Menée à partir de données de la "Global Biobank Meta-analysis Initiative" incluant 1,8 million de participants, cette étude analyse l'association entre une bronchopneumopathie chronique obstructive (BPCO) et le risque de cancer (10 localisations)

Associations between chronic obstructive pulmonary disease and ten common cancers: novel insights from Mendelian randomization analyses

Liao, Shixia ; Wang, Yanwen ; Zhou, Jian ; Liu, Yuting ; He, Shuangfei ; Zhang, Lanying ; Liu, Maomao ; Wen, Dongmei ; Sun, Pengpeng ; Lu, Guangbing ; Wang, Qi ; Ouyang, Yao ; Song, Yongxiang

Background: Chronic obstructive pulmonary disease (COPD) is a significant global health issue, suspected to elevate the risk for various cancers. This study sought to discern whether COPD serves as a risk marker or a causative factor for prevalent cancers. Methods: We employed univariable MR (UVMR) analyses to investigate the causal relationship between COPD and the top ten common cancers. Sensitivity analyses were performed to validate the main findings. Multivariable MR (MVMR) and two-step MR [...]

Menée au Canada par questionnaire auprès de 127 852 participants (âge : moins de 50 ans), cette étude identifie des facteurs associés au risque de cancer colorectal de survenue précoce

Risk factors for early-onset colorectal cancer: A Canadian prospective cohort study

O’Sullivan, Dylan E. ; Ruan, Yibing ; Farah, Eliya ; Hutchinson, John M. ; Hilsden, Robert J. ; Brenner, Darren R.

Purpose: The incidence of early-onset (<50 years of age) colorectal cancer (eoCRC) has been steadily increasing in high-income countries including Canada. Despite this increase in incidence, the etiology of eoCRC remains unclear and prospective cohort studies of potential risk factors are limited. Methods: We examined two prospective cohorts of healthy individuals (<50 years of age) who completed baseline questionnaires in the Ontario Health Study and Alberta’s Tomorrow Project. We examined the [...]

Menée à l'aide des données d'une étude d'association sur le génome entier, cette étude analyse l'association entre des caractéristiques du sommeil (durée, ronflement, chronotype, insomnie, sieste) et le risque de cancer de la thyroïde

Causal association of sleep traits with the risk of thyroid cancer: A mendelian randomization study

Zong, Liang ; Liu, Guiping ; He, Hongsheng ; Huang, Deliang

Background: This study was to explore the causal associations of sleep traits including sleep duration, snoring, chronotype, sleep disorders, getting up in the morning, sleeplessness/insomnia and nap during day with the risk of thyroid cancer based on Mendelian randomization (MR) analysis. Method: Summary single nucleotide polymorphism (SNP)-phenotype association data were obtained from published genome-wide association studies (GWASs) using the FinnGen and UK Biobank databases. A series of [...]

Menée à partir de données de la base "UK Clinical Practice Research Datalink" portant sur 65 687 témoins et 6 586 patients atteints d'un cancer gastrique, cette étude analyse l'association entre une maladie auto-immune et le risque de cancer gastrique

Autoimmune conditions and gastric cancer risk in a population-based study in the United Kingdom

Murphy, John D. ; Gadalla, Shahinaz M. ; Anderson, Lesley A. ; Rabkin, Charles S. ; Cardwell, Chris R. ; Song, Minkyo ; Camargo, M. Constanza

Background: Although overall incidence of gastric cancer is decreasing, incidence has been increasing among young people in some Western countries. This trend may stem from the increase in autoimmune conditions. Methods: A nested case-control study of gastric cancer in UK Clinical Practice Research Datalink. Up to ten cancer-free controls were matched to cases by age and sex. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données pangénomiques portant sur 199 741 personnes, cette étude analyse l'association entre un dysfonctionnement thyroïdien et le risque de cancer de l'ovaire

Causal relationship between thyroid dysfunction and ovarian cancer: a two-sample Mendelian randomization study

Wang, Tingting ; Wang, Xiaoqin ; Wu, Jun ; Li, Xin

Purpose: Observational studies and clinical validation have suggested a link between thyroid dysfunction and an elevated ovarian cancer (OC) risk. However, whether this association indicates a cause-and-effect relationship remains uncertain. We aimed to investigate the plausible causal impact of thyroid dysfunction on OC through a Mendelian randomization (MR) study. Methods: Genome-wide association study (GWAS) data for thyrotropin (TSH), free thyroxine (FT4), hypothyroidism, and [...]