Menée en Iran par questionnaire auprès de 100 patients atteints d'un cancer de la vessie et 200 témoins (âge moyen : 65,4 ans), cette étude multicentrique analyse l'association entre l'adhésion au régime alimentaire nordique traditionnel et le risque de développer la maladie

Association of the Healthy Nordic Food Index with risk of bladder cancer: a case–control study

Hajjar, Melika ; Rezazadeh, Arezoo ; Naja, Farah ; Kardoust Parizi, Mehdi ; Jalali, Saba ; Rashidkhani, Bahram

Background: Bladder cancer (BC) is the ninth recurrent neoplasm in the world. In Iran, incidence of BC is the third most common among men. Few dietary patterns are related to reduced carcinogenesis and consequently are amenable to modification in order to reduce the BC risk. Adherence to the traditional Nordic diet, as measured by the Healthy Nordic Food Index (HNFI), have shown a beneficial effect on chronic disease prevention, including cancer. The principal objective of this study was to [...]

Menée au Royaume-Uni à partir de données 1990-2018 portant sur 973 281 nouveaux utilisateurs d'inhibiteurs de la pompe à protons et sur 193 306 nouveaux utilisateurs d'antagonistes des récepteurs de l'histamine-2 (durée médiane de suivi : 5 ans), cette étude analyse l'association entre ces utilisations et le risque de cancer de l'estomac

Proton pump inhibitors and risk of gastric cancer: population-based cohort study

Abrahami, Devin ; McDonald, Emily Gibson ; Schnitzer, Mireille E ; Barkun, Alan N ; Suissa, Samy ; Azoulay, Laurent

Objective: To determine whether new users of proton pump inhibitors (PPIs) are at an increased risk of gastric cancer compared with new users of histamine-2 receptor antagonists (H2RAs). Design: Using the UK Clinical Practice Research Datalink, we conducted a population-based cohort study using a new-user active comparator design. From 1 January 1990 to 30 April 2018, we identified 973 281 new users of PPIs and 193 306 new users of H2RAs. Cox proportional hazards models were fit to estimate HRs [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2021 (63 études, 18 millions de participants), cette méta-analyse évalue l'association entre la maladie de Parkinson et le risque de cancer

Parkinson’s disease and cancer: a systematic review and meta-analysis of over 17 million participants

Zhang, Xinyaun ; Guarin, David ; Mohammadzadehhonarvar, Niyaz ; Chen, Xiqun ; Gao, Xiang

Objective: To systematically review and qualitatively evaluate epidemiological evidence on associations between Parkinson’s disease (PD) and cancer via meta-analysis. Data sources: MEDLINE via PubMed, Web of Science and EMBASE, until March 2021. Study selection: Included were publications that (1) were original epidemiological studies on PD and cancer; (2) reported risk estimates; (3) were in English. Exclusion criteria included: (1) review/comments; (2) biological studies; (3) case [...]

Menée au Royaume-Uni à partir de données 1990-2018 portant sur 1,3 million d'utilisateurs d'inhibiteurs de la pompe à protons et sur 292 387 utilisateurs d'antagonistes des récepteurs de l'histamine-2 (durée médiane de suivi : 4,9 ans), cette étude analyse l'association entre ces utilisations et le risque de cancer colorectal

Proton pump inhibitors and risk of colorectal cancer

Abrahami, Devin ; McDonald, Emily Gibson ; Schnitzer, Mireille E ; Barkun, Alan N ; Suissa, Samy ; Azoulay, Laurent

Objective: To determine whether proton pump inhibitors (PPIs) are associated with an increased risk of colorectal cancer, compared with histamine-2 receptor antagonists (H2RAs). Design: The United Kingdom Clinical Practice Research Datalink was used to identify initiators of PPIs and H2RA from 1990 to 2018, with follow-up until 2019. Cox proportional hazards models were fit to estimate marginal HRs and 95% CIs of colorectal cancer. The models were weighted using standardised mortality ratio [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2021 (29 articles), cette étude analyse l'association entre une utilisation de différents groupes de médicaments (anti-inflammatoires non stéroïdiens, contraceptifs oraux, laxatifs, inhibiteurs de la pompe à protons, statines, anti-hypertenseurs, metformine, ...) et le risque de cancer du côlon proximal

Medication use and risk of proximal colon cancer: a systematic review of prospective studies with narrative synthesis and meta-analysis

Harewood, Rhea ; Disney, Ruth ; Kinross, James ; von Wagner, Christian ; Cross, Amanda J.

Purpose: Evidence of differences in the etiology of, and poorer survival from, proximal colon compared to the distal colorectum, necessitates research into its risk factors. This systematic review summarizes the evidence on medication use and proximal colon cancer risk. Methods: MEDLINE and EMBASE were searched for prospective studies investigating nine medication groups, namely non-steroidal anti-inflammatory drugs (NSAIDs), exogenous hormones, i.e., hormone replacement therapy (HRT) or oral [...]

Menée aux Pays-Bas à l'aide de données portant sur 963 patients atteints d'un carcinome d'origine primitive inconnue (CAPI), cette étude analyse l'association entre des antécédents familiaux de cancer et le risque de développer un CAPI

Family history of cancer in first degree relatives and risk of cancer of unknown primary

Grewcock, Alexander L. R. ; Hermans, Karlijn E. P. E. ; Weijenberg, Matty P. ; van den Brandt, Piet A. ; Loef, Caroline ; Jansen, Rob L. H. ; Schouten, Leo J.

Objective: Cancer of Unknown Primary (CUP) refers to the presence of metastatic lesions, with no identifiable primary site during the patient's lifetime. Poor survival and lack of available treatment highlight the need to identify potential CUP risk factors. We investigated whether a family history of cancer is associated with increased CUP risk. Methods: We performed a case cohort analysis using data from the Netherlands Cohort Study, which included a total of 963 CUP cases and 4,288 subcohort [...]

Menée auprès de 864 témoins et 703 patientes atteintes d'un cancer de l'ovaire, cette étude analyse l'association entre les taux sanguins de prolactine et le risque de développer la maladie

Prolactin and Risk of Epithelial Ovarian Cancer

Hathaway, Cassandra A. ; Rice, Megan S. ; Townsend, Mary K. ; Hankinson, Susan E. ; Arslan, Alan A ; Buring, Julie E. ; Hallmans, Göran ; Idahl, Annika ; Kubzansky, Laura D. ; Lee, I-Min ; Lundin, Eva A ; Sluss, Patrick M ; Zeleniuch-Jacquotte, Anne ; Tworoger, Shelley S.

Background: Prolactin is synthesized in the ovaries and may play a role in ovarian cancer etiology. One prior prospective study observed a suggestive positive association between prolactin levels and risk of ovarian cancer. Methods: We conducted a pooled case-control study of 703 cases and 864 matched controls nested within five prospective cohorts. We used unconditional logistic regression to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between [...]

A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2020, une première méta-analyse compare à la population générale le risque de développer un cancer du poumon chez des patientes atteintes d'un cancer du sein (15 études, 1,2 millions de patientes) et une seconde identifie des facteurs associés au risque de cancer du poumon après un traitement pour un cancer du sein (22 études, 3 millions de patientes)

Risk and influencing factors for subsequent primary lung cancer after treatment of breast cancer: a systematic review and two meta-analyses based on four million cases

Wang, Yan ; Li, Jialong ; Chang, Shuai ; Dong, Yingxian ; Che, Guowei

Purpose: To compare the risk of developing lung cancer between breast cancer patients and the general population and explore the risk factors for the development of primary lung cancer after treatment for breast cancer. Methods: The PubMed, EMBASE and Web of Science databases were searched from the establishment date to October 11, 2020. Two separate meta-analyses were performed: one focused on studies reporting the risk of subsequent lung cancer after breast cancer and one focused on studies [...]

Menée à l'aide des données de 2 études et de la cohorte européenne EPIC portant, au total, sur 999 témoins et sur 612 patients atteints d'un cancer du côlon, cette étude analyse l'association entre les niveaux plasmatiques de tryptophane, de sérotonine ou de kynurénine et le risque de développer la maladie

Circulating tryptophan metabolites and risk of colon cancer: results from case-control and prospective cohort studies

Papadimitriou, Nikos ; Gunter, Marc J ; Murphy, Neil ; Gicquiau, Audrey ; Achaintre, David ; Brezina, Stefanie ; Gumpenberger, Tanja ; Baierl, Andreas ; Ose, Jennifer ; Geijsen, Anne JMR ; van Roekel, Eline H ; Gsur, Andrea ; Gigic, Biljana ; Habermann, Nina ; Ulrich, Cornelia M ; Kampman, Ellen ; Weijenberg, Matty P ; Ueland, Per-Magne ; Kaaks, Rudolf ; Katzke, Verena ; Krogh, Vittorio ; Bueno-de-Mesquita, Bas ; Ardanaz, Eva ; Travis, Ruth C ; Schulze, Matthias B ; Sánchez, María-José ; Colorado-Yohar, Sandra M ; Weiderpass, Elisabete ; Scalbert, Augustin ; Keski-Rahkonen, Pekka

Dysregulation of tryptophan metabolism has been linked to colorectal tumorigenesis, however, epidemiological studies investigating tryptophan metabolites in relation to colorectal cancer risk are limited. We studied associations of plasma tryptophan, serotonin, and kynurenine with colon cancer risk in two studies with cancer patients and controls, and in one prospective cohort: ColoCare Study (110 patients/153 controls), the Colorectal Cancer Study of Austria (CORSA; 46 patients/390 controls), [...]

Menée en Suède à l'aide de données d'un registre portant sur 2 572 témoins et sur 1 274 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre les taux sanguins de cadmium et le risque de développer la maladie

Is cadmium a risk factor for breast cancer - results from a nested case-control study using data from the Malmö Diet and Cancer Study

Andersson, Eva M ; Sandsveden, Malte ; Forsgard, Niklas ; Sallsten, Gerd ; Manjer, Jonas ; Engstrom, Gunnar ; Barregard, Lars

Background: Some studies have shown that cadmium is associated with breast cancer risk. One hypothesis is that cadmium has estrogen-like properties. This case-control study investigates the association between breast cancer risk and blood cadmium levels. Methods: All breast cancers in the Malmö Diet and Cancer cohort were identified through linkage to the Swedish Cancer Registry, baseline (1991-1996) through 2014. Two controls per case were selected from the same cohort. Blood cadmium (BCd) was [...]

Menée aux Etats-Unis auprès de 116 patients pédiatriques ayant subi une intervention chirurgicale pour un nodule thyroïdien entre 2003 et 2019 (âge médian : 16,1 ans ; 93 % de filles), cette étude analyse l'association entre l'obésité (score lié à l'indice de masse corporelle) et le risque de développer des tumeurs malignes des nodules thyroïdiens chez les jeunes de moins de 21 ans

Evaluation of Thyroid Nodule Malignant Neoplasms and Obesity Among Children and Young Adults

Ortega, Carlos A. ; Gallant, Jean-Nicolas ; Chen, Sheau-Chiann ; Ye, Fei ; Wang, Huiying ; Belcher, Ryan H. ; Weiss, Vivian L.

While the prevalence of thyroid nodules in children, adolescents, and young adults in the United States has remained stable since the middle of the 20th century, the incidence of malignant nodules has been increasing among younger patients of all sexes, races, and ethnic groups. This trend cannot solely be explained by increased surveillance or improved detection because the diagnoses of small, early-stage and larger, late-stage thyroid cancers have both increased.1 Given that the rate of [...]