Menée en Australie sur la période 2006-2009 par questionnaire auprès de 226 162 participants âgés de 45 ans ou plus et à l'aide de données 2013 d'un registre des cancers (durée médiane de suivi : 5,4 ans), cette étude analyse l'association entre les habitudes de consommation d'alcool et le risque de cancer par localisation (17 332 cas)

Alcohol consumption, drinking patterns and cancer incidence in an Australian cohort of 226,162 participants aged 45 years and over

Sarich, Peter ; Canfell, Karen ; Egger, Sam ; Banks, Emily ; Joshy, Grace ; Grogan, Paul ; Weber, Marianne F.

Background: Although overall alcohol consumption is known to increase the risk of a number of cancers internationally, evidence for Australia and evidence regarding the pattern of drinking and cancer risk is limited. Methods: Adjusted hazard ratios (HR) and 95% confidence intervals (CI) for cancer risk in relation to overall alcohol consumption (drinks/week) and pattern of drinking were calculated using Cox proportional hazard regressions for 226,162 participants aged ≥45 years (2006–2009) in [...]

Menée aux Etats-Unis à partir des données d'une enquête réalisée sur la période 2011-2014 et portant sur 4 527 hommes de plus de 18 ans, cette étude analyse l'association entre le fait d'avoir effectué le service militaire (1 352 hommes) et le risque de développer un cancer

Is there an association between a history of military service and cancer diagnosis? Results from a US national-level study of self-reported outcomes

Goldberg, Hanan ; Noorani, Rodrigo ; Benton, John Z. ; Lodh, Atul ; Berlin, Alejandro ; Chandrasekar, Thenappan ; Wallis, Christopher J. D. ; Ahmad, Ardalan E. ; Klaassen, Zachary ; Fleshner, Neil E.

Purpose: To examine cancer prevalence in men with and without military service history, using national-level self-reported outcomes. Methods: A cross-sectional survey-based US study, including men aged 18 and above from the Health Information National Trends Survey database between 2011 and 2014. The primary endpoint was self-reported cancer prevalence. Multivariable logistic regression analyses assessed the association of various covariates with the prevalence of cancer. Results: A total of [...]

Menée au Royaume-Uni à l'aide de données portant sur 4 113 patients atteints d'un cancer du pancréas et sur 16 072 témoins, cette étude analyse l'association entre une utilisation de digoxine (indiquée pour une insuffisance cardiaque) et le risque de développer la maladie, ainsi que la survie associée

Digoxin use is associated with pancreatic cancer risk but does not affect survival

Boursi, Ben ; Huber, Jared S. ; Haynes, Kevin ; Mamtani, Ronac ; Yang, Yu-Xiao

Purpose: Digoxin affects several cellular pathways involved in tumorigenesis. We sought to determine the association between digoxin use and pancreatic cancer risk and survival. Methods: A nested case–control study using The Health Improvement Network (THIN), a population-representative database from the United Kingdom (UK). Cases included all individuals with incident diagnosis of pancreatic cancer. Each case was matched to up to four controls using incidence density sampling based on age, [...]

Menée auprès d'une cohorte française incluant 7 670 patients ayant survécu à un premier cancer diagnostiqué durant l'enfance entre 1946 et 2000, cette étude identifie, en fonction du type de tumeur et des traitements reçus, des facteurs associés au risque de développer une tumeur cérébrale (512 cas)

Risk factors of subsequent central nervous system tumors after childhood and adolescent cancers: findings from the French Childhood Cancer Survivor Study

Journy, Neige Marie Yvanne ; Zrafi, Wael Salem ; Bolle, Stéphanie ; Fresneau, Brice ; Alapetite, Claire ; ALLODJI, Rodrigue S ; Berchery, Delphine ; Haddy, Nadia ; Kobayashi, Isao ; Labbé, Martine ; Pacquement, Hélène ; Pluchart, Claire ; Schwartz, Boris ; Souchard, Vincent ; Thomas-Teinturier, Cécile ; Veres, Cristina ; Vu-Bezin, Giao ; Diallo, Ibrahima ; de Vathaire, Florent

Background: Childhood or adolescent cancer survivors are at increased risks of subsequent primary neoplasms (SPN) of the central nervous system (CNS) after cranial irradiation. In a large multicentric cohort, we investigated clinical and therapeutic factors associated with the long-term risk of CNS SPN, and quantified the dose-response relationships. Methods: We selected all CNS SPN cases diagnosed up to 2016 among members of the French Childhood Cancer Survivor Study at least 5 years after [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données issues de consortiums génétiques portant sur 114 530 patients atteints d'un cancer et sur 245 284 témoins, cette étude analayse l'association entre les concentrations sériques d'adipokines spécifiques et le risque de cancers liés à l'obésité (colon-rectum, pancréas, rein, ovaire et endomètre)

Circulating adipokine concentrations and risk of five obesity-related cancers: a Mendelian randomization study

Dimou, Niki L ; Papadimitriou, Nikos ; Mariosa, Daniela ; Johansson, Mattias ; Brennan, Paul ; Peters, Ulrike ; Chanock, Stephen J ; Purdue, Mark ; Bishop, D Timothy ; Gago-Dominquez, Manuela ; Giles, Graham G ; Moreno, Víctor ; Platz, Elizabeth A ; Tangen, Catherine M ; Wolk, Alicja ; Zheng, Wei ; Wu, Xifeng ; Campbell, Peter T ; Giovannucci, Edward ; Lin, Yi ; CCFR, Endometrial Cancer Association Consortium ; Gunter, Marc J ; Murphy, Neil

Obesity is considered a chronic inflammatory state characterised by continued secretion of adipokines and cytokines. Experimental and epidemiological evidence indicates that circulating adipokines may be associated with the development of obesity-related cancers, but it is unclear if these associations are causal or confounded. We examined potential causal associations of specific adipokines [adiponectin, leptin, soluble leptin receptor (sOB-R), and plasminogen activator inhibitor-1 (PAI-1)] [...]

Menée en Chine en milieu hospitalier sur la période 2018-2019 auprès de 208 patientes atteintes d'un cancer du sein et 340 témoins (âge : 40-70 ans), cette étude analyse l'association entre le volume du sein et le risque de développer la maladie

Relationship between formulaic breast volume and risk of breast cancer based on linear measurements

Li, Xiaoxia ; Zhou, Chunlan ; Wu, Yanni ; Chen, Xiaohong

Background: Whether breast volume is a risk factor for breast cancer is controversial. This study aimed to evaluate whether a significant association between breast volume and risk of breast cancer, based on linear measurements, was present by applying propensity score matching (PSM). Methods: The study was designed as a hospital-based case-control study. Between March 2018 and May 2019, 208 cases and 340 controls were retrospectively reviewed. Information on menarche, smoking, feeding mode, [...]

Menée en Italie auprès de 3 184 patientes ayant été traitées chirugicalement pour des lésions cervicales intraépithéliales de haut grade (durée de suivi : 20 022 personnes-années), cette étude analyse le risque de survenue de tumeurs extra-cervicales liées au papillomavirus humain

Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia

Preti, Mario ; Rosso, Stefano ; Micheletti, Leonardo ; Libero, Carola ; Sobrato, Irene ; Giordano, Livia ; Busso, Paola ; Gallio, Niccolò ; Cosma, Stefano ; Bevilacqua, Federica ; Benedetto, Chiara

Background: The aim was to estimate the risk of subsequent extra-cervical Human Papillomavirus (HPV) related cancer in patients surgically treated for high grade cervical intraepithelial neoplasia (CIN 2–3). This is the first study in Italy investigating the occurrence of extra-cervical tumors in this cohort of patients. Methods: 3184 patients surgically treated for CIN2–3 since 1992 at the Department of Surgical Sciences of University of Torino were considered. The risk of HPV-related cancer [...]