Menée aux Etats-Unis à partir de données portant sur 8 060 adolescentes et jeunes femmes atteintes d'un cancer diagnostiqué entre 2004 et 2015 (âge : 15-39 ans), cette étude analyse les disparités dans le recours à des techniques de préservation de la fertilité après le diagnostic de la maladie

Disparities in fertility preservation use among adolescent and young adult women with cancer

Meernik, Clare ; Engel, Stephanie M. ; Wardell, Ally ; Baggett, Christopher D. ; Gupta, Parul ; Rodriguez-Ormaza, Nidia ; Luke, Barbara ; Baker, Valerie L. ; Wantman, Ethan ; Rauh-Hain, Jose Alejandro ; Mersereau, Jennifer E. ; Olshan, Andrew F. ; Smitherman, Andrew B. ; Cai, Jianwen ; Nichols, Hazel B.

Purpose : Women face multiple barriers to fertility preservation after cancer diagnosis, but few studies have examined disparities in use of these services. Methods : Women aged 15–39 years diagnosed with cancer during 2004–2015 were identified from the North Carolina Central Cancer Registry and linked to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System. Women who cryopreserved oocytes or embryos for fertility preservation (n = 96) were compared to women who [...]

Menée en Angleterre à partir de données 2007-2013 de registres électroniques de médecine générale portant sur 250 606 patients, cette étude évalue, en fonction de l'âge et du sexe, l'association entre la survenue récente de symptômes de fatigue et le risque de diagnostic de cancer dans les mois suivants

Risk of cancer following primary care presentation with fatigue: a population-based cohort study of a quarter of a million patients

White, Becky ; Rafiq, Meena ; Gonzalez-Izquierdo, Arturo ; Hamilton, Willie ; Price, Sarah ; Lyratzopoulos, Georgios

Background : The management of adults presenting with fatigue presents a diagnostic challenge, particularly regarding possible underlying cancer. Methods : Using electronic health records, we examined cancer risk in patients presenting to primary care with new-onset fatigue in England during 2007–2013, compared to general population estimates. We examined variation by age, sex, deprivation, and time following presentation. Findings : Of 250,606 patients presenting with fatigue, 12-month cancer [...]

Menée en Espagne à partir de données portant sur des patients atteints d'un cancer colorectal traité par chirurgie, cette étude de cohorte prospective analyse l'association entre des comorbidités et la survenue de complications, les réadmissions hospitalières, les ré-opérations, l'évolution des symptômes auto-déclarés et la mortalité (durée de suivi : 5 ans)

Effect of comorbidities on long-term outcomes of colorectal cancer patients

Quintana, José M. ; Anton-Ladislao, Ane ; Lázaro, Santiago ; Gonzalez, Nerea ; Baré, Marisa ; Fernandez-de-Larrea, Nerea ; Redondo, Maximino ; Escobar, Antonio ; Sarasqueta, Cristina ; Garcia-Gutierrez, Susana ; Aguirre, Urko ; for the REDISSEC-CARESS/CCR group

Objective : The objective of this work is to evaluate the association of comorbidities with various outcomes in patients diagnosed with colon or rectal cancer. Methods : We conducted a prospective cohort study of patients diagnosed with colon or rectal cancer who underwent surgery. Data were gathered on sociodemographic, clinical characteristics, disease course, and the EuroQol EQ-5D and EORTC QLQ-C30 scores, up to 5 years after surgery. The main outcomes of the study were mortality, [...]

A partir d'une revue systématique de la littérature (55 études), cette étude présente, à une échelle internationale et pour l'année 2020, une estimation de la prévalence et de l'incidence du sarcome de Kaposi associé ou non à une infection par le VIH

Burden of Kaposi sarcoma according to HIV status: A systematic review and global analysis

Ibrahim Khalil, Ahmadaye ; Franceschi, Silvia ; de Martel, Catherine ; Bray, Freddie ; Clifford, Gary M.

In 2020, over 34 000 cases of Kaposi sarcoma (KS) were estimated globally, all attributable to KS herpesvirus (KSHV). Prior to the HIV epidemic, KS already existed in KSHV endemic regions, notably in sub-Saharan Africa (SSA). The HIV epidemic has vastly increased the KS burden. We developed a methodology to provide global estimates of KS burden according to HIV status. A systematic review identified studies reporting HIV prevalence in consecutive KS series. Pooled estimates of HIV prevalence, [...]

Menée au Danemark à partir de données portant sur 2 004 patientes atteintes d'un cancer du sein ayant récidivé tardivement (durée supérieure ou égale à 10 ans après le premier diagnostic), cette étude identifie les facteurs associés au risque de décès

Mortality After Late Breast Cancer Recurrence in Denmark

Rikke Nørgaard Pedersen ; Lene Mellemkjær ; Bent Ejlertsen ; Mette Nørgaard ; Deirdre P. Cronin-Fenton

PURPOSE : Late breast cancer (BC) recurrence (ie, ≥ 10 years after primary diagnosis) may have a more favorable prognosis than earlier recurrence. We investigated the risk of BC death after late recurrence, identified prognostic factors, and compared survival after early and late recurrence. METHODS : Using the Danish Breast Cancer Group and other nationwide databases, we identified women with early or late BC recurrence during 2004-2018, who were alive 6 months after recurrence. We followed [...]

Menée à partir de données portant sur 9 719 patientes atteintes d'un cancer du sein HR+ ERBB2- de stade précoce et incluses dans un essai randomisé, cette étude analyse l'association entre l'origine ethnique et la survie (délai avant récidive et survie globale) en fonction de la couverture de santé individuelle et du niveau socioéconomique du voisinage

Assessment of Racial Disparity in Survival Outcomes for Early Hormone Receptor–Positive Breast Cancer After Adjusting for Insurance Status and Neighborhood Deprivation: A Post Hoc Analysis of a Randomized Clinical Trial

Sadigh, Gelareh ; Gray, Robert J. ; Sparano, Joseph A. ; Yanez, Betina ; Garcia, Sofia F. ; Timsina, Lava R. ; Obeng-Gyasi, Samilia ; Gareen, Ilana ; Sledge, George W. ; Whelan, Timothy J. ; Cella, David ; Wagner, Lynne I. ; Carlos, Ruth C.

Importance : Racial disparities in survival outcomes among Black women with hormone receptor–positive breast cancer have been reported. However, the association between individual-level and neighborhood-level social determinants of health on such disparities has not been well studied. Objective : To evaluate the association between race and clinical outcomes (ie, relapse-free interval and overall survival) adjusting for individual insurance coverage and neighborhood deprivation index (NDI), [...]

Menée aux Etats-Unis par enquête auprès de 7 498 patients ayant survécu à un cancer, cette étude transversale analyse l'association entre l'utilisation de la cigarette électronique et une dépression auto-déclarée

Association between e-cigarette use and depression in US cancer survivors: a cross-sectional study

Antwi, Godfred O. ; Rhodes, Darson L.

Purpose : Though prior studies have observed significant association between e-cigarette use and mental health outcomes including depression in the general population, the relationship between e-cigarette use and clinical depression in the cancer survivor subpopulation is unknown. The purpose of this study was to examine the cross-sectional association between e-cigarette use and self-reported clinical depression among cancer survivors. Methods : Pooled data from the 2017 and 2018 Behavioral [...]

Menée aux Etats-Unis par questionnaire auprès de 180 patients atteints d'un myélome multiple, cette étude transversale analyse leur qualité de vie, leur détresse psyschologique et leurs perceptions vis-à-vis du pronostic selon le nombre de lignes thérapeutiques reçues

Quality of life, psychological distress, and prognostic perceptions in patients with multiple myeloma

O’Donnell, Elizabeth K. ; Shapiro, Yael N. ; Yee, Andrew J. ; Nadeem, Omar ; Hu, Bonnie Y. ; Laubach, Jacob P. ; Branagan, Andrew R. ; Anderson, Kenneth C. ; Mo, Clifton C. ; Munshi, Nikhil C. ; Ghobrial, Irene M. ; Sperling, Adam S. ; Agyemang, Emerentia A. ; Burke, Jill N. ; Harrington, Cynthia C. ; Richardson, Paul G. ; Raje, Noopur S. ; El-Jawahri, Areej

Background : Multiple myeloma (MM) is an incurable hematologic malignancy requiring long-term, continuous therapy. Despite its chronic and unrelenting course, studies examining quality of life (QOL), psychological distress, and perceptions of prognosis by line of therapy are lacking. Methods : The authors conducted a cross-sectional, multisite study of patients undergoing treatment for MM (excluding maintenance) between June 2020 and January 2021. The authors conducted purposeful sampling and [...]

A partir d'une revue de la littérature (323 revues systématiques), cette étude fait le point sur les interventions dédiées à l'après-cancer pour des patientes ayant survécu à un cancer du sein

Mapping Systematic Reviews of Breast Cancer Survivorship Interventions: A Network Analysis

Emma B. Kemp ; Olaf P. Geerse ; Reegan Knowles ; Richard Woodman ; Leila Mohammadi ; Larissa Nekhlyudov ; Bogda Koczwara

PURPOSE : Despite a large volume of research, breast cancer survivors continue to experience high levels of unmet need. To better understand the breadth of evidence, we mapped systematic review-level evidence across cancer survivorship domains and outcomes and conducted network analyses of breast cancer survivorship care interventions. METHODS : Umbrella review methodology was used to identify published systematic reviews reporting on survivorship care interventions for breast cancer survivors. [...]