Menée aux Etats-Unis auprès de 532 patients atteints d’un cancer, cette étude pilote analyse la faisabilité et l’intérêt d’une intervention intégrant les membres de la famille du patient pour l’aider dans le sevrage tabagique (durée de l’intervention : 18 mois)

Using a Family Systems Approach to Treat Tobacco Use Among Cancer Patients

Ellen Ruebush, Sara Mitra, Colleen Meyer (et al.)

Tobacco use treatment is an essential component of cancer care. Family members play a significant role in smoking behavior, but more research is needed regarding the development, implementation, and impact of family-based interventions in cancer care. The UNC Tobacco Treatment Program conducted an 18-month pilot study to examine the feasibility of implementing a family systems approach to treat tobacco use among patients at the North Carolina Cancer Hospital and to measure the impact of such an [...]

Menée en Allemagne à partir de données portant sur 481 patients atteints d’un cancer de stade avancé récemment diagnostiqué (âge moyen : 62,4 ans), cette étude de cohorte évalue la sévérité des symptômes et le niveau de qualité de vie

Severe symptoms and very low quality-of-life among outpatients newly diagnosed with advanced cancer: data from a multicenter cohort study

Siemens, W., Schönsteiner, S.S., Orellana-Rios, C.L. (et al.)

Purpose : The aim of this study was to identify symptoms of severe intensity or very low scores for quality of life (QoL) domains in newly diagnosed outpatients with advanced cancer. Methods : This multicenter cohort study from a state-wide palliative care network included adult outpatients with advanced cancer diagnosed within the preceding 8 weeks from four comprehensive cancer centers (DRKS00006162, registered on 19 May 2014). We used the Palliative Outcome Scale (POS), Hospital Anxiety and [...]

A partir d’une revue systématique de la littérature publiée jusqu’en février 2019 (19 articles, 6 088 patientes), cette étude analyse les effets, sur la qualité de vie, d’une mastectomie controlatérale prophylactique chez les patientes atteintes d’un cancer du sein de stade précoce et à risque moyen de récidive

Contralateral prophylactic mastectomy for unilateral breast cancer in women at average risk? systematic review of patient reported outcomes

Amilee Srethbhakdi, Meagan E. Brennan, Geaty Hamid (et al.)

Objective : The rate of contralateral prophylactic mastectomy (CPM) in women with early, unilateral cancer is relatively high and is increasing around the world.1, 2 Women choose this option for many reasons other than reducing their risk of future cancer, including symmetry, reasons related to breast reconstruction and attempting to manage fear of recurrence. This systematic review evaluated patient?reported quality of life outcomes following CPM. Methods : A literature search of MEDLINE, [...]

Menée en Belgique par questionnaire auprès de 185 patientes ayant survécu à un cancer du sein et souffrant d’un lymphœdème lié à la maladie, cette étude transversale analyse l’association entre des facteurs liés à la patiente (âge, activité physique, indice de masse corporelle, etc.), des facteurs cliniques (stade, durée du lymphœdème, volume du bras, etc.), les traitements anticancéreux reçus et des dysfonctionnements physiques

Physical activity level and age contribute to functioning problems in patients with breast cancer-related lymphedema: a multicentre cross-sectional study

Tessa De Vrieze, Nick Gebruers, Ines Nevelsteen (et al.)

Purpose : Breast cancer survivors face a high risk of developing breast cancer-related lymphedema (BCRL). Besides physical symptoms such as swelling, BCRL can have a psychosocial impact and lead to problems in daily functioning. Understanding contributing variables to problems in functioning yields possibilities to improve treatment modalities and consequently patients’ quality of life. Therefore, the aim of this study was to explore the association between patient-, lymphedema-, and cancer [...]

Menée aux Etats-Unis à partir de données portant sur 1 815 patients ayant survécu 1 an ou plus à un cancer du testicule, cette étude analyse l’association entre la survenue d’événements indésirables induits par une chimiothérapie à base de cisplatine (neuropathie périphérique, perte auditive, acouphènes, maladie rénale, etc.), des caractéristiques sociodémographiques et ethniques et la situation professionnelle (chômage)

Relationship of Cisplatin-Related Adverse Health Outcomes with Disability and Unemployment Among Testicular Cancer Survivors

Sarah L Kerns, Chunkit Fung, Sophie D Fossa (et al.)

Background : Few data exist on the relationship of cisplatin-related adverse health outcomes (AHOs) with disability, unemployment, and self-reported health (SRH) among testicular cancer survivors (TCS). Methods : 1,815 TCS ?1 year post-chemotherapy underwent clinical examination and completed questionnaires. Treatment data were abstracted from medical records. A cumulative burden of morbidity score (CBMPt) encompassed the number/severity of platinum-related AHOs (peripheral sensory neuropathy [...]

Menée au Canada par enquête auprès de 223 patients atteints d’un cancer de la tête et du cou récemment diagnostiqué, cette étude prospective analyse leurs besoins en soins de support juste après les traitements anticancéreux

Immediate post-treatment supportive care needs of patients newly diagnosed with head and neck cancer

Melissa Henry, Ali Alias, Maria Cherba (et al.)

Objective : This study aimed at identifying supportive care needs of patients with head and neck cancer (HNC-P) immediately post-treatment, finding early predictors of unmet needs, and contrasting how immediate post-treatment needs differed from needs in longer-term survivorship. Methods : Prospective longitudinal study of 223 consecutive adults (313 approached; 72% participation) newly diagnosed with a first occurrence of primary HNC. Patients completed the Supportive Care Needs Survey–Short [...]

Menée sur la période 1990-2017, cette étude internationale analyse l’évolution des facteurs associés au risque de cancer primitif du foie

Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990-2017

Zhenqiu Liu, Chen Suo, Xianhua Mao (et al.)

Background : The incidence of primary liver cancer (PLC) continues to increase worldwide. The incidence trends and patterns of PLC associated with different age at diagnosis remain unknown. Methods : We collected detailed information on PLC between 1990 and 2017 from Global Burden of Disease Study 2017. Estimated annual percentage changes in the PLC age?standardized incidence rate (ASR) diagnosed by age, sex, region, and etiology were calculated to quantify the temporal trends in PLC ASR. [...]

Menée en France par questionnaire auprès de 2 965 patients ayant survécu à un cancer pendant l’enfance, cette étude analyse les facteurs associés au risque de petite taille à l’âge adulte (âge lors des traitements, type de traitement reçu, taille au diagnostic, etc.)

Risk Factors for Small Adult Height in Childhood Cancer Survivors

Charlotte Demoor-Goldschmidt, Rodrigue S. Allodji, Neige Journy (et al.)

PURPOSE : Between 10% and 20% of childhood cancer survivors (CCS) experience impaired growth, leading to small adult height (SAH). Our study aimed to quantify risk factors for SAH or growth hormone deficiency among CCS. METHODS : The French CCS Study holds data on 7,670 cancer survivors treated before 2001. We analyzed self-administered questionnaire data from 2,965 CCS with clinical, chemo/radiotherapy data from medical records. SAH was defined as an adult height ? 2 standard deviation scores [...]

Menée aux Etats-Unis sur la période 2004-2014 à partir de données portant sur 72 036 patients atteints d’un cancer de la prostate à haut risque de récidive (âge médian : 63 ans), cette étude de cohorte analyse l’association entre des facteurs sociodémographiques, médicaux et ethniques, et l’utilisation d’une thérapie non définitive (traitement systémique, surveillance active) en traitement initial

Association of Sociodemographic and Health-Related Factors With Receipt of Nondefinitive Therapy Among Younger Men With High-Risk Prostate Cancer

Alexander F. Bagley, Mitchell S. Anscher, Seungtaek Choi (et al.)

Importance : Multiple randomized clinical trials have shown that definitive therapy improves overall survival among patients with high-risk prostate cancer. However, many patients do not receive definitive therapy because of sociodemographic and health-related factors. Objective : To identify factors associated with receipt of nondefinitive therapy (NDT) among patients aged 70 years and younger with high-risk prostate cancer. Design, Setting, and Participants : This cohort study identified [...]

Menée à Taïwan à partir des données du registre des cancers portant sur 16 676 patients atteints d’un diabète et d’un cancer colorectal diagnostiqué entre 2004 et 2014, cette étude de cohorte analyse l’association entre une utilisation de metformine après le diagnostic de cancer et la survie (période de suivi : 64 322 personnes-années ; 11 438 utilisateurs de metformine ; 7 393 décès dont 4 845 décès par cancer colorectal)

Postdiagnostic Metformin Use and Survival of Patients With Colorectal Cancer: A Nationwide Cohort study

Wen?Kuan Huang, Shu?Hao Chang, Hung?Chih Hsu (et al.)

Epidemiological evidence for the association between postdiagnostic metformin use and survival in patients with colorectal cancer (CRC) remains limited. Using the Taiwan Cancer Registry database, a cohort of 16,676 diabetic patients newly diagnosed with CRC from January 1, 2004 through December 31, 2014, followed until December 31, 2016, was identified. Postdiagnostic use of metformin (two or more prescriptions after CRC diagnosis) was defined as a time?dependent covariate with 6?month lag. [...]

Menée à partir des données portant sur 1 244 patients atteints d’un ostéosarcome (âge moyen au diagnostic : 16 ans), cette étude de séquençage de l’exome entier (pour 1 104 patients) ou de séquençage ciblé (pour 104 patients) identifie la fréquence de variants constitutionnels pathogènes dans des gènes de susceptibilité à la maladie

Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma

Lisa Mirabello, Bin Zhu, Roelof Koster (et al.)

Importance : Osteosarcoma, the most common malignant bone tumor in children and adolescents, occurs in a high number of cancer predisposition syndromes that are defined by highly penetrant germline mutations. The germline genetic susceptibility to osteosarcoma outside of familial cancer syndromes remains unclear. Objective : To investigate the germline genetic architecture of 1244 patients with osteosarcoma. Design, Setting, and Participants Whole-exome sequencing (n?=?1104) or targeted [...]

A partir d’une revue systématique de la littérature (14 études), cette étude analyse les coûts associés à la conciliation médicamenteuse dans le cadre du traitement des patients atteints d’un cancer, et évalue l’effet de ces bilans comparatifs de médicaments sur les erreurs de médication et l’utilisation de soins de santé

Clinical and economic impact of medication reconciliation in cancer patients: a systematic review

Chloé Herledan, Amandine Baudouin, Virginie Larbre (et al.)

Purpose : Medication reconciliation can reduce drug-related iatrogenesis by facilitating exhaustive information transmission at care transition points. Given the vulnerability of cancer patients to adverse drug events, medication reconciliation could provide a significant clinical benefit in cancer care. This review aims to synthesize existing evidence on medication reconciliation in cancer patients. Methods : A comprehensive search was performed in the PubMed/Medline, Scopus, and Web of [...]

Menée aux Etats-Unis, cette étude passe en revue les données permettant d’analyser l’évolution depuis 2010 des effets, sur l’accès aux soins pour les patients atteints d’un cancer, de la loi sur la protection des patients et les soins abordables ("Obamacare")

The Affordable Care Act and access to care across the cancer control continuum: A review at 10 years

Jingxuan Zhao, Ziling Mao BS, Stacey A. Fedewa (et al.)

Lack of health insurance coverage is strongly associated with poor cancer outcomes in the United States. The uninsured are less likely to have access to timely and effective cancer prevention, screening, diagnosis, treatment, survivorship, and end?of?life care than their counterparts with health insurance coverage. On March 23, 2010, the Patient Protection and Affordable Care Act (ACA) was signed into law, representing the largest change to health care delivery in the United States since the [...]

Menée aux Etats-Unis par enquête sur la période 2011-2017 auprès d’un total de 10 276 patients ayant survécu à un cancer (6 176 cas âgés de 18 à 64 ans et 4 100 cas âgés de 65 à 74 ans), cette étude analyse l’effet de la loi sur la protection des patients et les soins abordables ("Obamacare") sur l’utilisation des médicaments en lien avec leur coût

Impact of the Patient Protection and Affordable Care Act on cost?related medication underuse in nonelderly adult cancer survivors

Justin M. Barnes, Kimberly J. Johnson, Eric Adjei Boakye (et al.)

Background : Cost?related medication underuse (CRMU), a measure of access to care and financial burden, is prevalent among cancer survivors. The authors quantified the impact of the Patient Protection and Affordable Care Act (ACA) on CRMU in nonelderly cancer survivors. Methods : Using National Health Interview Survey data (2011?2017) for cancer survivors aged 18 to 74 years, the authors estimated changes in CRMU (defined as taking medication less than prescribed due to costs) before [...]

Menée aux Etats-Unis par enquête auprès d’oncologues, cette étude analyse leurs connaissances relatives aux coûts liés aux traitements anticancéreux, leurs compétences pour aller trouver de l’information en matière d’aides financières pour leurs patients et leur capacité à communiquer avec eux au sujet de la toxicité financière des traitements et des soins

Cost health literacy as a physician skill-set: the relationship between oncologist reported knowledge and engagement with patients on financial toxicity

Fischer, K.A., Walling, A., Wenger, N. (et al.)

Introduction : Oncologists are increasingly encouraged to communicate with patients about cost; however, they may lack the cost health literacy required to effectively perform this task. Methods : We conducted a pilot survey of oncologists in an academic medical center to assess potential factors that may influence provider attitudes and practices related to financial toxicity. We assessed perceived provider knowledge of treatment costs, insurance coverage and co-pays, and financially focused [...]

Menée aux Etats-Unis à partir de données portant sur 15 092 patients décédés d’un cancer entre 2010 et 2017, cette étude de cohorte rétrospective analyse l’association entre la présence de maladies chroniques, la rédaction de directives anticipées, et l’utilisation et l’intensité des soins de fin de vie

The Association between Chronic Conditions, End-of-Life Health Care Use, and Documentation of Advance Care Planning among Patients with Cancer

Cara L. McDermott, Ruth A. Engelberg, James Sibley (et al.)

Background: Multiple chronic conditions (MCCs) are associated with increased intensity of end-of-life (EOL) care, but their effect is not well explored in patients with cancer. Objective: We examined EOL health care intensity and advance care planning (ACP) documentation to better understand the association between MCCs and these outcomes. Design: Retrospective cohort study. Setting/Subjects: Patients aged 18+ years at UW Medicine who died during 2010–2017 with poor prognosis cancer, with or [...]