A partir d'une revue systématique de la littérature (7 études, 427 patients), cette méta-analyse évalue l'intérêt d'une supplémentation en guarana pour soulager la fatigue chez des patients atteints d'un cancer

The use of guarana (Paullinia cupana) as a dietary supplement for fatigue in cancer patients: a systematic review with a meta-analysis

de Araujo, Daise Pereira ; Pereira, Paula Tâmara Vieira Teixeira ; Fontes, Ariadina Jansen Campos ; Marques, Karla Danielle Silva ; de Moraes, Érica Brandão ; Guerra, Rosane Nassar Meireles ; Garcia, João Batista Santos

Objective : The objective of the present study was to carry out a systematic review with a meta-analysis to assess evidence about the use of guarana fruit to manage fatigue in cancer patients. Methodology : The data were extracted from the EMBASE, Scopus, MEDLINE, CENTRAL, and CINAHL databases, in any language, using the descriptors “neoplasms” and “Paullinia” or “guarana powder” and “placebos” and “fatigue”. Searches were also conducted to identify any grey literature. Clinical studies with [...]

Menée en Allemagne auprès de 102 patients atteints d'un cancer, cette étude analyse l'intérêt de courriels de rappel pour poursuivre leur pratique du yoga et évalue l'efficacité, du point de vue de l'amélioration de la qualité de vie et de la réduction de la fatigue et des symptômes de dépression, de cette pratique sur le long terme

Yoga therapy to reduce fatigue in cancer: effects of reminder e-mails and long-term efficacy

Zetzl, Teresa ; Pittig, Andre ; Renner, Agnes ; van Oorschot, Birgitt ; Jentschke, Elisabeth

Objective : To examine the efficacy of reminder e-mails to continue yoga therapy on practice frequency and fatigue in cancer patients and long-term effects of yoga on fatigue, depression, and quality of life. Methodology : One hundred two cancer patients who completed an 8-week yoga therapy were randomly allocated to two groups: reminder (N = 51) vs. no-reminder group (N = 51). After completing yoga therapy, the reminder group received weekly e-mails for 24 weeks, which reminded them of [...]

Menée au Royaume-Uni à partir de données portant sur 83 patients ayant survécu à un cancer de la prostate, cette étude analyse, chez les hommes jeunes et chez les plus âgés (âge : supérieur ou inférieur à 75 ans) l'association entre une obésité, la pratique d'une activité physique et le risque de maladie cardiovasculaire

Obesity and low levels of physical activity impact on cardiopulmonary fitness in older men after treatment for prostate cancer

Faithfull, Sara ; Lemanska, Agnieszka ; Poole, Karen ; Aning, Jonathan ; Manders, Ralph ; Marshall, John ; Saxton, John ; Turner, Lauren ; Griffin, Bruce

The purpose of this study was to compare fitness parameters and cardiovascular disease risk of older and younger men with prostate cancer (PCa) and explore how men's fitness scores compared to normative age values. 83 men were recruited post-treatment and undertook a cardiopulmonary exercise test (CPET), sit-to-stand, step-and-grip strength tests and provided blood samples for serum lipids and HbA1c. We calculated waist-to-hip ratio, cardiovascular risk (QRISK2), Charlson comorbidity index [...]

Menée en Corée à partir de données portant sur 20 674 patients ayant survécu à un cancer colorectal diagnostiqué entre 2006 et 2013 (âge médian : 64 ans), cette étude de cohorte analye l'association entre la pratique d'une activité physique et le risque d'accident vasculaire cérébral

Association of physical activity with stroke among long-term colorectal cancer survivors

Jeong, Seogsong ; Lee, Gyeongsil ; Choi, Seulggie ; Kim, Kyae Hyung ; Chang, Jooyoung ; Kim, Kyuwoong ; Son, Joung Sik ; Kim, Sung Min ; Oh, Yun Hwan ; Park, Sang Min

Purpose : Cancer survivors are currently considered high-risk populations for cardiovascular disease. However, no studies have directly evaluated risks and benefits of physical activity for stroke among long-term colorectal cancer survivors. Methods : This large-scale observational cohort study used data from the Korean National Health Insurance Service database. Newly diagnosed colorectal cancer patients diagnosed between 2006 and 2013 who survived at least 5 years were studied. The primary [...]

Menée en France à partir de données 1990-2018 de registres (FRANCIM, CépiDc), cette étude analyse les tendances dans l'incidence et la mortalité des cancers, en fonction du sexe

Cancer incidence and mortality trends in France over 1990–2018 for solid tumors: the sex gap is narrowing

Defossez, G. ; Uhry, Z. ; Delafosse, P. ; Dantony, E. ; d’Almeida, T. ; Plouvier, S. ; Bossard, N. ; Bouvier, A. M. ; Molinié, F. ; Woronoff, A. S. ; Colonna, M. ; Grosclaude, P. ; Remontet, L. ; Monnereau, A. ; Amadeo, Brice ; Baldi, Isabelle ; Bara, Simona ; Bouvier, Anne-Marie ; Bouvier, Veronique ; Colonna, Marc ; Coureau, Gaelle ; Cowppli-Bony, Anne ; Dabakuyo-Yonli, Sandrine ; d’Almeida, Tania ; Daubisse-Marliac, Laetitia ; Defossez, Gautier ; Delafosse, Patricia ; Désandes, Emmanuel ; Grosclaude, Pascale ; Guizard, Anne-Valérie ; Lacour, Brigitte ; Lapôtre-Ledoux, Bénédicte ; Hammas, Karima ; Molinié, Florence ; Nousbaum, Jean-Baptiste ; Plouvier, Sandrine ; Pouchieu, Camille ; Robaszkiewicz, Michel ; Schvartz, Claire ; Tretarre, Brigitte ; Velten, Michel ; Woronoff, Anne-Sophie ; the French Network of Cancer, Registries

Objective: To analyze trends in cancer incidence and mortality (France, 1990–2018), with a focus on men-women disparities. Methods: Incidence data stemmed from cancer registries (FRANCIM) and mortality data from national statistics (CépiDc). Incidence and mortality rates were modelled using bidimensional penalized splines of age and year (at diagnosis and at death, respectively). Trends in age-standardized rates were summarized by the average annual percent changes (AAPC) for all-cancers [...]

Menée à partir des données des registres américains des cancers sur la période 2000-2017, cette étude analyse les disparités ethniques dans l'incidence des cancers chez les enfants et jeunes adultes (âge : 0-39 ans) en fonction de l'âge

Racial and ethnic disparities in pediatric cancer incidence among children and young adults in the United States by single year of age

Marcotte, Erin L. ; Domingues, Allison M. ; Sample, Jeannette M. ; Richardson, Michaela R. ; Spector, Logan G.

Background : Incidence rates of pediatric cancers in the United States are typically reported in 5-year age groups, obscuring variation by single year of age. Additionally, racial and ethnic variation in incidence is typically presented in broad categories rather than by narrow age ranges. Methods : The Surveillance, Epidemiology, and End Results (SEER) 18 data (2000-2017) were examined to calculate frequencies and age-adjusted incidence rates among individuals aged birth to 39 years. Incidence [...]

Menée auprès de 2 352 patientes atteintes d'un cancer épithélial de l'ovaire, cette étude d'association sur le génome entier identifie un nouveau locus associé à la survie sans progression de la maladie (12q24.33)

Identification of a locus near ULK1 associated with progression-free survival in ovarian cancer

Quinn, Michael CJ ; McCue, Karen ; Shi, Wei ; Johnatty, Sharon E. ; Beesley, Jonathan ; Civitarese, Andrew ; O'Mara, Tracy A ; Glubb, Dylan M ; Tyrer, Jonathan P ; Armasu, Sebastian M. ; Ong, Jue-Sheng ; Gharahkhani, Puya ; Lu, Yi ; Gao, Bo ; Patch, Ann-Marie ; Fasching, Peter A. ; Beckmann, Matthias W. ; Lambrechts, Diether ; Vergote, Ignace ; Velez Edwards, Digna ; Beeghly-Fadiel, Alicia ; Benítez, Javier ; Garcia, Maria J ; Goodman, Marc T. ; Dörk, Thilo ; Dürst, Matthias ; Modugno, Francesmary ; Moysich, Kirsten ; du Bois, Andreas ; Pfisterer, Jacobus ; Bauman, Klaus ; Karlan, Beth Y. ; Lester, Jenny ; Cunningham, Julie M. ; Larson, Melissa C. ; McCauley, Bryan M ; Kjaer, Susanne K. ; Jensen, Allan ; Høgdall, Claus K. ; Høgdall, Estrid ; Schildkraut, Joellen M. ; Riggan, Marjorie J. ; Berchuck, Andrew ; Cramer, Daniel W. ; Terry, Kathryn L. ; Borge, Line ; Webb, Penelope M. ; Friedlander, Michael ; Pejovic, Tanja ; Moffit, Melissa ; Glasspool, Rosalind ; May, Taymaa ; Ene, Gabrielle EV ; Huntsman, David G. ; Woo, Michelle ; Carney, Michael E. ; Hinsley, Samantha ; Heitz, Florian ; Fereday, Sian ; Kennedy, Catherine J ; Edwards, Stacey L ; Winham, Stacey J. ; Defazio, Anna ; Pharoah, Paul D. P. ; Goode, Ellen L. ; MacGregor, Stuart ; Chenevix-Trench, Georgia

Background: Many loci have been found to be associated with risk of epithelial ovarian cancer (EOC). However, although there is considerable variation in progression-free survival (PFS), no loci have been found to be associated with outcome at genome-wide levels of significance. Methods: We carried out a genome-wide association study (GWAS) of PFS in 2352 women with EOC who had undergone cytoreductive surgery and standard carboplatin/paclitaxel chemotherapy. Results: We found seven single [...]

Menée à l'aide de données portant sur 272 patientes atteintes d'un cancer du sein de stade 0 à III (durée médiane de suivi : 4 ans), cette étude analyse l'effet, sur la survie sans maladie invasive ou la survie globale, de la stimulation ovarienne pour la préservation de la fertilité, en fonction du statut des récepteurs des estrogènes

The impact of fertility preservation on the timing of breast cancer treatment, recurrence, and survival

Greer, Anna C. ; Lanes, Andrea ; Poorvu, Philip D. ; Kennedy, Patricia ; Thomas, Ann M. ; Partridge, Ann H. ; Ginsburg, Elizabeth S.

Background: Many young women with breast cancer undergo fertility preservation (FP) before cancer treatment. This study examined the impact of FP on breast cancer outcomes. Methods: The authors performed a retrospective cohort study of 272 women aged 20 to 45 years with newly diagnosed stage 0 to III breast cancer who underwent an FP consultation between 2005 and 2017. Among these women, 123 (45.2%) underwent FP (fertility preservation–positive [FP+]). The remaining 149 women did not undergo FP [...]

Menée à partir des données de 954 patientes ayant survécu à un cancer du sein et incluses dans un essai randomisé (âge moyen : 56,6 ans), cette étude analyse les facteurs de risque modifiables (polypharmacie, médication supplémentaire) associés à un abandon précoce du traitement endocrinien adjuvant

Association of Modifiable Risk Factors With Early Discontinuation of Adjuvant Endocrine Therapy: A Post Hoc Analysis of a Randomized Clinical Trial

Yanez, Betina ; Gray, Robert J. ; Sparano, Joseph A. ; Carlos, Ruth C. ; Sadigh, Gelareh ; Garcia, Sofia F. ; Gareen, Ilana F. ; Whelan, Timothy J. ; Sledge, George W. ; Cella, David ; Wagner, Lynne I.

Importance Early discontinuation of adjuvant endocrine therapy (ET) is problematic among breast cancer survivors, with previous studies suggesting that up to 50% of women do not adhere to the recommended full 5 years of ET treatment. Objective To identify the association between early discontinuation of ET in the Trial Assigning Individualized Options for Treatment (TAILORx) and modifiable risk factors, polypharmacy, and types of additional medications such as antidepressants and opioids. [...]

Menée en Chine, cette étude analyse l'évolution, sur la période 1983-2012, de l'incidence du cancer de la thyroïde et présente des projections jusqu'en 2032

Changing incidence and projections of thyroid cancer in mainland China, 1983–2032: evidence from Cancer Incidence in Five Continents

Li, Mandi ; Pei, Jiao ; Xu, Minghan ; Shu, Ting ; Qin, Chengjie ; Hu, Meijing ; Zhang, Yawei ; Jiang, Min ; Zhu, Cairong

Purpose : An increasing incidence of thyroid cancer has been seen in China during the past several decades. The aim of this study was to analyze potential age, period, and cohort effects on the incidence of thyroid cancer in mainland China and to predict new cases up to 2032. Methods : We calculated age-adjusted and age-specific incidence rates of thyroid cancer, conducted an age–period–cohort analysis of 35,037 thyroid cancer incidence cases reported to Cancer Incidence in Five Continents from [...]

Menée au Brésil auprès de 797 patients atteints d'un carcinome épidermoïde de l'oropharynx diagnostiqué entre 2008 et 2018, cette étude analyse la prévalence de l'infection par le papillomavirus humain et la survie globale associée

HPV-induced oropharyngeal squamous cell carcinomas in Brazil: prevalence, trend, clinical and epidemiological characterization

Carvalho, Raiany Santos ; Scapulatempo-Neto, Cristovam ; Curado, Maria Paula ; Capuzzo, Renato de Castro ; Teixeira, Fernanda Marsico ; Pires, Rafael Cardoso ; Cirino, Maria Thereza ; Martins, Jessica Cambrea Joaquim ; Silva, Isabella Almeida Oliveira ; Oliveira, Marco Antonio ; Watanabe, Marcel ; Ribeiro, Adeylson Guimaraes ; Caravina de Almeida, Gisele ; Reis, Rui Manuel ; Gama, Ricardo Ribeiro ; Carvalho, André Lopes ; de Carvalho, Ana Carolina

Background: Tobacco or human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCC) represent different clinical and epidemiological entities. This study investigated the prevalence of HPV-positive and HPV-negative OPSCC in a reference cancer hospital in Brazil and its association with clinical and demographic data, as well as its impact on overall survival. Methods: HPV infection was determined by p16-immunohistochemistry (p16-IHC) in pre-treatment FFPE samples from all [...]