Menée aux Etats-Unis, cette étude (950 cas et 1 146 témoins) évalue l'association entre l'indice de masse corporelle à l'âge de 18 ans, une activité physique au début de l'âge adulte et le risque de lymphome non hodgkinien, en fonction du sexe

The association between early life and adult body mass index and physical activity with risk of non-Hodgkin lymphoma: impact of gender

Kelly, Jennifer L. ; Fredericksen, Zachary S. ; Liebow, Mark ; Shanafelt, Tait D. ; Thompson, Carrie A. ; Call, Timothy G. ; Habermann, Thomas M. ; Macon, William R. ; Wang, Alice H. ; Slager, Susan L. ; Cerhan, James R.

To evaluate the association of body mass index (BMI) and physical activity (PA) during adulthood and at the age of 18 years with risk of non-Hodgkin lymphoma (NHL). We enrolled 950 newly diagnosed NHL patients and 1146 frequency-matched clinic-based controls. Height, weight, and PA (recent adult and at the age of 18 years) were self-reported. Odds ratios (ORs), 95% confidence intervals, and tests for trend were estimated using unconditional logistic regression adjusted for age, gender, and [...]

A partir des données de 100 participants italiens et britannniques, cette étude analyse l'association entre une infection par le papillomavirus humain et le risque de cancer du poumon

Testing of human papillomavirus in lung cancer and non-tumor lung tissue

Galvan, Antonella ; Noci, Sara ; Taverna, Francesca ; Lombardo, Claudia ; Franceschi, Silvia ; Pastorino, Ugo ; Dragani, Tommaso

BACKGROUND:Risk factors for lung cancer, such as cigarette smoking, environmental pollution, asbestos, and genetic determinants, are well-known, whereas involvement of the human papillomavirus (HPV) is still unclear.METHODS:We examined a series of 100 lung cancer patients from Italy and the UK for the presence of HPV DNA in both lung tumor specimens and adjacent non-tumoral specimens from the same patients. Thirty-five of the most clinically relevant HPV types were assayed using PCR [...]

Cette étude de cohorte canadienne incluant 89 835 participantes évalue l'association entre le rapport taille/poids et le risque de cancer pour 19 localisations différentes

Scaling of Weight for Height in Relation to Risk of Cancer at Different Sites in a Cohort of Canadian Women

Kabat, Geoffrey C. ; Heo, Moonseong ; Miller, Anthony B. ; Rohan, Thomas E.

Many studies have examined the associations of body mass index (weight (kg)/height (m)2) with risk of various cancers. However, optimal scaling of weight for height may depend on the population studied. The authors used data from a large cohort study of women (Canadian National Breast Cancer Screening Study, 1980–2000; n = 89,835) to examine how the scaling of weight for height (W/Hx) influenced the association with risk of 19 different cancers. Cox proportional hazards models were used to [...]

Cette étude de cohorte irlandaise incluant 447 663 enfants nés entre 1971 et 1986 évalue l'association entre diverses caractéristiques natales et périnatales (âge gestationnel, poids de naissance, âge des parents) et le risque de mélanome malin

Do perinatal and early life exposures influence the risk of malignant melanoma? A Northern Ireland birth cohort analysis

O’Rorke, M. A. ; Black, C. ; Murray, L. J. ; Cardwell, C. R. ; Gavin, A. T. ; Cantwell, M. M.

Intrauterine, early life and maternal exposures may have important consequences for cancer development in later life. The aim of this study was to examine perinatal and birth characteristics with respect to Cutaneous malignant melanoma (CMM) risk. The Northern Ireland Child Health System database was used to examine gestational age adjusted birth weight, infant feeding practices, parental age and socioeconomic factors at birth in relation to CMM risk amongst 447,663 infants delivered between [...]

A partir de données issues de 14 études chinoises incluant 5 510 patientes non fumeuses atteintes d'un cancer du poumon et 4 544 témoins, cette étude identifie trois loci de susceptibilité à la maladie, indépendamment du statut tabagique, chez les femmes chinoises

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

Lan, Qing ; Hsiung, Chao A. ; Matsuo, Keitaro ; Hong, Yun-Chul ; Seow, Adeline ; Wang, Zhaoming ; Hosgood, H. Dean ; Chen, Kexin ; Wang, Jiu-Cun ; Chatterjee, Nilanjan ; Hu, Wei ; Wong, Maria Pik ; Zheng, Wei ; Caporaso, Neil ; Park, Jae Yong ; Chen, Chien-Jen ; Kim, Yeul Hong ; Kim, Young Tae ; Landi, Maria Teresa ; Shen, Hongbing ; Lawrence, Charles ; Burdett, Laurie ; Yeager, Meredith ; Yuenger, Jeffrey ; Jacobs, Kevin B. ; Chang, I. Shou ; Mitsudomi, Tetsuya ; Kim, Hee Nam ; Chang, Gee-Chen ; Bassig, Bryan A. ; Tucker, Margaret ; Wei, Fusheng ; Yin, Zhihua ; Wu, Chen ; An, She-Juan ; Qian, Biyun ; Lee, Victor Ho Fun ; Lu, Daru ; Liu, Jianjun ; Jeon, Hyo-Sung ; Hsiao, Chin-Fu ; Sung, Jae Sook ; Kim, Jin Hee ; Gao, Yu-Tang ; Tsai, Ying-Huang ; Jung, Yoo Jin ; Guo, Huan ; Hu, Zhibin ; Hutchinson, Amy ; Wang, Wen-Chang ; Klein, Robert ; Chung, Charles C. ; Oh, In-Jae ; Chen, Kuan-Yu ; Berndt, Sonja I. ; He, Xingzhou ; Wu, Wei ; Chang, Jiang ; Zhang, Xu-Chao ; Huang, Ming-Shyan ; Zheng, Hong ; Wang, Junwen ; Zhao, Xueying ; Li, Yuqing ; Choi, Jin Eun ; Su, Wu-Chou ; Park, Kyong Hwa ; Sung, Sook Whan ; Shu, Xiao-Ou ; Chen, Yuh-Min ; Liu, Li ; Kang, Chang Hyun ; Hu, Lingmin ; Chen, Chung-Hsing ; Pao, William ; Kim, Young-Chul ; Yang, Tsung-Ying ; Xu, Jun ; Guan, Peng ; Tan, Wen ; Su, Jian ; Wang, Chih-Liang ; Li, Haixin ; Sihoe, Alan Dart Loon ; Zhao, Zhenhong ; Chen, Ying ; Choi, Yi Young ; Hung, Jen-Yu ; Kim, Jun Suk ; Yoon, Ho-Il ; Cai, Qiuyin ; Lin, Chien-Chung ; Park, In Kyu ; Xu, Ping ; Dong, Jing ; Kim, Christopher ; He, Qincheng ; Perng, Reury-Perng ; Kohno, Takashi ; Kweon, Sun-Seog ; Chen, Chih-Yi ; Vermeulen, Roel ; Wu, Junjie ; Lim, Wei-Yen ; Chen, Kun-Chieh ; Chow, Wong-Ho ; Ji, Bu-Tian ; Chan, John K. C. ; Chu, Minjie ; Li, Yao-Jen ; Yokota, Jun ; Li, Jihua ; Chen, Hongyan ; Xiang, Yong-Bing ; Yu, Chong-Jen ; Kunitoh, Hideo ; Wu, Guoping ; Jin, Li ; Lo, Yen-Li ; Shiraishi, Kouya ; Chen, Ying-Hsiang ; Lin, Hsien-Chih ; Wu, Tangchun ; Wu, Yi-Long ; Yang, Pan-Chyr ; Zhou, Baosen ; Shin, Min-Ho ; Fraumeni, Joseph F. ; Lin, Dongxin ; Chanock, Stephen J. ; Rothman, Nathaniel

To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10−6) in an additional 1,099 cases and 2,913 controls. We identified three [...]

A partir d'échantillons tumoraux de 92 patients atteints d'un cancer colorectal, cette étude analyse l'association entre des polymorphismes des gènes VEGFR2, PDGFRalpha et PDGFRbeta et le risque de cancer colorectal ainsi que la survie

PDGFRalpha/beta and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome

Estevez-Garcia, Purificacion ; Castano, Angel ; Martin, Ana ; López-Ríos, Fernando ; Iglesias, Joaquin ; Munoz-Galvan, Sandra ; Lopez-Calderero, Iker ; Molina-Pinelo, Sonia ; Pastor, Maria ; Carnero, Amancio ; Paz-Ares, Luis ; Garcia-Carbonero, Rocio

BACKGROUND:Angiogenesis plays an essential role in tumor growth and metastasis, and is a major target in cancer therapy. VEGFR and PDGFR are key players involved in this process. The purpose of this study was to assess the incidence of genetic variants in these receptors and its potential clinical implications in colorectal cancer (CRC).METHODS:VEGFR2, PDGFRalpha and PDGFRbeta mutations were evaluated by sequencing their tyrosine kinase domains in 8 CRC cell lines and in 92 samples of patients [...]

Cette étude australienne passe en revue les travaux récents sur l'association entre le niveau sanguin d'estrogènes et le risque, pour les femmes, de cancer du côlon associé à l'obésité en fonction de l'âge

Estrogen in obesity-associated colon cancer: friend or foe? Protecting postmenopausal women but promoting late-stage colon cancer

Chen, Jiezhong ; Iverson, Don

Obesity is associated with the increased incidence of colon cancer. Many cancer risk factors have been identified including increased blood levels of insulin, leptin, interleukin-6, interleukin-17, tumor necrosis factor-alpha, and decreased blood levels of adiponectin. However, the role of blood levels of estrogen in obesity-associated colon cancer is controversial. Evidence showed that obesity affected men more strongly than women in the carcinogenesis of colon cancer, indicating protective [...]

Couplée à la cohorte "Black Women's Health Study", cette étude (1 199 cas et 1 948 témoins) analyse l'association entre des polymorphismes à simple nucléotide de 21 loci et le risque de cancer du sein par sous-type, dans une population afro-américaine

Genetic susceptibility loci for subtypes of breast cancer in an African American population

Palmer, Julie R. ; Ruiz-Narvaez, Edward A ; Rotimi, Charles N. ; Cupples, L. Adrienne ; Cozier, Yvette C ; Adams-Campbell, Lucile L. ; Rosenberg, Lynn

Background:Most genome-wide association scans (GWAS) have been carried out in European ancestry populations; no risk variants for breast cancer have been identified solely from African ancestry GWAS data. Few GWAS hits have replicated in African ancestry populations. Methods:In a nested case-control study of breast cancer in the Black Women's Health Study (1,199 cases/1,948 controls), we evaluated index SNPs in 21 loci from GWAS of European or Asian ancestry populations, overall, in subtypes [...]

Menée en Thaïlande, cette étude (681 cas et 1 078 témoins) évalue l'association entre des variants des gènes CHRNA3 et TERT, le statut tabagique et le risque de carcinome du rhinopharynx

Tobacco consumption and genetic susceptibility to nasopharyngeal carcinoma (NPC) in Thailand

Fachiroh, Jajah ; Sangrajrang, Suleeporn ; Johansson, Mattias ; Renard, Hélène ; Gaborieau, Valérie ; Chabrier, Amélie ; Chindavijak, Somjin ; Brennan, Paul ; McKay, JamesD

Background The incidence of nasopharyngeal carcinoma (NPC) varies substantially worldwide, with an endemic pocket in Southeast Asia. Method We assessed lifestyle and genetic factors in relation to NPC risk among 681 NPC cases and 1,078 controls from Thailand. Evaluated lifestyle factors included traditionally preserved foods, tobacco smoking, betel quid chewing, and alcohol consumption. Genetic factors included six variants implicated in a previous a genome-wide association study (GWAS) of NPC [...]

Cet article passe en revue les promesses et les limites des études d'association sur le génome entier

The promise and limitations of genome-wide association studies

Klein C, Lohmann K. Ziegler A.

As of May 30, 2012, the catalog of published genome-wide association studies (GWAS) lists an impressive 1269 GWAS, covering a broad spectrum of conditions including Alzheimer disease, breast cancer, and human immunodeficiency virus susceptibility. The catalog also contains studies on common traits such as height and freckles, as well as responses to drugs for various medical conditions. It is difficult to discuss GWAS without sounding megalomaniacal. Considerably more than 1000 published GWAS, [...]