Menée auprès de 74 patients atteints de cancer de stade avancé et inclus dans un centre pratiquant des essais cliniques de phase I d'évaluation de thérapies ciblées, cette étude prospective française analyse leur qualité de vie, leur sexualité et leur dépression

Evaluation of sexuality, health-related quality-of-life and depression in advanced cancer patients: A prospective study in a Phase I clinical trial unit of predominantly targeted anticancer drugs

Rouanne, Mathieu ; Massard, Christophe ; Hollebecque, Antoine ; Rousseau, Vanessa ; Varga, Andrea ; Gazzah, Anas ; Neuzillet, Yann ; Lebret, Thierry ; Soria, Jean-Charles

The advent of molecular targeted agents (MTA) has opened a new era of therapy in oncology. However, some of the toxicities and side-effects of these new drugs are not explored as is the case with the potential impact of MTA on sexuality. This study aimed to prospectively evaluate health-related quality of life (HRQoL), depression and sexual function in advanced cancer patients treated in a Phase I drug unit evaluating MTA. In total, 63 of 74 eligible patients agreed to participate in the study. [...]

Mené auprès de 185 participants, cet essai randomisé évalue l'efficacité et la toxicité de la kétamine, un anesthésiant, pour traiter la douleur liée au cancer

Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Toxicity of Subcutaneous Ketamine in the Management of Cancer Pain

Hardy, Janet ; Quinn, Stephen ; Fazekas, Belinda ; Plummer, John ; Eckermann, Simon ; Agar, Meera ; Spruyt, Odette ; Rowett, Debra ; Currow, David C.

Purpose The anesthetic ketamine is widely used for pain related to cancer, but the evidence to support its use in this setting is weak. This study aimed to determine whether ketamine is more effective than placebo when used in conjunction with opioids and standard adjuvant therapy in the management of chronic uncontrolled cancer pain. Ketamine would be considered of net benefit if it provided clinically relevant improvement in pain with limited breakthrough analgesia and acceptable [...]

Menée à 6 mois (547 participants), 12 mois (519 participants) et 24 mois (443 participants) après un diagnostic de cancer, cette étude longitudinale analyse l'évolution des besoins en soins de support de soignants de survivants d'un cancer

Some things change, some things stay the same: a longitudinal analysis of cancer caregivers' unmet supportive care needs

Girgis, Afaf ; Lambert, Sylvie D. ; McElduff, Patrick ; Bonevski, Billie ; Lecathelinais, Christophe ; Boyes, Allison ; Stacey, Fiona

Objective The objective of this study was to identify caregivers' unmet needs and the psychosocial variables associated with unmet need count within the first 24 months post-survivor diagnosis. Methods Caregivers completed a comprehensive survey measuring the primary outcome, psychosocial variables, and demographics of interest at 6 (n=547), 12 (n=519), and 24 (n=443) months post-survivor diagnosis. Results Although prevalence of unmet needs significantly decreased over time, almost a third of [...]

Menée par entretiens auprès de 12 soignants de patients atteints de cancer, cette étude qualitative américaine analyse leurs perceptions relatives à une intervention axée sur la nutrition et l'activité physique ciblant à la fois le patient et le soignant

Cancer caregivers’ perceptions of an exercise and nutrition program

Anton, Philip ; Partridge, Julie ; Morrissy, Margaret

Purpose Little research has addressed exercise and nutrition-based interventions for cancer caregivers. This study explored cancer caregivers’ perceptions of participating in a structured exercise and nutrition program alongside cancer survivors for whom they provided care. Methods In-depth, semi-structured interviews were conducted by one interviewer with 12 cancer caregivers about their experiences participating in a structured, 12-week exercise and nutrition program designed for cancer [...]

Menée auprès de 319 survivants d'un lymphome non hodgkinien agressif, cette étude analyse leur qualité de vie, physique et psychologique, 2 à 5 ans après le diagnostic

Health-related quality of life among survivors of aggressive non-Hodgkin lymphoma

Jensen, Roxanne E. ; Arora, Neeraj K. ; Bellizzi, Keith M. ; Rowland, Julia H. ; Hamilton, Ann S. ; Aziz, Noreen M. ; Potosky, Arnold L.

BACKGROUND: Non-Hodgkin lymphoma (NHL) is the fifth most common cancer among men and women. Patients with aggressive NHL receive intense medical treatments that can significantly compromise health-related quality of life (HRQOL). However, knowledge of HRQOL and its correlates among survivors of aggressive NHL is limited. METHODS: Self-reported data on HRQOL (physical and mental function, anxiety, depression, and fatigue) were analyzed for 319 survivors of aggressive NHL. Survivors 2 to 5 years [...]

Menée aux Etats-Unis auprès de 83 participants, cette étude analyse l'utilisation des services d'aide psychosociale et de soins de support par les soignants et aidants familiaux de patients atteints d'un cancer du poumon

Support service use and interest in support services among distressed family caregivers of lung cancer patients

Mosher, Catherine E. ; Champion, Victoria L. ; Hanna, Nasser ; Jalal, Shadia I. ; Fakiris, Achilles J. ; Birdas, Thomas J. ; Okereke, Ikenna C. ; Kesler, Kenneth A. ; Einhorn, Lawrence H. ; Given, Barbara A. ; Monahan, Patrick O. ; Ostroff, Jamie S.

Objective This study examined support service use and interest in support services among distressed family caregivers of patients recently entering comprehensive cancer care facilities. Methods Primary family caregivers of lung cancer patients (N = 83) were recruited from three medical centers within 12 weeks of the patient's new visit to the oncology clinic. All family caregivers were screened for psychological distress, and those reporting significant anxiety or depressive symptoms were [...]

A partir d'une revue systématique de la littérature (12 essais incluant 1 767 patients), cette méta-analyse évalue l'efficacité des biphosphonates pour traiter la douleur de patients atteints d'un cancer du poumon et de métastases osseuses

Bisphosphonates in the treatment of patients with lung cancer and metastatic bone disease: a systematic review and meta-analysis

Lopez-Olivo, Maria ; Shah, Nimit ; Pratt, Greg ; Risser, Jan ; Symanski, Elaine ; Suarez-Almazor, Maria

Purpose Bisphosphonates are known to prevent skeletal-related events (SREs) in advanced breast cancer, prostate cancer, and multiple myeloma. This systematic review assessed the efficacy of bisphosphonates in preventing SREs, controlling pain, and overall survival in patients with bone metastases from lung cancer. Methods We searched MEDLINE, EMBASE, Web of Science, and the Cochrane Library databases through November 10, 2011 for controlled trials that included lung cancer patients with bone [...]

Menée auprès de 261 survivants d'un cancer colorectal, cette étude américaine évalue l'association entre des facteurs cliniques, psychosociaux et des dysfonctionnements sexuels à long terme

The association between psychosocial and medical factors with long-term sexual dysfunction after treatment for colorectal cancer

Milbury, Kathrin ; Cohen, Lorenzo ; Jenkins, Rosell ; Skibber, John ; Schover, Leslie

Purpose Colorectal cancer patients usually receive treatments (e.g., pelvic surgery or radiotherapy, colostomy) that increase their risk for sexual problems. Previous research has mainly focused on demographic and medical risk factors. Because little is known about the role of psychosocial variables in sexual dysfunction, this research sought to identify the contribution of demographic, medical, and psychosocial factors to sexual dysfunction using multivariate analyses. Methods Male and female [...]

Menée par questionnaire auprès de 2 461 participants, cette étude analyse la qualité de vie et l'anxiété des participants à un programme de dépistage du cancer colorectal

Quality of life in participants of a CRC screening program

Kapidzic, A. ; Korfage, I. J. ; van Dam, L. ; van Roon, A. Hc ; Reijerink, J. Ciy ; Zauber, A. G. ; van Ballegooijen, M. ; Kuipers, E. J. ; van Leerdam, M. E.

Background: Little is known about the effect of participating in a colorectal cancer (CRC) screening programme on quality of life (QOL), neither for participants with a negative nor for those with a positive test result. These findings, however, are important to evaluate the impact of CRC screening. Methods: Participants from CRC screening trials were sent a questionnaire, which included validated measures on generic health-related QOL, generic anxiety and screen-specific anxiety. Both faecal [...]

Mené auprès de 2 046 participantes, cet essai randomisé de phase III analyse et compare les effets du dénosumab et de l'acide zolédronique pour traiter la douleur de patientes atteintes d'un cancer du sein de stade avancé et de métastases osseuses

Pain outcomes in patients with advanced breast cancer and bone metastases

Cleeland, Charles S. ; Body, Jean-Jacques ; Stopeck, Alison ; von Moos, Roger ; Fallowfield, Lesley ; Mathias, Susan D. ; Patrick, Donald L. ; Clemons, Mark ; Tonkin, Katia ; Masuda, Norikazu ; Lipton, Allan ; de Boer, Richard ; Salvagni, Stefania ; Oliveira, Celia Tosello ; Qian, Yi ; Jiang, Qi ; Dansey, Roger ; Braun, Ada ; Chung, Karen

BACKGROUND: In this study, the authors evaluated the effect of denosumab versus zoledronic acid (ZA) on pain in patients with advanced breast cancer and bone metastases. METHODS: The prevention of pain, reduction in pain interference with daily life activities, and the proportion of patients requiring strong opioid analgesics were assessed in a randomized, double-blind, double-dummy phase 3 study comparing denosumab with ZA for preventing skeletal-related events in 2046 patients who had breast [...]

A partir des données du registre californien des cancers portant sur la période 1988 à 2005, cette étude analyse les caractéristiques cliniques et démographiques des survivants à long terme d'un cancer de l'estomac

Long-Term Survivors of Gastric Cancer: A California Population-Based Study

Kunz, Pamela L. ; Gubens, Matthew ; Fisher, George A. ; Ford, James M. ; Lichtensztajn, Daphne Y. ; Clarke, Christina A.

Purpose In the United States, gastric cancer is rapidly fatal with a 25% 5-year survival. Of the few patients who survive, little is known about their demographic, clinical, and tumor characteristics.Patients and Methods Data regarding all cases of gastric and gastroesophageal junction (GEJ) adenocarcinoma diagnosed in California between 1988 and 2005 were obtained from the California Cancer Registry, a member of the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) [...]

Menée auprès de 102 participants, cette étude multicentrique prospective analyse l'état des fonctions cognitives de patients ayant reçu une greffe allogénique de cellules souches hématopoïétiques

Cognitive functioning in allogeneic hematopoietic stem cell transplantation recipients and its medical correlates: a prospective multicenter study

Scherwath, Angela ; Schirmer, Lena ; Kruse, Margitta ; Ernst, Gundula ; Eder, Matthias ; Dinkel, Andreas ; Kunze, Sabine ; Balck, Friedrich ; Bornhäuser, Martin ; Ehninger, Gerhard ; Dolan, Karin ; Gramatzki, Martin ; Kolb, Hans-Jochem ; Heußner, Pia ; Wilhelm, Hans ; Beelen, Dietrich W. ; Schulz-Kindermann, Frank ; Zander, Axel R. ; Koch, Uwe ; Mehnert, Anja

Background Owing to its neurotoxicity, allogeneic hematopoietic stem cell transplantation (HSCT) carries risks for cognitive impairment. In this multicenter study, we prospectively evaluated cognitive functioning and its medical and demographic correlates in patients undergoing allogeneic HSCT. Methods A total of 102 patients were consecutively assessed prior to (T0), 100 ± 20 days (T1) after, and 12 ± 1 months (T2) after HSCT (61% men, 41% acute myeloid leukemia). A comprehensive [...]

Menée auprès de 62 survivants adultes d'un lymphome hodgkinien pédiatrique (âge médian :42, 2 ans), cette étude analyse l'état de leurs fonctions neurocognitives et cardiopulmonaires

Neurocognitive Function and CNS Integrity in Adult Survivors of Childhood Hodgkin Lymphoma

Krull, Kevin R. ; Sabin, Noah D. ; Reddick, Wilburn E. ; Zhu, Liang ; Armstrong, Gregory T. ; Green, Daniel M. ; Arevalo, Alejandro R. ; Krasin, Matthew J. ; Srivastava, Deo Kumar ; Robison, Leslie L. ; Hudson, Melissa M.

Purpose Long-term survivors of childhood Hodgkin lymphoma (HL) are at risk for cardiopulmonary complications and CNS stroke, although neurocognitive function has not been previously examined. The aim of this study was to examine neurocognitive and brain imaging outcomes in adult survivors of childhood HL.Patients and Methods In all, 62 adult survivors (mean age, 42.2 years; standard deviation [SD], 4.77; mean age at diagnosis, 15.1 years; SD, 3.30) were identified by stratified random selection [...]

A partir de données de 17 études, cette méta-analyse évalue l'association entre le brassage de diverses populations dans des zones rurales, l'incidence et la prévalence de leucémie pédiatrique

An examination, with a meta-analysis, of studies of childhood leukaemia in relation to population mixing

Kinlen, L. J.

Background: Marked influxes of people into rural areas, termed rural population mixing (PM), have been associated with excesses of childhood leukaemia (CL), consistent with mini-epidemics of a mainly immunising, subclinical infection to which CL is a rare response. For such situations of rural PM would promote contacts between infected and susceptible individuals, the latter tending to have a higher than average prevalence in rural or isolated areas. Confusion has arisen from some workers [...]

Menée auprès de 662 participants, cette étude de cohorte américaine analyse l'association entre la densité minérale osseuse et l'incidence de calculs rénaux chez des survivants à long terme d'une leucémie lymphoblastique aiguë pédiatrique

Association of bone mineral density with incidental renal stone in long-term survivors of childhood acute lymphoblastic leukemia

Gawade, Prasad ; Ness, Kirsten ; Sharma, Shelly ; Li, Zhenghong ; Srivastava, Deo ; Spunt, Sheri ; Nottage, Kerri ; Krasin, Matthew ; Hudson, Melissa ; Kaste, Sue

Purpose Our objective was to evaluate the association between low bone mineral density (BMD) and incidental renal stones among long-term survivors of childhood acute lymphoblastic leukemia (ALL). Methods Adult participants who were 10+ years from their childhood ALL diagnosis and members of the St. Jude Lifetime Cohort study were recruited between December 2007 and March 2011. During their risk-based medical evaluations, they underwent quantitative computed tomography (QCT) to evaluate BMD. [...]

A partir des données du registre néerlandais des cancers portant sur la période 1989 à 2008 (89 451 cas), cette étude analyse l'évolution de la mortalité de patients ayant survécu à long terme à un cancer du côlon

Minimal excess mortality for long-term colon cancer survivors in the Netherlands 1989–2008

van Steenbergen, L. N. ; Steur, M. ; Lemmens, V. E. P. P. ; Rutten, H. J. T. ; van Spronsen, D. J. ; Janssen-Heijnen, M. L. G.

We determined conditional 5-year relative survival rates for colon cancer patients, according to age, gender and tumour stage for each additional year of survival up to 15years after diagnosis. All 89,451 patients diagnosed in the Netherlands with colon cancer stage I–III in 1989–2008 aged 15–89years were selected from the Netherlands Cancer Registry. Conditional 5-year relative survival was computed for every additional year of survival up to 15years. There was minimal excess mortality [...]

A partir des données d'un registre suisse des cancers, cette étude analyse l'évolution de l'incidence d'un second cancer colorectal primitif, sur la période 1974 à 2008

High constant incidence of second primary colorectal cancer

Levi, Fabio ; Randimbison, Lalao ; Blanc-Moya, Rafael ; Maspoli-Conconi, Manuela ; Rosato, Valentina ; Bosetti, Cristina ; La Vecchia, Carlo

Patients who had a colorectal cancer have a 1.5- to 2-fold excess risk of a second colorectal cancer as compared to the general population, the excess being higher at younger age at diagnosis. To further investigate the risk and the age-relation of the incidence of second primary colorectal cancer, we considered 9,389 first colon and rectal cancers registered in the Vaud Cancer Registry, Switzerland, between 1974 and 2008, and followed-up to the end of 2008 for a total of 44,113 person-years. [...]

A partir des données du registre des Pays-Bas des cancers, cette étude analyse l'évolution, sur la période 1995 à 2005, du taux d'interventions chirurgicales chez les patientes âgées de plus de 75 ans et atteintes d'un cancer du sein résécable

Omission of surgery in elderly patients with early stage breast cancer

Hamaker, Marije E. ; Bastiaannet, Esther ; Evers, Dorothea ; Water, Willemien van de ; Smorenburg, Carolien H. ; Maartense, Ed ; Zeilemaker, Anneke M. ; Liefers, Gerrit-Jan ; Geest, Lydia van der ; de Rooij, Sophia E. ; van Munster, Barbara C. ; Portielje, Johanneke E. A.

To assess national trends over time in surgery for elderly patients with resectable breast cancer (BC) and to evaluate clinical outcome and cause of death after the omission of surgery in a regional cohort of elderly patients. National trends in 1995–2005 were calculated using cancer registry data. In addition, a chart review was performed in a cohort of patients aged ⩾75years, with early stage BC but no primary surgery, diagnosed at five Dutch hospitals in 1990–2005. Patient characteristics, [...]

Cette étude australienne développe et présente un outil permettant de mesurer l'auto-efficacité, c'est-à-dire la croyance d'un individu en sa capacité d’atteindre ou non un objectif, chez les soignants de patients atteints d'un cancer de stade avancé

Development of an instrument to measure self-efficacy in caregivers of people with advanced cancer

Ugalde, Anna ; Krishnasamy, Meinir ; Schofield, Penelope

Objective Informal caregivers of people with advanced cancer experience many negative impacts as a result of their role. There is a lack of suitable measures specifically designed to assess their experience. This study aimed to develop a new measure to assess self-efficacy in caregivers of people with advanced cancer. Methods The development and testing of the new measure consisted of four separate, sequential phases: generation of issues, development of issues into items, pilot testing and [...]

A partir d'une revue systématique de la littérature (9 études), cette méta-analyse évalue l'efficacité d'une intervention psychosociale destinée à améliorer la gestion du stress, de l'anxiété et de la dépression de patientes atteintes d'un cancer du sein

The efficacy of mindfulness-based stress reduction on mental health of breast cancer patients: a meta-analysis

Zainal, Nor Zuraida ; Booth, Sara ; Huppert, Felicia A.

Objective This study aims to investigate the evidence of the efficacy of mindfulness-based stress reduction (MBSR) in improving stress, depression and anxiety in breast cancer patients. Methods An extensive systematic electronic review (PubMed, Embase, CINAHL, PsyArticles, PsycINFO, Scopus, Ovid, Web of Science and The Cochrane Library) and a hand search were carried out from 15 October 2011 to 30 November 2011 to retrieve relevant articles using ‘mindfulness’ or ‘mindfulness-based stress [...]

Menée auprès de 90 participants, cette étude randomisée analyse diverses stratégies éducatives pour améliorer les connaissances du public relatives au cancer du pharynx et de la cavité buccale

Evaluation of the different strategies to oral cancer knowledge: a randomized controlled study

López-Jornet, Pia ; Camacho-Alonso, Fabio ; Molina Miñano, Francisco ; Sanchez-Siles, Mariano

Objectives Oral cavity and pharyngeal cancer has been well recognized as a public health problem. Prognosis for oral cancer is substantially improved when diagnosed early. A study was made of the impact of different educational strategies upon knowledge of oral cancer, evaluating the intervention after 4 weeks. Methods Ninety subjects over 40 years of age were consecutively included and randomized to three different groups (video, leaflet, verbal information). All subjects completed a 20-item [...]

Menée en Corée auprès de 181 participants, cette étude prospective observationnelle analyse les événements cliniques précédant la mort imminente de patients atteints d'un cancer

Clinical changes in terminally ill cancer patients and death within 48 h: when should we refer patients to a separate room?

Hwang, In ; Ahn, Hong ; Park, Sang ; Shim, Jae ; Kim, Kyoung

Background There is scant research concerning the prediction of imminent death, and current studies simply list events “that have already occurred” around 48 h of the death. We sought to determine what events herald the onset of dying process using the length of time from “any change” to death. Methods This is a prospective observational study with chart audit. Inclusion criteria were terminal cancer patients who passed away in a palliative care unit. The analysis was limited to 181 patients [...]