Oh GxE! The Complexity of Body Mass Index and Colon Cancer Risk

Menée aux Etats-Unis à partir de données de registres portant sur 14 059 patients atteints d'un cancer colorectal et sur 14 416 témoins (53,2% de femmes), cette étude d'association sur le génome entier analyse l'influence de l'indice de masse corporelle sur le risque, lié à des variants de susceptibilité, de développer la maladie, en fonction du sexe

Résumé en anglais

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women in the world with 1.8 million new cases reported in 2018. Colorectal cancer has a complex etiology involving genetic, environmental and behavioral interactions that are poorly understood. The association between body mass index (BMI) and outcomes in patients diagnosed with CRC has been previously described and analyses of other surrogates of obesity, e.g., waist circumference and/or waist-to-hip ratio have shown similar relationship to CRC. The relationship of BMI with CRC cancer risk, however, remains nuanced, complex and debatable.