Menée aux Etats-Unis à partir de données portant sur 4 562 témoins et 2 233 patientes atteintes d'un cancer du sein diagnostiqué entre 2006 et 2013, cette étude analyse le rôle de la densité mammaire dans l'association entre la consommation quotidienne d'alcool et le risque de développer la maladie

Association of daily alcohol intake, volumetric breast density, and breast cancer risk

Rustagi, Alison S ; Scott, Christopher G ; Winham, Stacey J ; Brandt, Kathleen R ; Norman, Aaron D ; Jensen, Matthew R ; Shepherd, John A ; Hruska, Carrie ; Heine, John J ; Pankratz, Vernon S ; Kerlikowske, Karla ; Vachon, Celine M

High alcohol intake and breast density increase breast cancer (BC) risk, but their interrelationship is unknown. We examined whether volumetric density modifies and/or mediates the alcohol-BC association. BC cases (n = 2233) diagnosed from 2006–2013 in the San Francisco Bay Area had screening mammograms ≥6 months before diagnosis; controls (n = 4562) were matched on age, mammogram date, race/ethnicity, facility, and mammography machine. Logistic regression was used to estimate alcohol-BC [...]

Menée auprès de 119 316 participants (durée moyenne de suivi : 25,6 ans), cette étude analyse l'association entre le risque de carcinome hépatocellulaire (142 cas) et cinq types de scores évaluant le potentiel inflammatoire et insulinique de l'alimentation et du mode de vie

Association of Inflammatory and Insulinemic Potential of Diet and Lifestyle with Risk of Hepatocellular Carcinoma

Yang, Wanshui ; Sui, Jing ; Zhao, Longgang ; Ma, Yanan ; Tabung, Fred K. ; Simon, Tracey G ; Lee, Dong Hoon ; Zeng, Xufen ; Nguyen, Long H. ; Meyerhardt, Jeffrey A. ; Chan, Andrew T ; Giovannucci, Edward L. ; Zhang, Xuehong

Background: We prospectively examined the extent to which greater inflammatory and insulinemic potential of diet and lifestyle are associated with the risk of developing hepatocellular carcinoma (HCC) in two nationwide cohorts. Methods: Five kinds of pattern scores including the empirical dietary inflammatory pattern (EDIP), empirical dietary index for hyperinsulinemia (EDIH) and insulin resistance (EDIR), empirical lifestyle pattern score for hyperinsulinemia (ELIH) and insulin resistance [...]

Menée à partir de données du registre danois des cancers portant sur 38 375 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre l'exposition professionnelle aux ultra-violets au cours de la vie et le risque de développer la maladie, par sous-type

Occupational exposure to solar ultraviolet B radiation and risk of subtypes of breast cancer in Danish women

Pedersen, Julie Elbaek ; Strandberg-Larsen, Katrine ; Andersson, Michael ; Hansen, Johnni

Objectives: Previous epidemiological studies have indicated that solar ultraviolet B radiation (UVR) may have a protective effect on breast cancer. However, the evidence remains inconclusive. Despite the fact that outdoor work history may be considered a reliable measure of long-term UVR exposure, objective information on lifetime employment has not been included in previous investigations focusing on breast cancer. To address this issue, we explored the association between occupational UVR [...]

Menée à partir de données 2007-2015 du SNDS français portant sur 253 777 filles ou femmes ayant commencé l'utilisation d'acétate de cyprotérone entre 2007 et 2014 (âge moyen : 29,4 ans ; durée moyenne de suivi : 2,1-3,8 ans), cette étude analyse l'association entre l'utilisation de ce progestatif indiqué en cas d'hyperandrogénie et le risque de méningiome (89 cas)

Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

Weill, Alain ; Nguyen, Pierre ; Labidi, Moujahed ; Cadier, Benjamin ; Passeri, Thibault ; Duranteau, Lise ; Bernat, Anne-Laure ; Yoldjian, Isabelle ; Fontanel, Sylvie ; Froelich, Sébastien ; Coste, Joel

Objective: To assess the risk of meningioma associated with use of high dose cyproterone acetate, a progestogen indicated for clinical hyperandrogenism. Design: Observational cohort study. Setting: Data from SNDS, the French administrative healthcare database, between 2007 and 2015. Participants: 253 777 girls and women aged 7-70 years living in France who started cyproterone acetate between 2007 and 2014. Participants had at least one reimbursement for high dose cyproterone acetate and no [...]

Menée aux Etats-Unis à partir de données portant sur plus de 5,2 millions de personnes, cette étude analyse l'association entre une utilisation de produits contenant de l'hydrochlorothiazide (traitements de l'hypertension ou de l'oedème) et le risque de carcinome basocellulaire ou épidermoïde de la peau

Risk of Non-Melanoma Skin Cancer in Association with Use of Hydrochlorothiazide-Containing Products in the United States

Eworuke, Efe ; Haug, Nicole ; Bradley, Marie ; Cosgrove, Austin ; Zhang, Tancy ; Dee, Elizabeth C ; Adimadhyam, Sruthi ; Petrone, Andrew ; Lee, Hana ; Woodworth, Tiffany ; Toh, Sengwee

European studies reported an increased risk of non-melanoma skin cancer associated with hydrochlorothiazide (HCTZ)-containing products. We examined the risks of basal cell (BCC) and squamous cell carcinoma (SCC) associated with HCTZ compared to angiotensin-converting enzyme inhibitors (ACEIs) in a US population.We conducted a retrospective cohort study in the US Food and Drug Administration’s Sentinel System. From the date of HCTZ or ACEI dispensing, patients were followed until a SCC or BCC [...]

Menée à partir de données françaises portant sur 98 995 femmes, cette étude analyse l'association entre une utilisation de faibles doses d'aspirine ou de clopidogrel (antiagrégant plaquettaire) et le risque de cancer du sein (2 864 cas)

Antiplatelet drug use and breast cancer risk in a prospective cohort of postmenopausal women

Cairat, Manon ; Al Rahmoun, Marie ; Gunter, Marc J. ; Severi, Gianluca ; Dossus, Laure ; Fournier, Agnès

Background: Epidemiological evidence is insufficient to draw conclusions on the impact of low-dose aspirin use on breast cancer risk, and the potential impact of other antiplatelet drugs such as clopidogrel needs to be explored. Methods: We investigated the association between breast cancer risk and low-dose aspirin or clopidogrel use in the E3N cohort, which includes 98,995 women, with information on breast cancer risk factors collected from biennial questionnaires matched with drug [...]

Menée aux Etats-Unis à l'aide de données portant sur 6 310 témoins et sur 3 432 patientes atteintes d'un cancer de l'ovaire, cette étude analyse l'association entre des antécédents au 1er et 2nd degré de cancer de l'ovaire ou du sein et le risque de développer un cancer de l'ovaire, par type histologique et en fonction de l'origine ethnique

First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and White women

Bethea, Traci N. ; Ochs-Balcom, Heather M. ; Bandera, Elisa V. ; Beeghly-Fadiel, Alicia ; Camacho, Fabian ; Chyn, Deanna ; Cloyd, Emily K. ; Harris, Holly R. ; Joslin, Charlotte E. ; Myers, Evan ; Moorman, Patricia G. ; Peres, Lauren C. ; Rosenow, Will ; Setiawan, Veronica W. ; Wu, Anna H. ; Rosenberg, Lynn ; Schildkraut, Joellen M.

Family history (FH) of ovarian cancer and breast cancer are well-established risk factors for ovarian cancer, but few studies have examined this association in African American (AA) and White women by histotype. We assessed first- and second-degree FH of ovarian and breast cancer and risk of epithelial ovarian cancer in the Ovarian Cancer in Women of African Ancestry Consortium. Analyses included 1,052 AA cases, 2,328 AA controls, 2,380 White cases, and 3,982 White controls. Race-specific odds [...]

Menée à l'aide des données de 7 études portant au total sur 802 patients atteints d'une leucémie lymphoïde chronique, cette étude identifie 2 loci associés à la progression de la maladie

Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia

Lin, Wei-Yu ; Fordham, Sarah E. ; Sunter, Nicola ; Elstob, Claire ; Rahman, Thahira ; Willmore, Elaine ; Shepherd, Colin ; Strathdee, Gordon ; Mainou-Fowler, Tryfonia ; Piddock, Rachel ; Mearns, Hannah ; Barrow, Timothy ; Houlston, Richard S. ; Marr, Helen ; Wallis, Jonathan ; Summerfield, Geoffrey ; Marshall, Scott ; Pettitt, Andrew ; Pepper, Christopher ; Fegan, Christopher ; Forconi, Francesco ; Dyer, Martin J. S. ; Jayne, Sandrine ; Sellors, April ; Schuh, Anna ; Robbe, Pauline ; Oscier, David ; Bailey, James ; Rais, Syed ; Bentley, Alison ; Cawkwell, Lynn ; Evans, Paul ; Hillmen, Peter ; Pratt, Guy ; Allsup, David J. ; Allan, James M.

Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic locations associated with time from diagnosis to treatment, including 10q26.13 (rs736456, hazard ratio (HR) = 1.78, 95% confidence interval (CI) = 1.47–2.15; P = 2.71 × 10−9) and 6p [...]

Menée au Mexique auprès de 150 patientes atteintes d'un cancer du sein et 150 témoins, cette étude analyse l'association de 9 polymorphismes de gènes de la voie des oestrogènes avec le risque de cancer du sein et des caractéristiques clinicopathologiques de mauvais pronostic (taille de la tumeur, état du ganglion sentinelle, statut des récepteurs hormonaux et survie)

Pathological characteristics, survival, and risk of breast cancer associated with estrogen and xenobiotic metabolism polymorphisms in Mexican women with breast cancer

Martínez-Ramírez, O. C. ; Castro-Hernández, C. ; Pérez-Morales, R. ; Casas-Ávila, L. ; de Lorena, Ramos-García M. ; Salazar-Piña, A. ; Rubio, J.

Prolonged exposure to estrogens is the main factor associated with the risk and prognosis of breast cancer (BC). The genes involved in the biotransformation of estrogens and xenobiotics have allelic variants with modified enzymatic activities. We investigated the association of nine polymorphisms of some genes from the classical estrogen pathway with the risk of breast cancer and their role in the clinicopathological characteristics of poor clinical prognosis in a sample of Mexican women with [...]

Menée à l'aide du génotypage de 2 321 témoins et 1 855 patients atteints d'un carcinome différencié de la thyroïde, cette étude d'association sur le génome entier confirme ou identifie des loci de susceptibilité à la maladie, en fonction de l'origine ethnique

Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium

Truong, Thérèse ; Lesueur, Fabienne ; Sugier, Pierre-Emmanuel ; Guibon, Julie ; Xhaard, Constance ; Karimi, Mojgan ; Kulkarni, Om ; Lucotte, Elise A. ; Bacq-Daian, Delphine ; Boland-Auge, Anne ; Mulot, Claire ; Laurent-Puig, Pierre ; Schvartz, Claire ; Guizard, Anne-Valérie ; Ren, Yan ; Adjadj, Elisabeth ; Rachédi, Frédérique ; Borson-Chazot, Françoise ; Ortiz, Rosa Maria ; Lence-Anta, Juan J. ; Pereda, Celia María ; Comiskey Jr, Daniel F. ; He, Huiling ; Liyanarachchi, Sandya ; de la Chapelle, Albert ; Elisei, Rossella ; GEMIGNANI, Federica ; Thomsen, Hauke ; Försti, Asta ; Herzig, Anthony F. ; Leutenegger, Anne-Louise ; Rubino, Carole ; Ostroumova, Evgenia ; Kesminiene, Ausrele ; Boutron-Ruault, Marie-Christine ; Deleuze, Jean-Francois ; Guénel, Pascal ; de Vathaire, Florent

Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to identify new ones, we conducted a multiethnic genome-wide association study (GWAS) in individuals of [...]

Cette étude compare 2 méthodes d'estimation du risque de cancer colorectal attribuable aux facteurs de risque modifiables (activité physique, indice de masse corporelle, alcool, viande rouge, viande transformée, fibres alimentaires, calcium alimentaire et tabagisme)

A comparison of methods in estimating population attributable risk for colorectal cancer in the United States

Kim, Hanseul ; Wang, Kai ; Song, Mingyang ; Giovannucci, Edward L.

Population attributable risk (PAR) is becoming more widely used for quantifying preventability of cancer. However, its estimations have had a wide range, leading to questions about the true preventability. Our study aimed to compare the two PAR estimation methods (ie, literature-based method and low-risk method) for colorectal cancer (CRC) in the US population based on the same set of modifiable risk factors: physical activity, body mass index, alcoholic drinks, red meat, processed meat, [...]