A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2022, cette étude analyse l'association entre une exposition au tabagisme passif et le risque de cancer du sein ou du poumon

Health effects associated with exposure to secondhand smoke: a Burden of Proof study

Flor, Luisa S. ; Anderson, Jason A. ; Ahmad, Noah ; Aravkin, Aleksandr ; Carr, Sinclair ; Dai, Xiaochen ; Gil, Gabriela F. ; Hay, Simon I. ; Malloy, Matthew J. ; McLaughlin, Susan A. ; Mullany, Erin C. ; Murray, Christopher J. L. ; O’Connell, Erin M. ; Okereke, Chukwuma ; Sorenson, Reed J. D. ; Whisnant, Joanna ; Zheng, Peng ; Gakidou, Emmanuela

Despite a gradual decline in smoking rates over time, exposure to secondhand smoke (SHS) continues to cause harm to nonsmokers, who are disproportionately children and women living in low- and middle-income countries. We comprehensively reviewed the literature published by July 2022 concerning the adverse impacts of SHS exposure on nine health outcomes. Following, we quantified each exposure–response association accounting for various sources of uncertainty and evaluated the strength of the [...]

Cet article passe en revue les caractéristiques épidémiologiques, cliniques et génomiques du cancer du poumon chez les personnes n'ayant jamais fumé, présente les données sur les facteurs de risque génétiques et environnementaux puis décrit les stratégies de diagnostic et de traitement

Lung cancer in patients who have never smoked — an emerging disease

LoPiccolo, Jaclyn ; Gusev, Alexander ; Christiani, David C. ; Jänne, Pasi A.

Lung cancer is the most common cause of cancer-related deaths globally. Although smoking-related lung cancers continue to account for the majority of diagnoses, smoking rates have been decreasing for several decades. Lung cancer in individuals who have never smoked (LCINS) is estimated to be the fifth most common cause of cancer-related deaths worldwide in 2023, preferentially occurring in women and Asian populations. As smoking rates continue to decline, understanding the aetiology and [...]

Menée à partir de données iraniennes portant sur 3 477 témoins et 717 patients atteints d'un cancer de la vessie, cette étude analyse l'association entre l'utilisation du narguilé et le risque de développer la maladie

Unveiling an Association between Waterpipe Smoking and Bladder Cancer Risk: A Multicenter Case-Control Study in Iran

Hadji, Maryam ; Rashidian, Hamideh ; Marzban, Maryam ; Rezaianzadeh, Abbas ; Ansari-Moghaddam, Alireza ; Bakhshi, Mahdieh ; Nejatizadeh, Azim ; Seyyedsalehi, Monireh Sadat ; Naghibzadeh-Tahami, Ahmad ; Haghdoost, AliAkbar ; Mohebbi, Elham ; Freedman, Neal D. ; Malekzadeh, Reza ; Etemadi, Arash ; Kamangar, Farin ; Weiderpass, Elisabete ; Pukkala, Eero ; Boffetta, Paolo ; Zendehdel, Kazem

Background: Limited data exist for the association between bladder cancers and waterpipe smoking, an emerging global public health concern. Methods: We used the IROPICAN database in Iran and employed multivariable logistic regression, adjusting for cigarette smoking, opium use, and other confounding factors. In addition, we studied the association between exclusive waterpipe smoking and bladder cancer. Results: We analyzed 717 cases and 3477 controls and a subset of 215 patients and 2145 [...]

Menée en Chine à partir de données de questionnaires portant sur 59 844 hommes, cette étude analyse l'association entre 142 aliments et nutriments et le risque de cancer du foie (431 cas)

A diet-wide association study for liver cancer risk: findings from a prospective cohort study in Chinese men

Tuo, Jia-Yi ; Li, Zhuo-Ying ; Shen, Qiu-Ming ; Tan, Yu-Ting ; Li, Hong-Lan ; Xiang, Yong-Bing

Dietary factors have been extensively investigated as possible risk factors for liver cancer, but the evidence is inconclusive. Our study systematically assessed the association between 142 foods and nutrients and liver cancer risk in a Chinese population using a diet-wide association study. Based on data from 59,844 men in the Shanghai Men’s Health Study (SMHS), we assessed the diet intake by dietary questionnaires. Cox regression was used to quantify the association between each food and [...]

Menée au Mexique par questionnaire auprès de 794 témoins et 394 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre la consommation de produits laitiers (lait entier, fromage, crème et yaourt) et le risque de développer la maladie

Differential association between dairy intake patterns and incident prostate cancer: a potential dairy matrix effect

Armenta-González, Leticia Lizbeth ; Hernández-Pérez, Jesús Gibran ; Feeney, Emma L. ; Vázquez-Salas, Argelia ; Galván-Portillo, Marcia ; Lopez, David S. ; Torres-Sánchez, Luisa

Objective: To evaluate the association between dairy intake patterns and the risk of prostate cancer (PC), and its histological differentiation, among men from Mexico City. Methods: We analyzed the information from 394 incident PC cases paired by age (± 5 years) with 794 population controls. According to the Gleason score at diagnosis, cases were classified as well- (  [...]

Menée par questionnaire auprès de 300 témoins et 150 patients atteints d'un cancer colorectal, cette étude analyse l'association entre un régime pauvre en glucides, l'indice insulinique et le risque de développer la maladie

Dietary insulin indices and low-carbohydrate diet and the odds of colorectal cancer: a case-control study

Bahrami, Alireza ; Parastouei, Karim ; Taghdir, Maryam ; Ghadyani, Mojtaba

Background: Regarding the role of insulin and insulin-inducing dietary factors in some cancers’ etiology, we hypothesized that the risk of colorectal cancer may be lessened by following a lower carbohydrate and insulinogenic diet. Therefore, we performed this study to explore the association between a low-carbohydrate diet and insulin indices and the odds of colorectal cancer. Method: This hospital-based case-control study was conducted on 150 newly diagnosed colorectal cancer patients and 300 [...]

Menée à l'aide de données 2005-2017 de la cohorte "AGRICAN" portant sur 59 391 agricultrices, cette étude analyse l'association entre des expositions agricoles spécifiques (pendant l'enfance, la puberté et la ménopause ; herbicides, type de culture ou d'élevage) et le risque de cancer de l'ovaire (262 cas)

Agricultural exposure and risk of ovarian cancer in the AGRIculture and CANcer (AGRICAN) cohort

Marine Renier ; Juliette Hippert ; Weiswald Louis-Bastien ; Séverine Tual ; Matthieu Meryet-Figuiere ; Nicolas Vigneron ; Elisabeth Marcotullio ; Isabelle Baldi ; Pierre Lebailly

Background: Ovarian cancer is rare with a poor prognosis and few established risk factors. Hormones and reproductive factors significantly impact its development, suggesting a potential link with endocrine disrupters. Methods: In the AGRICAN cohort, 59 391 female farmers completed data on lifelong agricultural exposures and reproductive life. Cox models with attained age as timescale (HR and 95% CI) were used. The role of hormonal factors as potential confounders was considered along with [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2022 (8 études), cette méta-analyse évalue l'association entre le travail de nuit et le risque de cancer de la prostate

Association between night work and prostate cancer: a systematic review and meta-analysis

Jahn, Alexander ; Nielsen, Mathilde Lumbye ; Kyndi, Marianne ; Dalbøge, Annett

Objective: The aim was to conduct a systematic review and meta-analysis to study the association between night work and the development of prostate cancer. Methods: A systematic literature search was conducted in CINAHL, Embase, MEDLINE, and Web of Science. Studies were included based on a PECOS; the population included men in/above the working age, exposure defined as night work, outcome defined as prostate cancer, and study design restricted to cohort studies. The exclusion of articles, [...]

Menée auprès de 983 témoins et 565 patients atteints d'un cancer des voies aérodigestives supérieures, cette étude analyse l'association entre une exposition aux particules fines ambiantes (PM2.5) et le risque de développer la maladie

Association between ambient exposure to PM2.5 and upper aerodigestive tract cancer in Los Angeles

Fang, Fang ; Ritz, Beate ; Rao, Jianyu ; Zhu, Yifang ; Tashkin, Donald P. ; Morgenstern, Hal ; Zhang, Zuo-Feng

Fine particulate matter (PM2.5) contains carcinogens similar to those generated by tobacco smoking, which may increase the risks of developing smoking-related cancers, such as upper aerodigestive track (UADT) cancers, for both smokers and never-smokers. Therefore, it is imperative to understand the relation between ambient PM2.5 exposure and risk of UADT cancers. A population-based case–control study involving 565 incident UADT cancer cases and 983 controls was conducted in Los Angeles County [...]

Menée à l'aide de données de la "UK Biobank" portant sur 464 244 personnes (durée médiane de suivi : 12,6 ans), cette étude analyse l'association entre une consommation régulière de paracétamol et le risque de cancer du foie (627 cas)

Regular use of paracetamol and risk of liver cancer: a prospective cohort study

Tian, Liang ; Mi, Ningning ; Wang, Leiqing ; Huang, Chongfei ; Fu, Wenkang ; Bai, Mingzhen ; Gao, Long ; Ma, Haidong ; Zhang, Chao ; Lu, Yawen ; Zhao, Jinyu ; Zhang, Xianzhuo ; Jiang, Ningzu ; Lin, Yanyan ; Yue, Ping ; Xia, Bin ; He, Qiangsheng ; Yuan, Jinqiu ; Meng, Wenbo

Background: Paracetamol induces hepatotoxicity and subsequent liver injury, which may increase the risk of liver cancer, but epidemiological evidence remains unclear. We conducted this study to evaluate the association between paracetamol use and the risk of liver cancer. Methods: This prospective study included 464,244 participants free of cancer diagnosis from the UK Biobank. Incident liver cancer was identified through linkage to cancer and death registries and the National Health Service [...]

Menée auprès de 543 595 patients atteints d'un diabète de type 2 (âge moyen : 59,9 ans), cette étude analyse l'association entre un traitement antidiabétique par agonistes des récepteurs GLP-1 et le risque de cancer du pancréas (1 665 cas)

Glucagon-Like Peptide-1 Receptor Agonists and Pancreatic Cancer Risk in Patients With Type 2 Diabetes

Dankner, Rachel ; Murad, Havi ; Agay, Nirit ; Olmer, Liraz ; Freedman, Laurence S.

Concerns have been raised that glucagon-like peptide-1 receptor agonists (GLP-1RA) may increase the risk of pancreatic cancer.To investigate the association of GLP-1RA treatment with pancreatic cancer incidence over 9 years of follow-up.In this population-based historical cohort study, adult patients (aged 21 to 89 years) with type 2 diabetes insured by Clalit Healthcare Services, the largest state-mandated health organization in Israel, were followed up from 2009, when GLP-1RA became available [...]

Menée à partir de données de l'Assurance maladie coréenne portant sur 1 430 054 personnes (âge : au moins 40 ans ; durée médiane de suivi : 6,4 ans), cette étude analyse l'association entre une altération de la glycémie à jeun évaluée à l'aide d'un score et le risque de cancer gastro-intestinal

Cumulative exposure to impaired fasting glucose and gastrointestinal cancer risk: A nationwide cohort study

Ahn, Byeong Yun ; Kim, Bokyung ; Park, Sanghyun ; Kim, Sang Gyun ; Han, Kyungdo ; Cho, Soo-Jeong

Background: Impaired fasting glucose (IFG) is associated with the risk of various cancers, but the cumulative effect of IFG on gastrointestinal cancer risk remains unclear. This study evaluated the association between the cumulative exposure to IFG and gastrointestinal cancer risk. Methods: The authors extracted data from the Korean National Health Insurance Service and health examination data sets. Among individuals ≥40 years old who were free of diabetes or cancer, 1,430,054 who underwent [...]

Menée à l'aide de données portant sur 65 personnes atteintes du syndrome de Li-Fraumeni, cette étude analyse l'association entre ce syndrome et le risque d'adénocarcinome de la jonction oesogastrique

Li Fraumeni Syndrome predisposes to gastro-esophageal junction tumours

Tjandra, Douglas ; Boussioutas, Alex

Li-Fraumeni Syndrome (LFS), caused by germline pathogenic variants in TP53, predisposes to a wide range of young-onset malignancies, particularly sarcoma, breast and brain cancer. More recently, an increased risk of gastric adenocarcinoma has been recognised, although uptake of surveillance upper endoscopy is unclear. Our retrospective review of 65 patients with LFS, of whom 53.8% had undergone endoscopy, identified four patients (6.2%) with gastro-esophageal junction (GEJ) adenocarcinomas. Two [...]

Menée à l'aide de données de registres danois portant sur 8 386 patients atteints d'une néoplasie myélodysplasique, d'une leucémie myéloïde aiguë ou d'une leucémie lymphoblastique aiguë, cette étude analyse le risque, pour leurs parents au 1er ou 2nd degré, de développer ces maladies

Risk of cancer in relatives of patients with myelodysplastic neoplasia and acute leukemias

Nitschke, Nikolaj Juul ; Rostgaard, Klaus ; Andersen, Mette Klarskov ; Hjalgrim, Henrik ; Grønbæk, Kirsten

Background: The risk of cancer among relatives of patients with either myelodysplastic neoplasia (MDS), acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) has not been thoroughly examined. Methods: We linked the Danish Civil Registration System with the Danish Cancer Registry, the Danish National Acute Leukemia Registry, and the Danish Myelodysplastic Syndrome Database to estimate the relative risk of cancer among relatives of patients with MDS/AML/ALL. We used standardized [...]

Menée à partir de données internationales d'études d'association sur le génome entier portant sur 64 897 personnes, cette étude identifie 5 nouveaux loci de susceptibilité au risque de cancer du poumon, en fonction du statut tabagique

Lung cancer in ever- and never-smokers: findings from multi-population GWAS studies

Li, Yafang ; Xiao, Xiangjun ; Li, JianRong ; Han, Younghun ; Cheng, Chao ; Fernandes, Gail F. ; Slewitzke, Shannon E. ; Rosenberg, Susan M. ; Zhu, Meng ; Byun, Jinyoung ; Bosse, Yohan ; McKay, James D. ; Albanes, Demetrius ; Lam, Stephen ; Tardon, Adonina ; Chen, Chu ; Bojesen, Stig E. ; Landi, Maria Teresa ; Johansson, Mattias ; Risch, Angela ; Bickeböller, Heike ; Wichmann, H-Erich ; Christiani, David C. ; Rennert, Gad ; Arnold, Susanne M. ; Goodman, Gary E. ; Field, John K. ; Davies, Michael P A. ; Shete, Sanjay ; Le Marchand, Loic ; Liu, Geoffrey ; Hung, Rayjean J. ; Andrew, Angeline S. ; Kiemeney, Lambertus A. ; Sun, Ryan ; Zienolddiny, Shanbeh ; Grankvist, Kjell ; Johansson, Mikael ; Caporaso, Neil E. ; Cox, Angela ; Hong, Yun-Chul ; Lazarus, Philip ; Schabath, Matthew B. ; Aldrich, Melinda C. ; Schwartz, Ann G. ; Gorlov, Ivan ; Purrington, Kristen S. ; Yang, Ping ; Liu, Yanhong ; Bailey-Wilson, Joan E. ; Pinney, Susan M. ; Mandal, Diptasri ; Willey, James C. ; Gaba, Colette ; Brennan, Paul ; Xia, Jun ; Shen, Hongbing ; Amos, Christopher I.

Background: Clinical, molecular, and genetic epidemiology studies displayed remarkable differences between ever- and never-smoking lung cancer. Methods: We conducted a stratified multi-population (European, East Asian, and African descent) association study on 44,823 ever-smokers and 20,074 never-smokers to identify novel variants that were missed in the non-stratified analysis. Functional analysis including eQTL colocalization and DNA damage assays, and annotation studies were conducted to [...]

Menée dans trois pays d'Afrique subsaharienne auprès de 6 274 femmes, cette étude analyse l'association entre des tumeurs bégnines du sein et le risque de cancer du sein

Benign breast disease and breast cancer risk in African women: a case–control study

Omoleye, Olasubomi J. ; Freeman, Jincong Q. ; Oluwasanu, Mojisola ; Adeniji-Sofoluwe, Adenike ; Woodard, Anna E. ; Aribisala, Benjamin S. ; Adejumo, Prisca O. ; Ntekim, Atara ; Makumbi, Timothy ; Ndom, Paul ; Ajayi, IkeOluwapo O. ; Olopade, Olufunmilayo I. ; Huo, Dezheng

Purpose: To examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women. Methods: BC cases and controls were enrolled in three sub-Saharan African countries, Nigeria, Cameroon, and Uganda, between 1998 and 2018. Multivariable logistic regression was used to test the association between BBD and BC. Risk factors dually associated with BBD and BC were selected. Using a parametric mediation analysis model, we assessed if selected [...]