A partir d'une revue systématique de la littérature publiée entre janvier 2009 et avril 2019 (25 articles), cette étude analyse la perception des effets de la cigarette électronique sur la santé chez des adolescents de 12 à 17 ans aux États-Unis, au Royaume-Uni, au Canada, en Australie et en Nouvelle-Zélande

Adolescent's Health Perceptions of E-Cigarettes: A Systematic Review

Sharma, Anupriya ; McCausland, Kahlia ; Jancey, Jonine

Context: E-cigarette use is increasing among adolescents, particularly in high-income countries. This review examines the health perceptions of E-cigarettes among adolescents (aged 12–17 years) residing in the U.S., United Kingdom, Canada, Australia, and New Zealand and their sources of E-cigarette information. Evidence acquisition: Peer-reviewed literature published in January 2009–April 2019 in MEDLINE, Embase, and ProQuest were systematically reviewed using identified keywords. The search [...]

Menée aux Etats-Unis à partir de données 1980-2016 de la cohorte "the Nurses’ Health Study" portant sur 86 320 femmes (âge : 30-55 ans), cette étude analyse l'association entre l'apport alimentaire en folates et le risque de cancer colorectal (1 988 cas)

Association of folate intake and colorectal cancer risk in the postfortification era in US women

Wang, Fenglei ; Wu, Kana ; Li, Yanping ; Song, Rui ; Wu, You ; Zhang, Xuehong ; Song, Mingyang ; Liang, Liming ; Smith-Warner, Stephanie A ; Giovannucci, Edward L ; Willett, Walter C

Folate may play a preventive role in the early stages of colorectal carcinogenesis, but long latencies may be needed to observe a reduction in colorectal cancer (CRC) incidence. In addition, concerns have been raised about the potential for cancer promotion with excessive folate intake, especially after the mandatory folic acid fortification in the United States in 1998.We aimed to examine the association between folate intake in different chemical forms and CRC risk, especially in the [...]

Mené sur 32 patients présentant des foyers de cryptes aberrantes rectales, cet essai randomisé de phase II évalue l'efficacité, du point de vue de la réduction du nombre de cryptes, et la toxicité d'un traitement à base de polyphénon E pendant 6 mois

Randomized Phase II Trial of Polyphenon E versus Placebo in Patients at High Risk of Recurrent Colonic Neoplasia

Sinicrope, Frank A. ; Viggiano, Thomas R ; Buttar, Navtej S ; Wong Kee Song, Louis M ; Schroeder, Kenneth W ; Kraichely, Robert E. ; Larson, Mark V ; Sedlack, Robert E ; Kisiel, John B ; Gostout, Christopher J ; Kalaiger, Abdul M. ; Patai, Árpád V ; Della'Zanna, Gary ; Umar, Asad ; Limburg, Paul J. ; Meyers, Jeffrey P ; Foster, Nathan R ; Yang, Chung S. ; Sontag, Stephen

Polyphenon E (Poly E) is a green tea polyphenol preparation whose most active component is epigallocatechin gallate (EGCG). We studied the cancer preventive efficacy and safety of Poly E in subjects with rectal aberrant crypt foci (ACF) which represent putative precursors of colorectal cancers. Eligible subjects had prior colorectal advanced adenomas or cancers, and had > 5 rectal ACF at a pre-registration chromoendoscopy. Subjects (N=39) were randomized to 6-months of oral Poly E (780 mg [...]

Menée auprès de 587 témoins et 301 patientes ayant des antécédents de carcinome canalaire in situ, cette étude analyse l'association entre une utilisation de bisphosphonates et le risque de cancer invasif

Bisphosphonate Use and Breast Cancer Risk among Women with Ductal Carcinoma In Situ

Li, Christopher I. ; Flanagan, Meghan R. ; Tang, Mei-Tzu C. ; Porter, Peggy L. ; Malone, Kathleen E.

Women with a history of ductal carcinoma in situ (DCIS) have an elevated risk of a subsequent invasive breast cancer, but there are few established potentially modifiable factors known to lower this risk. Bisphosphonates are a commonly used treatment for patients with osteoporosis and have been shown to lower risks of recurrence and mortality in patients with invasive breast cancer; however, their use has not previously been investigated within the context of DCIS. Utilizing a population-based [...]

Menée auprès de 102 patientes atteintes d'un cancer du sein (âge moyen : 55,7 ans), cette étude analyse l'intérêt d'une plateforme permettant d'orienter des personnes à risque héréditaire vers le conseil génétique

Clinical implementation of an oncology‐specific family health history risk assessment tool

Fung, Si Ming ; Wu, R. Ryanne ; Myers, Rachel A. ; Goh, Jasper ; Ginsburg, Geoffrey S. ; Matchar, David ; Orlando, Lori A. ; Ngeow, Joanne

Background: The presence of hereditary cancer syndromes in cancer patients can have an impact on current clinical care and post-treatment prevention and surveillance measures. Several barriers inhibit identification of hereditary cancer syndromes in routine practice. This paper describes the impact of using a patient-facing family health history risk assessment platform on the identification and referral of breast cancer patients to genetic counselling services. Methods: This was a hybrid [...]