A partir d'une revue systématique de la littérature (29 essais randomisés, 2 423 participants), cette étude analyse l'intérêt des interventions non pharmacologiques pour prendre en charge l'essoufflement chez des patients atteints d'un cancer de stade avancé (réadaptation respiratoire, activité physique, psychothérapies comportementales , médecine intégrative, ...)

Nonpharmacological Interventions for Managing Breathlessness in Patients With Advanced Cancer: A Systematic Review

Gupta, Arjun ; Sedhom, Ramy ; Sharma, Ritu ; Zhang, Allen ; Waldfogel, Julie M. ; Feliciano, Josephine L. ; Day, Jeff ; Gersten, Rebecca A. ; Davidson, Patricia M. ; Bass, Eric B. ; Dy, Sydney M.

Importance : Breathlessness is a frequent and debilitating symptom in patients with advanced cancer. Often, in the context of breathlessness, aggressive cancer treatment is not beneficial, feasible, or aligned with goals of care. Targeted symptom-focused interventions may be helpful in this scenario. Objective :To evaluate the advantages and harms of nonpharmacological interventions for managing breathlessness in adults with advanced cancer. Evidence :Review PubMed, Embase, CINAHL, Web of [...]

Menée en France auprès de 100 patientes atteintes d'un cancer métastatique du sein, cette étude prospective analyse l'intérêt des soins de support pour améliorer la qualité de vie et réduire le recours à des soins hospitaliers non programmés

Role of supportive care in improving the quality of life and reducing unscheduled hospital care in patients with metastatic breast cancer

Arnaud, Antoine ; Grenier, Julien ; Boustany, Rania ; Kirscher, Sylvie ; Mege, Alice ; de Rauglaudre, Gaëtan ; Vazquez, Léa ; Debourdeau, Philippe

Background : Metastatic breast cancer (MBC) patients experience long survival and report poorer quality of life than localized breast cancer patients. Comprehensive supportive care (CSC) has been shown to improve the quality of life (QoL) of MBC. The respective part of each support care has not been fully examined, and little is known about whether meeting patients’ needs is accompanied by decreased unscheduled hospital care (UHC). Methods : This prospective monocentric study included women who [...]

Menée à partir de données portant sur 284 patientes atteintes d'un cancer du sein de stade précoce, cette étude analyse, selon la catégorie d'âge (inférieure ou supérieure à 65 ans), la sévérité de leurs symptômes auto-déclarés, la survenue d'événements indésirables en lien avec divers protocoles de chimiothérapies et l'impact de ces symptômes sur les activités de leur vie quotidienne

Patient-reported symptom severity, interference with daily activities, and adverse events in older and younger women receiving chemotherapy for early breast cancer

Nyrop, Kirsten A. ; Deal, Allison M. ; Chen, Yi Tang ; Reeve, Bryce B. ; Basch, Ethan M. ; Wood, William A. ; Shachar, Shlomit S. ; Carey, Lisa A. ; Reeder-Hayes, Katherine E. ; Dees, E. Claire ; Jolly, Trevor A. ; Kimmick, Gretchen G. ; Karuturi, Meghan S. ; Reinbolt, Raquel E. ; Speca, JoEllen C. ; Lee, Jordan T. ; Brenizer, Addison ; Muss, Hyman B.

Background : To the authors' knowledge, it is unknown whether patient‐reported symptom severity and symptom interference with daily activities differ between younger (aged <65 years) and older (aged ≥65 years) women receiving similar chemotherapy regimens for early breast cancer (EBC). Methods : Study participants rated 17 side effects of chemotherapy regimens currently in use in clinical practice (2014‐2019). Results : Of 284 women with EBC (stage I‐III), approximately 57% were aged <65 years [...]

Menée en Belgique, cette étude présente la faisabilité et l'intérêt d'une intervention, dispensée sur une plateforme numérique, de promotion de l'activité physique à domicile avant et après une cystectomie radicale, pour améliorer la santé physique et psychique des patients atteints d'un cancer de la vessie

Development of a pre- and postoperative physical activity promotion program integrated in the electronic health system of patients with bladder cancer (The POPEYE study): An intervention mapping approach

Rammant, Elke ; Deforche, Benedicte ; Van Hecke, Ann ; Verhaeghe, Sofie ; Van Ruymbeke, Barbara ; Bultijnck, Renée ; Van Hemelrijck, Mieke ; Fox, Louis ; Pieters, Ronny ; Decaestecker, Karel ; Fonteyne, Valérie

Introduction : Uptake of sufficient physical activity before and after radical cystectomy is important to improve physical and psychosocial outcomes in bladder cancer (BC) patients. Methods : In this paper, we describe the development of an evidence‐based and theory‐informed intervention, guided by the steps of the Intervention Mapping approach, to promote physical activity before and after radical cystectomy in patients with BC. Results : The intervention is a home‐based physical activity [...]

Menée à partir de données portant sur 7 728 patients ayant survécu à la bombe atomique et atteints d'un cancer gastrointestinal diagnostiqué entre 1958 et 2009, cette étude analyse l'association entre une exposition à différentes doses de radiations avant le diagnostic et la survie spécifique et globale

Gastrointestinal Cancer Survival and Radiation Exposure among Atomic Bomb Survivors: The Life Span Study

Bockwoldt, Brandie R ; Sugiyama, Hiromi ; Tsai, Kevin ; Bhatti, Parveen ; Brenner, Alina V. ; Hu, Audrey ; Kerr, Kathleen F ; Morenz, Eric ; French, Benjamin ; Phipps, Amanda I.

Background: Radiation exposure is an established risk factor for the development of several forms of cancer, including gastrointestinal cancers. However, few studies have investigated the relationship between pre-diagnostic radiation exposure and survival after cancer diagnosis. Methods: Participants in the Life Span Study (LSS) of atomic bomb survivors who were diagnosed with a first primary invasive stomach, colon, or rectal cancer between 1958-2009 were followed for mortality during [...]

Menée aux Etats-Unis, cette étude présente une projection, pour la période 2012-2040, de l'incidence du cancer hépatocellulaire associé à une infection par le virus de l'hépatite B en lien avec une utilisation d'antiviraux à action directe

Assessment of Incidence of and Surveillance Burden for Hepatocellular Carcinoma Among Patients With Hepatitis C in the Era of Direct-Acting Antiviral Agents

Chen, Qiushi ; Ayer, Turgay ; Adee, Madeline G. ; Wang, Xiaojie ; Kanwal, Fasiha ; Chhatwal, Jagpreet

Importance : In the US, hepatocellular carcinoma (HCC), primarily associated with hepatitis C virus (HCV) infection, is the fastest rising cause of cancer-related death. Wider use of highly effective direct-acting antiviral agents (DAAs) substantially reduces the burden of chronic HCV infection, but the subsequent impacts with HCV-associated HCC remain unknown. Objective : To assess projected changes in the incidence rate of and surveillance burden for HCC in the era of DAA treatment for HCV. [...]

Menée au Canada, aux Etats-Unis et en Australie, cette étude analyse l'évolution, sur la période 1985-2013, de l'incidence du cancer hépatique chez les enfants âgés de moins de 15 ans, ainsi que la survie relative à 5 ans

Pediatric hepatic cancer incidence and survival: 30-year trends in Ontario, Canada; the United States; and Australia

Di Giuseppe, Giancarlo ; Youlden, Danny R. ; Aitken, Joanne F. ; Pole, Jason D.

Background : Pediatric hepatic cancer is a rare malignancy, comprising only approximately 2% of all cancers diagnosed in children aged <15 years. The authors sought to describe trends in pediatric hepatic cancer incidence and survival in Ontario, Canada; the United States; and Australia. Methods : Children aged <15 years who were diagnosed with hepatic cancer from 1985 through 2013 were ascertained through population-based registries and followed from the time of diagnosis until December 31, [...]

Menée aux Etats-Unis à partir de données portant sur 129 487 patients atteints d'un carcinome hépatocellulaire, cette étude évalue l'efficacité, du point de vue de la mortalité spécifique, d'une greffe de foie

The Impact of Liver Transplantation on Hepatocellular Carcinoma Mortality in the United States

Mahale, Parag ; Shiels, Meredith S. ; Lynch, Charles F. ; Chinnakotla, Srinath ; Wong, Linda L ; Hernandez, Brenda Y. ; Pawlish, Karen S. ; Li, Jie ; Alverson, Georgetta ; Schymura, Maria J ; Engels, Eric A.

Background: Hepatocellular carcinoma (HCC) carries a poor prognosis. Liver transplantation (LT) is potentially curative for localized HCC. We evaluated the impact of LT on US general population HCC-specific mortality rates. Methods: The Transplant Cancer Match Study links the US transplant registry with 17 cancer registries. We calculated age-standardized incidence (1987-2017) and incidence-based mortality (IBM) rates (1991-2017) for adult HCCs. We partitioned population-level IBM rates by [...]

Menée en Norvège à partir d'échantillons d'urine collectés auprès de 10 149 filles de 17 ans et testés pour 37 génotypes du papillomavirus humain (HPV), cette étude analyse la présence d'infections concomitantes par différents types de HPV en fonction du statut vaccinal

Concurrent infection with multiple human papillomavirus types among unvaccinated and vaccinated 17-year-old Norwegian girls

Laake, Ida ; Feiring, Berit ; Jonassen, Christine Monceyron ; Pettersson, John H-O ; Frengen, Torstein Gjølgali ; Kirkeleite, Ingerid Ørjansen ; Trogstad, Lill

Whether type-specific human papillomavirus (HPV) infection influences the risk of acquiring infections with other HPV types is unclear. We studied concurrent HPV infections in 17-year-old girls from two birth cohorts; the first vaccine-eligible cohort in Norway and a pre-vaccination cohort.Urine samples were collected and tested for 37 HPV genotypes. This study was restricted to unvaccinated girls from the pre-vaccination cohort (n=5245) and vaccinated girls from the vaccine-eligible cohort [...]

Menée en Suède à partir de données portant sur 1 718 patients atteints d'un cancer, cette étude analyse les facteurs sociodémographiques et cliniques associés à l'utilisation des soins pendant la première année suivant le diagnostic

Factors associated with healthcare utilisation during first year after cancer diagnose—a population-based study

Ullgren, Helena ; Sharp, Lena ; Olofsson, Anna ; Fransson, Per

Background : Improved cancer treatments and models of care (such as early palliative care) has developed during recent years. Aspects of healthcare utilisation—unplanned care have been used for evaluation of coordination and quality. The aim was to explore factors associated with cancer healthcare utilisation, during the first year after a cancer diagnosis. Methods : Population‐based registry and patient‐reported data, (The European Organisation of Research and Treatment of Cancer (EORTC), QLQ‐ [...]

Menée à partir de données 1980-2013 du registre des cancers danois portant sur 1 336 patients atteints d'une leucémie pendant l'enfance et sur 5 330 témoins, cette étude analyse l'association entre des facteurs socioéconomiques et le risque de développer la maladie, en fonction du type de leucémie et de l'âge au moment du diagnostic

Is the risk of childhood leukaemia associated with socioeconomic measures in Denmark?: A nationwide register-based case-control study

Erdmann, Friederike ; Hvidtfeldt, Ulla Arthur ; Feychting, Maria ; Sørensen, Mette ; Raaschou-Nielsen, Ole

The aetiology of childhood leukaemia is poorly understood. Knowledge about differences in risk by socioeconomic status (SES) may enhance etiologic insights. We conducted a nationwide register-based case-control study to evaluate socioeconomic differences in the risk of childhood leukaemia in Denmark and to access whether associations varied by different measures of SES, time point of assessment, leukaemia type, and age at diagnosis. We identified all cases of leukaemia in children aged [...]

Menée en Allemagne à partir de données portant sur 232 patients ayant survécu à un cancer du poumon, cette étude transversale analyse les facteurs associés à leur retour à l'emploi

Returning to work in lung cancer survivors—a multi-center cross-sectional study in Germany

Rashid, Humayra ; Eichler, Martin ; Hechtner, Marlene ; Gianicolo, Emilio ; Wehler, Beatrice ; Buhl, Roland ; Schmidberger, Heinz ; Stratmann, Jan A. ; Gohrbandt, Bernhard ; Kortsik, Cornelius ; Nestle, Ursula ; Wirtz, Hubert ; Blettner, Maria ; Singer, Susanne

Purpose : To investigate the work situation of lung cancer survivors and to identify the factors associated with their returning to work. Methods : Descriptive analysis and logistic regression were used to evaluate study population characteristics and independent factors of subsequently returning to work. To analyze time to return to work, Cox regression was used. Results : The study sample included 232 lung cancer survivors of working age from 717 enrolled participants in the multi-center [...]

Menée aux Etats-Unis à partir de données portant sur 73 patientes atteintes d'un cancer du sein de stade précoce après la ménopause (âge moyen : 63,7 ans), cette étude transversale analyse l'association entre l'activité physique, les fonctions cognitives et la santé respiratoire, avant le début d'un traitement systémique adjuvant

Physical activity, cardiorespiratory fitness, and cognitive function in postmenopausal women with breast cancer

Bender, Catherine M. ; Sereika, Susan M. ; Gentry, Amanda L. ; Duquette, Jennie E. ; Casillo, Frances E. ; Marsland, Anna ; Brufsky, Adam M. ; Evans, Steven ; Gorantla, Vikram C. ; Grahovac, Tara L. ; McAuliffe, Priscilla F. ; Steiman, Jennifer G. ; Zhu, Yehui ; Erickson, Kirk I.

Physical activity may improve cognitive function in women with breast cancer. In a cross-sectional study, we explored the relationship between cognitive function and physical activity (actigraph) and cardiorespiratory fitness (sub-maximal graded exercise test) in 73 postmenopausal women with early stage breast cancer prior to the initiation of systemic adjuvant therapy. Cognitive function was assessed with a standardized battery of neurocognitive measures assessing eight domains. Data were [...]

Menée à partir de données portant sur 8 932 patientes atteintes d'un cancer du sein de stade I à III, cette étude prospective analyse l'association entre l'indice et la charge glycémiques de l'alimentation, l'indice et la charge insuliniques mesurés après le diagnostic de cancer et la mortalité spécifique et toutes causes confondues

Post-diagnostic dietary glycemic index, glycemic load, dietary insulin index, and insulin load and breast cancer survival

Farvid, Maryam S. ; Tamimi, Rulla M. ; Poole, Elizabeth M. ; Chen, Wendy Y. ; Rosner, Bernard A ; Willett, Walter C. ; Holmes, Michelle D. ; Eliassen, A. Heather

Background: We investigated the associations of post-diagnostic dietary glycemic index (GI), glycemic load (GL), insulin index (II), and insulin load (IL) with breast cancer-specific and all-cause mortality. Methods: Among 8,932 women with stage I-III breast cancer identified in the Nurses' Health Study (NHS) (1980-2010) and NHSII (1991-2011), we prospectively evaluated the associations between post-diagnostic GI, GL, II, and IL, and breast cancer-specific and all-cause mortality. Participants [...]

Menée en Suède à partir de données portant sur 1 275 patientes atteintes d'un cancer du sein, cette étude de cohorte analyse leur santé reproductive (nombre d'enfants vivants à la naissance, utilisation de techniques de reproduction médicalement assistée) selon leur recours aux techniques de préservation de la fertilité au moment du diagnostic de cancer (425 cas et 850 témoins)

Reproductive Outcomes After Breast Cancer in Women With vs Without Fertility Preservation

Marklund, Anna ; Lundberg, Frida E. ; Eloranta, Sandra ; Hedayati, Elham ; Pettersson, Karin ; Rodriguez-Wallberg, Kenny A.

Importance : The practice of fertility preservation (FP) in women with breast cancer (BC) is spreading, but long-term reproductive outcomes after FP are largely unknown. Objective :To investigate the long-term reproductive outcomes in women who did or did not undergo FP at the time of BC diagnosis. Design, Setting, and Participants : A Swedish nationwide cohort study was conducted to investigate the long-term reproductive outcomes of women with BC receiving FP at 1 of the regional FP programs [...]

Menée au Royaume-Uni à partir de données portant sur 11 337 patientes atteintes d'un carcinome canalaire in situ diagnostiqué entre 2003 et 2012, cette étude de cohorte prospective analyse les caractéristiques de la maladie et les traitements associés (durée médiane de suivi : 9,4 ans)

Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project

Shaaban, Abeer M. ; Hilton, Bridget ; Clements, Karen ; Provenzano, Elena ; Cheung, Shan ; Wallis, Matthew G. ; Sawyer, Elinor ; Thomas, Jeremy S. ; Hanby, Andrew M. ; Pinder, Sarah E. ; Thompson, Alastair M. ; on behalf of the Sloane Project Steering, Committee

Background : The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes. Methods : This was a national, prospective cohort study of DCIS diagnosed during 2003–2012. Results : Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion of high-grade disease increased (from 60 to 65%), low-grade DCIS decreased (from 10 to 6%) and mean size increased (from 21.4 to 24.1 mm). Mastectomy was more common for [...]

Menée en Autriche auprès de 848 patients atteints d'un cancer, cette étude transversale analyse la corrélation entre la présence d'une douleur et l'intensité de la douleur, des symptômes de stress post-traumatique ainsi que des symptômes de dépression et d'anxiété

Prevalence of Pain and its Association with Symptoms of Post-Traumatic Stress Disorder, Depression, Anxiety, and Distress in 846 Cancer Patients: a Cross Sectional Study

Matthias, Unseld ; Zeilinger Elisabeth, L. ; Matthäus, Fellinger ; Simone, Lubowitzki ; Katharina, Krammer ; Nader Ingo, W. ; Matthias, Hafner ; Anna, Kitta ; Feroniki, Adamidis ; Masel Eva, K. ; Matthias, Preusser ; Ulrich, Jäger ; Alexander, Gaiger

Objective : Pain depicts a severe physical symptom but its relationship to mental health problems is not well studied in cancer patients. The aim of this study was to investigate the prevalence of pain and its correlation with symptoms of post-traumatic stress disorder (PTSD), depression, anxiety, and psychological distress in a large sample of cancer patients. Methods : From 2010 to 2019, cancer patients who received outpatient treatment at the Medical University of Vienna, were assessed with [...]

Menée au Danemark par questionnaire auprès de 117 patients atteints d'un cancer et recevant des traitements, cette étude analyse l'intérêt d'un outil leur permettant de mesurer leur capacité à retourner travailler et leur sentiment d'auto-efficacité au travail ainsi que de déclarer leur détresse psychologique

Validation of the Return To Work Self-Efficacy questionnaire in a population of employees undergoing treatment for cancer

Rosbjerg, Rikke ; Hansen, Dorte Gilså ; Zachariae, Robert ; Stapelfeldt, Christina Malmose ; Hoejris, Inger ; Rasmussen, Mathias Tvilling ; Drysdale, Susanne Wiben ; Labriola, Merete

Objective : Several Return To Work Self‐Efficacy (RTWSE) questionnaires have been developed and found relevant to understanding the return to work (RTW) process of employees with various health problems, including employees with cancer. The aim of the present study was to examine the reliability and validity of the Danish 19‐item RTWSE questionnaire (RTWSE‐19DK) in a sample of employees with cancer. Methods : Employees undergoing treatment for cancer completed the RTWSE‐19DK at baseline (n = [...]

Menée par questionnaire auprès de 40 patients ayant survécu à un cancer de la tête et du cou, cette étude analyse l'association entre la capacité de résilience et la qualité de vie

Resilience: an essential element in head and neck cancer survivorship and quality of life

MacDonald, Chelsea ; Theurer, Julie A. ; Fung, Kevin ; Yoo, John ; Doyle, Philip C.

Individuals with head and neck cancer (HNCa) face myriad biopsychosocial challenges. Even after treatment completion, these challenges may cause continued disablement and diminished quality of life (QoL). Resilience may serve to minimize the disabling impact of HNCa and, in turn, maximize QoL. The purpose of this study was to formally assess resilience in HNCa survivors and explore its relationship with QoL.

Menée aux Etats-Unis par enquêtes sur la période 2008-2017 (3 enquêtes, 10 063 répondants), cette étude analyse l'évolution des perceptions du grand public vis-à-vis de la dangerosité du cancer et le sentiment de fatalisme

Perceptions of Cancer as a Death Sentence: Tracking Trends in Public Perceptions from 2008 to 2017

Moser, Richard P. ; Arndt, Jamie ; Jimenez, Tyler ; Liu, Benmei ; Hesse, Bradford W.

Objective : There has been steady progress in reducing cancer mortality in the United States; however, this progress hasn't been evenly distributed across regions. This paper assesses trends in cancer mortality salience (CMS), that is, agreeing that getting cancer is a death sentence, over time in the US and examines correlates of CMS. Methods : Data from three administrations of the Health Information National Trends Survey (HINTS), gathered in 2008, 2013 and 2017, were merged, resulting in a [...]