Menée à partir de données portant sur 2 924 personnes, cette étude analyse l'association entre un score de risque polygénique, le nombre de paquets-années fumés et le risque de cancer du poumon

Interaction between continuous pack-years smoked and polygenic risk score on lung cancer risk: prospective results from the framingham heart study

Duncan, Meredith S. ; Diaz-Zabala, Hector ; Jaworski, James ; Tindle, Hilary A. ; Greevy, Robert A. ; Lipworth, Loren ; Hung, Rayjean J. ; Freiberg, Matthew S. ; Aldrich, Melinda C.

Background: Lung cancer risk attributable to smoking is dose-dependent, yet few studies examining a polygenic risk score (PRS) by smoking interaction have included comprehensive lifetime pack-years smoked. Methods: We analyzed data from participants of European ancestry in the Framingham Heart Study Original (n=454) and Offspring (n=2,470) cohorts enrolled in 1954 and 1971, respectively, and followed through 2018. We built a PRS for lung cancer using participant genotyping data and genome-wide [...]

A partir d'une revue systématique de la littérature (7 études), cette méta-analyse évalue l'association entre une exposition professionnelle aux fumées de soudage et le risque de cancers urogénitaux (prostate, vessie, rein)

Risk of bladder, kidney and prostate cancer from occupational exposure to welding fumes: a systematic review and meta-analysis

Collatuzzo, Giulia ; Hamdani, Maha ; Boffetta, Paolo

Background: Our aimed to conduct a meta-analysis of cohort studies on risk of genitourinary (GU) cancers in workers exposed to welding fumes (WF). Methods: We performed a systematic review of studies published on Pubmed, Scopus and Embase following PRISMA criteria. Two researchers selected cohort studies on WF exposure. From 2582 articles, 7 non-overlapping studies were included. Quality of studies was scored according to CASP. We run a random effects meta-analysis to calculate the relative [...]

Menée aux Etats-Unis auprès de 55 276 femmes afro-américaines ou d'origine africaine (durée de suivi : jusqu'à 26 ans), cette étude analyse l'association entre l'obésité et le risque de myélome multiple (292 cas)

Body size and risk of multiple myeloma in the Black Women’s Health Study

Kataria, Yachana ; Niharika Pillalamarri, Bala ; Zirpoli, Gary ; Szalat, Raphael ; Palmer, Julie R. ; Bertrand, Kimberly A.

Background: Obesity is an established risk factor for multiple myeloma (MM). Relatively few prior studies, however, have evaluated associations in Black populations. Methods: Among 55,276 participants in the Black Women’s Health Study, a prospective U.S. cohort established in 1995, we confirmed 292 incident diagnoses of MM over 26 years of follow-up. Multivariable Cox proportional hazard models, adjusted for age and putative MM risk factors, were used to estimate hazard ratios (HRs) and 95% [...]