Menée sur 338 patients atteints d'un adénocarcinome in situ et à partir des données d'une étude incluant 6 039 cas et 2 073 témoins, cette étude évalue, par rapport aux autres sous-types de cancer du poumon non à petites cellules, l'association entre le tabagisme et le risque de développer la maladie

Cigarette Smoking Associated With Lung Adenocarcinoma In Situ in a Large Case-Control Study (SFBALCS)

Bracci, Paige M. ; Sison, Jennette ; Hansen, Helen ; Walsh, Kyle M. ; Quesenberry, Charles P. ; Raz, Dan J. ; Wrensch, Margaret ; Wiencke, John K.

Introduction: Adenocarcinoma in situ (AIS), formerly bronchioloalveolar carcinoma, is an uncommon subtype of lung adenocarcinoma and accounts for approximately 3% to 4% of lung cancers. Compared with other lung cancer histologies, AIS patients are less likely to be smokers, yet associations with other lung cancer risk factors and differences by sex have not been determined. Methods: A total of 338 AIS patients and frequency-matched controls from the parent study (cases = 6039, controls = 2073) [...]

Menée sur 1 857 patients atteints d'un cancer localisé ou avancé de la prostate et sur 1 096 témoins, cette étude évalue, en fonction du mode de cuisson et de la présence de variants génétiques d'enzymes impliquées dans le métabolisme de carcinogènes, l'association entre la consommation de viande rouge ou de volaille et le risque de développer la maladie

Red meat and poultry, cooking practices, genetic susceptibility and risk of prostate cancer: results from the California Collaborative Prostate Cancer Study

Joshi, Amit D ; Corral, Roman ; Catsburg, Chelsea ; Lewinger, Juan-Pablo ; Koo, Jocelyn ; John, Esther M ; Ingles, Sue ; Stern, Mariana C.

Red meat, processed and unprocessed, has been considered a potential prostate cancer (PCA) risk factor; epidemiological evidence, however, is inconclusive. An association between meat intake and PCA may be due to potent chemical carcinogens that are generated when meats are cooked at high temperatures. We investigated the association between red meat and poultry intake and localized and advanced PCA taking into account cooking practices and polymorphisms in enzymes that metabolize carcinogens [...]

Menée en Turquie dans la province de Sivas, à partir de données de registres médicaux portant sur 533 patients (100 cas de mésothéliome malin, 133 cas présentant des plaques pleurales, 161 cas de cancer de la prostate et 139 cas de cancer du sein), cette étude montre une association entre la présence environnementale d'ophiolites à proximité du lieu de naissance et un risque élevé de développer un mésothéliome malin ou des plaques pleurales

Hight risk of malignant mesothelioma and pleural plaques in subjects born close to ophiolites

Mehmet Bayram1, MD; Isa Dongel2, MD; Nur Dilek Bakan3, MD; Hüseyin Yalç

Background: Ophiolites– a special sequence of geologic rock units – are known sources of naturally occurring asbestos. The aim of the study was to test whether the occurrence of malignant mesothelioma (MM) or pleural plaques (PP) in the province of Sivas, Turkey, is determined by the proximity of the patient’s birthplace with respect to ophiolites and, if so, to establish the magnitude of the risk. Methods: The birthplaces of patients with MM or PP (cases) and patients with prostate or breast [...]

A partir d'une revue de la littérature publiée jusqu'en 2011 (13 études cas-témoins, 3 études de cohorte), cette méta-analyse évalue l'association entre une infection par le virus de l'hépatite B ou C et le risque de cholangiocarcinome intrahépatique

Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis

Zhou, Yanming ; Zhao, Yanfang ; Li, Bin ; Huang, Jiyi ; Wu, Lupeng ; Xu, Donghui ; Yang, Jiamei ; He, Jia

BACKGROUND:Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship.METHODS:A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were [...]

Menée à partir d'échantillons tumoraux prélevés sur 264 patients brésiliens atteints d'un carcinome épidermoïde de l'œsophage, cette étude évalue, en analysant les caractéristiques clinicopathologiques des tumeurs et les biomarqueurs qu'elles expriment, le rôle du papillomavirus humain dans la survenue de la maladie

HPV infection in Brazilian patients with esophageal squamous cell carcinoma : interpopulational differences, lack of correlation with surrogate markers and clinicopathological parameters

Herbster, Suellen ; Ferraro, Cintia Tereza Lima ; Koff, Natália Kirsch ; Rossini, Ana ; Kruel, Cleber Dario Pinto ; Andreollo, Nelson Adami ; Rapozo, Davy Carlos Mendes ; Blanco, Tânia Cristina Moita ; Faria, Paulo Antonio Silvestre de ; Santos, Paulo Thiago de Souza ; Albano, Rodolpho Matos ; Simão, Tatiana de Almeida ; Pinto, Luis Felipe Ribeiro

The role of HPV in esophageal squamous cell carcinoma (ESCCs) is controversial. Therefore, we determined, through different methodologies, the prevalence of HPV in 264 ESCC samples from Brazil, and correlated it with the presence of surrogate markers and clinicopathological characteristics. HPV is present in 13% of ESCC, and with a 3-fold variation between high and medium incidence areas. Most HPV positive tumors were infected with HPV16, but this was not associated with p16 expression, TP53 [...]

Couplée à l'essai "Prostate Cancer Prevention Trial", cette étude prospective cas-témoins (614 cas et 616 témoins) évalue l'association entre une séropositivité au cytomégalovirus et le risque de cancer de la prostate

Prospective study of cytomegalovirus serostatus and prostate cancer risk in the Prostate Cancer Prevention Trial

Sutcliffe, Siobhan ; Till, Cathee ; Gaydos, Charlotte ; Jenkins, Frank ; Goodman, Phyllis ; Hoque, Ashraful ; Hsing, Ann ; Thompson, Ian ; Zenilman, Jonathan ; Nelson, William ; De Marzo, Angelo ; Platz, Elizabeth

Purpose To investigate serologic evidence of infection by cytomegalovirus (CMV), a herpesvirus with known oncogenic potential that has been detected in malignant prostate tissue, in relation to prostate cancer (PCa) risk in a large case–control study nested in the Prostate Cancer Prevention Trial (PCPT). Methods Cases were men with a confirmed diagnosis of PCa after visit 2 ( n = 614), and controls were men not diagnosed with PCa during the trial who also had a negative end-of-study biopsy ( n [...]

Menée sur 699 patientes ne présentant pas de lésions du col de l'utérus et d'infection par le papillomavirus humain selon les tests de dépistage en vigueur, cette étude évalue l'association entre une infection par le VIH (420 cas et 279 témoins) et le risque de lésions précancéreuses ou de cancer du col de l'utérus

RIsk of cervical precancer and cancer among hiv-infected women with normal cervical cytology and no evidence of oncogenic hpv infection

Keller Mj, Burk R. D. Xie X. ; et al.,

Context  US cervical cancer screening guidelines for human immunodeficiency virus (HIV)–uninfected women 30 years or older have recently been revised, increasing the suggested interval between Papanicolaou (Pap) tests from 3 years to 5 years among those with normal cervical cytology (Pap test) results who test negative for oncogenic human papillomavirus (HPV). Whether a 3-year or 5-year screening interval could be used in HIV-infected women who are cytologically normal and oncogenic [...]

Couplée à une cohorte de 14 372 patients ayant survécu à un cancer pédiatrique, cette étude cas-témoins (105 cas et 422 témoins) évalue, en fonction de la dose reçue et du type de cancer au premier diagnostic, le risque de second sarcome après une exposition à des agents chimiothérapeutiques ou à des rayonnements ionisants

Risk Factors Associated with Secondary Sarcomas in Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study

Henderson, Tara O. ; Rajaraman, Preetha ; Stovall, Marilyn ; Constine, Louis S. ; Olive, Aliza ; Smith, Susan A. ; Mertens, Ann ; Meadows, Anna ; Neglia, Joseph P. ; Hammond, Sue ; Whitton, John ; Inskip, Peter D. ; Robison, Leslie L. ; Diller, Lisa

Childhood cancer survivors have an increased risk of secondary sarcomas. To better identify those at risk, the relationship between therapeutic dose of chemotherapy and radiation and secondary sarcoma should be quantified. We conducted a nested case-control study of secondary sarcomas (105 cases, 422 matched controls) in a cohort of 14,372 childhood cancer survivors. Radiation dose at the second malignant neoplasm (SMN) site and use of chemotherapy were estimated from detailed review of medical [...]

Menée sur 369 patients chinois atteints d'un cancer du pancréas et sur 412 témoins en bonne santé, cette étude évalue l'association entre des polymorphismes du gène CD86 et la susceptibilité à cette maladie

CD86 gene variants and susceptibility to pancreatic cancer

Xiang, Honggang ; Zhao, Wei ; Sun, Yanping ; Qian, Winnie ; Xing, Junjie ; Zhou, Yujia ; Yao, Jun ; Xu, Jian ; Wang, Yi ; Yao, Houshan ; Hu, Zhiqian

Background Pancreatic cancer is one of the most lethal cancers worldwide. CD86 (B7-2) is a costimulatory molecule on antigen-presenting cells and plays critical roles in tumor immunity. It has been reported that polymorphisms in CD86 gene can be involved in the development of various cancers. Here, we investigated the association of two CD86 polymorphisms, +1057G/A (rs1129055) and +2379G/C (rs17281995), with pancreatic cancer in the Chinese population. Methods The two polymorphisms were [...]

Menée en population suédoise à partir de données médicales portant sur 5 003 patients atteints d'un cancer de la prostate et sur 4 693 témoins, cette étude évalue l'association entre la mutation germinale G84E du gène HOXB13, 14 autres polymorphismes de ce gène et le risque de développer la maladie

A Population-based Assessment of Germline G84E Mutation and Prostate Cancer Risk

Robert, Karlsson ; Markus, Aly ; Mark, Clements ; Lilly, Zheng ; Jan, Adolfsson ; Jianfeng, Xu ; Henrik, Grönberg ; Fredrik, Wiklund

Background : A rare but recurrent missense mutation (G84E, rs138213197) in the gene homeobox B13 (HOXB13) was recently reported to be associated with hereditary prostate cancer. Objective : To explore the prevalence and penetrance of HOXB13 G84E in a general population. Design, setting, and participants : G84E and 14 additional HOXB13 polymorphisms were genotyped in two population-based, Swedish, case-control samples (Cancer of the Prostate in Sweden [CAPS] and Stockholm-1) comprising 4693 [...]