A partir d'une revue systématique de la littérature publiée jusqu'en mai 2020 (5 études, 1 179 patients), cette méta-analyse évalue l'association entre une exposition au tabagisme passif et le risque de cancer de la cavité buccale

Secondhand smoke exposure and oral cancer risk: a systematic review and meta-analysis

Mariano, Lorena C. ; Warnakulasuryia, Saman ; Straif, Kurt ; Monteiro, Luís

Objectives: Inhalation of secondhand smoke (SHS) causes several diseases, including lung cancer. Tobacco smoking is a known cause of oral cancer; however, it has not been established whether SHS also causes oral cancer . The aim of this study was to evaluate the potential association between SHS exposure and the risk of oral cancer. Methods: A systematic review and meta-analysis study (following the PRISMA guidelines) was developed to examine the studies reporting on the associations of SHS and [...]

Menée à l'aide de données de la cohorte européenne EPIC portant sur 450 111 participants (durée médiane de suivi : 14,9 ans), cette étude analyse l'association entre un apport alimentaire en produits de glycation avancée (présents dans les aliments riches en graisses et hautement transformés) et le risque de cancers hépatobiliaires (528 cas)

Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: a multinational cohort study

Mayén, Ana-Lucia ; Aglago, Elom K. ; Knaze, Viktoria ; Cordova, Reynalda ; Schalkwijk, Casper G. ; Wagner, Karl-Heinz ; Aleksandrova, Krasimira ; Fedirko, Veronika ; Keski-Rahkonen, Pekka ; Leitzmann, Michael F. ; Katzke, Verena ; Srour, Bernard ; Schulze, Matthias B. ; Masala, Giovanna ; Krogh, Vittorio ; Panico, Salvatore ; Tumino, Rosario ; Bueno-de-Mesquita, Bas ; Brustad, Magritt ; Agudo, Antonio ; Chirlaque López, María Dolores ; Amiano, Pilar ; Ohlsson, Bodil ; Ramne, Stina ; Aune, Dagfinn ; Weiderpass, Elisabete ; Jenab, Mazda ; Freisling, Heinz

Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their pro-inflammatory and pro-oxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer aetiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n=450,111). Dietary intake of three AGEs, [...]

Menée en Australie à l'aide de données 2006-2014 portant sur 16 663 adultes (âge moyen : 43,7 ans), cette étude analyse l'association entre le poids pris après un sevrage tabagique et le risque de cancer

Weight Gain After Smoking Cessation and Risk of Major Chronic Diseases and Mortality

Sahle, Berhe W. ; Chen, Wen ; Rawal, Lal B. ; Renzaho, Andre M. N.

Smoking cessation is frequently followed by weight gain; however, whether weight gain after quitting reduces the health benefits of quitting is unclear.To examine the association between weight change after smoking cessation and the risk of cardiovascular diseases (CVD), type 2 diabetes, cancer, chronic obstructive pulmonary disease (COPD), and all-cause mortality.This cohort study analyzed data from a nationally representative sample of Australian adults aged 18 years or older who were studied [...]

Menée en Norvège auprès d'une cohorte de 151 710 femmes (âge : 30-75 ans ; durée moyenne de suivi : 18,5 ans), cette étude analyse l'association entre la pratique d'une activité physique, l'exposition aux rayons ultraviolets et le risque de mélanome cutané (1 565 cas)

Physical activity and cutaneous melanoma risk: A Norwegian population-based cohort study

Perrier, Flavie ; Ghiasvand, Reza ; Lergenmuller, Simon ; Robsahm, Trude E. ; Green, Adèle C. ; Borch, Kristin B. ; Sandanger, Torkjel M. ; Weiderpass, Elisabete ; Rueegg, Corina S. ; Veierød, Marit B.

Physical activity (PA) is an important factor in cancer prevention, but positive association between PA and risk of cutaneous melanoma found in recent studies may complicate this strategy. Ultraviolet radiation (UVR) exposure during outdoor PA is a plausible explanation for a positive association. We investigated the associations between PA, UVR and melanoma risk in the Norwegian Women and Cancer cohort. Overall PA was reported by 151,710 women, aged 30–75 at inclusion, using a validated [...]

Menée à partir de données de registres néo-zélandais portant sur des femmes âgées de 35 à 69 ans, cette étude analyse l'association entre plusieurs méthodes de contraception (acétate de médroxyprogestérone-retard, dispositifs intra-utérins et vasectomie du partenaire sexuel) et le risque de cancer de l'ovaire

Method of Contraception and Risk of Ovarian Cancer Data

Chesang, Jacqueline ; Richardson, Ann ; Potter, John ; Sneyd, Mary ; Coope, Pat

The data presented here were obtained for New Zealand nationwide population-based case-control analysis undertaken to assess the association between ovarian cancer and depot medroxyprogesterone acetate (DMPA), intrauterine contraceptive devices (IUDs), and vasectomy of a woman's sexual partner [1]. Approval to conduct the research was obtained from Southern Health and Disability Ethics Committee (13/STH/26) and the University of Canterbury Ethics Committee (HEC 2013/08). Recruitment of [...]

Menée à partir de données sur l'exome entier de 30 223 adultes, cette étude analyse la prévalence du variant pathogène CDH1 et le risque de cancer de l'estomac ou du sein associé à ce variant

CDH1 pathogenic variants and cancer risk in an unselected patient population

Bar-Mashiah, Ariel ; Soper, Emily R. ; Cullina, Sinead ; Belbin, Gillian M. ; Kenny, Eimear E. ; Lucas, Aimee L. ; Abul-Husn, Noura S.

CDH1 pathogenic variants confer a markedly elevated lifetime risk of developing diffuse gastric cancer (DGC) and lobular breast cancer (LBC). The aim of this study was to evaluate the prevalence and clinical impact of CDH1 pathogenic variants in the unselected and ancestrally diverse BioMe Biobank. We evaluated exome sequence data from 30,223 adult BioMe participants to identify CDH1 positive individuals, defined as those harboring a variant previously classified as pathogenic or likely [...]

Menée en Corée à partir de données portant sur 83 886 adultes ayant subi un examen médical en 2002 ou 2003 (durée moyenne de suivi : 11,6 ans), cette étude analyse l'association entre une anémie et le risque de cancer

Anemia may increase the overall risk of cancer: Findings from a cohort study with a 12-year follow-up period in South Korea

Oh, Tak Kyu ; Song, In-Ae

Background: No previous study has assessed cancer risk in individuals with anemia diagnosed based on hemoglobin levels. Thus, we aimed to investigate whether anemia increases the risk of cancer. Methods: Adult individuals who underwent a standardized medical examination during 2002-2003 in South Korea were included, and their cancer status was evaluated between January 2004 and December 2015 (12 years) as a primary endpoint. Anemia was defined as serum hemoglobin levels of <12 g/dL  and [...]

Menée en Suisse à l'aide de données 1969-2015 portant sur 1 403 enfants atteints d'une leucémie, cette étude analyse l'association entre des caractéristiques liées à la naissance (âge parental à la naissance, âge gestationnel, poids à la naissance, ordre dans la fratrie) et le rique de développer la maladie

Birth characteristics and childhood leukemia in Switzerland: a register-based case–control study

Lupatsch, Judith E. ; Kreis, Christian ; Konstantinoudis, Garyfallos ; Ansari, Marc ; Kuehni, Claudia E. ; Spycher, Ben D.

Purpose: Initial genetic alterations in the development of childhood leukemia occur in utero or before conception; both genetic and environmental factors are suspected to play a role. We aimed to investigate the associations between childhood leukemia and perinatal characteristics including birth order, birth interval to older siblings, parental age, birth weight, and multiple birth. Methods: We identified cases diagnosed between 1981 and 2015 and born in Switzerland between 1969 and 2015 from [...]

Menée à partir de données 1968-2015 de registres danois portant sur 178 enfants atteints d'une tumeur germinale et sur 4 355 témoins (âge au diagnostic : moins de 16 ans), cette étude analyse l'association entre le métier des parents et le risque pour l'enfant de développer la maladie

Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016

Hall, Clinton ; Hansen, Johnni ; Olsen, Jørn ; He, Di ; von Ehrenstein, Ondine S. ; Ritz, Beate ; Heck, Julia E.

Purpose: To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). Methods: This population-based case–control study included childhood GCT cases in Denmark diagnosed 1968–2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was [...]

Menée à partir de données de la "UK Biobank" portant sur 333 530 participants puis menée à l'aide d'une méthode de randomisation mendélienne et de données génétiques portant sur 42 752 témoins et sur 42 866 patients atteints d'un cancer colorectal, cette étude analyse l'association entre les taux de testostérone ou de globuline de liaison des hormones stéroïdes sexuelles (SHBG) et le risque de développer la maladie

Circulating levels of testosterone, sex hormone binding globulin and colorectal cancer risk: observational and Mendelian randomization analyses

Dimou, Niki ; Mori, Nagisa ; Harlid, Sophia ; Harbs, Justin ; Martin, Richard M. ; Smith-Byrne, Karl ; Papadimitriou, Nikos ; Bishop, D. Timothy ; Casey, Graham ; Colorado-Yohar, Sandra M. ; Cotterchio, Michelle ; Cross, Amanda J ; Le Marchand, Loic ; Lin, Yi ; Offit, Kenneth ; Onland-Moret, N. Charlotte ; Peters, Ulrike ; Potter, John D. ; Rohan, Thomas E. ; Weiderpass, Elisabete ; Gunter, Marc J. ; Murphy, Neil

Background: Epidemiological studies evaluating associations between sex steroid hormones and colorectal cancer risk have yielded inconsistent results. To elucidate the role of circulating levels of testosterone, and sex hormone-binding globulin (SHBG) in colorectal cancer risk we conducted observational and Mendelian randomization (MR) analyses. Methods: The observational analyses included 333,530 participants enrolled in the UK Biobank with testosterone and SHBG measured. Hazard ratios (HRs) [...]

Menée auprès de 1 483 femmes en bonne santé et 2 578 femmes atteintes d'une dysplasie cervicale ou d'un cancer du col de l'utérus (âge médian au diagnostic : 31 ou 44 ans), cette étude analyse l'association entre des variants des gènes PBX2 et PAX8 et le risque de développer ces maladies

Association of genomic variants at PAX8 and PBX2 with cervical cancer risk

Ramachandran, Dhanya ; Wang, Yingying ; Schürmann, Peter ; Hülse, Fabienne ; Mao, Qianqian ; Jentschke, Matthias ; Böhmer, Gerd ; Strauß, Hans-Georg ; Hirchenhain, Christine ; Schmidmayr, Monika ; Muller, Florian ; Runnebaum, Ingo ; Hein, Alexander ; Koch, Martin ; Ruebner, Matthias ; Beckmann, Matthias W. ; Fasching, Peter A. ; Luyten, Alexander ; Dürst, Matthias ; Hillemanns, Peter ; Dörk, Thilo

Cervical malignancy is triggered by human papillomavirus infection but the risk for cervical cancer has a hereditary component. From a recent GWAS meta-analysis, 2q14.1 (PAX8) and 6p21.32 (PBX2) have been proposed as novel cervical cancer susceptibility loci. We investigated the two main signals at these loci in an independent case-control series of 2,578 cases with cervical dysplasia or carcinoma and 1,483 healthy females. We find significant associations for both variants, rs10175462 at PAX8 [...]