A partir d'une revue systématique de la littérature publiée entre janvier 2014 et juin 2020 (12 études, 8 362 participants), cette méta-analyse évalue l'efficacité de la cigarette électronique en tant qu'aide au sevrage tabagique

Effectiveness of Electronic Cigarettes in Smoking Cessation: a Systematic Review and Meta-Analysis

Grabovac, I ; Oberndorfer, M ; Fischer, J ; Wiesinger, W ; Haider, S ; Dorner, T E

Reports of the effectiveness of e-cigarettes (ECs) for smoking cessation vary across different studies making implementation recommendations hard to attain. We performed a systematic review and meta-analysis to assess the current evidence regarding effectiveness of ECs for smoking cessation.PubMed, PsycInfo and Embase databases were searched for randomized controlled trials comparing nicotine ECs with non-nicotine ECs or with established smoking cessation interventions (nicotine replacement [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2020 (6 essais randomisés, 8 541 patients), cette méta-analyse évalue l'association entre une utilisation de metformine et le risque de cancer de la peau chez des patients diabétiques

Risk of skin cancer associated with metformin use: A meta-analysis of randomized controlled trials and observational studies

Chang, Michael S. ; Hartman, Rebecca I ; Xue, Junchao ; Giovannucci, Edward L. ; Nan, Hongmei ; Yang, Keming

Previous studies demonstrate mixed evidence regarding the association between metformin and skin cancer risk. To synthesize prior evidence and evaluate the association between metformin and skin cancer risk in patients with diabetes/prediabetes, we conducted a meta-analysis. A systematic literature search was performed up to March 23, 2020 to identify randomized controlled trials (RCTs) and observational studies of metformin that reported any event of squamous cell carcinoma (SCC), basal cell [...]

Menée à l'aide de données de l'assurance maladie taïwanaise portant sur 221 361 témoins et sur 222 024 utilisateurs de psychotropes ISRS (inhibiteurs sélectifs de la recapture de la sérotonine ; âge : au moins 16 ans), cette étude analyse l'association entre une utilisation de ces médicaments et le risque de cancer du rein

Association Between Selective Serotonin Reuptake Inhibitors and Kidney Cancer Risk: A Nationwide Population-Based Cohort Study

Lee, Min-Jing ; Huang, Chien-Wei ; Chen, Yi-Lung ; Yang, Yao-Hsu ; Chen, Vincent Chin-Hung

The association between selective serotonin reuptake inhibitor (SSRI) exposure and cancer incidence has been investigated; however, no epidemiological study has investigated the association between exposure to individual SSRIs and kidney cancer incidence. The aim of this study is to examine whether SSRI use affected the risk of kidney cancer. We conducted a population-based retrospective cohort study using data from Taiwan’s National Health Insurance Research Database. After adjusting for sex, [...]

Mené sur 21 patients présentant des lésions précancéreuses de stade avancé de la cavité buccale ou du larynx, cet essai de phase 1b évalue la toxicité d'un traitement chimiopréventif combinant un extrait de thé vert (polyphénon E) et l'erlotinib pendant 6 mois

Phase 1B Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck

Shin, Dong M. ; Nannapaneni, Sreenivas ; Patel, Mihir R. ; Shi, Qiuying ; Liu, Yuan ; Chen, Zhengjia ; Chen, Amy ; El-Deiry, Mark W. ; Beitler, Jonathan J ; Steuer, Conor E ; Roser, Steven M ; Klein, Adam M ; Owonikoko, Taofeek K. ; Ramalingam, Suresh S. ; Khuri, Fadlo Raja ; Chen, Zhuo G ; Saba, Nabil F.

Purpose: Based on synergistic effects between green tea polyphenon E (PPE) and epidermal growth factor receptor-tyrosine kinase inhibitor in preclinical studies, we conducted a phase 1b study of the PPE and erlotinib combination in patients with advanced premalignant lesions (APL) of the oral cavity and larynx. Patients and Methods: Patients were treated with a fixed dose of PPE (200mg 3x day) and dose escalation of erlotinib (50, 75, 100 mg daily) for 6-months (6-M) with tissue biopsy at [...]

Mené aux Etats-Unis en 2017-2018 sur 2 415 fumeurs de cigarettes (durée de suivi : jusqu'à 12 mois), cet essai randomisé évalue l'efficacité, du point de vue de l'abstinence tabagique auto-déclarée, d'une application pour smartphone basée sur la thérapie d'acceptation et d'engagement (ACT)

Efficacy of Smartphone Applications for Smoking Cessation: A Randomized Clinical Trial

Bricker, Jonathan B. ; Watson, Noreen L. ; Mull, Kristin E. ; Sullivan, Brianna M. ; Heffner, Jaimee L.

Smoking is a leading cause of premature death globally. Smartphone applications for smoking cessation are ubiquitous and address barriers to accessing traditional treatments, yet there is limited evidence for their efficacy.To determine the efficacy of a smartphone application for smoking cessation based on acceptance and commitment therapy (ACT) vs a National Cancer Institute smoking cessation application based on US clinical practice guidelines (USCPG).A 2-group, stratified, double-blind, [...]