Menée en Allemagne à l'aide de données 2002-2013 de registres des cancers portant sur 135 589 personnes ayant survécu à un cancer du poumon (68,2 % d'hommes ; durée moyenne de suivi : 30,8 mois), cette étude analyse le risque de développer un second cancer lié au tabagisme (5 298 cas de cancer), en fonction du sexe et par localisation

Incidence of smoking-related second primary cancers after lung cancer in Germany: an analysis of nationwide cancer registry data

Eberl, Marian ; Tanaka, Luana F. ; Kraywinkel, Klaus ; Klug, Stefanie J.

Introduction: About 80% of lung cancer cases in Germany are attributable to smoking. Patients with a lung cancer diagnosis may remain at increased risk of developing smoking-related second primary cancers (SPC). Methods: Anonymous data from 11 population-based cancer registries covering about 50% of the German population were pooled for the analysis. Included patients were diagnosed with an index lung cancer between 2002 and 2013, 30 to 99 years old at diagnosis and survived for at least 6 [...]

Menée à l'aide de données 1988-2012 d'un registre ukrainien portant sur 458 témoins et sur 149 patients atteints d'un cancer de la thyroïde, cette étude analyse l'association entre la dose de rayonnement thyroïdien reçue à l'âge adulte et le risque de développer la maladie chez des employés de nettoyage ayant travaillé pour la première fois dans la zone de Tchernobyl entre 18 et 59 ans

Risk of thyroid cancer in Ukrainian cleanup workers following the Chornobyl accident

Gudzenko, Natalia ; Mabuchi, Kiyohiko ; Brenner, Alina V. ; Little, Mark P. ; Hatch, Maureen ; Drozdovitch, Vladimir ; Vij, Vibha ; Chumak, Vadim ; Bakhanova, Elena ; Trotsyuk, Natalia ; Kryuchkov, Victor ; Golovanov, Ivan ; Bazyka, Dimitry ; Cahoon, Elizabeth K.

Although much is known about the radiation-related risk of thyroid cancer in those exposed at young ages, less is known about the risk due to adult exposure, particularly in men. We aimed to examine the association between thyroid radiation dose received during adulthood and thyroid cancer risk in men. We conducted a nested case–control study (149 cases; 458 controls) of male, Ukrainian cleanup workers who first worked in the Chornobyl zone between ages 18 and 59 years, with cases identified [...]

Cet article fait le point sur le rôle carcinogène des radiofréquences

Radiofrequency Radiation and Cancer: A Review

Grimes, David Robert

Concerns over radiofrequency radiation (RFR) and carcinogenesis have long existed, and the advent of 5G mobile technology has seen a deluge of claims asserting that the new standard and RFR in general may be carcinogenic. For clinicians and researchers in the field, it is critical to address patient concerns on the topic and to be familiar with the existent evidence base. This review considers potential biophysical mechanisms of cancer induction, elucidating mechanisms of electromagnetically [...]

Menée en Israël auprès de 145 617 hommes diabétiques âgés de 21 à 90 ans (période de suivi : 2002-2012), cette étude analyse l'association entre un traitement par la metformine et le risque de cancer de la prostate (1 592 cas)

Metformin Treatment Among Men With Diabetes and the Risk Of Prostate Cancer, a Population-Based Historical Cohort Study

Freedman, Laurence S ; Agay, Nirit ; Farmer, Ruth ; Murad, Havi ; Olmer, Liraz ; Dankner, Rachel

There is conflicting evidence regarding the association between metformin treatment and prostate cancer risk in diabetic men. We investigated this association in an Israeli population-based cohort of 145,617 diabetes-incident men, aged 21-90y, followed over 2002-2012. We implemented a time-dependent covariate Cox model, using weighted cumulative exposure to relate metformin history to prostate cancer risk, adjusting for other glucose-lowering medications, age, ethnicity and socioeconomic [...]

Menée en Belgique auprès de 6 749 témoins et 1 705 patients atteints d'un cancer colorectal diagnostiqué entre 2010 et 2015, cette étude analyse l'association entre le nombre de prescription d'antibiotiques et le risque de développer la maladie

Use of antibiotics and colorectal cancer risk: a primary care nested case–control study in Belgium

Van der Meer, Johannes ; Mamouris, Pavlos ; Nassiri, Vahid ; Vaes, Bert ; van den Akker, Marjan

Objectives: To examine the association between the use of oral antibiotics and subsequent colorectal cancer risk. Design: Matched case–control study. Setting: General practice centres participating in the Integrated Computerised Network database in Flanders, Belgium. Participants: In total, 1705 cases of colorectal cancer diagnosed between 01 January 2010 and 31 December 2015 were matched to 6749 controls by age, sex, comorbidity and general practice centre. Primary outcome measure: The [...]

Menée à partir de données de la "UK Biobank" portant sur 334 385 personnes (âge moyen : 56,8 ans ; 46 % d'hommes), cette étude d'association sur le phénome entier identifie des phénotypes prédisposant au risque de cancer colorectal

Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank

Zhang, Xiaomeng ; Li, Xue ; He, Yazhou ; Law, Philip J. ; Farrington, Susan M. ; Campbell, Harry ; Tomlinson, Ian P. M. ; Houlston, Richard S. ; Dunlop, Malcolm G. ; Timofeeva, Maria ; Theodoratou, Evropi

Background: Associations between colorectal cancer (CRC) and other health outcomes have been reported, but these may be subject to biases, or due to limitations of observational studies. Methods: We set out to determine whether genetic predisposition to CRC is also associated with the risk of other phenotypes. Under the phenome-wide association study (PheWAS) and tree-structured phenotypic model (TreeWAS), we studied 334,385 unrelated White British individuals (excluding CRC patients) from the [...]

Menée à partir du séquençage de l'ADN de 464 patientes atteintes d'un cancer du sein d'apparition précoce, cette étude analyse l'association entre des mutations constitutionnelles de TP53 et le risque de développer la maladie précocement

Prevalence of germline TP53 mutation among early onset middle eastern breast cancer patients

Siraj, Abdul Khalid ; Masoodi, Tariq ; Bu, Rong ; Parvathareddy, Sandeep Kumar ; Iqbal, Kaleem ; Azam, Saud ; Al-Rasheed, Maha ; Ajarim, Dahish ; Tulbah, Asma ; Al-Dayel, Fouad ; Al-Kuraya, Khawla Sami

Background: The data on prevalence and clinical relevance of TP53 germline mutations in early onset Middle-Eastern breast cancer (BC) is limited. Methods: We determined TP53 germline mutations in a cohort of 464 early onset BC patients from Saudi Arabia using capture sequencing based next generation sequencing. Results: Germline TP53 pathogenic mutations were found in 1.5% (7/464) of early onset Saudi BC patients. A total of six pathogenic missense mutations, one stop gain mutation and two [...]