A partir d'une revue systématique de la littérature (5 études, 461 patients pédiatriques), cette étude analyse l'effet, sur la prise en charge et la réduction d'une mucite buccale induite par la chimiothérapie, d'une mastication de chewing-gum chez des enfants atteints d'un cancer

Effect of chewing gum on the management of chemotherapy-induced oral mucositis in children: Systematic review of experimental studies

Semerci, Remziye ; Kocaaslan, Esra Nur

Objective : It was aimed to systematically synthesise the available literature on examining the effect of chewing gum in the management/reduction of chemotherapy-induced oral mucositis in children. Methods : The PRISMA was followed for the systematic review. All published studies obtained from the relevant databases were examined while the research question and inclusion and exclusion criteria were considered. The Joanna Briggs Institute (JBI) critical appraisal tools were used to evaluate the [...]

Menée aux Etats-Unis à partir de données portant sur 257 patientes atteintes d'un cancer métastatique du sein, cette étude rétrospective analyse les facteurs associés au risque de neutropénie de grade 3/4 induite par le palbociclib

Risk factors associated with palbociclib-induced neutropenia in patients with metastatic breast cancer

Lavery, Lesli ; DiSogra, Kristyn ; Lea, Julia ; Trufan, Sally J. ; Symanowski, James T. ; Roberts, Ashley ; Moore, Donald C. ; Heeke, Arielle ; Pal, Sridhar

Background : Neutropenia is the most common adverse event with palbociclib, an oral cyclin-dependent kinase 4/6 inhibitor, with grade 3/4 neutropenia occurring in up to 67% of patients in phase III trials evaluating this agent in metastatic breast cancer. This retrospective chart review assessed characteristics of patients on palbociclib to evaluate for risk factors in the development of grade 3/4 neutropenia. Patients and methods : Patients with metastatic breast cancer who received [...]

A partir d'une revue systématique de la littérature (27 études), cette étude analyse la capacité de mastication des patients traités pour un cancer de la cavité buccale et l'impact sur la qualité de vie

Mastication in health-related quality of life in patients treated for oral cancer: A systematic review

Vermaire, Jorine A. ; Partoredjo, Abbergayle S. K. ; de Groot, Reilly J. ; Brand, Henk S. ; Speksnijder, Caroline M.

Introduction : Treatment for oral cancer can impair oral functions such as mastication, which may negatively affect quality of life (QoL). In this review, an overview is provided of masticatory ability in patients treated for oral cancer. Methods : The PubMed (MEDLINE), Embase and Cochrane databases were systematically searched for scientific literature on masticatory ability in relation to QoL in patients treated for oral cancer. Studies were included when oral cancer treatment was provided, [...]

Menée à partir des données 2000-2017 des registres amériains des cancers portant sur 1 099 enfants et adolescents atteints d'un cancer hépatique (âge : 0-19 ans), cette étude analyse l'évolution de l'incidence de la maladie en fonction de facteurs sociodémographiques et du sous-type histologique

Incidence and trends of hepatic cancer among children and adolescents in the United States from 2000 to 2017: Evidence from the Surveillance, Epidemiology, and End Results registry data

Li, Peiyi ; Kong, Yujia ; Guo, Jing ; Ji, Xu ; Han, Xuesong ; Zhang, Bo

Objective : Primary liver tumors are rare pediatric malignancies. Knowledge of the epidemiology of pediatric liver tumors is limited. This study aims to present the national incidence trends of pediatric liver tumors over 18 years, according to sociodemographic and histological subtype variation. Methods : The Surveillance, Epidemiology, and End Results registry was queried from 2000 to 2017 for 1,099 patients between ages 0 and 19 with liver tumors. Age-standardized incidence rates by age, [...]

Menée en France à partir des données d'un registre régional des cancers digestifs portant sur 26 813 patients atteints d'un cancer colorectal diagnostiqué entre 1976 et 2018, cette étude analyse l'évolution de l'incidence de métastatases hépatiques synchrones et métachrones d'origine colorectale, ainsi que la survie

Incidence and Survival in Synchronous and Metachronous Liver Metastases From Colorectal Cancer

Reboux, Noémi ; Jooste, Valérie ; Goungounga, Juste ; Robaszkiewicz, Michel ; Nousbaum, Jean-Baptiste ; Bouvier, Anne-Marie

Importance : Although treatment and prognosis of synchronous liver metastases from colorectal cancer are relatively well known, a comparative description of the incidence, epidemiological features, and outcomes of synchronous and metachronous liver metastases is lacking. The difference in prognosis between patients with synchronous and metachronous liver metastases is controversial. Objective : To investigate temporal patterns in the incidence and outcomes of synchronous vs metachronous liver [...]

Menée à partir de données internationales, cette étude compare l'évolution, sur la période 1998-2012, de l'incidence du cancer de l'estomac et du cancer de l'oesophage par sous-type

Population-based investigation of common and deviating patterns of gastric cancer and oesophageal cancer incidence across populations and time

Li, Mengmeng ; Park, Jin Young ; Sheikh, Mahdi ; Kayamba, Violet ; Rumgay, Harriet ; Jenab, Mazda ; Narh, Clement Tetteh ; Abedi-Ardekani, Behnoush ; Morgan, Eileen ; de Martel, Catherine ; McCormack, Valerie ; Arnold, Melina

Background :The subtypes of gastric cancer (GC) and oesophageal cancer (EC) manifest distinct epidemiological profiles. Here, we aim to examine correlations in their incidence rates and to compare their temporal changes globally, both overall and by subtype. Menée Methods: Long-term incidence data were obtained from population-based registries available from the Cancer Incidence in Five Continents series. Variation in the occurrence of EC and GC (overall and by subtype) was assessed using the [...]

Menée aux Etats-Unis à partir de données portant sur 656 patients atteints d'un cancer colorectal de stade IV, cette étude analyse l'association entre une obésité avant le diagnostic, une utilisation d'aspirine après le diagnostic et la survie globale

Association of Prediagnosis Obesity and Postdiagnosis Aspirin With Survival From Stage IV Colorectal Cancer

Davis, Jennifer S. ; Chavez, Janelle C. ; Kok, Melissa ; San Miguel, Yazmin ; Lee, Hwa Young ; Henderson, Henry ; Overman, Michael J. ; Morris, Van ; Kee, Bryan ; Fogelman, David ; Advani, Shailesh M. ; Johnson, Benny ; Parseghian, Christine ; Shen, John Paul ; Dasari, Arvind ; Shaw, Kenna R. ; Vilar, Eduardo ; Raghav, Kanwal P. ; Shureiqi, Imad ; Wolff, Robert A. ; Meric-Bernstam, Funda ; Maru, Dipen ; Menter, David G. ; Kopetz, Scott ; Chang, Shine

Importance: The potential relationship between obesity and colorectal cancer (CRC) outcome is poorly understood in patients with late-stage disease. Increased body mass index may negate aspirin use for cancer prevention, but its role as a factor on the effectiveness of postdiagnosis aspirin use is unclear. Objective : To evaluate how prediagnosis obesity and postdiagnosis aspirin use may be associated with overall survival in patients with late-stage colorectal cancer. Design, Setting, and [...]

Menée à partir de données portant sur 33 662 patientes atteintes d'un cancer du sein, cette étude multicentrique compare les caractéristiques clinico-pathologiques et les résultats cliniques des cancers lobulaires invasifs et des cancers canalaires invasifs

Clinicopathological Features and Outcomes Comparing Patients With Invasive Ductal and Lobular Breast Cancer

Oesterreich, Steffi ; Nasrazadani, Azadeh ; Zou, Jian ; Carleton, Neil ; Onger, Tiffany ; Wright, Matthew D. ; Li, Yujia ; Demanelis, Kathryn ; Ramaswamy, Bhuvaneswari ; Tseng, George ; Lee, Adrian V. ; Williams, Nicole ; Kruse, Megan

Background : There is increasing interest in better understanding the biology and clinical presentation of invasive lobular cancer (ILC), which is the most common special histological subtype of breast cancer. Limited large contemporary data sets are available allowing comparison of clinicopathologic features between ILC and invasive ductal cancer (IDC). Methods : The Great Lakes Breast Cancer Consortium was formed to compare clinical behavior of ILC (n = 3617) and IDC (n = 30 045) from 33 662 [...]

A partir d'une revue systématique de la littérature (28 essais randomisés, 3 876 patients), cette méta-analyse évalue l'intérêt, pour améliorer leur qualité de vie et soulager leur détresse psychologique, d'interventions psycho-pédagogiques dédiées aux aidants d'adultes atteints d'un cancer

The Effectiveness of Psychoeducational Interventions on Caregiver-Oriented Outcomes in Caregivers of Adult cancer patients: A Systematic Review and Meta-analysis

Kusi, Grace ; Atenafu, Eshetu G. ; Boamah Mensah, Adwoa Bemah ; Lee, Charlotte T. ; Viswabandya, Auro ; Puts, Martine ; Mayo, Samantha

Objective : Cancer caregiving can result in increased psychosocial distress and poor health-related quality of life. Psychoeducation has been shown to be effective in enhancing caregiving-oriented outcomes. A systematic assessment of the overall effect of psychoeducational intervention (PEI) and identification of individual intervention characteristics that may contribute to the effectiveness of PEI is needed. Methods : For this meta-analysis, relevant articles were identified through [...]

Cette étude présente une intervention psychosociale en ligne destinée aux jeunes adultes ayant survécu à un cancer (âge : 18-39 ans) et comportant des exercices de relaxation, une psychothérapie de groupe et de l'éducation à la santé

Development and initial testing of TOGETHER-YA: an eHealth-delivered and group-based psychosocial intervention for young adult cancer survivors

Oswald, Laura B. ; Lyleroehr, Madison ; Gudenkauf, Lisa M. ; Armstrong, Grace E. ; Tometich, Danielle B. ; Sanford, Stacy D. ; Loecher, Nele ; Geiss, Carley ; Rodriguez, Yvelise ; Scheel, Kelsey L. ; Nieves-Lopez, Amarilis ; Jim, Heather S. L. ; Gonzalez, Brian D. ; Antoni, Michael H. ; Penedo, Frank J. ; Reed, Damon ; Katsanis, Emmanuel ; Salsman, John M. ; Victorson, David ; Fox, Rina S.

Purpose : This study aimed to (1) develop TOGETHER-YA, an e-Health-delivered and group-based health-related quality of life (HRQOL) intervention for young adult (YA) cancer survivors aged 18–39 (Part 1), and (2) determine its initial feasibility and acceptability in a single-arm pilot trial (Part 2). Methods : TOGETHER-YA is a manualized, 10-week intervention for YA survivors that includes elements of relaxation training, cognitive-behavioral therapy, and health education. In Part 1, content [...]

Menée par enquête en ligne auprès de 269 patientes atteintes d'un cancer du sein HR+, cette étude analyse les facteurs associés à la confiance des patientes en leur médecin, et l'association entre cette confiance et l'adhésion à une thérapie endocrinienne adjuvante

The role of trust in the acceptance of adjuvant endocrine therapy in breast cancer patients

C, Elfgen ; U, Güth ; CJ, Tausch ; K, Däster ; D, Ritter ; Urte, Scholz ; W, Bierbauer

Objective : Despite adjuvant endocrine therapy (AET) considerably reducing mortality and recurrence in hormonal receptor-positive (HR+) breast cancer (BC) patients, acceptance of AET remains an issue. The reasoning behind the lack of acceptance is complex and multifactorial, and some associated risk factors have been previously analyzed. Our study aims to assess women's beliefs and concerns toward AET and women’s trust in the treating physician, focusing on determining the importance of these [...]

Menée par enquête en ligne auprès de 204 patientes ayant survécu à un cancer du sein, cette étude analyse l'association entre leur peur de la récidive de la maladie et leur façon d'affronter la maladie

Fear of cancer recurrence and coping attitudes of breast cancer survivors

Oztas, Bediye ; Ugurlu, Meltem ; Kurt, Gonul

Objective : This study aimed to determine the fear of cancer recurrence levels and coping orientation of breast cancer survivors. Methods : This descriptive exploratory study was conducted using a web-based online survey. This article is written using the STROBE checklist. The study was completed with 204 women participants. Data were collected using the ‘Demographic and Clinical Information Form’, ‘Fear of Cancer Recurrence Inventory (FCRI)’ and ‘Coping Orientation to Problems Experienced [...]

Menée aux Etats-Unis dans un contexte de vie réelle, cette étude analyse le rapport coût-efficacité des traitements de première ligne (prostatectomie radicale, curiethérapie, radiothérapie par faisceau d'électrons, ...) chez des patients atteints d'un cancer localisé de la prostate

Cost-effectiveness analysis of primary treatments for localised prostate cancer: A population-based Markov analysis using real-world evidence

Weng, Xiuhua ; Zhong, Lixian ; Xiang, Pin ; Li, Yiyuan ; Paciorek, Alan ; Dong, Liangliang ; Broering, Jeanette ; Carroll, Peter R. ; Sanda, Martin ; Wilson, Leslie

Objective : We evaluate cost-effectiveness of primary treatments for localised prostate cancer by uniquely combining prospectively collected real-world outcomes and costs from UCSF Cancer of Prostate Strategic Urologic Research Endeavor (CaPSURE™). Methods : Markov models assessed cost-effectiveness of radical prostatectomy (RP), brachytherapy, electron beam radiation therapy (EBRT) and brachytherapy with EBRT by risk from US payers perspective over 8 years. Treatment costs included office [...]

Menée dans un contexte américain, cette étude compare le rapport coût-efficacité de deux stratégies de chimiothérapies néoadjuvantes pour traiter les patients atteints d'un cancer de la vessie avec envahissement musculaire, l'une à base de méthotrexate, vinblastine, doxorubicine et cisplatine, et l'autre
à base de gemcitabine et cisplatine

Comparative cost-effectiveness of neoadjuvant chemotherapy regimens for muscle-invasive bladder cancer: Results according to VESPER data

Joyce, Daniel D. ; Wymer, Kevin M. ; Sharma, Vidit ; Moriarty, James P. ; Borah, Bijan J. ; Geynisman, Daniel M. ; Plimack, Elizabeth R. ; Costello, Brian A. ; Pagliaro, Lance C. ; Boorjian, Stephen A.

Background : The VESPER trial demonstrated improved progression-free (PFS) and (preliminarily) overall survival (OS) with six cycles of neoadjuvant dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVACx6) versus four cycles of gemcitabine and cisplatin (GCx4) before radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC), but with increased toxicity. This study compares the cost-effectiveness of these regimens. Methods : A cost-effectiveness analysis of neoadjuvant [...]