A partir d'une revue de la littérature publiée jusqu'en janvier 2012 (22 études non randomisées, 7 essais contrôlés randomisés), cette étude évalue, en fonction des techniques utilisées et du point de vue de la durée de l'hospitalisation, des événements indésirables, du temps de récupération physique et de la mortalité, la qualité de vie et les résultats péri-opératoires après une néphrectomie partielle ou une néphrectomie radicale pour un carcinome localisé à cellules rénales

Systematic Review of Perioperative and Quality-of-life Outcomes Following Surgical Management of Localised Renal Cancer

Steven, MacLennan ; Mari, Imamura ; Marie, C. Lapitan ; Muhammad Imran, Omar ; Thomas, B. L. Lam ; Ana, M. Hilvano-Cabungcal ; Pam, Royle ; Fiona, Stewart ; Graeme, MacLennan ; Sara, J. MacLennan ; Philipp, Dahm ; Steven, E. Canfield ; Sam, McClinton ; T. R. Leyshon Griffiths ; Börje, Ljungberg ; James, N'Dow, ; Ucan Systematic Review Reference Group

Context : For the treatment of localised renal cell carcinoma (RCC), uncertainties remain over the perioperative and quality-of-life (QoL) outcomes for the many different surgical techniques and approaches of nephrectomy. Controversy also remains on whether newer minimally invasive nephron-sparing interventions offer better QoL and perioperative outcomes, and whether adrenalectomy and lymphadenectomy should be performed simultaneously with nephrectomy. These nononcologic outcomes are important [...]

A partir de données en population britannique portant sur 25 853 enfants atteints d'un cancer pédiatrique diagnostiqué entre 1978 et 2005, cette étude analyse, en fonction du type de cancer, l'évolution de la survie selon les périodes d'inclusion de nouveaux patients dans les essais cliniques

Population survival from childhood cancer in Britain during 1978–2005 by eras of entry to clinical trials

Stiller, C. A. ; Kroll, M. E. ; Pritchard-Jones, K.

Background Inclusion in clinical trials is generally viewed as best practice for most newly diagnosed childhood cancers, but the impact on population-based survival has rarely been examined.Patients and methods The population-based data were analysed for 25 853 children (66% of all registered childhood cancers) diagnosed in Britain during 1978–2005 with acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML), Hodgkin lymphoma, non-Hodgkin lymphoma, medulloblastoma, neuroblastoma, [...]

A partir des données de 23 registres italiens du cancer, cette étude analyse la variabilité géographique de la prévalence partielle à 5 ans de la maladie

Cancer prevalence in Italy: an analysis of geographic variability

Guzzinati, Stefano ; Buzzoni, Carlotta ; De Angelis, Roberta ; Rosso, Stefano ; Tagliabue, Giovanna ; Vercelli, Marina ; Pannozzo, Fabio ; Mangone, Lucia ; Piffer, Silvano ; Fusco, Mario ; Giacomin, Adriano ; Traina, Adele ; Capocaccia, Riccardo ; Dal Maso, Luigino ; Crocetti, Emanuele ; Airtum working group

Purpose Statistics on cancer prevalence are scanty. The objectives of this study were to describe the cancer prevalence in Italy and to explore determinants of geographic heterogeneity. Methods The study included data from 23 population-based cancer registries, including one-third of the Italian population. Five-year cancer prevalence was observed, and complete prevalence (i.e., all patients living after a cancer diagnosis) was estimated through sex-, age-, cancer site-, and observation period [...]

Cet article passe en revue les études épidémiologiques concernant la relation entre un diabète de type 1, l'incidence de cancers et la mortalité spécifique

Epidemiological evidence of a relationship between type-1 diabetes mellitus and cancer: A review of the existing literature

Gordon-Dseagu, Vanessa L. Z. ; Shelton, Nicola ; Mindell, Jennifer S.

This review explores the epidemiological evidence relating to type-1 diabetes (T1DM) and cancer incidence and mortality. Mortality rates among those with T1DM are higher in every age group compared with the general population; the majority of this mortality is due to factors related to the consequences of diabetes, such as cardiovascular and renal disease. For over 100 years, researchers have explored the relationships between diabetes and cancer and although there is now a large body of work [...]

A partir des données du registre suédois du cancer portant sur 9 384 patients atteints d'une néoplasie myéloproliférative diagnostiquée entre 1973 et 2008, cette étude évalue le taux de survie relative à 10 ans en fonction des sous-types de la maladie (thrombocythémie essentielle, polycythémie vera)

Patterns of Survival Among Patients With Myeloproliferative Neoplasms Diagnosed in Sweden From 1973 to 2008: A Population-Based Study

Hultcrantz, Malin ; Kristinsson, Sigurdur Yngvi ; Andersson, Therese M.-L. ; Landgren, Ola ; Eloranta, Sandra ; Derolf, Åsa Rangert ; Dickman, Paul W. ; Björkholm, Magnus

Purpose Reported survival in patients with myeloproliferative neoplasms (MPNs) shows great variation. Patients with primary myelofibrosis (PMF) have substantially reduced life expectancy, whereas patients with polycythemia vera (PV) and essential thrombocythemia (ET) have moderately reduced survival in most, but not all, studies. We conducted a large population-based study to establish patterns of survival in more than 9,000 patients with MPNs.Patients and Methods We identified 9,384 patients [...]

Menée sur 802 patients atteints d'une myélofibrose primitive, cette étude multicentrique internationale compare, en fonction de la période de diagnostic (1980-1995, 1996-2007), les caractéristiques clinico-pathologiques de la maladie et la survie des patients

Improving Survival Trends In Primary Myelofibrosis: An International Study

Cervantes, Francisco ; Dupriez, Brigitte ; Passamonti, Francesco ; Vannucchi, Alessandro M. ; Morra, Enrica ; Reilly, John T. ; Demory, Jean-Loup ; Rumi, Elisa ; Guglielmelli, Paola ; Roncoroni, Elisa ; Tefferi, Ayalew ; Pereira, Arturo

Purpose Despite the lack of major improvements in the treatment of primary myelofibrosis (PMF), there are recent indications that the survival of patients might have increased over the years. This study was aimed at ascertaining whether survival prolongation has actually occurred in PMF.Patients and Methods A total of 802 patients diagnosed with PMF in four European countries were compared for the presentation of features and survival according to the diagnostic periods 1980 to 1995 (n = 434) [...]

Menée entre 1997 et 2004 dans le Nord-Est de l'Angleterre auprès de 29 563 patients atteints d'un cancer colorectal, cette étude en population évalue le taux de guérison en fonction de l'âge des patients et du stade de la maladie au diagnostic

Cure by age and stage at diagnosis for colorectal cancer patients in North West England, 1997–2004: A population-based study

Shack, L. G. ; Shah, A. ; Lambert, P. C. ; Rachet, B.

Background: Stage and age at diagnosis are important prognostic factors for patients with colorectal cancer. However, the proportion cured by stage and age is unknown in England. Materials and methods: This population-based study includes 29,563 adult patients who were diagnosed and registered with colorectal cancer during 1997–2004 and followed till 2007 in North West England. Multiple imputation was used to provide more reliable estimates of stage at diagnosis, when these data were missing. [...]

A partir d'une comparaison entre les fonds collectés pour la recherche sur le cancer et les dépenses de santé, cette étude montre, par rapport à la charge sociale que représente chaque type de cancer, des disparités au niveau de la répartition de ces fonds

A comparison of cancer burden and research spending reveals discrepancies in the distribution of research funding

Carter, Ashley ; Nguyen, Cecine

BACKGROUND:Ideally, the distribution of research funding for different types of cancer should be equitable with respect to the societal burden each type of cancer imposes. These burdens can be estimated in a variety of ways; "Years of Life Lost" (YLL) measures the severity of death in regard to the age it occurs, "Disability-Adjusted Life-Years" (DALY) estimates the effects of non-lethal disabilities incurred by disease and economic metrics focus on the losses to tax revenue, productivity or [...]

Cet article passe en revue 5 systèmes électroniques utilisés en oncologie clinique pour recueillir les données rapportées par les patients sur leur état de santé (symptômes, état psychologique, physique et fonctionnel)

Electronic patient-reported outcome systems in oncology clinical practice

Bennett, Antonia V. ; Jensen, Roxanne E. ; Basch, Ethan

Answer questions and earn CME/CNE Patient-reported outcome (PRO) questionnaires assess topics a patient can report about his or her own health. This includes symptoms (eg, nausea, fatigue, diarrhea, pain, or frequent urination), physical functioning (eg, difficulty climbing stairs or difficulty fastening buttons), and mental health (eg, anxiety, fear, or worry). Electronic PRO (ePRO) systems are used in oncology clinical care because of 1) their ability to enhance clinical care by flagging [...]

Menée sur 1 206 patients atteints d'un cancer du côlon ou du rectum, cette étude française évalue, par rapport aux recommandations de bonnes pratiques, la qualité des soins (du diagnostic au traitement chirurgical) et identifie les facteurs associés au non respect de ces recommandations

Quality indicators for colorectal cancer surgery and care according to patient-, tumor-, and hospitalrelated factors

Mathoulin-Pelissier, Simone ; Becouarn, Yves ; Belleannee, Genevieve ; Pinon, Elodie ; Jaffre, Anne ; Coureau, Gaelle ; Auby, Dominique ; Renaud-Salis, Jean-Louis ; Rullier, Eric

Background and methods: Colorectal cancer (CRC) care has considerably improved considerably, particularly since the implementation of a quality of care program centered around national evidence-based guidelines. Formal quality assessmentevaluation of the quality of care is however still needed. The aim of this research was to identify factors associated with practice variation in CRC patient care. CRC patients identified from all cancer centers in South-West France were included. We [...]