Menée à l'aide de données japonaises portant sur 18 158 cinquantenaires, cette étude analyse l'association entre la taille, l'indice de masse corporelle, l'activité physique et le risque de cancer colorectal par sous-type, en fonction du niveau d'expression des récepteurs à insuline

Height, body mass index, physical activity, and risk of colorectal cancer in relation to expression of insulin receptor: The Japan Public Health Center-based Prospective Study

Nishihara, Kenshiro ; Nakano, Shiori ; Yamaji, Taiki ; Goto, Atsushi ; Hidaka, Akihisa ; Shimazu, Taichi ; Kuchiba, Aya ; Saito, Masahiro ; Kunishima, Fumihito ; Nakaza, Ryouji ; Kato, Ikuma ; Sawada, Norie ; Inoue, Manami ; Tsugane, Shoichiro ; Iwasaki, Motoki ; for the Japan Public Health Center-based Prospective Study Group

To ascertain the involvement of insulin receptors (IRs) in colorectal carcinogenesis, we investigated the association of height, body mass index (BMI), and physical activity with colorectal cancer (CRC) and two subtypes of CRC according to the expression level of IR. We utilized data from a large-scale, population-based prospective cohort study of 18,158 middle-aged and elderly subjects in Akita and Okinawa, Japan. In the statistical analysis, we used the Cox proportional hazards model and [...]

Menée à partir de données multicentriques portant sur 1,6 million de patients atteints de diabète de type 2 (âge moyen : 59,8 ans ; 47 % de femmes ; durée de suivi : 15 ans), cette étude analyse l'association entre l'utilisation d'un traitement par agonistes des récepteurs du GLP-1 et le risque de cancer lié à l'obésité (13 localisations)

Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients With Type 2 Diabetes

Wang, Lindsey ; Xu, Rong ; Kaelber, David C. ; Berger, Nathan A.

Thirteen human malignant neoplasms have been identified as obesity-associated cancers (OACs), ie, the presence of excess body fat is associated with increased risk of developing cancer and worse prognosis in patients with these specific tumors. The glucagon-like peptide receptor agonist (GLP-1RA) class of pharmaceuticals are effective agents for the treatment of type 2 diabetes (T2D) and for achieving weight loss, but the association of GLP-1RAs with the incident risk of 13 OACs is unclear.To [...]

Cette étude passe en revue les progrès réalisés dans les stratégies de chimioprévention des cancers de la tête et du cou

Chemoprevention of head and neck cancer: a review of current approaches and future perspectives

Han, Sanghoon ; Bommireddy, Ramireddy ; Kim, Pauline ; Selvaraj, Periasamy ; Shin, Dong M.

Head and neck squamous cell carcinoma (HNSCC) is a spectrum of heterogeneous malignancies. A variety of genetic, environmental, and lifestyle factors contribute to the development of HNSCC. Carcinogenesis is a multistep process in which cell proliferation-associated oncogenes and cell cycle regulation-associated tumor suppressor genes are dysregulated resulting in premalignant lesions. Immune evasion is a critical step in the progression of benign lesions to advanced cancer. This review [...]

Mené sur 146 adolescents vaccinés contre le papillomavirus humain (âge moyen : 13,3 ans), cet essai international de phase III évalue l'effet, sur l'immunogénicité et la sécurité du vaccin nonavalent, d'un allongement du délai entre les 2 doses (intervalle : 12-53 mois)

Immunogenicity and Safety of Extended-Interval 2-Dose Regimens of 9vHPV Vaccine

Klein, Nicola P. ; Wiesner, Amy ; Bautista, Oliver ; Group, Thomas ; Kanu, Kevin ; Li, Zhongyi “Lucy” ; McCauley, Jennifer ; Saxena, Kunal ; Tota, Joseph ; Luxembourg, Alain ; Bonawitz, Rachael

Nine-valent human papillomavirus (9vHPV) vaccines can be administered in 2 doses 6 to 12 months apart in adolescents. The impact of extended dose intervals is unknown. We report immunogenicity and safety data in adolescents of a second 9vHPV vaccine dose administered ≥1 year after the first.This open-label safety and immunogenicity study (NCT04708041) assessed extended-interval 2-dose regimens of 9vHPV vaccine among adolescents (10 to 15 years) who received 2 9vHPV vaccine doses: the first ≥1 [...]

Menée en 2022 par questionnaire auprès de 407 Françaises (âge : 25-40 ans), cette étude analyse les facteurs associés à un dépistage du cancer du col de l'utérus et/ou à la vaccination contre les papillomavirus humains

A transversal cross-sectional study of factors related to HPV vaccination status and cancer screening participation among French women aged 25–40

Serman, Fanny ; Lisembard, Gabrielle ; Sahraoui, Maxence ; Berkhout, Christophe ; Rochoy, Michaël ; Haro, Anthony ; Calafiore, Matthieu

Background: In 2020, uterine cervical cancer (UCC) was the 12th most common cancer among women in France and the 4th worldwide. French health authorities wanted to increase Human Papilloma Virus (HPV) vaccination and screening rates. There were still many barriers to these measures among young women, their families, and health professionals and teachers. Between 2014 and 2019, international studies found inconsistent effects of HPV vaccination on UCC screening. In 2022, a survey was conducted [...]

Menée à l'aide de données d'une enquête américaine, cette étude analyse, pour la période 2000-2019, l'association entre le prix des cigarettes, les dépenses pour la lutte antitabac au niveau de l'État et l'évolution des comportements tabagiques des 18-24 ans

Cigarette smoking decline among US young adults from 2000 to 2019, in relation to state-level cigarette price and tobacco control expenditure

Messer, Karen ; Pierce, John P ; Chen, Jiayu ; Luo, Man ; Stone, Matthew D ; Leas, Eric C ; Shi, Yuyan ; Strong, David R ; Trinidad, Dennis R ; McMenamin, Sara B

Objective: To investigate the association of state-level cigarette price and tobacco control expenditure with the large 2000–2019 decline in cigarette smoking among US 18–24 year-olds. Methods: Smoking behaviour was assessed in the 24 most populous US states using the 1992–2019 Tobacco Use Supplements to the Current Population Survey; association with price and expenditure was tested using adjusted logistic regression. States were ranked by inflation-adjusted average price and tobacco control [...]

Menée à partir de données 2009-2022 concernant la vaccination contre le papillomavirus humain, les recommandations nationales et la gestion du dépistage, cette étude analyse l'effet des mesures de prévention sur l'incidence du cancer du col de l’utérus au Danemark

Cervical cancer incidence in Denmark: Disentangling determinants of time trend

Lynge, Elsebeth ; Bennekou Schroll, Jeppe ; Andersen, Berit ; Balasubramaniam, Kirubakaran ; Poulsgaard Frandsen, Anna ; Ibfelt, Else Helene ; Jochumsen, Kirsten Marie ; Bruun Laustsen, Maja Ulrikka ; Nielsen, Susanne ; Salmani, Rouzbeh ; Schledermann, Doris ; Hall Viborg, Petra Birgitta ; Waldstrøm, Marianne ; Napolitano, George ; Serizawa, Reza

Cervical cancer is a preventable disease. Nevertheless, stagnation has been seen in incidence rates also in countries with well-functioning healthcare. On this basis, we investigated associations between control interventions and changes in cervical cancer incidence in Denmark from 2009 to 2022. Data on human papillomavirus (HPV)-vaccination were retrieved from Staten's Serum Institute; on screening recommendations from Danish Health Authority, on screening performance from Danish Quality [...]