A partir d'une revue systématique de la littérature (287 études publiées jusqu'en 2000), cette méta-analyse présente l'association entre le tabagisme et le risque de cancer du poumon

Systematic review with meta-analysis of the epidemiological evidence in the 1900s relating smoking to lung cancer

Lee, Peter ; Forey, Barbara ; Coombs, Katharine

BACKGROUND:Smoking is a known lung cancer cause, but no detailed quantitative systematic review exists. We summarize evidence for various indices.METHODS:Papers published before 2000 describing epidemiological studies involving 100+ lung cancer cases were obtained from Medline and other sources. Studies were classified as principal, or subsidiary where cases overlapped with principal studies. Data were extracted on design, exposures, histological types and confounder adjustment. RRs/ORs and 95% [...]

A partir des données d'un registre allemand des cancers portant sur la période 2002-2008, cette étude évalue l'association entre l'uranium contenu dans l'eau potable et le risque de cancer

Association between drinking water uranium content and cancer risk in Bavaria, Germany

Radespiel-Tröger, M. ; Meyer, M.

Objective To evaluate the possible association between uranium (U) content in public drinking water on the one hand and the risk of cancer of the colorectum, lung, female breast, prostate, kidney, and urinary bladder, total cancer, and leukemia on the other hand in Bavaria, an ecologic study on the level of municipalities was performed. Methods Cancer incidence data for the years 2002–2008 were obtained from the population-based cancer registry Bavaria according to sex. Current U content data [...]

Cette étude passe en revue les associations entre une infection par le papillomavirus humain, des néoplasies intraépithéliales et le risque de cancer anal

HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues

Stanley, Margaret ; Winder, David ; Sterling, Jane ; Goon, Peter

BACKGROUND:Human papillomavirus (HPV) is well known as the major etiological agent for ano-genital cancer. In contrast to cervical cancer, anal cancer is uncommon, but is increasing steadily in the community over the last few decades. However, it has undergone an exponential rise in the men who have sex with men (MSM) and HIV + groups. HIV + MSM in particular, have anal cancer incidences about three times that of the highest worldwide reported cervical cancer incidences.DISCUSSION:There has [...]

Menée en France, au Royaume-Uni et aux Pays-Bas auprès de 1 993 participantes porteuses de mutations BRCA1 ou BRCA2 , cette étude de cohorte rétrospective évalue l'association entre une exposition à des rayonnements médicaux avant l'âge de 30 ans et le risque de cancer du sein

Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK)

Anouk Pijpe ; Nadine Andrieu ; Douglas F Easton ; Ausrele Kesminiene ; Elisabeth Cardis ; Catherine Noguès ; Marion Gauthier-Villars ; Christine Lasset ; Jean-Pierre Fricker ; Susan Peock ; Debra Frost ; D Gareth Evans ; Rosalind A Eeles ; Joan Paterson ; Peggy Manders ; Christi J van Asperen ; Margreet G E M Ausems ; Hanne Meijers-Heijboer ; Isabelle Thierry-Chef ; Michael Hauptmann ; David Goldgar ; Matti A Rookus ; Flora E van Leeuwen

Objective To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. Design Retrospective cohort study (GENE-RAD-RISK). Setting Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, Participants 1993 female carriers of BRCA1/2 mutations recruited in 2006-09. Main outcome measure Risk of breast cancer estimated with a weighted Cox proportional hazards model with a time dependent individually estimated [...]

A partir des données de huit études américaines, cette méta-analyse évalue l'association entre le groupe sanguin A, B et O et le risque de cancer épithélial de l'ovaire

ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

Poole, Elizabeth ; Gates, Margaret ; High, Brigit ; Chanock, Stephen ; Cramer, Daniel ; Cunningham, Julie ; Fridley, Brooke ; Gayther, Simon ; Goode, Ellen ; Iversen, Edwin ; Lissowska, Jolanta ; Weber, Rachel ; Pharoah, Paul ; Phelan, Catherine ; Ramus, Susan ; Schildkraut, Joellen ; Sutphen, Rebecca ; Tsai, Ya-Yu ; Tyrer, Jonathan ; Vierkant, Robert ; Wentzensen, Nicolas ; Yang, Hannah ; Terry, Kathryn ; Tworoger, Shelley

Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In eight studies participating in the Ovarian Cancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results Compared to [...]

Menée en Chine auprès de 5 022 patientes hospitalisées, cette étude évalue l'association entre le phénotype du groupe sanguin Duffy et le risque de cancer du sein

Correlation between Duffy blood group phenotype and breast cancer incidence

Liu, Xiao-feng ; Li, Lian-fang ; Ou, Zhou-luo ; Shen, Rong ; Shao, Zhi-Min

BACKGROUND:Different ethnicities have different distribution of Duffy blood group (DBG) phenotypes and different breast cancer morbidity. A study in our lab demonstrated that Duffy antigen/receptor for chemokines (DARC, also known as DBGP, the Duffy protein phenotype), led to the inhibition of tumorigenesis. Therefore, we tested the hypothesis that DBGP is correlated with breast cancer occurrence.METHODS:DBGP proteins were examined by indirect antiglobulin testing with anti-FYa and anti-FYb [...]

Menée initialement sur une cohorte de 2 031 patients chinois atteints d'un carcinome épidermoïde de l'œsophage et 2 044 témoins, puis validée sur une cohorte indépendante de 8 092 cas et 8 620 témoins, cette étude identifie des loci de susceptibilité à la maladie et des interactions entre des loci et la consommation d'alcool

Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions

Wu, Chen ; Kraft, Peter ; Zhai, Kan ; Chang, Jiang ; Wang, Zhaoming ; Li, Yun ; Hu, Zhibin ; He, Zhonghu ; Jia, Weihua ; Abnet, Christian C. ; Liang, Liming ; Hu, Nan ; Miao, Xiaoping ; Zhou, Yifeng ; Liu, Zhihua ; Zhan, Qimin ; Liu, Yu ; Qiao, Yan ; Zhou, Yuling ; Jin, Guangfu ; Guo, Chuanhai ; Lu, Changdong ; Yang, Haijun ; Fu, Jianhua ; Yu, Dianke ; Freedman, Neal D. ; Ding, Ti ; Tan, Wen ; Goldstein, Alisa M. ; Wu, Tangchun ; Shen, Hongbing ; Ke, Yang ; Zeng, Yixin ; Chanock, Stephen J. ; Taylor, Philip R. ; Lin, Dongxin

We conducted a genome-wide association study (GWAS) and a genome-wide gene-environment interaction analysis of esophageal squamous-cell carcinoma (ESCC) in 2,031 affected individuals (cases) and 2,044 controls with independent validation in 8,092 cases and 8,620 controls. We identified nine new ESCC susceptibility loci, of which seven, at chromosomes 4q23, 16q12.1, 17q21, 22q12, 3q27, 17p13 and 18p11, had a significant marginal effect (P = 1.78 × 10−39 to P = 2.49 × 10−11) and two of which, at [...]

A partir des données de la cohorte "Nurses' Health Study II" incluant 1 825 femmes travaillant par rotation, cette étude analyse la relation entre des variants de 15 gènes impliqués dans le système circadien et le risque de cancer du sein

Circadian genes and breast cancer susceptibility in rotating shift workers

Monsees, Genevieve M. ; Kraft, Peter ; Hankinson, Susan E. ; Hunter, David J. ; Schernhammer, Eva S.

Rotating night shift work is associated with increased risk of breast cancer, likely via circadian disruption. We hypothesized that circadian pathway genes influence breast cancer risk, particularly in rotating night shift workers. We selected 178 common variants across 15 genes pertinent to the circadian system. Using a mixed candidate- and tag-single nucleotide polymorphism approach, we tested for associations between these variants and breast cancer risk in 1,825 women within the Nurses' [...]