Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Understanding the Impact of COVID-19 on Chronic Lymphocytic Leukemia (CLL) Caregiving and Related Resource Needs

Bagautdinova, Diliara ; Bacharz, Kelsey C. ; Bylund, Carma L. ; Sae-Hau, Maria ; Weiss, Elisa S. ; Rajotte, Michelle ; Lincoln, Greg ; Vasquez, Taylor S. ; Parker, Naomi D. ; Wright, Kevin B. ; Fisher, Carla L.

Chronic lymphocytic leukemia (CLL) caregivers play a central role in disease management—a role that has been heightened during the COVID-19 pandemic given the healthcare system’s reliance on frontline family caregivers and CLL patients’ increased risk of infection and mortality. Using a mixed-method design, we investigated the impact of the pandemic on CLL caregivers (Aim 1) and their perceived resource needs (Aim 2): 575 CLL caregivers responded to an online survey; 12 spousal CLL caregivers [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

The Humoral Response of Patients With Cancer to Breakthrough COVID-19 Infection or the Fourth BNT162b2 Vaccine Dose

Cohen, Idan ; Campisi-Pfinto, Salvatore ; Rozenberg, Orit ; Colodner, Raul ; Bar-Sela, Gil

Since January 2022 in Israel, high-risk populations with underlying health conditions were advised to receive a fourth dose of the BNT162b2 vaccine (Pfizer-BioNTech) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We monitored vaccine-induced immunity among oncology patients undergoing systemic anti-cancer therapy before and after the 4th-BNT162b2-dose. Three groups of patients were included in the study: those who received 3rd-BNT162b2-dose and had no breakthrough [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

mRNA—From COVID-19 Treatment to Cancer Immunotherapy

Krause, Werner

This review provides an overview covering mRNA from its use in the COVID-19 pandemic to cancer immunotherapy, starting from the selection of appropriate antigens, tumor-associated and tumor-specific antigens, neoantigens, the basics of optimizing the mRNA molecule in terms of stability, efficacy, and tolerability, choosing the best formulation and the optimal route of administration, to summarizing current clinical trials of mRNA vaccines in tumor therapy.

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

The Mental Health Burden of Patients with Colorectal Cancer Receiving Care during the COVID-19 Pandemic: Results of the PICO-SM Study

Lim, Kok Haw Jonathan ; Ntellas, Panagiotis ; Anderson, Daniel ; Simpson, Lilly ; Braun, Michael ; Adamou, Marios ; Barriuso, Jorge ; Dadouli, Katerina ; Connell, Jacqueline ; Williams, Joseph ; Germetaki, Theodora ; Lehwald, Deirdre ; Fitzpatrick, Niall ; Cutting, Mark ; McCool, Danielle ; Hasan, Jurjees ; Mullamitha, Saifee ; Marti, Kalena ; Saunders, Mark ; Kamposioras, Konstantinos

The COVID-19 pandemic has resulted in unprecedented changes to the life of patients with cancer. In this study, we aim to evaluate the impact of the COVID-19 pandemic on the mental health and general well-being of patients with colorectal cancer by carrying out a prospective longitudinal questionnaire. We found that around one in four participants reported symptoms of anxiety and poor well-being, with 15% at risk of moderate to severe depression. Amongst others, those who were worried that the [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Anticancer Therapy and Mortality of Adult Patients with Hematologic Malignancy and COVID-19: A Systematic Review and Meta-Analysis

Lin, Wen-Li ; Nguyen, Thi-Hoang-Yen ; Wu, Li-Min ; Huang, Wen-Tsung ; Su, Shih-Bin

Coronavirus disease 2019 (COVID-19) might affect cancer treatment outcomes. This systematic review and meta-analysis identified the prognostic predictors of adult patients with hematologic malignancies and COVID-19, and evaluated the effect of anticancer therapy on mortality. We performed a literature search of electronic databases and identified additional studies from the bibliographies of the articles that were retrieved. Two investigators independently extracted data according to the [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Impact of the COVID-19 pandemic on cancer care in Ireland – Perspectives from a COVID-19 and Cancer Working Group

O'Reilly, Seamus ; Kathryn Carroll, Hailey ; Murray, Deirdre ; Burke, Louise ; McCarthy, Triona ; O’Connor, Robert ; Kilty, Claire ; Lynch, Sonya ; Feighan, Jennifer ; Cloherty, Maeve ; Fitzpatrick, Patricia ; Falvey, Katrina ; Murphy, Verena ; Jane O'Leary, Mary ; Gregg, Sophie ; Young, Leonie ; McAuliffe, Eilish ; Hegarty, Josephine ; Gavin, Anna ; Lawler, Mark ; Kavanagh, Paul ; Spillane, Susan ; McWade, Terry ; Heffron, Mairead ; Ryan, Karen ; Kelly, Paul ; Murphy, Aileen ; Corrigan, Mark ; Redmond, H. Paul ; Redmond, Patrick ; Walsh, Paul ; Tierney, Paula ; Zhang, Mengyang ; Bennett, Kathleen ; Mullooly, Maeve

Upon the COVID-19 pandemic onset in Ireland, cancer service disruptions occurred due to prioritisation of COVID-19 related care, redeployment of staff, initial pausing of screening, diagnostic, medical and surgical oncology procedures, staff shortages due to COVID-19 infection and impacts on the physical and mental health of cancer healthcare workers. This was coupled with reluctance among people with symptoms suspicious for cancer to attend for clinical evaluation, due to concerns of [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Influence of COVID-19 Pandemic on Colorectal Cancer Presentation, Management and Outcome during the COVID-19 Pandemic

Pirozzi, B. M. ; Siragusa, L. ; Baldini, G. ; Pellicciaro, M. ; Grande, M. ; Efrati, C. ; Finizio, R. ; Formica, V. ; Del Vecchio Blanco, G. ; Sica, G. S.

The aim of the study was to investigate whether the COVID-19 pandemic and related measures had an influence on colorectal cancer (CRC) presentation, management, and outcomes; it was a retrospective monocentric study. CRC patients undergoing surgery during the COVID-19 pandemic (1 March 2020–28 February 2022) (group B) were compared with patients operated on in the previous two years (1 March 2018–29 February 2020) in the same unit (group A). The primary outcome was to investigate whether there [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Effectiveness of nirmatrelvir plus ritonavir treatment for patients with CLL during the Omicron Surge

Tadmor, Tamar ; Alapi, Hillel ; Rokach, Lior

Patients with CLL, even in the omicron era and post-vaccination, suffer from persistent covid, higher complications and mortality compared to the general population. In the current study, we evaluated retrospectively the effectiveness of Nirmatrelvir plus ritonavir among 1,080 patients with CLL that were infected with SARS-CoV-2. Nirmatrelvir administration was associated with a reduction in Covid-19-related hospitalization or death by day 35. Specifically, the rate of Covid-19-related [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Impact of COVID-19 Pandemic on Frontline Pembrolizumab-Based Treatment for Advanced Lung Cancer

Tanvetyanon, Tawee ; Chen, Dung-Tsa ; Gray, Jhanelle E.

Background: Pembrolizumab monotherapy or pembrolizumab plus chemotherapy has become an important frontline treatment for advanced non-small cell lung cancer (NSCLC). To date, it remains unclear how the coronavirus disease 2019 (COVID-19) pandemic impacted the treatment outcome. Methods: A quasi-experimental study was conducted based on a real-world database, comparing pandemic with pre-pandemic patient cohorts. The pandemic cohort consisted of patients who initiated treatment from March to July [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

The Impact of the Early COVID-19 Global Pandemic on Children Undergoing Active Cancer Treatment and Their Parents

Tran, Andrew ; Hou, Sharon H. J. ; Forbes, Caitlin ; Cho, Sara ; Forster, Victoria J. ; Stokoe, Mehak ; Wakefield, Claire E. ; Wiener, Lori ; Heathcote, Lauren C. ; Michel, Gisela ; Patterson, Pandora ; Reynolds, Kathleen ; Schulte, Fiona S. M.

Background: The COVID-19 global pandemic has impacted people worldwide with unique implications for vulnerable groups. In this cross-sectional study, we examined the impact of the early pandemic on children undergoing active cancer treatment and their parents. (2) Methods: In May 2020, 30 parents of children undergoing active cancer treatment completed an online survey regarding the impact of COVID-19 on their child’s cancer care, perceived utility of telemedicine, and child and parent mental [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

The Effect of Vinyasa Yoga Practice on the Well-Being of Breast-Cancer Patients during COVID-19 Pandemic

Zok, Agnieszka ; Matecka, Monika ; Zapala, Joanna ; Izycki, Dariusz ; Baum, Ewa

Background: Vinyasa yoga practice improves body fitness and potentially positively affects practitioners’ well-being and health. Due to the diverse intensity of practice and positions customized to the practitioner’s needs, it can also support cancer patients. Undertaking physical activity that has a potentially positive effect on well-being and health was particularly important during the self-isolation that followed the COVID-19 pandemic. The purpose of this study was to evaluate the impact [...]

Menée au Canada à partir de données portant sur 2 737 patients âgés atteints d'un cancer (âge : supérieur ou égal à 65 ans), cette étude analyse l'association entre une utilisation d'antibiotiques antérieure au traitement par inhibiteurs de points de contrôle immunitaire et la survie globale

Impact of Antibiotic Exposure Before Immune Checkpoint Inhibitor Treatment on Overall Survival in Older Adults With Cancer: A Population-Based Study

Lawson Eng ; Rinku Sutradhar ; Yue Niu ; Ning Liu ; Ying Liu ; Yosuf Kaliwal ; Melanie L. Powis ; Geoffrey Liu ; Jeffrey M. Peppercorn ; Philippe L. Bedard ; Monika K. Krzyzanowska

PURPOSE: Antibiotic exposure before immune checkpoint inhibitor (ICI) treatment can negatively affect outcomes through alteration in the gut microbiome, but large-scale evaluations are lacking. We performed a population-level retrospective cohort study to evaluate the impact of antibiotic exposure before starting ICI on overall survival (OS). PATIENT AND METHODS: Patients with cancer, age 65 years or older, who initiated treatment with ICIs between June 2012 and October 2018 in Ontario, Canada, [...]

Menée au Canada à partir de données portant sur 2 737 patients âgés atteints d'un cancer (âge : supérieur ou égal à 65 ans), cette étude analyse l'association entre une utilisation d'antibiotiques antérieure au traitement par inhibiteurs de points de contrôle immunitaire et la survie globale

Antibiotic Therapy: The Cornerstone of Iatrogenic Resistance to Immune Checkpoint Inhibitors

David J. Pinato ; Alessio Cortellini

The past decade has been testament to the diffusion of immune checkpoint inhibitors (ICIs) as part of the therapeutic armamentarium of nearly every oncologic indication. The unquestionable advances in the management of solid and hematologic malignancies ushered by selective modulation of programmed cell-death 1, cytotoxic T-lymphocyte–associated protein 4, and a growing additional number of putative actionable drivers of anticancer immunity have been accompanied by the compelling need to [...]