Menée en Italie à partir de données 1996-2018 d'un registre sur les expositions professionnelles aux agents cancérogènes portant sur 13 715 travailleurs impliqués dans le désamiantage et l'élimination de l'amiante après son interdiction, cette étude analyse la mortalité spécifique (142 décès)

Occupational exposure register-based cohort study on mortality among asbestos-related workers in Italy after the ban

Scarselli, Alberto ; Corfiati, Marisa ; Marinaccio, Alessandro

Objective: Asbestos is a human carcinogen and can cause some types of cancer, including mesothelioma. A relevant number of workers are still engaged in asbestos removal and disposal activities, whose actual risk of asbestos-related diseases is still scarcely recognized. The main objective of this study is to assess the cause-specific mortality among workers involved in asbestos removal and disposal after the ban in Italy. Methods: Data from the Information System on Occupational Exposure to [...]

Menée en Espagne sur la période 2008-2013 auprès de 927 témoins et 697 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre une ingestion de nitrates et de trihalométhanes contenus dans l'eau de boisson et le risque de développer la maladie

Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Prostate Cancer: A Multicase–Control Study in Spain (MCC-Spain)

Carolina Donat-Vargas ; Manolis Kogevinas ; Gemma Castaño-Vinyals ; Beatriz Pérez-Gómez ; Javier Llorca ; Mercedes Vanaclocha-Espí ; Guillermo Fernandez-Tardon ; Laura Costas ; Nuria Aragonés ; Inés Gómez-Acebo ; Victor Moreno ; Marina Pollan ; Cristina M. Villanueva

BACKGROUND: Nitrate and trihalomethanes (THMs) in drinking water are widespread and are potential human carcinogens. OBJECTIVE: We evaluated the association between drinking-water exposure to nitrate and THMs and prostate cancer. METHODS: During the period 2008–2013, 697 hospital-based incident prostate cancer cases (97 aggressive tumors) and 927 population-based controlswere recruited in Spain, providing information on residential histories and type of water consumed. Average nitrate and THMs [...]

Menée à partir de données 1959-1966 de registres californiens portant sur plus de 18 000 dyades mère-enfant(s), cette étude analyse l'association entre une exposition in utero aux antiémétiques et le risque, pour l'enfant, de développer un cancer colorectal à l'âge adulte

In utero exposure to anti-emetic and risk of adult-onset colorectal cancer

Murphy, Caitlin C ; Cirillo, Piera M ; Krigbaum, Nickilou Y ; Singal, Amit G ; Cohn, Barbara A

Incidence rates of colorectal cancer (CRC) are increasing among adults born in and after the 1960s, implicating pregnancy-related exposures introduced at that time as risk factors. Dicyclomine, an antispasmodic used to treat irritable bowel syndrome, was initially included in Bendectin (doxylamine/pyridoxine/dicyclomine), an anti-emetic prescribed during pregnancy in the 1960s.We estimated the association between in utero exposure to Bendectin and risk of CRC in offspring of the Child Health [...]

Menée auprès de 257 témoins et 281 patients atteints d'un carcinome hépatocellulaire et infectés par une hépatite B ou C, cette étude analyse l'association entre des biomarqueurs d'un dysfonctionnement de la barrière intestinale et le risque de développer un carcinome hépatocellulaire

Biomarkers of gut barrier dysfunction and risk of hepatocellular carcinoma in the REVEAL-HBV and REVEAL-HCV Cohort Studies

Petrick, Jessica L. ; Florio, Andrea A. ; Zen, Jane ; Wang, Yanyu ; Gewirtz, Andrew T. ; Pfeiffer, Ruth M. ; Loftus, Sarah ; Inglefield, Jon ; Koshiol, Jill ; Yang, Baiyu ; Yu, Kelly ; Hildesheim, Allan ; Chen, Chien-Jen ; Yang, Hwai-I ; Lee, Mei-Hsuan ; McGlynn, Katherine A.

Gut barrier dysfunction can result in the liver being exposed to an elevated level of gut-derived bacterial products via portal circulation. Growing evidence suggests that systemic exposure to these bacterial products promotes liver diseases including hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). However, prospective studies have not examined the association between biomarkers of gut barrier dysfunction and HCC risk in a population of hepatitis B or C viral (HBV/HCV) carriers. We [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mai 2022 (69 études), cette méta-analyse évalue l'association entre différents indicateurs anthropométriques d'adiposité (autres que l'indice de masse corporelle) et le risque de cancer primitif du foie

Anthropometric Indicators of Adiposity and Risk of Primary Liver Cancer: A Systematic Review and Dose-Response Meta-analysis

Yan, Lun-Jie ; Yang, Long-Shan ; Yan, Yu-Chuan ; Tan, Si-Yu ; Ding, Zi-Niu ; Liu, Hui ; Wang, Dong-Xu ; Dong, Zhao-Ru ; Li, Tao

Background & Aims: Adiposity is associated with an increased risk of primary liver cancer (PLC). As the most commonly used indicator of adiposity, the body mass index (BMI) has been questioned for its limitations in reflecting visceral fat. This study aimed to investigate the role of different anthropometric indicators in identifying the risk of PLC by accounting for potential nonlinear associations. Methods: Systematic searches were conducted in the PubMed, Embase, Cochrane Library, Sinomed, [...]

Menée lors d'une autopsie et à l'aide du séquençage ciblé de 61 gènes chez 99 témoins et 90 personnes atteintes d'un cancer sans antécédent familial, cette étude identifie des variants constitutionnels rares associés au risque de cancer du pancréas (72 cas)

Rare germline variants in pancreatic cancer and multiple primary cancers: an autopsy study

Fujitani, Hiroo ; Eguchi, Hidetaka ; Kochi, Yuta ; Arai, Tomio ; Muramatsu, Masaaki ; Okazaki, Yasushi

Background: There is a lack of information on rare germline variants of pancreatic cancer-predisposing genes. Risk genes for multiple primary cancers may overlap with those for pancreatic cancer. Methods: A retrospective study of autopsy cases with a negative family history in the Japanese single nucleotide polymorphism for geriatric research database examined rare germline variants in the protein-coding regions of 61 genes. Targeted sequencing of these genes was performed and classified for [...]