample (N = 341) of patients who only underwent surgery.Results The most common motives for [...]

A partir des données de 12 registres américains du cancer (environ 40 000 patients), cette étude analyse les disparités ethniques dans la survie des patients atteints d'un carcinome à cellules rénales, en fonction de critères démographiques et cliniques

Racial disparity in renal cell carcinoma patient survival according to demographic and clinical characteristics

Chow, Wong-Ho ; Shuch, Brian ; Linehan, W. Marston ; Devesa, Susan S.

BACKGROUND: Patients with renal cell carcinoma (RCC) who are black tend to have poorer prognosis than similar patients who are white. This study examined whether the racial disparity in RCC patient survival varies by demographic and clinical characteristics. METHODS: Nearly 40,000 patients (4359 black and 34,991 white) diagnosed with invasive RCC from 1992 to 2007 were identified from 12 registries in the National Cancer Institute Surveillance, Epidemiology, and End Results program, covering [...]

A partir de données de registres du cancer de 14 pays européens portant sur 114 312 femmes atteintes d'un cancer primitif du sein diagnostiqué entre 2000 et 2002 (âge : 15 à 99 ans), cette étude évalue, en fonction de la catégorie d'âge et de la zone géographique, la survie relative à 1, 5 et 10 ans des patientes

Predictions of survival up to 10 years after diagnosis for European women with breast cancer in 2000–2002

Allemani, Claudia ; Minicozzi, Pamela ; Berrino, Franco ; Bastiaannet, Esther ; Gavin, Anna ; Galceran, Jaume ; Ameijide, Alberto ; Siesling, Sabine ; Mangone, Lucia ; Ardanaz, Eva ; Hédelin, Guy ; Mateos, Antonio ; Micheli, Andrea ; Sant, Milena ; the, Eurocare Working Group

Few studies have addressed longer-term survival for breast cancer in European women. We have made predictions of 10-year survival for European women diagnosed with breast cancer in 2000–2002. Data for 114,312 adult women (15–99 years) diagnosed with a first primary malignant cancer of the breast during 2000–2002 were collected in the EUROCARE-4 study from 24 population-based cancer registries in 14 European countries. We estimated relative survival at 1, 5, and 10 years after diagnosis for [...]

Menée auprès de 107 patients ayant reçu une greffe de cellules souches hématopoïétiques, cette étude prospective longitudinale analyse leurs symptômes d'anxiété et de dépression pendant la période d'isolement en chambre stérile

Predictors of anxiety and depression in hematopoietic stem cell transplant patients during protective isolation

Tecchio, Cristina ; Bonetto, Chiara ; Bertani, Mariaelena ; Cristofalo, Doriana ; Lasalvia, Antonio ; Nichele, Ilaria ; Bonani, Anna ; Andreini, Angelo ; Benedetti, Fabio ; Ruggeri, Mirella ; Pizzolo, Giovanni

Objective To examine in a sample of hematopoietic stem cell transplant patients assessed throughout protective isolation (i) levels of anxiety and depression and (ii) pre-isolation factors (socio-demographics, biomedical variables and personality traits), which might predict higher levels of anxiety and depression during isolation. Methods The study used a longitudinal prospective design. Anxiety and depression were assessed in 107 participants by the State-Trait Anxiety Inventory and [...]

Menée auprès de 151 patients atteints de cancer et âgés de 15 à 39 ans, cette étude longitudinale analyse les facteurs associés à un stress post-traumatique 6 à 12 mois après un diagnostic de cancer

Prevalence and predictors of post-traumatic stress symptoms in adolescent and young adult cancer survivors: a 1-year follow-up study

Kwak, Minyoung ; Zebrack, Brad J. ; Meeske, Kathleen A. ; Embry, Leanne ; Aguilar, Christine ; Block, Rebecca ; Hayes-Lattin, Brandon ; Li, Yun ; Butler, Melissa ; Cole, Steven

Objectives Post-traumatic stress symptoms (PTSS) have been identified as a meaningful indicator of distress in cancer survivors. Distinct from young adult survivors of childhood cancer, young people diagnosed with cancer as adolescents and young adults (AYAs) face unique psychosocial issues; however, there is little published research of PTSS in the AYA population. This study examines prevalence and predictors of PTSS among AYAs with cancer. Methods As part of a longitudinal study of AYAs with [...]

Menée aux Etats-Unis auprès de 419 participantes âgées de moins de 40 ans, cette étude de cohorte prospective analyse les préoccupations relatives à leur image corporelle chez les femmes atteintes d'un cancer du sein de stade précoce récemment diagnostiqué

Body image in recently diagnosed young women with early breast cancer

Rosenberg, Shoshana M. ; Tamimi, Rulla M. ; Gelber, Shari ; Ruddy, Kathryn J. ; Kereakoglow, Sandra ; Borges, Virginia F. ; Come, Steven E. ; Schapira, Lidia ; Winer, Eric P. ; Partridge, Ann H.

Objective To assess body image concerns among young women following a breast cancer diagnosis. Methods A total of 419 women with recently diagnosed stage 0–III breast cancer were surveyed following enrollment as part of a prospective cohort study of women age 40 or younger at diagnosis. Body image was assessed using three items from the psycho-social scale of the Cancer Rehabilitation Evaluation System (CARES). CARES scores range from 0 to 4, with higher scores indicative of greater image [...]

Menée par questionnaire auprès de 59 membres d'équipes pluridisciplinaires en soins palliatifs et soins respiratoires, cette étude analyse leurs perceptions sur l'intérêt des soins de réadaptation pour les patients atteints d'un cancer du poumon

Lung cancer and rehabilitation—what are the barriers? Results of a questionnaire survey and the development of regional lung cancer rehabilitation standards and guidelines

Nwosu, AmaraCallistus ; Bayly, JoanneL ; Gaunt, KathrynE ; Mayland, CatrionaR

Background Evidence supports the role of rehabilitation in the management of lung cancer symptoms. Previous research reports that rehabilitation needs are inadequately recognised and managed, which may adversely affect patients’ quality-of-life and create burden for caregivers. Aims This study aims to explore the perceptions of palliative care and respiratory multidisciplinary team (MDT) members about the role of rehabilitation for lung cancer patients, examine patterns of referral for lung [...]

Cette étude américaine analyse l'impact de la publicité sur les prescriptions appropriées ou non de thérapies médicamenteuses en oncologie

Impact of oncology-related direct-to-consumer advertising

Abel, Gregory A. ; Chen, Kun ; Taback, Nathan ; Hassett, Michael J. ; Schrag, Deborah ; Weeks, Jane C.

BACKGROUND: Little is known about the impact of direct-to-consumer advertising (DTCA) on appropriate versus inappropriate prescribing. Aromatase inhibitor (AI) therapy for breast cancer provides an ideal paradigm for studying this issue, because AIs have been the focus of substantial DTCA, and because they should only be used in postmenopausal women, age can serve as a simple surrogate marker of appropriateness. METHODS: Data regarding national DTCA spending for the AIs were obtained from TNS [...]

Menée auprès de 126 patients recevant des soins palliatifs, cette étude norvégienne analyse la prévalence des morbidités buccales chez des patients atteints d'un cancer autre qu'un cancer de la tête et du cou

Oral health is an important issue in end-of-life cancer care

Wilberg, Petter ; Hjermstad, MarianneJ ; Ottesen, Stig ; Herlofson, BenteB

Purpose This study aims to assess the prevalence of oral morbidity in patients receiving palliative care for cancers outside the head and neck region and to investigate if information concerning oral problems was given. Methods Patients were recruited from two Norwegian palliative care inpatient units. All patients went through a face-to-face interview, completed the Edmonton Symptom Assessment System (ESAS) covering 10 frequent cancer-related symptoms, and went through an oral examination [...]

A partir d'une revue des essais cliniques prospectifs dédiés aux soins de support et soins palliatifs en oncologie, cette étude américaine analyse le taux d'abandon dans ce type d'essais et les facteurs associés

Attrition rates, reasons, and predictive factors in supportive care and palliative oncology clinical trials

Hui, David ; Glitza, Isabella ; Chisholm, Gary ; Yennu, Sriram ; Bruera, Eduardo

BACKGROUND: Attrition is common among supportive care/palliative oncology clinical trials. However, to the authors' knowledge, few studies to date have documented the reasons and predictors for dropout. In the current study, the authors' objective was to determine the rate, reasons, and factors associated with attrition both before reaching the primary endpoint and at the end of the study. METHODS: A review of all prospective interventional supportive care/palliative oncology trials conducted [...]