Menée à partir de données des cohortes "the Nurses’ Health Studies" portant sur 165 760 femmes, cette étude analyse l'association entre une exposition au tabagisme pendant l'enfance et à l'âge adulte et le risque de cancer de l'ovaire (1 448 cas), selon la quantité intratumorale de lymphocytes T

Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration

Hathaway, Cassandra A. ; Wang, Tianyi ; Townsend, Mary K. ; Vinci, Christine ; Jake-Schoffman, Danielle E. ; Saeed-Vafa, Daryoush ; Moran Segura, Carlos ; Nguyen, Jonathan V. ; Conejo-Garcia, Jose R. ; Fridley, Brooke L. ; Tworoger, Shelley S.

Exposure to cigarette smoke, particularly in early life, is modestly associated with ovarian cancer risk and may impact systemic immunity and the tumor immune response. However, no studies have evaluated whether cigarette smoke exposure impacts the ovarian tumor immune microenvironment.Participants in the Nurses’ Health Study (NHS) and NHSII reported on early life exposure to cigarette smoke and personal smoking history on questionnaires (n = 165,760). Multiplex immunofluorescence assays were [...]

Menée à partir de données des cohortes "the Nurses’ Health Studies" portant sur 133 756 femmes, cette étude analyse l'association entre le potentiel inflammatoire ou insulinémique de l'alimentation et le risque de cancer de l'endomètre (1 462 cas)

Inflammatory and insulinemic dietary patterns and risk of endometrial cancer among US women

Romanos-Nanclares, Andrea ; Tabung, Fred K ; Sinnott, Jennifer A ; Trabert, Britton ; De Vivo, Immaculata ; Playdon, Mary C ; Eliassen, A Heather

Whilst unopposed estrogen exposure is considered a major driver of endometrial carcinogenesis, chronic inflammation and insulin resistance/hyperinsulinemia are also major endometrial cancer risk factors. However, it is unclear whether diets with inflammatory or insulinemic potential are associated with risk of endometrial cancer.We followed 48,330 women from the Nurses’ Health Study (NHS, 1984-2016) and 85,426 women from the Nurses’ Health Study II (NHSII, 1989-2017). Using food frequency [...]

Menée aux Etats-Unis à partir de données 1990-2017 portant sur 13 617 enfants, cette étude analyse l'association entre une exposition in utéro au VIH et le risque de cancer chez les patients séronégatifs à la naissance

Cancer risk among HIV-exposed uninfected children in the United States

Horner, Marie-Josephe ; Hazra, Rohan ; Barnholtz-Sloan, Jill S. ; Shiels, Meredith S. ; Engels, Eric A.

In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero, who remained HIV-uninfected after birth (1990–2017). Risk of brain tumors was borderline elevated among these children (standardized incidence ratio 2.2, 95% confidence interval 0.8–4.8, P = 0.12, based on six cases). Risk was not significantly increased for leukemia or other [...]

Menée à partir des données de 18 études portant au total sur 19 033 témoins et 7 562 patients atteints d'un cancer gastrique, cette étude analyse l'association entre la taille à l'âge adulte et le risque de développer la maladie

Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

Giraldi, Luca ; Stojanovic, Jovana ; Arzani, Dario ; Persiani, Roberto ; Hu, Jinfu ; Johnson, Kenneth C. ; Zhang, Zuo-Feng ; Ferraroni, Monica ; Palli, Domenico ; Yu, Guo-Pei ; La Vecchia, Carlo ; Pelucchi, Claudio ; Lunet, Nuno ; Ferro, Ana ; Malekzadeh, Reza ; Muscat, Joshua ; Zaridze, David ; Maximovich, Dmitry ; Aragonés, Nuria ; Martin, Vicente ; Vioque, Jesús ; Navarrete-Muñoz, Eva M. ; Pakseresht, Mohammadreza ; Negri, Eva ; Rota, Matteo ; Pourfarzi, Farhad ; Mu, Lina ; Kurtz, Robert C. ; Lagiou, Areti ; Lagiou, Pagona ; Pastorino, Roberta ; Boccia, Stefania

Background: The association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium. Methods: Data from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was [...]

Menée à partir d'échantillons sériques prélevés sur 276 patients atteints d'un cancer hépatique primitif ou d'une maladie chronique du foie et sur 512 témoins (durée de suivi : 22 ans), cette étude évalue l'association entre le niveau d'insuline, le niveau de glucose, le niveau de l'insulino-résistance et le risque de développer ces maladies

Associations between serum glucose, insulin, insulin resistance and the risk of incident primary liver cancer or chronic liver disease mortality: a nested case–control study

Yin, Jian ; Freedman, Neal D. ; Liu, Yiwei ; Dawsey, Sanford M. ; Yang, Huan ; Taylor, Philip R. ; Yin, Liangyu ; Liu, Bin ; Cui, Jianfeng ; Fan, Jinhu ; Chen, Wen ; Qiao, Youlin ; Abnet, Christian C.

Background : To evaluate the associations between pre-diagnostic levels of serum insulin, glucose and insulin resistance (HOMA-IR) and future risk of incident primary liver cancer (PLC) or chronic liver disease (CLD)-related mortality. Methods : We used a nested case-control design to evaluate subjects over 22 years of follow-up. Glucose, insulin, and three markers of hepatitis B virus (HBV) and hepatitis C virus were measured in fasting baseline serum from 119 incident PLCs, 157 CLD-death [...]